scholarly journals Plasma Choline Concentration and Dietary Choline Intake of Some Korean Young Adults

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Young‐Jin Chung ◽  
Hyo‐Jung Cho ◽  
Jin‐Seok Na
Keyword(s):  
Young Adults ◽  
Choline Intake ◽  
Dietary Choline

Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study

2021 ◽  
pp. 1-10
Author(s):  
Jie Zhu ◽  
Yu-Hong Liu ◽  
Xiang-Long He ◽  
Martin Kohlmeier ◽  
Li-Li Zhou ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Case Control Study ◽  
Chinese Women ◽  
Case Control ◽  
Han Chinese ◽  
Food Frequency ◽  
Term Delivery ◽  
Choline Intake ◽  
Dietary Choline ◽  
Control Study

<b><i>Introduction and Aims:</i></b> Choline-metabolizing genetic variation may interact with choline intake on fetal programming and pregnancy outcome. This case-control study aims to explore the association of maternal choline consumption and phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphism rs7946 with preterm birth risk. <b><i>Methods:</i></b> 145 Han Chinese women with preterm delivery and 157 Han Chinese women with term delivery were recruited in Shanghai. Dietary choline intake during pregnancy was assessed using a validated food frequency questionnaire. Additionally, DNA samples were genotyped for PEMT rs7946 (G5465A) with plasma homocysteine (Hcy) levels measured. <b><i>Results:</i></b> Compared with the lowest quartile of choline intake, women within the highest consumption quartile had adjusted odds ratio (aOR) for preterm birth of 0.48 (95% confidence interval, CI [0.24, 0.95]). There was a significant interaction between maternal choline intake and PEMT rs7946 (<i>p</i> for interaction = 0.04), where the AA genotype carriers who consumed the energy-adjusted choline &#x3c;255.01 mg/day had aOR for preterm birth of 3.75 (95% CI [1.24, 11.35]), compared to those with GG genotype and choline intake &#x3e;255.01 mg/day during pregnancy. Additionally, the greatest elevated plasma Hcy was found in the cases with AA genotype and choline consumption &#x3c;255.01 mg/day (<i>p</i> &#x3c; 0.001). <b><i>Conclusion:</i></b> The AA genotype of PEMT rs7946 may be associated with increased preterm birth in these Han Chinese women with low choline intake during pregnancy.

Low dietary choline intake is associated with osteoporosis in elderly individuals: a population-based study

2021 ◽  
Author(s):  
Yuan-Wei Zhang ◽  
Pan-Pan Lu ◽  
Ying-Juan Li ◽  
Guang-Chun Dai ◽  
Mu-Min Cao ◽  
...  
Keyword(s):  
Bone Health ◽  
The Elderly ◽  
Population Based ◽  
Population Based Study ◽  
Elderly Individuals ◽  
Choline Intake ◽  
Dietary Choline ◽  
As If

Currently, little is known regarding the association between dietary choline intake and osteoporosis in the elderly individuals, as well as if such intakes affect bone health and result in fractures....

scholarly journals Dietary Choline Intake: Current State of Knowledge Across the Life Cycle

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1513 ◽  
Author(s):  
Alejandra Wiedeman ◽  
Susan Barr ◽  
Timothy Green ◽  
Zhaoming Xu ◽  
Sheila Innis ◽  
...  
Keyword(s):  
Life Cycle ◽  
Current Knowledge ◽  
Water Soluble ◽  
Food Sources ◽  
Soluble Form ◽  
Dietary Recommendations ◽  
Current State ◽  
Dietary Nutrient ◽  
Choline Intake ◽  
Dietary Choline

Choline, an essential dietary nutrient for humans, is required for the synthesis of the neurotransmitter, acetylcholine, the methyl group donor, betaine, and phospholipids; and therefore, choline is involved in a broad range of critical physiological functions across all stages of the life cycle. The current dietary recommendations for choline have been established as Adequate Intakes (AIs) for total choline; however, dietary choline is present in multiple different forms that are both water-soluble (e.g., free choline, phosphocholine, and glycerophosphocholine) and lipid-soluble (e.g., phosphatidylcholine and sphingomyelin). Interestingly, the different dietary choline forms consumed during infancy differ from those in adulthood. This can be explained by the primary food source, where the majority of choline present in human milk is in the water-soluble form, versus lipid-soluble forms for foods consumed later on. This review summarizes the current knowledge on dietary recommendations and assessment methods, and dietary choline intake from food sources across the life cycle.

