Comparison between sensitivity and specificity of thyroid elastography and fine needle aspiration cytology in differentiating the nature of thyroid nodules

Abstract Background Nodular goiter is the most frequent disease of the thyroid gland, it may affect up to 50% of adults and elderly people, Although malignancy only occurs in about 5% of thyroid nodules, the detection rate of papillary thyroid carcinoma has increased consistently both in women and men and in all ethnic groups Thus, the task of differentiating malignant from benign nodules is necessary. Ultrasound elastography (USE) is a non-invasive, completely painless for the patient and can be easily performed even during routine ultrasound examinations. It assesses lesion stiffness by evaluating tissue distortion in response to stress. Objective Study the role of strain elastography in the characterization of benign and malignant nature of the thyroid nodule Compare the sensitivity and specificity of ultrasound elastography (USE) and fineneedle aspiration cytology (FNAC) as preoperative predictor of malignancy in order to decrease the need for FNAC. Cytology report is the gold standard/ histopathology report if available. Patients and Methods Type of Study: Cross-sectional study. Study Setting: The study was conducted at Ain Shams University Hospitals. Patients: 32 patients, 16 benign, and 16 malignant Patients with thyroid nodules proven by FNAC referred to Ain Shams University Radiology Unit. Results After analysis of strain index (SI) and the elasto score with FNAC we found the cut of point for thyroid malignancy was >1.4 and >2 respectively. The sensitivity and specificity of strain index (SI) for thyroid malignancy diagnosis were 100% and 75%, respectively. The positive and negative predictive values were 80% and 100%, respectively its p-value was 0.000, being a highly significant test.The US-elastography score’s sensitivity and specificity for thyroid malignancy diagnosis both were 81.25%. The positive and negative predictive values both were 81.2%, its pvalue was 0.000, being a highly significant test. After the Postoperative histopathology which is done to only ten patients of the 32 patients with available results (31.3%), 4 of them were benign (12.5%), and six were malignant (18.8%), We conclude that the Elasto ratio is the most sensitive diagnostic test with NPP (negative predictive value) of 100 % being the best screening test while the FNAC is the most specific test with PPV(positive predictive value) of 100 % being the best diagnostic test while the elasto score’s p-value was 0.065, being a a non-significant test. Despite this good diagnostic performance, USE with SI assessment not yet meets all requirements for an optimal diagnostic tool as its specificity is only 75%, while that of FNAC is almost reaching 100% compared to the postoperative histopathology Conclusion Strain elastography was highlighted as a good tool for pre-operative differentiation of benign from malignant lesions showing high sensitivity and moderate specificity compared to other studies, thus further decreasing thyroid biopsies and surgeries. The most reliable tool in our study was the elasto ratio having the highest sensitivity. Ultrasound examination in combination with elastography is a well-tolerated, non-invasive, and cost-effective diagnostic tool in the pre-operative assessment of thyroid nodules, which is able to enhance the accuracy of assessing the risk of malignancy in thyroid nodules and for selecting nodules for FNAC, thus can be used to postpone the FNAC to decrease the amount of the unnecessary FNAC.

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THYROID NODULES EVALUATION BY STRAIN ULTRASOUND ELASTOGRAPHY AND HISTOCYTOLOGICAL CORRELATION

SRMS Journal of Medical Science ◽

10.21761/jms.v1i2.7124 ◽

2016 ◽

Vol 1 (2) ◽

Author(s):

Abhinav Pandit ◽

Neeraj Prajapati ◽

Harish Chandra Pant ◽

Rajneesh Madhok ◽

Rohit Sharma ◽

...

