Age at menarche predicts age at onset of major affective and anxiety disorders

2017 ◽  
Vol 39 ◽  
pp. 80-85 ◽  
Author(s):  
L. Tondo ◽  
M. Pinna ◽  
G. Serra ◽  
L. De Chiara ◽  
R.J. Baldessarini
Keyword(s):  
Anxiety Disorders ◽  
Depressive Disorders ◽  
Age At Onset ◽  
Age Groups ◽  
Age At Menarche ◽  
Onset Age ◽  
Major Depressive ◽  
Illness Onset ◽  
Rural Environments ◽  
Menarche Age

AbstractBackgroundMenarche age has been associated inconsistently with the occurrence, timing or severity of major depressive disorder (MDD), but rarely studied in women with bipolar (BDs) or anxiety disorders.MethodsWe investigated women patients at a Sardinian mood disorder center for associations of age at menarche with age at illness onset for major affective or anxiety disorders, year of birth, and other selected factors, using bivariate comparisons and multivariate regression modeling.ResultsAmong women (n = 1139) with DSM-IV MDD (n = 557), BD-I (n = 223), BD-II (n = 178), or anxiety disorders (n = 181), born in 1904–1998, of mean age 42.9 years, menarche age averaged 12.8 [CI: 12.7–12.9] years. Illness onset age averaged 30.9 [30.1–31.8] years, ranking: BD-I, 25.8; anxiety disorders, 28.0; BD-II, 30.3; MDD, 34.1 years. Menarche age declined secularly over birth years, and was associated with younger illness-onset, having no or fewer siblings, more psychiatrically ill first-degree relatives, living in rural environments, being suicidal, substance abuse, and being unemployed. Earlier menarche and earlier illness-onset were significantly associated for onset age groups of ≤ 20, 20–39, and > 40 years. Menarche age versus diagnosis ranked: BD-II < BD-I < anxiety disorders < MDD.ConclusionsAge at menarche in Sardinia, as elsewhere, has declined over the past decades. It was strongly associated with age at onset of bipolar and anxiety, as well as major depressive disorders across the age range, suggesting sustained effects of biological maturational factors.

The Comorbidity of Anxiety Disorders with Depression and the Associated Risk Factors in Geriatric Psychiatry Outpatients

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
F. Beskardes ◽  
T. Ertan ◽  
E. Eker
Keyword(s):  
Risk Factors ◽  
Depressive Disorder ◽  
Anxiety Disorders ◽  
Depressive Disorders ◽  
Depression Scale ◽  
Geriatric Psychiatry ◽  
Major Depressive ◽  
Outpatient Unit ◽  
Prevalence Of Depression ◽  
Associated Risk Factors

Aims:We aimed to study the prevalence of anxiety disorders with the comorbidity of depressive disorders and the effects of risk factors among the patients attending the general Geriatric Psychiatry Outpatient Unit.Methods:Subjects were evaluated in terms of Anxiety Disorders on the basis of DSM criteria, SCID. Each patient was asked to fill out Spielberger State-Trait Anxiety Scale, Beck Anxiety and Depression Scale. Sociodemographic features and risk factors were assesed the prepared questionnaire.Results:In a number of total 1209 applicants in 12 months, we found the prevalance of anxiety disorders was %9,48 with a number of 115 patients in outpatient department applications and the prevalence of Generalized Anxiety Disorder was found out to be %4,63(n:56), Panic Disorder with Agoraphobia %1,98(n:24), without Agoraphobia %0,90(n:11), the prevalence of OCD was %0,82(n:10), PTSD %0,49(n:6) and other anxiety disorders (SAD, SP, NOS) was %0,66(n:8).In the patients with anxiety disorders, the prevalence of depression comorbidity was found out to be %73,05(n:84), with the prevalence of the comorbid major depressive disorder %26,1(n:31), and the dysthymic/minor depressive disorder was %46,95(n:53). As a result of statistical analysis,we found that the risk factors associated with STAI-I and II scores were total years spent on education, but in reverse manners, as the education level increased, the STAI-I and II scores decreased.Conclusions:Anxiety disorders with comorbid depression might be frequent disorders among Turkish secondary care attenders. There is a need for further studies on the epidemiology of anxiety disorders and their comorbidity with depression among elderly in Turkey.

