Burkitt lymphoma: Age Specific Fertility Rate in 113 long-term female survivors after treatment with cyclophosphamide

2021 ◽  
Vol 67 (1) ◽  
Author(s):  
Peter B Hesseling PhD ◽  
Glenn M Afungchwi MSc ◽  
Vera Njamshi Dip. Nursing ◽  
Mariana Kruger PhD ◽  
Comfort Kimbi Dip Nursing ◽  
...  
Keyword(s):  
Age Groups ◽  
Personal Data ◽  
Fertility Rate ◽  
Age At Menarche ◽  
High Dose ◽  
Age Group ◽  
Female Survivors ◽  
Telephone Interviews ◽  
Rank Difference ◽  
Menarche Age

Abstract Introduction Reduced fertility risk is a risk in females treated with a high cumulative cyclophosphamide (CPM) dose. Objectives The objective of this study is to establish the age at menarche, record all pregnancies, calculate age-specific fertility rate (ASFR) in female BL survivors, treated in Cameroon, in the age groups 15–19 and 20–24 years, and association with an increasing cumulative CPM dose. Methods Data collection included personal data and telephone interviews for female survivors, aged ≥12 years with regards to menarche age, their mothers’ menarche age, incidence and outcome of all pregnancies. The cumulative CPM/m2 dose was categorized as low (<4723 mg/m2), medium (4724–10 635 mg/m/2) or high (>10 635 mg/m2). Results The median age at first treatment for 113 patients was 8 years (range 3–17 years), with median current age 17 years (range 12–26 years); the median duration of follow-up was 9 years (range 1.2–13.3 years). The median age of patients at menarche (n = 109; 4 unknown) was 14 years (range 10–17 years, SD 1.19) and that of their mothers (n = 68; 45 unknown) 15 years (range 10–17 years, SD 1.53). The median time to first pregnancy following menarche (the fertility time) was 3.04 years (n = 10) with low-dose CPM, 6.09 years with medium-dose CPM (n = 81) and 6.04 years with high-dose CPM (n = 32) (log rank difference p = 0.420). The ASFR in the age group 15–19 years was 82.19 (n = 73) and in the age group 20–24 years was 863.6 (n = 22), with significantly lower ASFR (p > 0.001) in children treated before the age of 10 years. Conclusion Fertility rates of girls treated for BL with CPM were normal but reduced in patients who commenced treatment before the age of 10 years.

Age at menarche predicts age at onset of major affective and anxiety disorders

2017 ◽  
Vol 39 ◽  
pp. 80-85 ◽  
Author(s):  
L. Tondo ◽  
M. Pinna ◽  
G. Serra ◽  
L. De Chiara ◽  
R.J. Baldessarini
Keyword(s):  
Anxiety Disorders ◽  
Depressive Disorders ◽  
Age At Onset ◽  
Age Groups ◽  
Age At Menarche ◽  
Onset Age ◽  
Major Depressive ◽  
Illness Onset ◽  
Rural Environments ◽  
Menarche Age

AbstractBackgroundMenarche age has been associated inconsistently with the occurrence, timing or severity of major depressive disorder (MDD), but rarely studied in women with bipolar (BDs) or anxiety disorders.MethodsWe investigated women patients at a Sardinian mood disorder center for associations of age at menarche with age at illness onset for major affective or anxiety disorders, year of birth, and other selected factors, using bivariate comparisons and multivariate regression modeling.ResultsAmong women (n = 1139) with DSM-IV MDD (n = 557), BD-I (n = 223), BD-II (n = 178), or anxiety disorders (n = 181), born in 1904–1998, of mean age 42.9 years, menarche age averaged 12.8 [CI: 12.7–12.9] years. Illness onset age averaged 30.9 [30.1–31.8] years, ranking: BD-I, 25.8; anxiety disorders, 28.0; BD-II, 30.3; MDD, 34.1 years. Menarche age declined secularly over birth years, and was associated with younger illness-onset, having no or fewer siblings, more psychiatrically ill first-degree relatives, living in rural environments, being suicidal, substance abuse, and being unemployed. Earlier menarche and earlier illness-onset were significantly associated for onset age groups of ≤ 20, 20–39, and > 40 years. Menarche age versus diagnosis ranked: BD-II < BD-I < anxiety disorders < MDD.ConclusionsAge at menarche in Sardinia, as elsewhere, has declined over the past decades. It was strongly associated with age at onset of bipolar and anxiety, as well as major depressive disorders across the age range, suggesting sustained effects of biological maturational factors.

