Self-reported sleep relates to hippocampal atrophy across the adult lifespan: results from the Lifebrain consortium

Abstract Objectives Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal atrophy is typically seen with higher age. Hence, it is critical to establish how the relationship between sleep and hippocampal volume loss unfolds across the adult lifespan. Methods Self-reported sleep measures and MRI-derived hippocampal volumes were obtained from 3105 cognitively normal participants (18–90 years) from major European brain studies in the Lifebrain consortium. Hippocampal volume change was estimated from 5116 MRIs from 1299 participants for whom longitudinal MRIs were available, followed up to 11 years with a mean interval of 3.3 years. Cross-sectional analyses were repeated in a sample of 21,390 participants from the UK Biobank. Results No cross-sectional sleep—hippocampal volume relationships were found. However, worse sleep quality, efficiency, problems, and daytime tiredness were related to greater hippocampal volume loss over time, with high scorers showing 0.22% greater annual loss than low scorers. The relationship between sleep and hippocampal atrophy did not vary across age. Simulations showed that the observed longitudinal effects were too small to be detected as age-interactions in the cross-sectional analyses. Conclusions Worse self-reported sleep is associated with higher rates of hippocampal volume decline across the adult lifespan. This suggests that sleep is relevant to understand individual differences in hippocampal atrophy, but limited effect sizes call for cautious interpretation.

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Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium

10.1101/737858 ◽

2019 ◽

Cited By ~ 1

Author(s):

Anders M. Fjell ◽

Øystein Sørensen ◽

Inge K. Amlien ◽

David Bartrés-Faz ◽

Didac Maciá Bros ◽

...

Keyword(s):

Sleep Quality ◽

Hippocampal Volume ◽

Poor Sleep ◽

Hippocampal Atrophy ◽

Special Role ◽

Volume Loss ◽

Cross Sectional ◽

Adult Lifespan ◽

Age Related ◽

The Relationship

AbstractBackgroundPoor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal atrophy is typically seen with higher age. Hence, it is critical to establish how the relationship between sleep and hippocampal volume loss unfolds across the adult lifespan.MethodsSelf-reported sleep measures and MRI-derived hippocampal volumes were obtained from 3105 cognitively normal participants (18-90 years) from major European brain studies in the Lifebrain consortium. Hippocampal volume change was estimated from 5116 MRIs from 1299 participants, covering up to 11 years. Cross-sectional analyses were repeated in a sample of 21390 participants from the UK Biobank.ResultsThe relationship between self-reported sleep and age differed across sleep items. Sleep duration, efficiency, problems, and use of medication worsened monotonously with age, whereas subjective sleep quality, sleep latency, and daytime tiredness improved. Women reported worse sleep in general than men, but the relationship to age was similar. No cross-sectional sleep – hippocampal volume relationships was found. However, worse sleep quality, efficiency, problems, and daytime tiredness were related to greater hippocampal volume loss over time, with high scorers showing on average 0.22% greater annual loss than low scorers. Simulations showed that longitudinal effects were too small to be detected as age-interactions in cross-sectional analyses.ConclusionsWorse self-reported sleep is associated with higher rates of hippocampal decline across the adult lifespan. This suggests that sleep is relevant to understand individual differences in hippocampal atrophy, but limited effect sizes call for cautious interpretation.

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Modeling Hearing Loss Progression and Asymmetry in the Older Old: A National Population-Based Survey

Innovation in Aging ◽

10.1093/geroni/igaa057.693 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 214-215

Author(s):

Rahul Sharma ◽

Anil Lalwani ◽

Justin Golub

Keyword(s):