scholarly journals Risks of Antidepressant induced psychotic events in patients with depression and psychosis

2022 ◽  
Author(s):  
Sourav Dakua
Keyword(s):  
Literature Review ◽  
Depressive Disorders ◽  
Meta Analysis ◽  
Antidepressant Drug ◽  
Age Groups ◽  
Antidepressant Drugs ◽  
Individual Risk ◽  
Major Depressive ◽  
Compulsive Disorder ◽  
Drug Classes

The aim of this ‘literature review’-based argumentative paper has been to find out the risks of developing psychotic and depressive disorders in patients having been treated with antidepressants. In order to reach a resounding supposition, this literature review-based argumentative study had taken an incisive look into previous research works and meta-analysis, which in effect had underscored the risks of antidepressant-induced psychotic and depressive disorders in patients with depression as well as psychosis even as the protagonists of antidepressant drug classes could not be undermined given their upscaled magnitude of benefits. While following a probing interpretation of past studies, this might be demystified that antidepressants could lead to psychotic events and depressive disorders in patients of all age groups with children and young adults being more susceptible to develop psychosis. The psychotic episodes could even be developed during initial phase of treatments in patients suffering from depressive and psychotic disorders such as bipolar mood disorder, unipolar depression, major depressive disorders, mania, OCD (Obsessive Compulsive Disorder), delusional depression (psychotic depression), schizophrenia, schizoaffective disorders alongside multiple somatic symptoms among others as well. Concomitantly, with efficaciousness of antidepressants in major depressive disorder still remaining a subject to utter dubitability, different antidepressant drug classes were found to be associated with a considerable scale of adverse effects after carrying out protracted arguments on findings of evidence-based past studies, meta-analysis of previous researches and relevant clinical cases. Therefore, following a systematized approach towards past studies, this argumentative research has reached a coherent conclusion that antidepressants are likely to cause psychotic events and exaggeration of depressive disorders up to some extent in several cases. Hence, there is a stipulation of individual risk-benefit assessment and intricate history taking in patients being contemplated for antidepressant drugs alongside a close observation and follow-up in patients of all age groups after introducing antidepressant medications.

P.1.a.020 GNB 3 825TT genotype: older age at onset in major depressive disorders?

2011 ◽  
Vol 21 ◽  
pp. S248
Author(s):  
F. Gressier ◽  
C. Verstuyft ◽  
C. Dutech ◽  
P. Hardy ◽  
L. Becquemont ◽  
...  
Keyword(s):  
Depressive Disorders ◽  
Age At Onset ◽  
Older Age ◽  
Major Depressive ◽  
Major Depressive Disorders

scholarly journals Secular Trends in Height, Body Mass and Mean Menarche Age in Romanian Children and Adolescents, 1936–2016

2021 ◽  
Vol 18 (2) ◽  
pp. 490
Author(s):  
Raluca-Monica Pop ◽  
Arava Tenenboum ◽  
Marian Pop
Keyword(s):  
Children And Adolescents ◽  
Body Mass ◽  
Secular Trend ◽  
Age Groups ◽  
Secular Trends ◽  
Age At Menarche ◽  
Data Sets ◽  
Anthropometric Parameters ◽  
Data Set ◽  
Menarche Age

Secular trends in anthropometric parameters have been documented in most European countries, but no data is available regarding Romanian. The aim of the study was to calculate secular trend in height, body mass and mean menarche age for Romanian children and adolescents. Methods: A secondary data analysis was performed using ten data sets for urban and eight data sets for rural boys and girls, age 5–15 years, covering 80 years (1936 to 2016). Secular trend in height (cm/decade), body mass(kg/decade) and mean menarche age (years) were calculated. Results: Overall, there was a positive secular trend for height in both genders, which parallels the gross domestic product (GDP)/capita difference, more pronounced in boys, across all age-groups, with a maximum for 15 years-old boys (~3 cm/decade) and 13 years-old girls (~2 cm/decade). Body mass trend was also positive, more accentuated in the rural population. Mean age at menarche was higher in rural compared to urban girls, had a negative trend with the disappearance of the difference in the latest available data set (2013). Conclusion: In summary, an overall positive and ongoing secular trend in height and body mass was documented in Romanian children and adolescents, especially for the pubertal age-range, in concordance to other western countries, but out of phase by approximately 20 years.

