scholarly journals AVATAR Therapy for Distressing Voices: A Comprehensive Account of Therapeutic Targets

2020 ◽  
Vol 46 (5) ◽  
pp. 1038-1044 ◽  
Author(s):  
Thomas Ward ◽  
Mar Rus-Calafell ◽  
Zeyana Ramadhan ◽  
Olga Soumelidou ◽  
Miriam Fornells-Ambrojo ◽  
...  
Keyword(s):  
Side Effects ◽  
Future Development ◽  
Full Range ◽  
Therapeutic Targets ◽  
Digital Representation ◽  
Face To Face ◽  
Comprehensive Account ◽  
First Time ◽  
Therapy Delivery ◽  
Complete Account

Abstract AVATAR therapy represents an effective new way of working with distressing voices based on face-to-face dialogue between the person and a digital representation (avatar) of their persecutory voice. To date, there has been no complete account of AVATAR therapy delivery. This article presents, for the first time, the full range of therapeutic targets along with information on acceptability and potential side effects. Interest in the approach is growing rapidly and this report acts as a necessary touchstone for future development.

scholarly journals Impact of immunogenicity on clinical efficacy and toxicity profile of biologic agents used for treatment of inflammatory arthritis in children compared to adults

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110026
Author(s):  
Chinar R. Parikh ◽  
Jaya K. Ponnampalam ◽  
George Seligmann ◽  
Leda Coelewij ◽  
Ines Pineda-Torra ◽  
...  
Keyword(s):  
Side Effects ◽  
Clinical Efficacy ◽  
Inflammatory Arthritis ◽  
Biologic Agents ◽  
Adult Patients ◽  
Therapeutic Drug ◽  
Biologic Drugs ◽  
Therapeutic Implications ◽  
The Impact ◽  
First Time

The treatment of inflammatory arthritis has been revolutionised by the introduction of biologic treatments. Many biologic agents are currently licensed for use in both paediatric and adult patients with inflammatory arthritis and contribute to improved disease outcomes compared with the pre-biologic era. However, immunogenicity to biologic agents, characterised by an immune reaction leading to the production of anti-drug antibodies (ADAs), can negatively impact the therapeutic efficacy of biologic drugs and induce side effects to treatment. This review explores for the first time the impact of immunogenicity against all licensed biologic treatments currently used in inflammatory arthritis across age, and will examine any significant differences between ADA prevalence, titres and timing of development, as well as ADA impact on therapeutic drug levels, clinical efficacy and side effects between paediatric and adult patients. In addition, we will investigate factors associated with differences in immunogenicity across biologic agents used in inflammatory arthritis, and their potential therapeutic implications.

scholarly journals The flora of Cunningham Inlet, Somerset Island, Nunavut: history, analysis, and new collections of vascular plants, mosses, lichens, and algae

2015 ◽  
Vol 129 (1) ◽  
pp. 24 ◽  
Author(s):  
Paul C. Sokoloff
Keyword(s):  
Vascular Plants ◽  
Vascular Plant ◽  
North Coast ◽  
University Of Alberta ◽  
Comprehensive Account ◽  
The North ◽  
National Herbarium ◽  
History Analysis ◽  
Somerset Island ◽  
First Time

New collections of vascular plants, bryophytes, lichen, and algae are reported for Cunningham Inlet on the north coast of Somerset Island, Nunavut. This list of 48 species of vascular plants, 13 bryophytes, 10 lichens, and five algae includes 136 specimens collected in 2013 and 39 previously unreported specimens from the National Herbarium of Canada at the Canadian Museum of Nature (CAN), Agriculture and Agri-Food Canada’s Vascular Plant Herbarium (DAO), and University of Alberta (ALTA). Ten vascular plants from previous collecting in 1958 are re-reported here to give a comprehensive account of the vascular plant flora of the region. Two vascular plants are recorded for the first time for Somerset Island: Smooth Draba (Draba glabella Pursh) and Edlund’s Fescue (Festuca edlundiae S. G. Aiken, Consaul & Lefkovitch).

scholarly journals A Face-to-face Questionnaire Survey on the Use of Multiple Antipsychotics and the Manifestation of Side Effects in Outpatients with Schizophrenia

2011 ◽  
Vol 131 (11) ◽  
pp. 1605-1611
Author(s):  
Iori HIROSAWA ◽  
Mio OGINO ◽  
Yasunari MANO ◽  
Masataka TAJIMA ◽  
Kaori OHUCHI ◽  
...  
Keyword(s):  
Side Effects ◽  
Questionnaire Survey ◽  
Face To Face

Do You Remember E-Ferol? The Penalty for Selling Untested Drugs in Neonatology: Fines and a Jail Sentence