Hearing Loss ◽

Pure Tone ◽

Population Level ◽

Population Based ◽

National Database ◽

Cross Sectional ◽

Adult Lifespan ◽

Pure Tone Average ◽

Age Related ◽

Public Datasets

Abstract The progression and asymmetry of age-related hearing loss has not been well characterized in those 80 years of age and older because public datasets mask upper extremes of age to protect anonymity. We aimed to model the progression and asymmetry of hearing loss in the older old using a representative, national database. This was a cross-sectional, multicentered US epidemiologic analysis using the National Health and Nutrition Examination Study (NHANES) 2005-2006, 2009-2010, and 2011-2012 cycles. Subjects included non-institutionalized, civilian adults 80 years and older (n=621). Federal security clearance was granted to access publicly-restricted age data. Outcome measures included pure-tone average air conduction thresholds and the 4-frequency pure tone average (PTA). 621 subjects were 80 years old or older (mean=84.2 years, range=80-104 years), representing 10,600,197 Americans. Hearing loss exhibited constant acceleration across the adult lifespan at a rate of 0.0052 dB/year2 (95% CI = 0.0049, 0.0055). Compounded over a lifetime, the velocity of hearing loss would increase five-fold, from 0.2 dB loss/year at age 20 to 1 dB loss/year at age 100. This model predicted mean PTA within 2 dB of accuracy for most ages between 20 and 100 years. There was no change in the asymmetry of hearing loss with increasing age over 80 years (linear regression coefficient of asymmetry over age=0.07 (95% CI=-0.01, 0.24). In conclusion, hearing loss steadily and predictably accelerates across the adult lifespan to at least age 100, becoming near-universal. These population-level statistics will guide treatment and policy recommendations for hearing health in the older old.

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POS1465-HPR THE RELATIONSHIP BETWEEN SEDENTARY BEHAVIOR AND SLEEP IN RHEUMATOID ARTHRITIS: A CROSS-SECTIONAL STUDY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.641 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1017.2-1018

Author(s):

N. Kelly ◽

E. Hawkins ◽

H. O’leary ◽

K. Quinn ◽

G. Murphy ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Physical Activity ◽

Sleep Quality ◽

Sedentary Behavior ◽

Disease Duration ◽

Cross Sectional Study ◽

P Value ◽

Poor Sleep ◽

Cross Sectional ◽

The Relationship

Background:Rheumatoid arthritis (RA) is a chronic, autoimmune inflammatory condition that affects 0.5% of the adult population worldwide (1). Sedentary behavior (SB) is any waking behavior characterized by an energy expenditure of ≤1.5 METs (metabolic equivalent) and a sitting or reclining posture, e.g. computer use (2) and has a negative impact on health in the RA population (3). Sleep is an important health behavior, but sleep quality is an issue for people living with RA (4, 5). Poor sleep quality is associated with low levels of physical activity in RA (4) however the association between SB and sleep in people who have RA has not been examined previously.Objectives:The aim of this study was to investigate the relationship between SB and sleep in people who have RA.Methods:A cross-sectional study was conducted. Patients were recruited from rheumatology clinics in a large acute public hospital serving a mix of urban and rural populations. Inclusion criteria were diagnosis of RA by a rheumatologist according to the American College of Rheumatology criteria age ≥ 18 and ≤ 80 years; ability to mobilize independently or aided by a stick; and to understand written and spoken English. Demographic data on age, gender, disease duration and medication were recorded. Pain and fatigue were measured by the Visual Analogue Scale (VAS), anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS), and sleep quality was assessed using the Pittsburgh Sleep Quality Index. SB was measured using the ActivPAL4™ activity monitor, over a 7-day wear period. Descriptive statistics were calculated to describe participant characteristics. Relationships between clinical characteristics and SB were examined using Pearson’s correlation coefficients and regression analyses.Results:N=76 participants enrolled in the study with valid data provided by N=72 participants. Mean age of participants was 61.5years (SD10.6) and the majority 63% (n = 47) were female. Participant mean disease duration was 17.8years (SD10.9). Mean SB time was 533.7 (SD100.1) minutes (8.9 hours per day/59.9% of waking hours). Mean sleep quality score was 7.2 (SD5.0) (Table 1). Correlation analysis and regression analysis found no significant correlation between sleep quality and SB variables. Regression analysis demonstrated positive statistical associations for SB time and body mass index (p-value=0.03846, R2 = 0.05143), SB time and pain VAS (p-value=0.009261, R2 = 0.07987), SB time and HADS (p-value = 0.009721, R2 = 0.08097) and SB time and HADSD (p-value = 0.01932, R2 = 0.0643).Conclusion:We found high levels of sedentary behavior and poor sleep quality in people who have RA, however no statistically significant relationship was found in this study. Future research should further explore the complex associations between sedentary behavior and sleep quality in people who have RA.References:[1]Carmona L, et al. Rheumatoid arthritis. Best Pract Res Clin Rheumatol 2010;24:733–745.[2]Anon. Letter to the editor: standardized use of the terms “sedentary” and “sedentary behaviours”. Appl Physiol Nutr Metab = Physiol Appl Nutr Metab 2012;37:540–542.[3]Fenton, S.A.M. et al. Sedentary behaviour is associated with increased long-term cardiovascular risk in patients with rheumatoid arthritis independently of moderate-to-vigorous physical activity. BMC Musculoskelet Disord 18, 131 (2017).[4]McKenna S, et al. Sleep and physical activity: a cross-sectional objective profile of people with rheumatoid arthritis. Rheumatol Int. 2018 May;38(5):845-853.[5]Grabovac, I., et al. 2018. Sleep quality in patients with rheumatoid arthritis and associations with pain, disability, disease duration, and activity. Journal of clinical medicine, 7(10)336.Table 1.Sleep quality in people who have RASleep variableBed Time N(%) before 10pm13(18%) 10pm-12pm43 (60%) after 12pm16 (22%)Hours Sleep mean(SD)6.56 (1.54)Fall Asleep minutes mean(SD)33.3(27.7)Night Waking N(%)45(63%)Self-Rate Sleep mean(SD)2.74 (0.90)Hours Sleep mean(SD)6.56 (1.54)Disclosure of Interests:None declared