scholarly journals Age at Onset of Menarche and Puberty of Girls in Aydin Region and the Factors Affecting Them

2021 ◽  
Author(s):  
Ebru Ataş Aslan
Keyword(s):  
Rural Areas ◽  
Age At Onset ◽  
Female Students ◽  
Age At Menarche ◽  
Early Age ◽  
Onset Age ◽  
Factors Affecting ◽  
The Mean ◽  
Experienced Physician ◽  
Age Of Menarche

INTRODUCTION: In this study, we aimed to determine the range of mean age at onset of menarche (AOM) and puberty (AOP) of girls living in Aydin province and to determine the factors affecting the onset age of menarche. METHODS: A total of 1891 girls aged between 8 and 16 years attending primary, secondary and high schools in Aydin province were planned to be included in the study. A questionnaire that was prepared in line with the literature was delivered to the parents in a closed envelope. The subjects who accepted to participate in the study were examined by an experienced physician by measuring height and weight and pubertal status was defined according to Tanner scale. BMI values were calculated. RESULTS: In total, 1520 female students were accepted to the study with the permission of their families. The mean AOM of participants was 12.11±1.32 years. The mean AOM was 13.12±1.46 years for their mothers, and 12.73±1.25 years for their sisters. June was the month that menarche occurred most frequently. We observed that the children living in rural areas had an earlier age of menarche. The mean age at onset of puberty was 9.71±1.46 years. DISCUSSION AND CONCLUSION: Our study is important in terms of being the first study conducted in Aydin province that determined the mean AOM and AOP of girls aged between 8 and 16. In our study, we showed that the age of menarche shifted to an early age, while the age of puberty did not shift. The age at onset of menarche and puberty were similar to the results obtained in other studies conducted in neighboring regions. We believe that larger scale studies may contribute to assess the actual mean age at menarche of girls living in Turkey.

Suicide Risk in Outpatients with Specific Mood and Anxiety Disorders

Crisis ◽  
2003 ◽  
Vol 24 (3) ◽  
pp. 105-112 ◽  
Author(s):  
Andrea P. Chioqueta ◽  
Tore C. Stiles
Keyword(s):  
Anxiety Disorder ◽  
Anxiety Disorders ◽  
Depressive Episode ◽  
Suicide Risk ◽  
Depressive Disorders ◽  
Major Depressive Episode ◽  
Suicide Ideation ◽  
Anxiety Symptoms ◽  
Major Depressive ◽  
Special Relevance

Summary: The present study examined the relationships between specific anxiety, mood disorders, levels of hopelessness, and suicide ideation. The sample consisted of 606 outpatients recruited from several psychiatric settings. It was found that dysthymia was significantly associated with hopelessness. Patients presenting major depressive episode with higher anxiety symptoms had significantly increased scores on the hopelessness scale. Major depressive episode and bipolar disorder, but not dysthymia, were significantly associated with higher levels of suicide ideation. Increased levels of anxiety symptoms in patients with dysthymia were associated with increased levels of suicide ideation, while increased depressive symptoms in patients with specific phobia and generalized anxiety disorder were associated with significantly lower levels of suicide ideation. The findings suggest that depressive disorders, but not anxiety disorders, constitute risk for suicide. Moreover, the differentiation between a depressive and an anxiety disorder as the principal diagnosis, as well as the assessment of anxiety-level symptoms in patients with major depressive episode and dysthymia, seems of special relevance when assessing suicide risk.

scholarly journals Is there a further acceleration in the age at onset of menarche? A cross-sectional study in 1840 school children focusing on age and bodyweight at the onset of menarche

2009 ◽  
Vol 160 (1) ◽  
pp. 107-113 ◽  
Author(s):  
A M Bau ◽  
A Ernert ◽  
L Schenk ◽  
S Wiegand ◽  
P Martus ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Status ◽  
Age At Onset ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Age At Menarche ◽  
Obesity Prevalence ◽  
Sectional Study ◽  
Cross Sectional