Keyword(s):

Predictive Value ◽

Thyroid Nodules ◽

Needle Aspiration ◽

Ultrasound Elastography ◽

Tissue Stiffness ◽

Benign Lesions ◽

Aspiration Cytology ◽

Dynamic Technique ◽

Needle Aspiration Cytology ◽

Diagnosis Of Thyroid Cancer

INTRODUCTION: Elastography is a newly developed dynamic technique that uses ultrasound to provide an estimation of tissue stiffness by measuring the degree of distortion under the application of an external force. Ultrasound elastography has been applied to differentiate malignant from benign lesions. MATERIAL AND METHODS: This study included 53 consecutive patients with thyroid nodules. High resolution ultrasound elastography examination, scoring and further fine needle aspiration cytology was done in all of the cases. Tissue stiffness on ultrasound elastography was scored from one (greatest elastic strain) to five (no strain). RESULTS: Fifty three cases were evaluated by real time ultrasound elastography. Seventeen (33%), 22 (39%), 6 (12%), 6 (12%), 2 (4%) were assigned score of 1,2,3,4 and 5 respectively. The elasticity scores 4–5 were highly predictive of malignancy with a sensitivity of 87.5%, a specificity of 97.6%, a positive predictive value of 87.5%, and a negative predictive value of 97.6%. CONCLUSION: Ultrasound elastography has great potential as an adjunctive tool for the diagnosis of thyroid cancer. Larger prospective studies are needed to confirm these results and establish the diagnostic accuracy of this new technique.

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Screening for aneurysms of the abdominal aorta using a simple screening device

The Ultrasound Journal ◽

10.1186/s13089-020-00192-5 ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

J. W. Brakel ◽

T. A. Berendsen ◽

P. M. C. Callenbach ◽

J. van der Burgh ◽

R. J. Hissink ◽

...

Keyword(s):

Negative Predictive Value ◽

Sensitivity And Specificity ◽

Abdominal Aorta ◽

Predictive Value ◽

Cost Effective ◽

Abdominal Ultrasound ◽

Predictive Values ◽

Bladder Scan ◽

Health Council ◽

Screening Device

Abstract Introduction Several countries advocate screening for aneurysms of the abdominal aorta (AAA) in selected patients. In the Netherlands, routine screening is currently under review by the National Health Council. In any screening programme, cost-efficiency and accuracy are key. In this study, we evaluate the Aorta Scan (Verathon, Amsterdam, Netherlands), a cost-effective and easy-to-use screening device based on bladder scan technology, which enables untrained personnel to screen for AAA. Methods We subjected 117 patients to an Aorta Scan and compared the results to the gold standard (abdominal ultrasound). We used statistical analysis to determine sensitivity and specificity of the Aorta Scan, as well as the positive and negative predictive values, accuracy, and inter-test agreement (Kappa). Results Sensitivity and specificity were 0.86 and 0.98, respectively. Positive predictive value was 0.98 and negative predictive value was 0.88. Accuracy was determined at 0.92 and the Kappa value was 0.85. When waist–hip circumferences (WHC) of > 115 cm were excluded, sensitivity raised to 0.96, specificity stayed 0.98, positive and negative predictive value were 0.98 and 0.96, respectively, accuracy to 0.97, and Kappa to 0.94. Conclusion Herein, we show that the Aorta Scan is a cost-effective and very accurate screening tool, especially in patients with WHC below 115 cm, which makes it a suitable candidate for implementation into clinical practice, specifically in the setting of screening selected populations for the presence of AAA.

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Accuracy of shear wave elastography in characterization of thyroid nodules in children and adolescents

Insights into Imaging ◽

10.1186/s13244-021-01074-7 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Mohammed Hazem ◽

Ossama M. Zakaria ◽

Mohamed Yasser Ibrahim Daoud ◽

Ibrahim Khalid Al Jabr ◽

Abdulwahab A. AlYahya ◽

...