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The relationship between sleep hygiene and sleep quality among residents of an elderly care institution in DKI Jakarta

UI Proceedings on Health and Medicine ◽

10.7454/uiphm.v4i1.258 ◽

2020 ◽

Vol 4 (1) ◽

Author(s):

Mutia Annisa ◽

Dwi Nurviyandari Kusuma Wati

Keyword(s):

Sleep Quality ◽

Sleep Problems ◽

Elderly Care ◽

Sleep Hygiene ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Cross Sectional ◽

Cross Sectional Design ◽

The Relationship ◽

Purposive Sample

Objective: Elderly are at risk of poor slepp quality and other health problems due to reduced sleep satisfaction. The objective of this study was to explore the association between sleep hygiene and sleep quality in elderly.Methods: This was a descriptive study with cross sectional design. The study was conducted in four elderly care institutions in Jakarta, Indonesia, involving a purposive sample of 103 elderly aged 60 to 111 years old. Data were collected using Sleep Hygiene Index (SHI) and Pittsburgh Sleep Quality Index (PSQI).Results: Over half of the residents had poor sleep hygiene (51.5%) and more than three quarter (81.6%) had poor sleep quality. The study revealed that there was a highly significant relationship between sleep hygiene and sleep quality (p = 0.001). The study also showed that those with poor sleep hygiene were 7.834 times more likely to have poor sleep quality.Conclusion: Nurses need to include interventions that may address residents’ sleep problems. They also need to promote sleep hygiene and improve residents’ sleep quality.Keywords: elderly, institution, sleep hygiene, sleep quality

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Power Vector Analysis of Corneal Astigmatism among Chinese over Fifty Years Old: a retrospective cross-sectional study

10.21203/rs.3.rs-17216/v1 ◽

2020 ◽

Author(s):

Yilin Pang ◽

Xiaoguang Cao ◽

Xianru Hou ◽

Li Yuan ◽

Yongzhen Bao

Keyword(s):