scholarly journals Secular Trends in Height, Body Mass and Mean Menarche Age in Romanian Children and Adolescents, 1936–2016

2021 ◽  
Vol 18 (2) ◽  
pp. 490
Author(s):  
Raluca-Monica Pop ◽  
Arava Tenenboum ◽  
Marian Pop
Keyword(s):  
Children And Adolescents ◽  
Body Mass ◽  
Secular Trend ◽  
Age Groups ◽  
Secular Trends ◽  
Age At Menarche ◽  
Data Sets ◽  
Anthropometric Parameters ◽  
Data Set ◽  
Menarche Age

Secular trends in anthropometric parameters have been documented in most European countries, but no data is available regarding Romanian. The aim of the study was to calculate secular trend in height, body mass and mean menarche age for Romanian children and adolescents. Methods: A secondary data analysis was performed using ten data sets for urban and eight data sets for rural boys and girls, age 5–15 years, covering 80 years (1936 to 2016). Secular trend in height (cm/decade), body mass(kg/decade) and mean menarche age (years) were calculated. Results: Overall, there was a positive secular trend for height in both genders, which parallels the gross domestic product (GDP)/capita difference, more pronounced in boys, across all age-groups, with a maximum for 15 years-old boys (~3 cm/decade) and 13 years-old girls (~2 cm/decade). Body mass trend was also positive, more accentuated in the rural population. Mean age at menarche was higher in rural compared to urban girls, had a negative trend with the disappearance of the difference in the latest available data set (2013). Conclusion: In summary, an overall positive and ongoing secular trend in height and body mass was documented in Romanian children and adolescents, especially for the pubertal age-range, in concordance to other western countries, but out of phase by approximately 20 years.

scholarly journals An Underlooked Cause of Periodic Fever (PFAPA) in an Adult Patient with No Response to Tonsillectomy

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Fiaz Alam ◽  
Mohammed Hammoudeh
Keyword(s):  
Periodic Fever ◽  
Age Groups ◽  
Febrile Illness ◽  
High Dose ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group ◽  
Cervical Adenitis ◽  
Aphthous Ulceration ◽  
Febrile Episodes

Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is an autoinflammatory disease manifested as recurrent febrile episodes associated with one of the following cardinal features: aphthous ulceration, pharyngitis, and cervical adenitis. It was initially described in children and thought to be a disease of pediatric age group. Few adult cases were also reported in the literature. We describe the case of a 39-year-old female affected by PFAPA who presented with a history of febrile episodes associated with aphthous ulceration, stomatitis, and tonsillitis for 4 years. The febrile episodes occurred at a regular interval of 4 weeks and resolved within 5 days. The patient underwent tonsillectomy without any significant improvement. The patient responded only to a single high dose of steroid during the attack. Although PFAPA was initially thought to be a disease of pediatric age group, it should be considered in patients with recurrent febrile illness in all age groups.

scholarly journals High Dose Mitoxantrone Based "5+1" Induction Chemotherapy Regimen in Newly Diagnosed Acute Myeloid Leukemia

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 1430-1430
Author(s):  
Neeraj Y Saini ◽  
Jan Cerny ◽  
Vanessa Furtado ◽  
Angela Desmond ◽  
Zheng Zhou ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Median Overall Survival ◽  
De Novo ◽  
Chemotherapy Regimen ◽  
Age Groups ◽  
High Dose ◽  
Age Group ◽  
Newly Diagnosed ◽  
Secondary Aml ◽  
De Novo Aml