ObjectiveMore than 30 years ago Frisch and Revelle proposed a body weight threshold for the onset of menarche. Based on this hypothesis, a further acceleration of age at menarche can be expected in times of childhood obesity.DesignA cross-sectional study of 1840 healthy school girls (Berlin school children's cohort, BSCOC) within the age groups 10–15 years was conducted in 2006–2007.MethodsMedian age of menarche was calculated by Kaplan–Meier survival analysis. Bi- and multivariate analyses were performed to analyze the associations between menarche age and weight status. A locally weighted regression was used to analyze the relationship respectively between height, weight, and body mass index (BMI)–SDS and age stratified by menarche status.ResultsNine hundred and thirty six (50.9%) girls had already experienced menarche at a median age of 12.8 years. Two hundred and thirty six of these girls reached their menarche recently. Obese/overweight girls reached menarche significantly earlier (12.5 years), than normal weight (12.9 years), and underweight girls (13.7 years). The mean total body weight was similar in all girls at menarche irrespective of age (mean 51.1 kg,s.d.8.1) and height. BMI–SDS remained the only significant factor for onset of menarche within a multiple regression model for early menarche (OR 2.1, 95% confidence interval 1.3–3.3,P=0.002).ConclusionsAge at onset of menarche did not accelerate even in a childhood population with more than 10% obesity prevalence. Nevertheless, a negative correlation of BMI–SDS with age at onset of menarche exists.

Burkitt lymphoma: Age Specific Fertility Rate in 113 long-term female survivors after treatment with cyclophosphamide

2021 ◽  
Vol 67 (1) ◽  
Author(s):  
Peter B Hesseling PhD ◽  
Glenn M Afungchwi MSc ◽  
Vera Njamshi Dip. Nursing ◽  
Mariana Kruger PhD ◽  
Comfort Kimbi Dip Nursing ◽  
...  
Keyword(s):  
Age Groups ◽  
Personal Data ◽  
Fertility Rate ◽  
Age At Menarche ◽  
High Dose ◽  
Age Group ◽  
Female Survivors ◽  
Telephone Interviews ◽  
Rank Difference ◽  
Menarche Age

Abstract Introduction Reduced fertility risk is a risk in females treated with a high cumulative cyclophosphamide (CPM) dose. Objectives The objective of this study is to establish the age at menarche, record all pregnancies, calculate age-specific fertility rate (ASFR) in female BL survivors, treated in Cameroon, in the age groups 15–19 and 20–24 years, and association with an increasing cumulative CPM dose. Methods Data collection included personal data and telephone interviews for female survivors, aged ≥12 years with regards to menarche age, their mothers’ menarche age, incidence and outcome of all pregnancies. The cumulative CPM/m2 dose was categorized as low (&lt;4723 mg/m2), medium (4724–10 635 mg/m/2) or high (&gt;10 635 mg/m2). Results The median age at first treatment for 113 patients was 8 years (range 3–17 years), with median current age 17 years (range 12–26 years); the median duration of follow-up was 9 years (range 1.2–13.3 years). The median age of patients at menarche (n = 109; 4 unknown) was 14 years (range 10–17 years, SD 1.19) and that of their mothers (n = 68; 45 unknown) 15 years (range 10–17 years, SD 1.53). The median time to first pregnancy following menarche (the fertility time) was 3.04 years (n = 10) with low-dose CPM, 6.09 years with medium-dose CPM (n = 81) and 6.04 years with high-dose CPM (n = 32) (log rank difference p = 0.420). The ASFR in the age group 15–19 years was 82.19 (n = 73) and in the age group 20–24 years was 863.6 (n = 22), with significantly lower ASFR (p &gt; 0.001) in children treated before the age of 10 years. Conclusion Fertility rates of girls treated for BL with CPM were normal but reduced in patients who commenced treatment before the age of 10 years.

scholarly journals Prevalence and Comorbidity of Anxiety and Depressive Disorders in Studies of PRIME-MD and PHQ (Patient Health Questionnaire) in Japan