Axial Length ◽

Linear Trend ◽

Linear Regression Analysis ◽

Corneal Astigmatism ◽

Vector Analysis ◽

Cross Sectional ◽

Age Related ◽

Relationship Of ◽

The Relationship ◽

Cataract Patients

Abstract Background: To investigate the relationship between corneal astigmatism and age, axial length (AL) among Chinese over fifty years old. Methods: This study enrolled 1,082 right eyes of age-related cataract patients over 50 years old in the clinic of Peking University People’s Hospital, Beijing, China. Axial length, magnitude and meridian of anterior corneal astigmatism were measured by IOLMaster. Restricted cubic splines and Spearman rank correlation coefficients were used to investigate the relationship of the magnitude of cornea astigmatism to age and AL. Power vector analysis method and linear regression analysis were used to assess the relationship of the meridian of astigmatism to age and AL. Results: For this study , mean age, AL, and corneal astigmatism value were 72.45 ±9.28 years, 23.90±1.93mm, and 1.12±0.74D, respectively. The magnitude of corneal astigmatism was 0.75D or higher in 63.8% eyes. The magnitude of corneal astigmatism increased with age after 65 years old. This correlation was statistically significant when AL was between 22.00mm and 26.00mm. The vector value in J 0 was inversely correlated with age. The mean vector value change from with-the-rule (WTR) to against-the-rule (ATR) corneal astigmatism was 0.22D/10 years during 50-65 years old and 0.15D/10 years during 65-85 years old, and was 0.22D/10 years in male and 0.12D/10 years in female, respectively. Conclusions: A large proportion of elderly Chinese cataract patients over 50 years old have corneal astigmatism more than 0.75D . There was a non-linear trend from WTR astigmatism towards ATR astigmatism with age, which was more obvious in elder age and in male. When AL is between 22.00mm and 26.00mm, the magnitude of corneal astigmatism increases with age after 65 years old.

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Exploring the relationship between local food environments and obesity in UK, Ireland, Australia and New Zealand: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2017-018701 ◽

2018 ◽

Vol 8 (2) ◽

pp. e018701 ◽

Cited By ~ 6

Author(s):

Andrea Fuentes Pacheco ◽

Gabriela Carrillo Balam ◽

Daryll Archibald ◽

Elizabeth Grant ◽

Valeria Skafida

Keyword(s):

New Zealand ◽

Assessment Tool ◽

Local Food ◽

Grey Literature ◽

Food Environments ◽

Longitudinal Case Study ◽

Cross Sectional ◽

Cross Sectional Studies ◽

The Uk ◽

The Relationship

IntroductionObesity is a global pandemic that affects all socioeconomic strata, however, the highest figures have been observed in the most disadvantaged social groups. Evidence from the USA and Canada showed that specific urban settings encourage obesogenic behaviour in the population living and/or working there. We aim to examine the evidence on the association between local food environments and obesity in the UK, Ireland, Australia and New Zealand.MethodsSix databases from 1990 to 2017 will be searched: MEDLINE (Ovid), Embase (Ovid), Scopus, The Cumulative Index to Nursing and Allied Health Literature (CINAHL), Applied Social Sciences Index and Abstracts (ASSIA) and Web of Science. Grey literature will also be sought by searching Opengrey Europe, The Grey Literature Report and relevant government websites. Additional studies will be retrieved from the reference lists of the selected articles. It will include cohort, longitudinal, case study and cross-sectional studies that have assessed the relationship between local food environments and obesity in the UK, Ireland, Australia and New Zealand regardless of sex, age and ethnicity of the population. Two researchers will independently select the studies and extract the data. Data items will incorporate: author names, title, study design, year of study, year exposure data collected, country, city, urban/rural, age range, study exclusions, special characteristics of study populations, aims, working definitions of food environments and food outlets, exposure and methods of data collection, outcomes and key findings. A narrative synthesis and a summary of the results will be produced separately for children and adults, according to the type of food exposure–outcome. All the selected studies will be assessed using The Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies.Ethics and disseminationThis study will be based on published literature, and therefore ethical approval has not been sought. Our findings will be presented at relevant national and international scientific conferences and published in a peer-reviewed journal.

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Diet and overweight and obesity in populations of African origin: Cameroon, Jamaica and the UK

Public Health Nutrition ◽

10.1017/s1368980007246762 ◽

2007 ◽

Vol 10 (2) ◽

pp. 122-130 ◽

Cited By ~ 20

Author(s):

M Jackson ◽

S Walker ◽

JK Cruickshank ◽

S Sharma ◽

J Cade ◽

...