PEDIATRICS ◽  
1992 ◽  
Vol 89 (1) ◽  
pp. 159-159
Author(s):  
Jerold F. Lucey
Keyword(s):  
Vitamin E ◽  
Side Effects ◽  
Intravenous Vitamin ◽  
First Time

The most recent therapeutic disaster in neonatology occurred in 1984 when E-Ferol killed at least 38 newborns.1 It's not the first time that this kind of thing has happened. Let's hope it will be the last. Previous iatrogenic disasters have been caused primarily by well-intentioned physicians using logical therapies which turned out to have unexpected, lethal side effects. The E-Ferol chapter was a different story. A poorly managed, avaricious company, O'Neil, Jones and Feldman, Inc, a subsidiary of Carter-Glogau, decided to get the jump on the market and sell an untested preparation of intravenous vitamin E. The physicians assumed it had been tested and approved for use.

First-time mothers' experiences of the first stage of labour in hospitals in the HhoHho region, Eswatini

2021 ◽  
Vol 15 (1) ◽  
pp. 1-8
Author(s):  
Nonhlahla Mamba ◽  
Oslinah B Tagutanazvo
Keyword(s):  
Normal Vaginal Delivery ◽  
Hospital Data ◽  
Face To Face ◽  
First Time Mothers ◽  
Open Coding ◽  
Analyse Data ◽  
Labour Pains ◽  
Postpartum Mothers ◽  
First Time ◽  
Purposive Sample

Background/Aims Women have different and varying experiences of labour and their coping strategies vary as well. Having support during labour may help women feel in control of their labour. This study aimed to explore and describe the experiences of first-time mothers during the first stage of labour. Methods The study used a qualitative, exploratory, descriptive design. A purposive sample of nine first-time postpartum mothers were selected to participate following normal vaginal delivery at Mbabane Government Hospital. Data were collected through face-to-face interviews and analysed thematically. Open coding was used to analyse data. Results Four themes emerged: 1. Ignorance of the signs of labour 2. Anxiety related to fear 3. Maintaining adequate nutrition 4. Coping with labour pains. Each theme had several subcategories. Most participants were ignorant of the signs of labour and reported anxiety related to fear of the unknown and practiced different ways of coping with labour pains. Conclusions First-time mothers require adequate preparation for labour, as many women in this study were ignorant of the signs of labour and reported anxiety related to fear of the unknown. Pregnant women should be educated about the physiological aspects of the first stage of labour and oriented in the labour ward during the prenatal period.

Some Origins of Nationalism in East Africa

1968 ◽  
Vol 9 (1) ◽  
pp. 119-146 ◽  
Author(s):  
J. M. Lonsdale
Keyword(s):  
Central Government ◽  
Colonial Period ◽  
Political Activity ◽  
Colonial Rule ◽  
Face To Face ◽  
National Movements ◽  
New Type ◽  
First Time ◽  
Official Recognition

This paper attempts to provide a frame of reference for evaluating the role of ordinary rural Africans in national movements, in the belief that scholarly preoccupation with élites will only partially illumine the mainsprings of nationalism. Kenya has been taken as the main field of enquiry, with contrasts and comparisons drawn from Uganda and Tanganyika. The processes of social change are discussed with a view to establishing that by the end of the colonial period one can talk of peasants rather than tribesmen in some of the more progressive areas. This change entailed a decline in the leadership functions of tribal chiefs who were also the official agents of colonial rule, but did not necessarily mean the firm establishment of a new type of rural leadership. The central part of the paper is taken up with an account of the competition between these older and newer leaderships, for official recognition rather than a mass following. A popular following was one of the conditions for such recognition, but neither really achieved this prior to 1945 except in Kikuyuland, and there the newer leaders did not want official recognition. After 1945 the newer leadership, comprising especially traders and officials of marketing co-operatives, seems everywhere to have won a properly representative position, due mainly to the enforced agrarian changes which brought the peasant face to face with the central government, perhaps for the first time. This confrontation, together with the experience of failure in earlier and more local political activity, resulted in a national revolution coalescing from below, co-ordinated rather than instigated by the educated élite.

scholarly journals Use of Tablet Video for Delivery of Neonatal Discharge Instructions to First-Time Parents

2021 ◽  
Vol 53 (2) ◽  
pp. 145-147
Author(s):  
Kristine L. Cece ◽  
Jane E. Chargot ◽  
Micheleen Hashikawa ◽  
Melissa A. Plegue ◽  
Katherine J. Gold
Keyword(s):  
Randomized Controlled Trial ◽  
Patient Satisfaction ◽  
Controlled Trial ◽  
Patient Perceptions ◽  
Discharge Instructions ◽  
Face To Face ◽  
Randomized Controlled ◽  
Use Of Technology ◽  
Video Group ◽  
First Time