Abstract Introduction In acute myeloid leukemia (AML), dose intensification of "7+3" has not produced improved outcomes. At our center, we evaluated an intensive "5+1" regimen of high dose mitoxantrone (HDM) with high dose cytarabine (HiDAC) in all newly diagnosed AML patients. We present here our experience of this regimen at our institution. Patients and Methods The treatment regimen included bolus HiDAC at 3000 mg/m2 over three hours on days 1 to 5 and HDM 80 mg/m2 once on the second day immediately after the completion of cytarabine infusion. A total of 101 consecutive patients were treated from January 2009 to March 2013 with this regimen. There were twelve exceptions to the regimen dosages, where patients received a lower dose of 60 mg/m2 of mitoxantrone due to their significant comorbidities. The mean doses of mitoxantrone and Cytarabine administered for the whole cohort was 76 mg/m2 and 2844 mg/m2/day respectively. Patients who achieved CR were further consolidated by HiDAC chemotherapy cycles (1-4) and/or hypomethylating agent q28 day cycles. Patients with intermediate/adverse risk group were evaluated and considered for allogeneic transplant. Survival rates were calculated by the Kaplan-Meier method. Results The median age was 65 years (range 18-90). The total number of patients in the age group <60, 60-69 and ≥70 were 30(29.7%), 35(34.6%) and 36(35.6%) respectively. Patients in favorable, intermediate and adverse cytogenetics group as per European Leukemia Net(ELN)-AML 2017 criteria were 16(15.8%), 40(39.6%) and 41(40.5%) respectively. 33 patients had secondary AML (therapy-related AML, AML with antecedent MDS or CMML, or de novo AML with MDS related cytogenetics abnormalities). The overall complete response (CR) was 76.2% (77/101). 22% (23/101) were either primary refractory or had partial responses. The CR rates in patients <60, 60-69 and ≥70 age groups were similar at 80% (24/30), 74.2% (26/35) and 77.1% (27/35) respectively. The de-novo AML patients had higher CR 83.5%(56/67) compared to secondary AML 63.6%(21/33), p=0.04. The 4 and 8-week mortality in our cohort was 3/101 (2.9%) and 7/99 (7%) respectively. Median follow-up among survivors was 62 months (range 1-109 months). The median overall survival (OS) stratified by age group < 60, 60-69 and >=70 years were 56, 31 and 9 months respectively (log-rank, p=0.02). The median overall survival in patients with secondary AML was 9 months versus 43 months in de-novo AML patients. Sixty patients underwent transplant during consolidation, 47 (46.5%) were allogeneic and 13 (12.8%) autologous. 51.7% (45/84) of patients with intermediate/adverse cytogenetic risk groups as per ENL/AML criteria proceeded to allogeneic transplants. Among these 84 patients, the percentage of patients able to proceed to transplant in age groups <60, 60-69 and ≥70 years were 75% (18/24), 60.7 % (17/28) and 31.2% (10/32) respectively. Conclusion In conclusion, HDM based chemotherapy regimen produces high CR rates, is well tolerated and more patients can undergo curative post-remission therapy including stem cell transplant. Together with the low number of toxic deaths this induction regimen warrants further investigation. Disclosures Raffel: Magenta Therapeutics: Employment, Equity Ownership.

scholarly journals A comparative study of sexual attitudes towards lesbianism and homosexuality with reference to age and gender

2020 ◽  
Author(s):  
Simran Sharma
Keyword(s):  
Sexual Attitudes ◽  
Age Groups ◽  
Personal Data ◽  
Sexual Attitude ◽  
Attitude Scale ◽  
The Other ◽  
Age Group ◽  
Age And Gender ◽  
Male And Female ◽  
And Gender

The aim of the present study was to find out whether age and gender have an influence on the sexual attitudes of people. The following components of sexual attitude were studied namely: Attitude towards lesbianism and homosexuality. The sample consisted of 100 subjects in which 50 were from the age group of 18-28 years further divided equally with respect to gender (25-male, 25-female) and the other 50 in the age group of 50-60 years similarly divided into male and female. 2×2 Factorial design was used as the research design for the present study. The sample was first divided in two groups on the basis of age and then further on the basis of gender. Personal data sheet and a questionnaire titled ‘Sexual Attitude Scale’ developed by Amit Abraham was used for data collection. Gathered data was calculated and analysed by F-test (ANOVA). The results revealed that subjects in the age group of 18-28 years had a favourable sexual attitude and 50-60 years had an unfavourable sexual attitude. On the basis of gender, males showed a favourable sexual attitude over females. While studying the interaction of age and gender on sexual attitudes it was found that males in the age group of 18-28 years had the most favourable sexual attitude whereas the females in the age groups of 50-60 years had the least favourable sexual attitude.

scholarly journals A Decomposition Analysis of Fertility: Evidence from DKI Jakarta and East Nusa Tenggara

