Clinical, Laboratory and Radiological Parameters in Children with Dengue Fever and Predictive Factors for Dengue Shock Syndrome

The article describes a clinical case of concurrent infectious diseases - dengue hemorrhagic fever and mycoplasma pneumonia in a patient who came back from the area endemic for dengue fever. Further, the patient was diagnosed with clostridial colitis which was the complication. Clinical, laboratory, and radiological parameters used in the diagnosis of diseases were evaluated.

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Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia

Journal of Clinical Medicine ◽

10.3390/jcm10061154 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1154

Author(s):

Eun Lee ◽

Yun Young Lee

Keyword(s):

Pleural Effusion ◽

Mycoplasma Pneumoniae ◽

Predictive Factors ◽

Respiratory Virus ◽

Clinical Laboratory ◽

Poor Response ◽

Response To Treatment ◽

Slow Response ◽

Response Group ◽

Time Of Admission

The prevalence of refractory Mycoplasma pneumoniae (MP) pneumonia is increasing. The present study aimed to identify the predictive factors of responses to treatment of MP pneumonia in children. A total of 149 children were diagnosed with MP pneumonia, of whom 56 were included in the good response group, 75 children in the slow response group, and 18 children in no response or progression group. Data on the clinical, laboratory, and radiologic features were retrospectively obtained through medical chart reviews. The severity of pneumonia, based on the extent of pneumonic lesions on chest x-ray (adjusted odds ratio (aOR), 10.573; 95% confidence intervals (CIs), 2.303−48.543), and lactate dehydrogenase (LDH) levels (aOR, 1.002; 95% CIs, 1.000–1.004) at the time of admission were associated with slow response to treatment of MP pneumonia. Pleural effusion (aOR, 5.127; 95% CIs, 1.404–18.727), respiratory virus co-infection (aOR, 4.354; 95% CIs, 1.374–13.800), and higher LDH levels (aOR, 1.005; 95% CIs, 1.002–1.007) as well as MP-specific IgM titer (aOR, 1.309; 95% CIs, 1.095–1.564) were associated with no response or progression of MP pneumonia. The area under the curve for the prediction of no or poor response in MP pneumonia using pleural effusion, respiratory virus co-infection, LDH levels, and MP-specific IgM titer at the time of admission was 0.8547. This study identified the predictive factors of responses to treatment of MP pneumonia in children, which would be helpful in establishing a therapeutic plan and predicting the clinical course of MP pneumonia in children.

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COMPARATIVE STUDY OF THE KNOWLEDGE AND THE CURRENT PRACTISE AMONG THE EMERGENCY PHYSICIANS AND OTHER PHYSICIANS REGARDING THE ADMISSION CRITERIA OF DENGUE FEVER IN KOLKATA.

10.36106/ijsr/3621794 ◽

2021 ◽

pp. 50-52

Author(s):

Rukuzo Nyeka ◽

Indraneel Dasgupta

Keyword(s):

Dengue Fever ◽

Dengue Shock Syndrome ◽

Hemorrhagic Fever ◽

Viral Disease ◽

Research Centre ◽

Admission Criteria ◽

Emergency Physicians ◽

Medicine Department ◽

Validated Questionnaire ◽

Surgery Department

Introduction: Dengue fever is a mosquito-borne viral disease caused by a avivirus. There are four distinct serotypes of dengue virus, namely DEN-1, 2, 3 and 4. Female Aedes aegypti and Aedes albopictus mosquitoes are the primary and secondary vectors in Malaysia, respectively. Evidently, dengue is the most rapidly spreading arboviral disease in the world. Aim: To know about the knowledge and current practice of the emergency physicians and other physicians regarding admission criteria of dengue fever in Kolkata. To preserve the resource and to prevent unnecessary utilization of hospital facilities during dengue epidemics by following up the proper criteria of admission for acute febrile patient suspecting of dengue fever/ dengue hemorrhagic fever/ dengue shock syndrome from the emergency department. Materials and methods: This is a questionnaire-based study and the study was conducted in peerless hospital and b.k roy research centre. The duration of the study was one year (from 1/01/2019- 31/12/2020). Apre validated questionnaire was distributed among the emergency physicians and other general physicians who deal with management of dengue patients and the responses so obtained were analysed. Total 125 participants were present in this study. Result: We found that 5(4.0%) doctors work in Cardiology department, 40(32.0%) doctors work in Emergency medicine department, 6(4.8%) doctors work in Gynecology department, 46(36.8%) doctors work in Medicine department, 8(6.4%) doctors work in Nephrology department, 8(6.4%) doctors work in Neurology department, 8(6.4%) doctors work in Orthopedic department and 4(3.2%) doctors work in Surgery department. Conclusion: However, a knowledge gap has been reported regarding important issues in clinical presentation, treatment, prevention, and control. Practices regarding frequent clinical monitoring were consistent with local and international guide-lines