Keyword(s):

Children And Adolescents ◽

Shear Wave ◽

Diagnostic Performance ◽

Thyroid Nodules ◽

Shear Wave Elastography ◽

Invasive Technique ◽

Predictive Values ◽

Patients Âgés ◽

Non Invasive

Abstract Background Thyroid nodules are an important health problem in children and adolescents. They possess a higher risk of malignancy in comparison to adults. This fact forms a great dilemma for clinicians. The aim of this study was to evaluate the reliability of shear wave elastography (SWE) as a non-invasive technique in the characterization of thyroid nodules in children and adolescents. Methods This prospective study included 56 patients with thyroid nodules. All the patients underwent clinical assessment, laboratory investigations, ultrasound, and Doppler examination, followed by an SWE assessment. Statistical analysis was performed and the best cut-off value to differentiate benign from malignant nodules was determined using the ROC curve and AUC. Results Seventy-two nodules were detected in the examined patients (ages ranged from 11 to 19 years, with mean age of 14.89 ± 2.3 years). Fifty-eight nodules (80.6%) were benign, and fourteen nodules (19.4%) were malignant (histopathologically proved). Highly suspicious criteria for prediction of malignancy by ultrasound and Doppler were hypoechoic echopattern, internal or internal and peripheral vascularity, microcalcifications, taller-than-wide dimensions, irregular outlines, and absence of halo (p < 0.05). The diagnostic performance for their summation was 70.69% sensitivity, 82.8% specificity, 80.45% accuracy, a 63.79% positive predictive value (PPV), and 87.9% negative predictive values (NPV). Regarding SWE, our results showed that 42.2 kPa was the best cut-off value, with AUC = 0.921 to differentiate malignant from benign nodules; the diagnostic performance was 85.71% sensitivity, 94.83% specificity, 93.06% accuracy, 76.9% PPV, and 93.2% NPV. Conclusion Shear wave elastography is a non-invasive technique that can assist in the diagnosis of malignant thyroid nodules among children and adolescents.

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Diagnostic Value of CK19, HBME-1 and TROP2 Biomarkers in Identification of Different Types of Thyroid Follicular Neoplasms

ACTA MEDICA IRANICA ◽

10.18502/acta.v59i1.5397 ◽

2021 ◽

Author(s):

Shohreh Vojuhi ◽

Masoud Mohebbi ◽

Zohreh Mousavi ◽

Mohammadali Yaghoubi ◽

Reza Ziaolhagh

Keyword(s):

Positive Predictive Value ◽

Papillary Carcinoma ◽

Predictive Value ◽

Thyroid Nodules ◽

Follicular Adenoma ◽

Thyroid Neoplasms ◽

Diagnostic Value ◽

Cross Sectional ◽

Predictive Values ◽

Different Types

Thyroid malignancies are found in 7% to 15% of all thyroid nodules. Immunohistochemical markers, including CK19, HBME-1and TROP2, have shown an effective role in identifying these malignancies. Hence, due to the lack of appropriate diagnostic tests for the identification of thyroid neoplasms, in this study, we aimed to determine the diagnostic value of these biomarkers in the identification of different types of follicular thyroid neoplasms. In this cross-sectional study, paraffin-embedded tissue blocks from the surgical resection of patients with thyroid nodules, referring to Imam Reza and Razavi Hospitals of Mashhad in 2017, were studied. Sensitivity, specificity, and positive and negative predictive values of these biomarkers for the identification of different types of follicular thyroid neoplasms were also studied. 129 patients with a mean age of 44.65±12.59 years participated in this study, of whom 101 (78.29%) were women. The most common type of follicular thyroid neoplasm was papillary carcinoma (60.47%). The highest sensitivity (94.87%) and positive predictive value (68.51%) in the detection of follicular neoplasms was observed by CK19 in papillary carcinoma. The sensitivity and positive predictive value of TROP2 in the detection of papillary neoplasms was 93.58% and 75.25%, respectively. In addition, HBME-1 had the highest specificity (72.54 %) and positive predictive value (81.57%) in identifying this neoplasm. The results of this study showed that CK19, HBME-1, and TROP2 had high diagnostic value in the detection of papillary thyroid neoplasms. Although these biomarkers had low diagnostic value in identifying follicular adenoma and carcinoma, given the high negative predictive value, they can be considered as powerful markers in identifying negative cases.