scholarly journals Associations Between Maternal Dietary Choline Intake During Pregnancy and Developmental Outcomes in Toddlers

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 980-980
Author(s):  
Kindann Fawcett ◽  
Clark Sims ◽  
Rosemary Gaitliff ◽  
Ginger McCorkle ◽  
Jayne Bellando ◽  
...  
Keyword(s):  
Adaptive Behavior ◽  
Infant Development ◽  
Linear Models ◽  
Secondary Data ◽  
Normal Weight ◽  
Social Emotional ◽  
Normal Range ◽  
Neurodevelopmental Outcomes ◽  
Choline Intake ◽  
Dietary Choline

Abstract Objectives Recent studies indicate that adequate choline intake in pregnancy results in increased cognitive, motor, language, and behavioral scores in toddlers. The objective was to examine the relationship between maternal choline intake during pregnancy and children's developmental scores during the first two years of life. Methods De-identified secondary data from a longitudinal study (NCT#0,328,1851) involving women with normal weight, overweight, and class I obesity (BMI:18.5- 35 kg/m,2 N = 251) during pregnancy and their children were analyzed using Pearson's correlations and linear models. Dietary choline intake was obtained by analyzing 3-day food records at each trimester using the Nutrient Data System for Research. Cognitive, motor, language, social emotional, and adaptive behavioral scores at 1 and 2 years of age were derived from the administration of the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). Results Adequate Intake (AI) for average maternal choline intake was only met by 4 of the 251 participants. Mean intake of maternal choline during pregnancy (281 mg/day) was significantly lower than the AI level of pregnant women (AI = 450 mg/day). Mean standard scores for Bayley-III domains were all within the normal range (102 for cognitive, 101 for motor, 96 for language, 109 for social-emotional, and 94 for adaptive behavior). Higher maternal choline intake yielded lower adaptive development at 12 months of age (P &lt; 0.001) and 24 months of age (P = 0.044) after adjusting for gestational age and birthweight. There were no associations between maternal choline intake and cognitive, motor, language and social-emotional scores at both ages. Conclusions In this cohort from Arkansas, maternal choline intake was not associated with four of the children's neurodevelopmental outcomes. Maternal Choline intake was negatively associated with the self-reported adaptive behavior scope, which is in contrast to previously published literature. It is important to note that infant development scores were all within normal range despite 98% of women not meeting the AI recommendations for dietary choline during pregnancy. Analyses of choline serum concentration from this cohort is underway to confirm these results. Funding Sources USDA ARS Project # 6026–51,000-012–06S, NIH R01 DK107516.

scholarly journals Examination of Prenatal Dietary Choline Intake, and Maternal and Infant Outcomes

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 993-993
Author(s):  
Rosemary Gatliff ◽  
Joshua Phelps ◽  
Christi Arthur ◽  
Aline Andres
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Diet Quality ◽  
Healthy Eating Index ◽  
Maternal Body Mass Index ◽  
Food Records ◽  
Choline Intake ◽  
Infant Birth ◽  
Dietary Choline ◽  
Maternal Bmi

Abstract Objectives The objectives of this study were to explore associations between maternal dietary choline intake and diet quality, maternal body mass index (BMI), and infant birth weight. Methods De-identified secondary data from 251 participants in a study involving pregnant women were analyzed to investigate associations between maternal dietary choline intake and infant birth weight; maternal dietary choline intake and 2015 Healthy Eating Index (HEI) scores; as well as 2015 HEI scores and maternal BMI. HEI scores were calculated from 3-day food records obtained during gestation (&lt;10, 12, 18, 24, 30, 36 weeks). Overall dietary choline intake during pregnancy was computed from all food records. Spearman's rank-order correlations, a one-sample Wilcoxon signed rank test, and a mixed linear model were used to test the hypotheses. Results There was a statistically significant correlation between maternal choline intake and the 1st trimester and 3rd trimester 2015-HEI scores (rs(207) = 0.204, P = 0.003 and rs(207) = 0.249, P = 0.00028, respectively). Median intake of dietary choline, 267 milligrams, was significantly lower (P &lt; 0.0005) than the adequate Intake for pregnant women (450 milligrams). There were trends (0.05 &lt; P &lt; 0.1) pointing to a pattern of negative association between maternal BMI and 1st, 2nd, and 3rd trimester 2015-HEI scores. Mixed model analysis revealed a statistically significant negative correlation (β = −0.001, P = 0.010) between maternal choline intake and infant birth weight. Conclusions As dietary choline increased, there was an associative decrease in birthweight; however, overall diet quality was poor and dietary choline intake was significantly lower than the recommended intake for pregnant women. These findings reflect the current body of evidence that pregnant women are at risk for choline inadequacy and that overall diet quality may help in preventing low choline intake during pregnancy. Funding Sources USDA-ARS Project.