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A STUDY ON CLINICAL, LABORATORY PROFILE AND OUTCOME OF DENGUE FEVER

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/1686 ◽

2013 ◽

Vol 2 (50) ◽

pp. 9739-9743

Author(s):

Vanamali D.R ◽

Venugopal L. ◽

Yeshwanth P ◽

Dilip Rampure

Keyword(s):

Dengue Fever ◽

Clinical Laboratory ◽

Laboratory Profile

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Tumbuhan Obat: Pendekatan Alternatif dalam Pengendalian Nyamuk Aedes aegypti dan Virus Dengue Penyebab Demam Dengue

JURNAL BIOLOGI PAPUA ◽

10.31957/jbp.541 ◽

2018 ◽

Vol 4 (2) ◽

pp. 83-90

Author(s):

Ign Joko Suyono ◽

Aditya K. Karim

Keyword(s):

Medicinal Plant ◽

Aedes Aegypti ◽

Dengue Fever ◽

Mosquito Control ◽

Dengue Shock Syndrome ◽

Viral Disease ◽

Mosquito Vector ◽

Major Health ◽

Alternative Approach ◽

Control And Prevention

Dengue is the most important emerging tropical viral disease of humans in the world today. Aedes aegypti is a major mosquito vector responsible for transmitting many viral diseases and this mosquito that spreads major health problems like dengue fever. The resistance of Ae. aegypti to insecticides is already widespread and represents a serious problem for programmes aimed at the control and prevention of dengue in tropical countries. The search for compounds extracted from medicinal plant preparations as alternatives insecticide for mosquito control is in immediate need. Alternative approach for control Ae. aegypti dan virus dengue using the medicinal plant will be discussed in this paper.Key words: Medicinal plant, Aedes aegypti, dengue fever, dengue haemorragi fever, dengue shock syndrome

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Prospective study on the clinico-hematological profile of dengue fever patients in Navi Mumbai

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20211057 ◽

2021 ◽

Vol 8 (4) ◽

pp. 569

Author(s):

Prachi Sankhe ◽

Priyanka Jadhav ◽

Praveen Meduri

Keyword(s):

Dengue Fever ◽

Prospective Observational Study ◽

Clinical Laboratory ◽

Dengue Infection ◽

Radiological Findings ◽

Hematological Profile ◽

Entire Duration ◽

Wbc Count ◽

Almost All ◽

Biochemical Abnormalities

Background: It has been seen that epidemiology and clinical presentation of dengue infection differs significantly across geographical areas. The present study was done to study clinico-hematological profile of patients with dengue fever in Navi Mumbai, Maharashtra.Methods: This prospective observational study was conducted at a tertiary level teaching hospital in Navi Mumbai. All patients were observed over their entire duration of their hospital stay (up to 7 days). We included adult patients of both gender (males or females) who were admitted with clinically and serological diagnosed dengue fever, consenting to participate in the study. The clinical, laboratory and radiological findings of the patients were noted.Results: All 80 patients presented with fever while 71.25% had myalgia. Retro-orbital pain, rash and vomiting was observed in 38%, 26% and 26% respectively, whereas 23.75% patients were having cough and bleeding from any site. Three fourths of the patients were diagnosed with dengue, 18.75% and 6.25% were diagnosed with DHF and DSS. respectively. Hepatosplenomegaly was increasing from day 1 (9%) to 6th (60%) and 7th (60%) day. Mean haemoglobin levels and haematocrit started increasing from second day onwards, while WBC count and platelet count increased gradually from first day onwards. Splenomegaly was diagnosed in 3.75% of patients while hepatosplenomegaly and fatty liver was observed in 8.75% and 2.5% respectively. There were two deaths, both were cases of DSS.Conclusions: Almost all the patients included in our study showed both haematological and biochemical abnormalities.