Background and Objectives: While video discharge instructions have been shown to improve retention of information and patient satisfaction, data are limited regarding patient perceptions of video tools. Methods: We conducted a randomized controlled trial to assess self-rated comprehension and overall satisfaction with video versus face-to-face neonatal discharge instructions in first-time mothers. Results: Video instructions were no different from face-to-face instructions, though there was a nonsignificant increase in confidence in caring for their newborn in the video group. Conclusions: Broader use of technology may allow for a more standardized approach to patient education and improve efficiency for clinicians, without compromising patient satisfaction and confidence in caring for themselves and their dependents.

scholarly journals RESTORATION OF STATEHOOD IN THE POLITICS OF MEMORY OF THE SECOND POLISH-LITHUANIAN COMMONWEALTH (THE CASE OF WESTERN UKRAINE)

2020 ◽  
pp. 24-40
Author(s):  
Vitalii Matviichuk
Keyword(s):  
The State ◽  
Reference Database ◽  
Politics Of Memory ◽  
Basic Principles ◽  
Memory Space ◽  
Western Ukraine ◽  
General Scientific ◽  
Historical Methods ◽  
First Time ◽  
Complete Account

The aim of the article is to study the politics of memory of the Second Polish-Lithuanian Commonwealth in the 1920s–1930s in Western Ukraine associated with the restoration of the Polish statehood. The methodology of scientific research is based on general scientific and special historical methods, including the basic principles of historical perception. The principles of historicism and scientific character of research enabled the author to recreate the politics of memory of the Second Polish-Lithuanian Commonwealth in Western Ukraine in all its complexity and diversity, as well as in interrelation and interdependence with the events of that time. The principle of objectivity facilitated the consideration of the outlined problems taking into account objective historical patterns and a critical analysis of the reference database. The principle of consistency provided the means to form a complete account of the corresponding commemorative practices. The scientific novelty of the research lies in the fact that for the first time the problem of reflecting the historical subject of the restoration of Poland in the political power of memory in Western Ukraine is studied on the basis of a big archive database. As a result, the author comes to the conclusion that the "memory" of the state restoration was actively implemented throughout its territory, including Western Ukraine. Due to the corresponding politics of memory, the Polish authorities tried to integrate Western Ukraine into a single social and cultural space, the creation of which was quite a difficult task for the postwar Poland. Historical subjects and various kinds of commemorations became unified on the entire territory of the state. Some of the local subjects, for example, "Lviv Eaglets" or the battles of legionnaires near Kostiukhnivka became national, and strengthened the position of the Polish state narrative in Western Ukrainian region. The author argues that the activity of memorialization in Western Ukrainian cities led to the filling of the memory space with Polish symbols. The paper considers the issue of formalism and monotony of Polish commemorative practices in Western Ukraine.

Genomics and Pharmacogenomics of Age-Related Hearing Loss

2021 ◽  
Vol 18 ◽  
Author(s):  
Joaquin Guerra ◽  
Vinogran Naidoo ◽  
Ramon Cacabelos
Keyword(s):  
Hearing Loss ◽  
Side Effects ◽  
Neurodegenerative Disorders ◽  
Therapeutic Targets ◽  
Vulnerable Population ◽  
Common Features ◽  
Control Side ◽  
Age Related ◽  
Human Genes ◽  
Age Related Hearing Loss

: Age-related hearing loss (ARHL) or presbycusis shares common features with conditions related to senescence and neurodegeneration. In this review, we explore the linking of genes involved in such processes with presbycusis, that has been proven to share important relationships with genes involved in dementia (APOE and MTHFR), ototoxicity (the GST group), and pharmacogenetics (NAT2). In this regard, we propose the construction of pharmacogenetics for the presbycusis database that could help better control side effects in this particularly vulnerable population susceptible to neurodegenerative disorders. Moreover, preliminary epigenetics studies have recently identified links in human genes involved in ARHL, which could serve as biomarkers or as therapeutic targets.

Peace Process

2021 ◽  
pp. 235-265
Author(s):  
Niall Ó Dochartaigh
Keyword(s):  
Peace Process ◽  
British Government ◽  
Face To Face ◽  
Joint Declaration ◽  
First Time ◽  
The Way

In February 1993, the British Government received, via the back-channel, a message purported to be from the IRA. It read: ‘The conflict is over but we need your advice on how to bring it to a close.’ This chapter elaborates the sequence of contacts that led to a secret face-to-face meeting between a British government representative and republican leaders for the first time since 1976 and that culminated in a secret IRA ceasefire offer in May 1993. It examines too the influence of the back-channel on the joint declaration by the British and Irish governments in December 1993, that helped to pave the way for an IRA ceasefire in August 1994.

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