2020 ◽  
Vol 66 (2) ◽  
pp. 79
Author(s):  
Farma Mangunsong
Keyword(s):  
Census Data ◽  
Population Policy ◽  
Age Groups ◽  
Growth Control ◽  
Decomposition Analysis ◽  
Fertility Control ◽  
Fertility Rate ◽  
Age Group ◽  
Fertility Reduction ◽  
Younger Age

Fertility control has been one of the priorities of development in Indonesia. However, the 2000 and 2010 population censuses showed an increase in fertility indicators. To identify the sources of increased fertility in developed and less developed areas, DKI Jakarta and East Nusa Tenggara Provinces were selected for comparison. Using 2000 and 2010 census data, the decomposition analysis shows that the increase in Total Fertility Rate (TFR) of DKI Jakarta was dominated by the increase in nuptiality rate, while the increase in TFR of East Nusa Tenggara was mainly caused by the increase in Marital Fertility Rate (MFR). The highest increase in the proportion of married women in DKI Jakarta occurs in the age group of 15-19 years old, followed by the age group of 20–24 years old. The increase in MFR in East Nusa Tenggara occurs in nearly all age groups, particularly in the age groups of 30–34 and 35–39 years old. Identifying the sources of the increase in TFR is important for population policy to support population growth control, fertility reduction, and human resource quality improvement. The main suggestions based on the findings are the promotion of higher educational level and the benefits of postponing marriage among the younger age groups in DKI Jakarta as well as the use of contraceptive methods to control birth rate in East Nusa Tenggara.

scholarly journals A comparative study of sexual attitudes towards lesbianism and homosexuality with reference to age and gender

2020 ◽  
Author(s):  
Simran Sharma
Keyword(s):  
Sexual Attitudes ◽  
Age Groups ◽  
Personal Data ◽  
Sexual Attitude ◽  
Attitude Scale ◽  
The Other ◽  
Age Group ◽  
Age And Gender ◽  
Male And Female ◽  
And Gender

The aim of the present study was to find out whether age and gender have an influence on the sexual attitudes of people. The following components of sexual attitude were studied namely: Attitude towards lesbianism and homosexuality. The sample consisted of 100 subjects in which 50 were from the age group of 18-28 years further divided equally with respect to gender (25-male, 25-female) and the other 50 in the age group of 50-60 years similarly divided into male and female. 2×2 Factorial design was used as the research design for the present study. The sample was first divided in two groups on the basis of age and then further on the basis of gender. Personal data sheet and a questionnaire titled ‘Sexual Attitude Scale’ developed by Amit Abraham was used for data collection. Gathered data was calculated and analysed by F-test (ANOVA). The results revealed that subjects in the age group of 18-28 years had a favourable sexual attitude and 50-60 years had an unfavourable sexual attitude. On the basis of gender, males showed a favourable sexual attitude over females. While studying the interaction of age and gender on sexual attitudes it was found that males in the age group of 18-28 years had the most favourable sexual attitude whereas the females in the age groups of 50-60 years had the least favourable sexual attitude.

The Effect of Collagen Mediated Platelet Release on Plasma Prekallikrein Activation

1984 ◽  
Vol 51 (01) ◽  
pp. 037-041 ◽  
Author(s):  
K M Weerasinghe ◽  
M F Scully ◽  
V V Kakkar
Keyword(s):  
Platelet Aggregation ◽  
Healthy Volunteers ◽  
Platelet Rich Plasma ◽  
Age Groups ◽  
Inhibitory Effect ◽  
Age Group ◽  
Platelet Factor ◽  
Activated Platelets ◽  
Platelet Release ◽  
Collagen Treatment

SummaryCollagen mediated platelet aggregation caused -5.6 ± 6.7% inhibition and +39.1 ± 15.2% potentiation of prekallikrein activation in plasma from normal healthy volunteers between 20–40 and 50–65 years of age, respectively (n = 15, p <0.01). The amouns of platelet factor-four (PF4) released in the two groups were not significantly different. Collagen treatment in the presence of indomethacin caused +11.5 ± 3.6% and +59.6 ± 19.5% potentiation in the 20–40 and 50–65 age groups respectively (p <0.02). Adrenaline mediated platelet aggregation caused -55.2 ± 7.1% and -35.2 ± 8.3% inhibition in the 20–40 and 50–65 age groups, respectively. Collagen treatment of platelet-deficient-plasma and platelet-rich-plasma in EDTA also caused potentiation of prekallikrein activation.The results indicate that the observed degree of prekallikrein activation after platelet aggregation is a net result of the inhibitory effect of PF4 and the potentiatory effect of activated platelets. The potentiatory effect was greater after collagen treatment as compared to adrenaline treatment, and in the 50–65 age group as compared to the 20–40 age group.