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A study on the outbreak of dengue fever in a tertiary care children’s hospital in southern Tamil Nadu, India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20192011 ◽

2019 ◽

Vol 6 (3) ◽

pp. 1194

Author(s):

Belgin Premkumar ◽

Baburaj S. ◽

Margaret Hepzibah N. ◽

Misha K. P. ◽

Binu Abraham

Keyword(s):

Dengue Fever ◽

Tamil Nadu ◽

Tertiary Care ◽

Case Fatality ◽

Dengue Shock Syndrome ◽

Viral Disease ◽

Severe Dengue ◽

Care Hospital ◽

Clinical Criteria ◽

Public Health Challenge

Background: Dengue fever is the most rapidly spreading mosquito-borne viral disease in the world.Incidence has increased 230-fold with increasing geographic expansion with potential for further spread. The rapidly expanding global footprint of dengue is a public health challenge with an economic burden. This study’s objective is to assess the outbreak of epidemic of dengue fever in a tertiary care children hospital and to describe their socio-demographic, clinical outcome and serological profile.Methods: It is an observational descriptive study conducted for a period of 1 year in less than 12 years old children in a tertiary care hospital at Southern Tamil Nadu.Results: Among the 360 children admitted with dengue fever, there were 198 boys (55%) and 162 (45%) were girls. Maximum incidence of dengue incidence was seen in infants less than 1 year (25%). The highest number of cases were admitted during September and October. The most common affected age group was less than 3 years with 179 (49%). Among the cases, 297 (82%) were of severe dengue which constitute dengue haemorrhagic fever-183(38%) and Dengue shock syndrome 114 (62%). Serological analysis showed NS1 Ag was positive in 144 children (40%), Dengue IgM was positive in 54 children (15%), both IgM and IgG positive in 126 children (35%) and IgG was positive in 36 children (10%). Out of the total children admitted with dengue fever, the case fatality was 0.5% (2 children).Conclusions: This study highlights the importance of WHO clinical criteria for early diagnosis of severe dengue. Moreover, the early and intensive management reduces the mortality significantly.

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Dengue fever complicated with acute liver failure: A case report of expanded dengue syndrome and literature review

SAGE Open Medical Case Reports ◽

10.1177/2050313x20913428 ◽

2020 ◽

Vol 8 ◽

pp. 2050313X2091342 ◽

Cited By ~ 1

Author(s):

Navaneethakrishnan Suganthan ◽

Gajawathana Sakthilingham ◽

Thirunavukarasu Kumanan

Keyword(s):

Liver Failure ◽

Acute Liver Failure ◽

Dengue Fever ◽

Dengue Infection ◽

Dengue Shock Syndrome ◽

Acute Hepatic Failure ◽

Fresh Frozen Plasma ◽

Uneventful Recovery ◽

Fresh Frozen ◽

Plasma Leakage

Dengue is the most common arboviral disease, the presentation of which ranges from asymptomatic illness to dengue shock syndrome. Liver is the most common organ affected in dengue, and liver involvement is asymptomatic in majority. Dengue fever is a rare, but a leading cause for acute liver failure in endemic regions. Here, we report a case of a 34-year-old male ethanol user (16 units per week), presented with typical features of dengue infection, which was confirmed serologically, complicated with acute liver failure without clinical, radiological or laboratory evidence of plasma leakage. He was managed with intravenous fresh frozen plasma and N-acetyl cysteine along with other recommended supportive therapies for acute hepatic failure. He made an uneventful recovery.