Keyword(s):

Overweight And Obesity ◽

African Origin ◽

Cross Sectional ◽

Food Frequency ◽

Jamaican Women ◽

Rural Cameroon ◽

The Uk ◽

Relationship Of ◽

The Relationship ◽

Dietary Data

AbstractObjectivesTo determine the relationship of diet to overweight and obesity among populations of African origin.Design and settingCross-sectional data were obtained from adults aged 25–74 years in rural Cameroon (n = 686), urban Cameroon (n = 975), Jamaica (n = 924) and Afro-Caribbeans in the UK (n = 257). Dietary data were collected using food-frequency questionnaires specifically designed for each site. Body mass index (BMI) was used as a measure of overweight.ResultsThe expected gradient in the distribution of overweight across sites was seen in females (rural Cameroon, 9.5%; urban Cameroon, 47.1%; Jamaica, 63.8%; UK, 71.6%); however, among males overweight was less prevalent in Jamaica (22.0%) than urban Cameroon (36.3%). In developing countries increased risks of overweight (BMI ≥ 25 kg m− 2) were influenced by higher energy (urban Cameroonian men) and protein (Jamaican women) intakes. No dietary variables were associated with obesity (BMI ≥ 30 kg m− 2) in Cameroon or Jamaica. In the UK, energy intakes were inversely related with overweight whereas increased risks of being overweight were associated with higher protein (men) and fat (women) intakes. Similarly, whereas higher protein and fat intakes in UK men and women were associated with obesity, carbohydrate intakes were associated with decreased risks of obesity in men.ConclusionsDiet and overweight were associated in the UK but few dietary variables were related to overweight in Jamaica and the Cameroon. These findings suggest that associations between diet and overweight/obesity are not generalisable among populations.

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Exploring awareness of age-related changes among over 50s in the UK: findings from the PROTECT study

International Psychogeriatrics ◽

10.1017/s104161022100123x ◽

2021 ◽

pp. 1-15

Author(s):

Serena Sabatini ◽

Obioha C. Ukoumunne ◽

Clive Ballard ◽

Rachel Collins ◽

Anne Corbett ◽

...

Keyword(s):

Thought Processes ◽

Physical And Mental Health ◽

Cross Sectional ◽

Written Comments ◽

Age Related ◽

Perceived Age ◽

The Uk ◽

Protect Study ◽

Age Related Changes ◽

Theoretical Conceptualization

ABSTRACT Objectives: Older people describe positive and negative age-related changes, but we do not know much about what contributes to make them aware of these changes. We used content analysis to categorize participants’ written comments and explored the extent to which the identified categories mapped onto theoretical conceptualizations of influences on awareness of age-related change (AARC). Design: Cross-sectional observational study. Participants: The study sample comprised 609 UK individuals aged 50 years or over (mean (SD) age = 67.9 (7.6) years), enrolled in the PROTECT study. Measurements: Between January and March 2019, participants provided demographic information, completed a questionnaire assessing awareness of age-related change (AARC-10 SF), and responded to an open-ended question asking them to comment on their responses. Results: While some of the emerging categories were in line with the existing conceptual framework of AARC (e.g. experiencing negative changes and attitudes toward aging), others were novel (e.g. engagement in purposeful activities or in activities that distract from age-related thoughts). Analysis revealed some of the thought processes involved in selecting responses to the questionnaire items, demonstrating different ways in which people make sense of specific items. Conclusions: Results support the ability of the AARC questionnaire to capture perceived age-related changes in cognitive functioning, physical and mental health, and engagement in social activities and in healthy and adaptive behaviors. However, findings also suggest ways of enriching the theoretical conceptualization of how AARC develops and offer insights into interpretation of responses to measures of AARC.