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Association of Bacteria Species with Positive Predictive Value of Bacteria Isolated from Cerebrospinal Fluid Cultures: A Retrospective Cohort Study

10.21203/rs.3.rs-703030/v1 ◽

2021 ◽

Author(s):

Yi Ye ◽

Guanghui Zheng ◽

Yueyue Kong ◽

Jiawei Ma ◽

Guojun Zhang ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Cohort Study ◽

Positive Predictive Value ◽

Retrospective Cohort Study ◽

Predictive Value ◽

Retrospective Cohort ◽

Klebsiella Oxytoca ◽

P Value ◽

Coagulase Negative Staphylococci ◽

Predictive Values

Abstract Background: Previous studies discuss the positive predictive value through whether the bacteria are coagulase-negative staphylococci. The view may need to be updated. The aim was to evaluate the positive predictive value of different bacteria species isolated from cerebrospinal fluid cultures and discuss the rationality to view coagulase-negative staphylococci as a group.Methods: This retrospective cohort study recruit all adults with positive cerebrospinal fluid cultures sampled by lumbar puncture 2012-2020 in the Department of Neurosurgery. The exposure was bacteria species, and the outcome was positive predictive value. An episode was defined as a patient with one bacteria. When episodes with a bacteria species reached five, the bacteria species was analyzed specifically. The positive predictive value was defined as the incidence of isolated-bacteria-related infected episodes. The isolated-bacteria-related infected episode was defined as the patient was with clinical features of bacterial meningitis, and the improvement was related to sensitive antibacterial agents. Then the differences of the positive predictive value of different bacteria in all specific bacteria species, coagulase-negative staphylococci, and non-coagulase-negative staphylococci bacteria were calculated, respectively. The results were statistically significant when P-value <.05.Results: 1180 episodes from 1133 patients with 79 bacteria were studied; the positive predictive value was 54.3%. The bacteria included 67 bacteria species, ten bacteria genus, viridans streptococci, and unclassified coagulase-negative staphylococci. Twenty-four specific bacteria species were analyzed. The range of positive predictive values of them was 29.4%-100.0% (P<.0001). The positive predictive value for Enterobacter aerogenes, Pseudomonas aeruginosa, Enterobacter cloacae, and Klebsiella oxytoca was the highest, while the positive predictive value for Staphylococcus cohnii was the lowest. Moreover, 767 (65.0%) were with coagulase-negative staphylococci, the positive predictive value was 46.4%, and the range was 29.4%-85.7% (P=.0020); 413 (35.0%) were with non-coagulase-negative staphylococci bacteria, the positive predictive value was 69.0%, and the range was 40.0%-100.0% (P<.0001).Conclusions: This study suggests that the positive predictive value of different bacteria species is different. It is more reasonable to discuss the positive predictive value of bacteria isolated from cerebrospinal fluid cultures through the bacteria species rather than whether they are coagulase-negative staphylococci.Trial registration: This is a retrospective study without interventions on participants.

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Early identification of patients at risk of acute severe pancreatitis with Systemic Inflammatory Response Syndrome score at admission

Journal of Kathmandu Medical College ◽

10.3126/jkmc.v8i2.28171 ◽

2019 ◽

Vol 8 (2) ◽

pp. 92-95

Author(s):

Uttam Laudari ◽

Abishek Thapa ◽

Tanka Prasad Bohara ◽

Shail Rupakheti ◽

Mukund Raj Joshi

Keyword(s):

Acute Pancreatitis ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Predictive Value ◽