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Clinical Profiles of Dengue Infection during an Outbreak in Northern India

Journal of Tropical Medicine ◽

10.1155/2016/5917934 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 9

Author(s):

Anish Laul ◽

Poonam Laul ◽

Vamsi Merugumala ◽

Ravi Pathak ◽

Urvashi Miglani ◽

...

Keyword(s):

Dengue Fever ◽

Dengue Infection ◽

Dengue Shock Syndrome ◽

Acalculous Cholecystitis ◽

Signs And Symptoms ◽

Hemorrhagic Fever ◽

Warning Signs ◽

Mosquito Vector ◽

Diagnostic Dilemma ◽

Atypical Presentations

Introduction.Dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS) with atypical presentations, thus posing a diagnostic dilemma. Unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. We studied the various clinical presentations of dengue infection during an outbreak of disease in 2015.Materials and Methods. A total of 115 confirmed cases of dengue infection from Department of Medicine of Deen Dayal Upadhyay Hospital, New Delhi, were enrolled in this observational study.Results.The common signs and symptoms of dengue infection were fever, headache, body ache, backache, retro-orbital pain, bleeding manifestations, and rash in 100%, 87%, 86%, 58%, 41%, 21%, and 21%, respectively. Nonspecific or warning signs and symptoms included vomiting, weakness, abdominal pain, breathlessness, vertigo, sweating, and syncope. Other possible signs and symptoms of coinfections, comorbidities, or complications included diarrhea, sore throat, and neurological manifestations. There were seven patients with coinfections and four with comorbidities. The final diagnosis of these patients was DF (73%), DHF (16.5%), DSS (1.7%), and EDS (4.3%). Among EDS patients, the atypical presentations included encephalopathy, lateral rectus nerve palsy, acalculous cholecystitis, and myocarditis. Four patients required ICU care and there was no death in this study.Conclusion. Knowledge of atypical presentations is a must for early diagnosis and timely intervention to prevent life-threatening complications.

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Effect of Prior Symptomatic Dengue Infection on Dengue Haemorrhagic Fever (DHF) in Children

Journal of Tropical Medicine ◽

10.1155/2021/8842799 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Randula Ranawaka ◽

Chamara Jayamanne ◽

Kavinda Dayasiri ◽

Dinuka Samaranayake ◽

Udara Sandakelum ◽

...

Keyword(s):

Dengue Fever ◽

Past History ◽

Secondary Infection ◽

Severe Disease ◽

Dengue Infection ◽

Dengue Shock Syndrome ◽

Dengue Haemorrhagic Fever ◽

Severe Dengue ◽

Haemorrhagic Fever ◽

History Of

Pathogenesis of dengue haemorrhagic fever is not fully understood, but it is thought that there is antibody enhancement during the secondary infection, which causes severe dengue haemorrhagic fever (DHF). Therefore, patients who have DHF should have a documented history of symptomatic dengue infection in the past. A retrospective descriptive-analytical study was conducted at the University Paediatric Unit at Lady Ridgeway Hospital for Children, Colombo, Sri Lanka. All children who had fulfilled the criteria for DHF admitted to the unit from April 2018 to September 2018 were recruited into the study. Relevant data were collected from bed head tickets. One hundred and eighty-four children were included in the final analysis. Thirty-three (17.9%) had a past history of documented symptomatic dengue infection, while 82.1% did not have a documented dengue infection. Twelve patients had dengue shock syndrome, and none of them had previously documented symptomatic dengue fever. Dextran was used in 96 patients in the critical phase. Twelve (42%) patients with past documented symptomatic dengue fever needed dextran while 84 (54.9%) patients without a documented past history of dengue fever needed dextran. In our clinical observation, we noticed that children with DHF mostly did not have a documented symptomatic prior dengue infection, while those with a documented symptomatic prior infection had a milder subsequent illness. In fact, the majority (82.1%) of patients with DHF did not have documented previous symptomatic dengue infection. It was also observed that the clinical course of subsequent dengue infection was less severe in patients with previously documented symptomatic dengue fever. This finding should be further evaluated in a larger scale study minimizing the all-confounding factors. This fact is more important in selecting recipients for vaccines against the dengue virus, which are supposed to produce immunity against the virus without causing the severe disease.

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