scholarly journals Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine-N-Oxide

mBio ◽  
2015 ◽  
Vol 6 (2) ◽  
Author(s):  
Kymberleigh A. Romano ◽  
Eugenio I. Vivas ◽  
Daniel Amador-Noguez ◽  
Federico E. Rey
Keyword(s):  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Human Life ◽  
Water Soluble ◽  
Human Gut ◽  
Choline Intake ◽  
Low Levels ◽  
And Function ◽  
Dietary Choline

ABSTRACT Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which upon absorption by the host is converted in the liver to trimethylamine-N-oxide (TMAO). Recent studies revealed that TMAO exacerbates atherosclerosis in mice and positively correlates with the severity of this disease in humans. However, which microbes contribute to TMA production in the human gut, the extent to which host factors (e.g., genotype) and diet affect TMA production and colonization of these microbes, and the effects TMA-producing microbes have on the bioavailability of dietary choline remain largely unknown. We screened a collection of 79 sequenced human intestinal isolates encompassing the major phyla found in the human gut and identified nine strains capable of producing TMA from choline in vitro. Gnotobiotic mouse studies showed that TMAO accumulates in the serum of animals colonized with TMA-producing species, but not in the serum of animals colonized with intestinal isolates that do not generate TMA from choline in vitro. Remarkably, low levels of colonization by TMA-producing bacteria significantly reduced choline levels available to the host. This effect was more pronounced as the abundance of TMA-producing bacteria increased. Our findings provide a framework for designing strategies aimed at changing the representation or activity of TMA-producing bacteria in the human gut and suggest that the TMA-producing status of the gut microbiota should be considered when making recommendations about choline intake requirements for humans. IMPORTANCE Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and increased trimethylamine N-oxide (TMAO) levels have been causally linked with CVD development. This work identifies members of the human gut microbiota responsible for both the accumulation of trimethylamine (TMA), the precursor of the proatherogenic compound TMAO, and subsequent decreased choline bioavailability to the host. Understanding how to manipulate the representation and function of choline-consuming, TMA-producing species in the intestinal microbiota could potentially lead to novel means for preventing or treating atherosclerosis and choline deficiency-associated diseases.

Reproductive state and choline intake influence enrichment of plasma lysophosphatidylcholine-DHA: a post hoc analysis of a controlled feeding trial

2019 ◽  
Vol 122 (11) ◽  
pp. 1221-1229
Author(s):  
Kevin C. Klatt ◽  
Melissa Q. McDougall ◽  
Olga V. Malysheva ◽  
J. Thomas Brenna ◽  
Mark S. Roberson ◽  
...  
Keyword(s):  
Linear Models ◽  
Major Facilitator Superfamily ◽  
Reproductive State ◽  
Lactating Women ◽  
Phosphatidylcholine Biosynthesis ◽  
Pregnancy And Lactation ◽  
Choline Intake ◽  
Major Facilitator ◽  
Post Hoc ◽  
Dietary Choline