College Teaching ◽

Systemic Inflammatory Response ◽

P Value ◽

Predictive Values ◽

Acute Severe Pancreatitis ◽

Severe Pancreatitis

Background: Clinically, the Systemic Inflammatory Response Syndrome (SIRS) is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnea and change in blood leukocyte count. The relationship between SIRS symptoms at the time of presentation and severity of pancreatitis is yet to be determined though progression of SIRS in subsequent days has already been correlated.Objectives: To determine the severity of pancreatitis with SIRS score at the time of admission.Methodology: A retrospective cohort study of patients admitted to Department of Surgery, Kathmandu Medical College Teaching Hospital (KMCTH) with diagnosis of Acute Pancreatitis (AP) from December 2014 to January 2016 was conducted. Clinical, biochemical and imaging data were collected from the medical record section. Patients with diagnosis of acute pancreatitis as per Revised Atlanta Classification 2012 were included in the study. SIRS score at time of admission was correlated with Modified Marshall scoring system for organ dysfunction. Patients were grouped into severe and nonsevere group. Sensitivity, specificity and predictive values of SIRS score at admission for organ failure were calculated.Results: Among the 41 patients admitted with diagnosis of acute pancreatitis irrespective of cause, the sensitivity of SIRS score ≥2 at admission in predicting severe pancreatitis was 60 %, specificity was 20%, positive predictive value was 28% and negative predictive value was 20 %, with p-value of 0.52 and odds ratio of 1.6 (CI: 0.376-6.808).Conclusion: SIRS score at admission cannot be solely used in predicting acute severe pancreatitis. Patients can be stratified in resource deficit setting for timely referral to tertiary centre.

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Volume of sputum to detect acid-fast bacilli as a measure of quality for the diagnosis of pulmonary tuberculosis at the Dr George Mukhari Hospital, South Africa

African Journal of Primary Health Care & Family Medicine ◽

10.4102/phcfm.v3i1.240 ◽

2011 ◽

Vol 3 (1) ◽

Author(s):

Iqbal Rashid ◽

Langalibalele H. Mabuza ◽

Indiran Govender ◽

Deidre Pretorius

Keyword(s):

South Africa ◽

Pulmonary Tuberculosis ◽

Positive Predictive Value ◽

Negative Predictive Value ◽

Predictive Value ◽

P Value ◽

Likelihood Ratios ◽

Cross Sectional ◽

Predictive Values ◽

Acid Fast Bacilli

Background: Optimum sputum results for acid-fast bacilli (AFB) microscopy are linked to a sputum quantity of at least 5.0 mL. This study was aimed at establishing the effect of sputum quantity in the pick-up rate of AFB microscopy by comparing sputum samples of 5.0 mL and 2.0 mL.Methods: An analytical cross-sectional study was carried out at the Dr George Mukhari Hospital (DGMH) in Pretoria, South Africa, from 05 January 2007 to 04 January 2008.Two sputum samples, 5.0 mL and 2.0 mL, were collected from each of the 330 adult PTB (pulmonary tuberculosis) suspects. Fluorescence microscopy was used in the sputum analysis. The yield through microscopy of the 2.0 mL specimen versus the 5.0 mL specimen was compared and analysed, using culture results as the gold standard.Results: From a sample of 330 specimens, 77 tested AFB positive on microscopy. In the 5.0 mL samples, the sensitivity was 76.6% (95% CI, 66.0% – 84.7%), specificity 99.6% (95% CI 97.8% – 99.9%), positive predictive value (PV+) 98.3% (95% CI 91.1% – 99.7%), negative predictive value (PV-) 93.3% (95% CI 89.7% – 95.7%), the likelihood ratio (LR) for a positive microscopy 192 and the LR for a negative test was 0.23. In the 2.0 mL specimens, the sensitivity was 75.3% (95% CI 64.6% – 83.6%), specificity 99.2% (95% CI 97.1% – 99.8%), positive predictive value (PV+) 96.7% (95% CI 88.6% – 99.1%), negative predictive value (PV-) 93.0% (95% CI 89.3% – 95.4%), the LR for a positive microscopy was 94 and 0.25 for a negative microscopy. There was a statistically significant association (p-value < 0.001) between the microscopy and culture tests in both the 5.0 mL and the 2.0 mL specimen categories. The strength of association between the microscopy and culture, as indicated by the kappa test was 0.83 and 0.81 in the 5.0 mL and 2.0 mL categories, respectively.Conclusion: Compared to the 2.0 mL specimen category, the yield for AFB microscopy in the 5.0 mL specimen category was consistently superior, as indicated by the higher sensitivity, specificity, predictive values and the likelihood ratios in the 5.0 mL specimen category. It is recommended that sputum specimen collection for AFB microscopy should aim for a minimum volume of 5.0 mL.