2021 ◽  
Author(s):  
Kumiko Muramatsu ◽  
Hitoshi Miyaoka ◽  
Kunitoshi Kamijima ◽  
Yoshiyuki Muramatsu ◽  
Katsuya Fuse ◽  
...  
Keyword(s):  
Primary Care ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Anxiety Disorders ◽  
Mood Disorders ◽  
Odds Ratio ◽  
Depressive Disorders ◽  
Health Questionnaire ◽  
Major Depressive ◽  
Patient Health

We examine two studies on the prevalence and comorbidity of anxiety and depressive disorders in Japanese patients in primary care settings. The PRIME-MD study (Primary Care Evaluation of Mental Disorders) in Japan was conducted in seven primary care sites. The sample group included 601 adult patients (249 males, 352 females, mean age = 58.9 years, SD = 16.5). Of the 12.5% of patients diagnosed with mood disorders, 5.0% (n = 29) were major depressive disorder, and 6.7% (n = 40) were minor depressive disorder. The odds ratio for co-occurrence of major depressive disorder with generalized anxiety disorders and major depressive disorder with anxiety disorders (NOS) was 11.5 (95% CI: 2.17–18.45) and 8.00 (95% CI: 3.19–20.07), respectively. The PHQ (Patient Health Questionnaire) study in Japan was conducted in eleven primary care sites. A total of 1409 adult patients (611 males, 797 females; mean age: 56.2 years, SD: ±20.4) completed the PHQ in full. The prevalence of diagnosis of any mood disorder or any anxiety disorder was 25.0%. Of the 15.8% of patients diagnosed with mood disorders, 5.3% were for major depression and 8.4% for other depressive disorders. The odds ratio for co-occurrence of major depressive disorder with other anxiety disorders was 30.4 (95% CI: 13.19–70.28).

scholarly journals A comparative study of prevalence of mental abnormalities among high school children in tribal, rural and urban Mysuru district, Karnataka, India

2017 ◽  
Vol 4 (3) ◽  
pp. 809 ◽  
Author(s):  
Pradeep Tarikere Satyanarayana ◽  
Prakash B. ◽  
Praveen Kulkarni ◽  
Kishor M. ◽  
Renuka M.
Keyword(s):  
High School ◽  
High Schools ◽  
Anxiety Disorders ◽  
School Children ◽  
Depressive Disorders ◽  
Age Group ◽  
Major Depressive ◽  
Rural And Urban ◽  
Major Depressive Disorders ◽  
Study Participants

Background: Adolescence is defined by WHO as period in human growth and development that occurs after childhood and before adulthood from ages 10 to 19 years. According to WHO, half of all mental health disorders in adulthood start by age 14 years, but most cases are undetected and untreated.Methods: The present study was community based cross sectional comparative study was conducted on study participants were high school children aged 14 years to 16 years in tribal, rural and urban areas of Mysuru from November 2014 to May 2016, i.e., one and a half years (eighteen months). Around 9 tribal high schools, 8 rural high schools and 13 urban high schools were selected and sampling was done according to probability proportionate to size. Institutional Ethics Committee clearance was obtained before start of the study. The study methodology was discussed with and permission obtained from all Principals and Headmasters of respective High Schools. Written informed assent was obtained from each study participant. Data thus Obtained were coded and entered into Microsoft excel Work sheet .This was analyzed using SPSS 22 version. Descriptive statistics like percentage, mean and standard deviation were applied. Inferential statistical tests like chi square test were applied to find out association. The difference, association were expressed statistically significant at p-value less than 0.05.Results: Among the study participants, in tribal area, 88 (47.3%) belonged to age group of 15 years, in rural area, 103 (51.5%) belonged to age group of 15 years and in urban area 116 (59.8%) belonged to age group of 14 years. Anxiety disorders were seen more in urban participants 26.3% and least in rural, major depressive disorders were seen more in urban participants (4.1%) and suicidality was seen more in rural participants (6.5%).Conclusions: Anxiety disorders were seen more in urban participants 26.3%, Major depressive disorders were seen more in urban participants (4.1%) and suicidality was seen more in rural participants (6.5%). The present study stresses importance of School-based specific diagnostic screenings such as for anxiety disorders, depression, ADHD should be implemented.

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