scholarly journals Development of a proof of concept bioassay core laboratory for in vivo testing of functional food products in animal models

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Kathleen Lee McCutcheon ◽  
Roy J Martin ◽  
Michael J Keenan
Keyword(s):  
Animal Models ◽  
Functional Food ◽  
Food Products ◽  
Proof Of Concept ◽  
In Vivo Testing

scholarly journals Scaffold-Free 3-D Cell Sheet Technique Bridges the Gap between 2-D Cell Culture and Animal Models

2019 ◽  
Vol 20 (19) ◽  
pp. 4926 ◽  
Author(s):  
Ayidah Alghuwainem ◽  
Alaa T. Alshareeda ◽  
Batla Alsowayan
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Animal Models ◽  
Tissue Repair ◽  
Cell Sheet ◽  
Cell Sheets ◽  
Systemic Injection ◽  
In Vivo Testing ◽  
D Cell

Various tissue engineering techniques have been created in research spanning two centuries, resulting in new opportunities for growing cells in culture and the creation of 3-D tissue-like constructs. These techniques are classified as scaffold-based and scaffold-free techniques. Cell sheet, as a scaffold-free technique, has attracted research interest in the context of drug discovery and tissue repair, because it provides more predictive data for in vivo testing. It is one of the most promising techniques and has the potential to treat degenerative tissues such as heart, kidneys, and liver. In this paper, we argue the advantages of cell sheets as a scaffold-free approach, compared to other techniques, including scaffold-based and scaffold-free techniques such as the classic systemic injection of cell suspension.

The in vivo digestibility study of banana flour with high content of resistant starch at different ripening stages

2020 ◽  
Vol 11 (12) ◽  
pp. 10945-10953
Author(s):  
Jie Yang ◽  
Yu Bi ◽  
Shangyun Liang ◽  
Zhengbiao Gu ◽  
Li Cheng ◽  
...  
Keyword(s):  
Resistant Starch ◽  
Functional Food ◽  
Nutritional Value ◽  
Food Products ◽  
Food Ingredient ◽  
Ripening Stages ◽  
Banana Flour

Resistant starch, a functional food ingredient, can improve the nutritional value of food products.

In vivo study of the potential of the carbohydrate-mineral complex from pine nut shells as an ingredient of functional food products

2019 ◽  
Vol 18 ◽  
pp. 100185 ◽  
Author(s):  
Olga Babich ◽  
Lyubov Dyshlyuk ◽  
Svetlana Noskova ◽  
Stanislav Sukhikh ◽  
Alexander Prosekov ◽  
...  
Keyword(s):  
Functional Food ◽  
Food Products ◽  
In Vivo Study ◽  
Mineral Complex ◽  
Pine Nut

scholarly journals In vivo testing possibilities of periodontal biomaterials with intra-oral and extra-oral approaches on laboratory rats

2021 ◽  
Vol 8 (2) ◽  
pp. 100-105
Author(s):  
Ioana Mitrut ◽  
◽  
Horia Octavian Manolea ◽  
Alex Ioan Salan ◽  
Ioana Neagu ◽  
...  
Keyword(s):  
Animal Models ◽  
Alveolar Bone ◽  
Dental Materials ◽  
Biological Response ◽  
Laboratory Rats ◽  
Biological Adaptation ◽  
Wide Range ◽  
In Vivo Testing ◽  
Materials Used

Introduction Periodontitis is an oral inflammatory disease of significant importance, that leads to gingival inflammation, alveolar bone loss and has a high impact on the quality of life and general health. There has been a continuous interest in the scientific world to test new therapies and therapeutic materials for periodontal disease. One of the most critical tools to investigate mechanisms of periodontal pathogenesis and test new therapeutic materials are animal models. In addition, there is a wide range of materials used in periodontal therapy, especially in terms of bone augmentation, so choosing the ideal material is often difficult to achieve. Methodology In this article, we have evaluated two methods for testing artificially induced periodontal defects - intra-orally and extra-orally - the biological adaptation of the materials used in periodontal and bone regeneration techniques on animal models. Results We have created two protocols for the extra-oral and intra-oral approaches. By following them we have succesfully managed to create the periodontal defects and to apply the therapeutic materials. We have also made a comparison between the two methods, and the possibilities of materials that can be used. Conclusion Tests performed on animal models will remain an important asset for evaluating new approaches for the improvement of tissue regeneration therapies. As there are continuous advances in the study of dental materials, we also have to search for new, easy to perform, ethics-friendly methods to evaluate the biological response of these materials.

Synthesis, Properties, and in vivo Testing of Biogenic Ferrihydrite Nanoparticles

2020 ◽  
Vol 84 (11) ◽  
pp. 1366-1369
Author(s):  
S. V. Stolyar ◽  
V. P. Ladygina ◽  
A. V. Boldyreva ◽  
O. A. Kolenchukova ◽  
A. M. Vorotynov ◽  
...  
Keyword(s):  
Synthesis Properties ◽  
In Vivo Testing
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