Health and Nutritional Status of Orphan Children’s Living in Orphanages with Special Reference to District Anantnag of Jammu and Kashmir

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Mashkoor Ahmad Lone ◽  
Dr. P. Ganesan
Keyword(s):  
Age Groups ◽  
Indian Academy ◽  
Dental Enamel ◽  
Nutritional Intake ◽  
Age Group ◽  
Asian Countries ◽  
Jammu And Kashmir ◽  
Material Resources ◽  
Height For Age ◽  
Weight For Age

The practice of placing deprived children having least or no emotional and material resources, in orphanages has since long been prevailing in socio -economically poor Asian countries. A sample of 30 children residing in orphanage in district Anantnag in the age group of 13-18 years was selected for the present study. Most of the children were found socially and psychologically disturbed. As per Indian Academy Paediatrics (IAP) classification with respect to weight for age the condition was not bad that as approximately 67% percent of the children were found to be normal. In the same way height for age as per Waterloo’s classification shown that more than half of the children were normal. On clinical examination approximately 47% of children were normal, while as rest were suffering from dispigmentation of hair, moon face, xerosis of skin cheilosis, magenta tongue, spongy bleeding gums, oedema, conjuctival xerosis, and mottled dental enamel. The findings indicated that nutritional intake was deficient for all nutrients when compared to, Recommended Daily Allowances Chart (RDA) for all age groups which may be linked to poor planning of menus in orphanages.

Employing Gamma Ray Irradiated Giardia lamblia as Trialed Vaccine in Experimental Animal

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Amal Kamil Abdul Sada ◽  
Amany Mohamed Al-Kaysi
Keyword(s):  
Giardia Lamblia ◽  
Gamma Ray ◽  
Age Groups ◽  
Active Phase ◽  
Study Groups ◽  
Negative Control ◽  
Control Group ◽  
High Dose ◽  
Histopathological Changes ◽  
Gamma Irradiated

This is an experimental trial to prepare a vaccine from gamma-irradiated Giardia lamblia which is evaluated in experimental animals. The study was conducted from December 2015 to April 2016. The field survey of the parasite was conducted from those patients attending the laboratories of the Alawi Children's Hospital in Rusafa and the Al-Yarmouk Teaching Hospital in Karkh, through which 1250 stool samples of different age groups were examined. Five groups of mice were used in the study; the first was injected with normal saline and considered as a negative control group, the second was injected with cystic form of non-irradiated Giardia lamblia and considered as a positive control group, whereas the other three groups were injected with gamma irradiated Giardia lamblia at three different doses 10, 15 and 25 rad respectively. Giardia lamblia was primarily cultivated in liver infusion agar for ten days to obtain the active phase. On the sixth day, the cystic phase was purified and standardized to be used in the infection of mice with or without the exposure of gamma rays. Mice showed high sensitivity to parasitic infestation, in the gamma non-irradiated and the irradiated with gamma 10 rad, and 15 rad irradiated groups which was 100%. The results expressed an excystation process of the depleted phases and the release of the feeder phases. The results of the three irradiated groups consisted of histopathological changes of the small, and the rectum by dissection after two weeks of infection, with intestine amputation lesions, as well as ulceration and inflammation of the inflammatory cells represented in small numbers of neutrophil, lymphocytes, and eosinophils. The presence of ulceration and fall of epithelial cells in the intestinal cavity has been shown, and different forms of the parasite have been observed. Mice which was injected with irradiated G lamblia at high dose (25 rad), not show and sensitivity to the challenge infection and no excystation of thy parasite had been done. After 2 wreaks, a comparison was achieved between all study groups in which no histopathological changes were noticed in the mice irradiated with dose of25 rad. After another two weeks, a challenge dose was given (un-attenuated G lamblia) and mice were dissected after another two weeks, no changes on the level of histopathology of intestinal tissue were noticed the results suggested that mice acquire an immunity against the parasite infection.

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