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Comparison of Elastographic Strain Index and Thyroid Fine-Needle Aspiration Cytology in 631 Thyroid Nodules

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2013-2672 ◽

2013 ◽

Vol 98 (12) ◽

pp. 4790-4797 ◽

Cited By ~ 24

Author(s):

Flavia Magri ◽

Spyridon Chytiris ◽

Valentina Capelli ◽

Margherita Gaiti ◽

Francesca Zerbini ◽

...

Keyword(s):

Negative Predictive Value ◽

Fine Needle Aspiration ◽

Predictive Value ◽

Fine Needle Aspiration Cytology ◽

Thyroid Nodules ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Strain Index ◽

Fine Needle ◽

Needle Aspiration Cytology

Context: Ultrasound (US) elastography (USE) was recently been reported as a sensitive, noninvasive tool for identifying thyroid cancer. However, the accuracy of this technique is hampered by the intra- and interoperator variability, some US features of the nodule, and the coexistence of autoimmune thyroid disease (ATD). Objectives: The purpose of this article was to assess the accuracy of USE findings in the differential diagnosis of thyroid nodules compared with other US features to evaluate its feasibility in the presence of ATDs and identify the strain index (SI) cutoff with the highest diagnostic performance. Design: We evaluated 528 consecutive patients for a total of 661 thyroid nodules. All nodules underwent fine-needle aspiration cytology (FNAC) and USE evaluation. The SI was calculated as a ratio of the nodule strain divided by the strain of the softest part of the surrounding normal tissue. Results: The median SI value was significantly higher in THY4 and THY5 than in THY2 nodules in ATD-positive, ATD-negative, and ATD-unknown patients. The cutoff of SI for malignancy was estimated to be 2.905 by receiver operating characteristic curve analysis in a screening set (379 FNAC results), and then tested in a replication set (252 FNAC results). In all cases, a SI value of ≥2.905 conferred to the nodule a significantly greater probability of being malignant. This SI cutoff had the greatest area under the curve, sensitivity, and negative predictive value, compared with the conventional US features of malignancy. Conclusion: The elastographic SI has a high sensitivity, specificity, and negative predictive value for the diagnosis of thyroid malignancy both in the presence and in the absence of ATD. If our data on USE are also confirmed in THY3 nodules, FNAC could be avoided in a number of thyroid nodules with certain features.

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Mentorship on malaria microscopy diagnostic service in Ethiopia: Baseline competency of microscopists and performance of health facilities

10.21203/rs.3.rs-87991/v2 ◽

2021 ◽

Author(s):

Bokretsion Gidey ◽

Desalegn Nega ◽

Adugna Abera ◽

Abnet Abebe ◽

Sindew Mekasha ◽

...

Keyword(s):