AbstractThe major facilitator superfamily domain 2a protein was identified recently as a lysophosphatidylcholine (LPC) symporter with high affinity for LPC species enriched with DHA (LPC-DHA). To test the hypothesis that reproductive state and choline intake influence plasma LPC-DHA, we performed a post hoc analysis of samples available through 10 weeks of a previously conducted feeding study, which provided two doses of choline (480 and 930 mg/d) to non-pregnant (n 21), third-trimester pregnant (n 26), and lactating (n 24) women; all participants consumed 200 mg of supplemental DHA and 22 % of their daily choline intake as 2H-labelled choline. The effects of reproductive state and choline intake on total LPC-DHA (expressed as a percentage of LPC) and plasma enrichments of labelled LPC and LPC-DHA were assessed using mixed and generalised linear models. Reproductive state interacted with time (P = 0·001) to influence total LPC-DHA, which significantly increased by week 10 in non-pregnant women, but not in pregnant or lactating women. Contrary to total LPC-DHA, patterns of labelled LPC-DHA enrichments were discordant between pregnant and lactating women (P < 0·05), suggestive of unique, reproductive state-specific mechanisms that result in reduced production and/or enhanced clearance of LPC-DHA during pregnancy and lactation. Regardless of the reproductive state, women consuming 930 v. 480 mg choline per d exhibited no change in total LPC-DHA but higher d3-LPC-DHA (P = 0·02), indicating that higher choline intakes favour the production of LPC-DHA from the phosphatidylethanolamine N-methyltransferase pathway of phosphatidylcholine biosynthesis. Our results warrant further investigation into the effect of reproductive state and dietary choline on LPC-DHA dynamics and its contribution to DHA status.

scholarly journals Plasma Free Choline Concentration Did Not Reflect Dietary Choline Intake in Early and Late Pregnancy: Findings from the APrON Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1825-1825
Author(s):  
Maria Mujica ◽  
Erin Lewis ◽  
Rene Jacobs ◽  
Nicole Letourneau ◽  
Rhonda Bell ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Maternal Age ◽  
Late Pregnancy ◽  
Linear Mixed Effects ◽  
Funding Sources ◽  
Wilcoxon Rank Sum Test ◽  
Free Choline ◽  
Canada Research Chair ◽  
Choline Intake ◽  
Dietary Choline

Abstract Objectives Choline is a critical nutrient for fetal development. Pregnancy studies showed that most women have choline intakes below the adequate intake (AI) level of 450 mg/d. Research on plasma free choline as an indicator of dietary choline intake showed conflicting results to date. We sought to compare plasma free choline concentration between women with different choline intakes and to explore the association between plasma free choline and dietary choline intake in early (EP) and late pregnancy (LP). Methods This study included data and non-fasting plasma samples from pregnant women enrolled in the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study. EP (&lt;20 weeks of gestation) and LP (&gt;20 weeks of gestation) dietary choline intake was estimated using a 24-hr recall. Two categories of dietary choline intake were created: 1) low choline (LCI), i.e., choline intake in 1st quartile (Q) in EP, with these women having choline intake in 1st or 2nd Q in LP (n = 61); 2) high choline intake (HCI), i.e., choline intake in 4th Q in EP and in 3rd or 4th Q in LP (n = 46). Linear mixed-effects models were used to explore the association between plasma free choline and dietary choline intake across EP and LP, after adjustment for maternal age, ethnicity and weeks of gestation. Results Median (IQR) maternal age was 32 (30–35) y, and 80% were Caucasian. LCI was 101 (86–109) and 109 (93–127) mg/day in EP and LP, respectively, and HCI was 251 (223–286) and 212 (177–274) mg/day. Plasma free choline (μmol/L) did not differ between LCI and HCI at EP [LCI: 10.6 (9.03, 12.9); HCI: 11.7 (10.2, 13.8)] and LP [LCI: 11.7 (10.6, 12.7); HCI: 12.7 (10.7, 15.8)] (P &gt; 0.05, Wilcoxon rank-sum test). Per 10 mg of choline intake, plasma free choline increased by 0.34 (95%CI 0.12, 0.56) in those with LCI, and 0.18 (95%CI 0.050, 0.31) in women with HCI, across EP and LP after adjustment. Conclusions In this subgroup of pregnant women, plasma free choline concentration did not reflect differences in dietary choline intake in EP or LP. This may be explained by an overall low choline intake (&lt;AI) which would promote rapid tissue uptake of choline. The identification of a sensitive and dynamic biomarker for choline status is required. Funding Sources UBC Four Year Doctoral Fellowship, Canada Research Chair Program, CIHR NTE Grant FRN 160,942, Alberta Innovates for the APrON cohort.

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