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Plasma carotenoids and diabetic retinopathy

British Journal Of Nutrition ◽

10.1017/s0007114508006545 ◽

2008 ◽

Vol 101 (2) ◽

pp. 270-277 ◽

Cited By ~ 56

Author(s):

Laima Brazionis ◽

Kevin Rowley ◽

Catherine Itsiopoulos ◽

Kerin O'Dea

Keyword(s):

Risk Factors ◽

Diabetic Retinopathy ◽

Vitamin A ◽

Cross Sectional Study ◽

Age Related Macular Degeneration ◽

Cross Sectional ◽

Carotenoid Concentration ◽

Age Related ◽

Lifestyle Questionnaire ◽

The Relationship

Diabetic retinopathy increases with duration of diabetes and may be associated with carotenoid status. Carotenoids alter the pro-oxidation/antioxidation balance, and circulating levels depend largely on dietary intake. Lower levels have been reported in diabetes and age-related macular degeneration; however, little is known of the relationship between carotenoids and diabetic complications. Consequently, the purpose of the present study was to evaluate the relationship between plasma carotenoids and diabetic retinopathy. We assessed the carotenoid–retinopathy relationship in 111 individuals with type 2 diabetes in a community-based, cross-sectional study. We photodocumented retinal status and used HPLC to measure plasma carotenoid concentrations. Data for clinical and demographic variables and risk factors for diabetic retinopathy were obtained from 24 h urine and fasting blood samples, and an interviewer-assisted lifestyle questionnaire. We found that the combined lycopene and lutein/zeaxanthin (non-pro-vitamin A (non-PVA) carotenoid) concentration when compared with the pro-vitamin A (PVA) carotenoids (α-carotene, β-carotene and β-cryptoxanthin) was significantly lower in the retinopathy than non-retinopathy group (OR 1·2 (95 % CI 1·0, 1·4)v.1·6 (95 % CI 1·4, 1·7), respectively;P = 0·009). A higher non-PVA:PVA ratio also predicted a lower risk of diabetic retinopathy, after adjustment for potential confounders (OR 0·33 (95 % CI 0·12, 0·95);P = 0·039). Finally, a higher concentration of PVA carotenoids was associated with greater odds of diabetic retinopathy, after adjustment for risk factors (P = 0·049). We suggest synergies between carotenoids are implicated in diabetic retinopathy, independent of established risk factors. Importantly, our observations indicate dietary modulation of retinopathy risk may be possible by increasing intakes of lutein- and lycopene-rich foods.

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Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson’s Disease: A Cross-Sectional Study

Parkinson s Disease ◽

10.1155/2018/3751516 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 6

Author(s):

Andreas Waldner ◽

Sarah Dassati ◽

Bernhard Redl ◽

Nicola Smania ◽

Marialuisa Gandolfi

Keyword(s):

Healthy Subjects ◽

Neurological Impairment ◽

Cross Sectional Study ◽

Cross Sectional ◽

Age Related ◽

Healthy Control ◽

Apolipoprotein D ◽

The Relationship ◽

Small Hydrophobic

Apolipoprotein D (ApoD), a lipocalin transporter of small hydrophobic molecules, plays an important role in several neurodegenerative diseases. ApoD is expressed in and secreted from a variety of peripheral and brain tissues. Increments of ApoD have been reported in relation with oxidative stress conditions, aging, and degeneration in the nervous system. Preliminary findings support the role of ApoD in neuroprotection. However, its role in PD remains unclear. To date, no studies have been performed on the relationship between ApoD in the blood and PD, as neurodegenerative pathology related to oxidative damage. We investigated the concentration of ApoD in the blood of healthy control subjects and PD patients with mild-to-moderate neurological impairment. ApoD plasma levels were measured using sandwich enzyme-linked immunosorbent assays (ELISA) in 90 healthy subjects (aging-analysis cohort) and in 66 PD patients at different stages compared with 19 age-matched healthy subjects. Significant age-related increase of ApoD was detected in subjects older than 65 years of age (p<0.002). In PD patients, a significant increase in ApoD plasma concentration was found compared with healthy subjects of the same age (p<0.05). ApoD and PD stage are significantly correlated (p<0.05). ApoD might be a valid marker for the progression of PD.

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