Sensitivity And Specificity ◽

Predictive Value ◽

False Negative ◽

Malaria Diagnosis ◽

Health Facilities ◽

Malaria Parasites ◽

Cross Sectional ◽

Predictive Values ◽

Microscopic Diagnosis ◽

Malaria Microscopy

Abstract Background: In Ethiopia, malaria cases are declining as a result of proven interventions and in 2017, the country launched a malaria elimination strategy in targeted settings. Accurate malaria diagnosis and prompt treatment are the key components of the strategy to prevent morbidity and stop the continuation of transmission. However, the quality of microscopic diagnosis in general is deteriorating as malaria burden declines. Therefore, this study was carried out to evaluate the competency of microscopists and the performance of health facilities on malaria microscopic diagnosis.Methods: A cross-sectional study was conducted from August 1st to September 30th, 2019 in nine regional states and one city administration. A standard checklist was used for on-site evaluation, archived patient slides were re-checked, and proficiency of microscopists was tested using WHO certified slides from the national slide bank at the Ethiopian Public Health Institute (EPHI). The strength of agreement, the sensitivity, the specificity, and the positive and negative predictive values were calculated.Results: In this study, 102 health facilities (84 health centers and 18 hospitals) were included; from which, 202 laboratory professionals participated. In slide re-checking, moderate agreement (Agreement: 76.0%; Kappa: 0.41) was observed between experts and microscopists on malaria detection in all health facilities. The sensitivity and specificity of routine slide reading and the re-checking results were 78.1% and 80.7%, respectively. Likewise, positive predictive value of 65.1% and negative predictive value of 88.8% were scored in the routine diagnosis. By panel testing, a substantial overall agreement (A: 91.8%; K: 0.79) was observed between microscopists and experts in detecting malaria parasites. The sensitivity and specificity in the detection of malaria parasites was 92.7% and 89.1%, respectively. Furthermore, in identifying species, a slight agreement (A: 57%; K: 0.18) was observed between microscopists and experts. Conclusion: The study found significant false positive and false negative results in routine microscopy on slide re-checking of Plasmodium parasites. Moreover, reduced grade in parasite species identification was reported on the panel tests. Therefore, implementing comprehensive malaria microscopy mentorship, in-service training, and supportive supervision are the key strategies to improve the overall performance of health facilities in malaria microscopy.

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Efficacy of Sonoelastography Images in Solitary Cold Thyroid Nodule and Compared with Fine Needle Aspiration Cytology Findings (FNAC)

Bangladesh Journal of Nuclear Medicine ◽

10.3329/bjnm.v19i2.35914 ◽

2018 ◽

Vol 19 (2) ◽

pp. 103 ◽

Cited By ~ 1

Author(s):

Jasmin Ferdous ◽

Mahbub Ur Rahman ◽

Hosne Ara Rahman ◽

Jamiul Hossain ◽

Samira Sharmin ◽

...

Keyword(s):

Thyroid Nodule ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Ultrasound Elastography ◽

Aspiration Cytology ◽

Predictive Values ◽

Fine Needle ◽

The Mean ◽

Needle Aspiration Cytology

Objective: To evaluate the validity of sonoelastography of cold thyroid nodule in diagnosis of malignant nodule with fine needle aspiration cytology analysis as the reference standard.Patients and Methods: This cross sectional study was conducted in the Institute of Nuclear Medicine & Allied Sciences (INMAS), Sir Salimullah Medical College (SMC) & Mitford Hospital campus, Dhaka, from July 2015 to June 2016 in 85 patients with solitary solid cold nodule. Eighty five nodules in these patients were examined by conventional ultrasound, ultrasound elastography and radionuclidescan. The final diagnosis was obtained from cytological findings. Tissue stiffness on ultrasound elastography was scored from 1 (low stiffness over the entire nodule) to 4 (high stiffness over the entire nodule).Results: The mean age was found 33.8±10.1 years with range from 12 to 58 years and male to female ratio was 1:5.1. The mean size of nodules was found 2.0±0.6 cm. Most (40.0%) of the patients were found in elastography score 2, 22(25.9%) score 1, 17(20.0%) score 4 and 12(14.1%) score 3. The validity of elastography scores had sensitivity 77.8%, specificity 86.2%, accuracy 83.5%, positive predictive values 72.4% and negative predictive values 89.3% for prediction of thyroid nodule.Conclusion: Considering the validity parameter the elastography may be effective diagnostic modality for evaluation of thyroid nodule.Bangladesh J. Nuclear Med. 19(2): 103-106, July 2016

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