scholarly journals Glucose and lipid metabolism are modified by short‐term alterations to milking frequency in grazing dairy cows

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Talia M Grala ◽  
Claire V C Phyn ◽  
Jane K Kay ◽  
Agustin G. Rius ◽  
Mathew D. Littlejohn ◽  
...  
1993 ◽  
Vol 128 (3) ◽  
pp. 251-258 ◽  
Author(s):  
Per H Andersen ◽  
Bjørn Richelsen ◽  
Jens Bak ◽  
Ole Schmitz ◽  
Niels S Sørensen ◽  
...  

In a short-term (eight days) double-blind crossover study involving 10 obese patients, the effects of dexfenfluramine on glucose and lipid metabolism were examined. The protocol comprised whole body in vivo measurements (hyperinsulinemic euglycemic clamp in combination with indirect calorimetry) and in vitro studies of isolated adipocytes (lipolysis and glucose transport). All study participants were weight stable during the study period (103.1±3.2, placebo vs 103.3±3.1 kg, dexfenfluramine, NS). The following parameters were significantly reduced after dexfenfluramine treatment: fasting levels of plasma glucose (6.2±0.2 vs 5.7±0.2 mmol/l, p<0.01), serum insulin (168.0±14.5 vs 138.9±7.9 pmol/l, p<0.05), serum C-peptide (0.68±0.03 vs 0.58±0.02 nmol/l, p<0.05) and total serum cholesterol (6.07±0.41 vs 5.48±0.38 mmol/l, p< 0.01). In the basal state glucose oxidation rate was significantly reduced by 36% (p<0.001), whereas non-oxidative glucose disposal was significantly increased by 41% (p<0.01), following dexfenfluramine treatment. Insulin-stimulated (2 mU·kg−1·min−1) glucose disposal rate tended to be increased (18%, p=0.10) after dexfenfluramine. In conclusion, dexfenfluramine possesses beneficial regulatory effects on glucose and lipid metabolism in non-diabetic obese patients, independently of weight loss.


2003 ◽  
Vol 70 (3) ◽  
pp. 267-276 ◽  
Author(s):  
C Richard Stockdale ◽  
Glen P Walker ◽  
William J Wales ◽  
Dawn E Dalley ◽  
Anne Birkett ◽  
...  

In five short-term experiments conducted in Victoria in 1997 and 1998, grazing dairy cows were given either pasture alone or pasture supplemented with high-energy concentrates, and the fatty acid profiles of milk fat were measured. We established the effects of these feeds on some aspects of milk fat of importance for human nutrition, but we specifically focused on the hypothesis that conjugated linoleic acid (CLA) concentrations in milk fat increase as pasture intake increases, and decrease as more concentrates are fed. In agreement with previous research, feeding fresh pasture alone resulted in high concentrations (1·0–1·8 g/100 g milk fat) of CLA. When the effect of level of pasture consumption on CLA content was examined, a significant positive relationship (r2=0·35; P<0·05) was obtained. When cereal grain concentrates were used to supplement pasture intake, the CLA content of milk fat generally declined (P<0·05), except where the amount of concentrates given led to a marked reduction in total milk fat concentration. The use of cereal grain concentrates also generally resulted in significant (P<0·05) increases in medium-chain saturated fatty acids, but always reduced the contribution of butyric acid to milk fat, from 4·5 to 3·9 g/100 g milk fat, on average.


2021 ◽  
Vol 22 (11) ◽  
pp. 6149
Author(s):  
Nathan Favalier ◽  
Vincent Véron ◽  
Michael Marchand ◽  
Anne Surget ◽  
Patrick Maunas ◽  
...  

Rainbow trout are considered as a poor user of dietary carbohydrates, displaying persistent postprandial hyperglycaemia when fed a diet containing high amounts of carbohydrates. While this phenotype is well-described in juveniles, less attention was given to broodstock. Our objective was to assess for the first time the short-term consequences of feeding mature female and male, and neomale trout with a low-protein high-carbohydrate diet on glucose and lipid metabolism. Fish were fed for two days with a diet containing either no or 32% of carbohydrates. We analysed plasma metabolites, mRNA levels and enzymatic activities of glycolysis, gluconeogenesis, de novo lipogenesis and β-oxidation in the liver. Results demonstrated that the glucose and lipid metabolism were regulated by the nutritional status in all sexes, irrespective of the carbohydrate intake. These data point out that carbohydrate intake during a short period (5 meals) at 8 °C did not induce specific metabolic changes in broodstock. Finally, we demonstrated, for the first time, sex differences regarding the consequences of two days of feeding on glucose and lipid metabolism.


1999 ◽  
Vol 39 (7) ◽  
pp. 803 ◽  
Author(s):  
C. R. Stockdale

Summary. The hypothesis tested in the experiment reported here was that levels of substitution would be lower and marginal responses to supplementation higher in grazing dairy cows that were subjected to long, compared with short, treatment periods. Forty cows were fed irrigated perennial pasture which contained ryegrass (Lolium perenne), white clover (Trifolium repens), paspalum (Paspalum dilatatum) and weeds at a herbage allowance of about 40 kg dry matter (DM)/cow.day. Of the 40 cows, 20 were under continuous treatment for 6 months (2 October 1995 to 24 March 1996, inclusive) (long term), while treatments were applied to the remaining 20 cows every second month (short term). The second group of cows, therefore, commenced 4 weeks of treatment on 3 occasions, 31 October, 1 January and 26 February. The cows in the short-term treatments were re-randomised for each of their 3 periods in the experiment. There were 2 long-term treatments, one where pasture was fed alone and the other where the same amount of pasture was supplemented with 5 kg DM/cow.day of a 75% barley –25% wheat grain pellet. There were 2 replicates of each treatment and 5 cows per group. The second set of 20 cows was allocated to the same treatments on a short-term basis. When not under treatment, all cows in this second group were offered about 40 kg DM of pasture/cow.day plus 5 kg DM of barley–wheat. Cows ate less pasture when concentrates were fed although total DM intake increased (P<0.05). The level of substitution averaged 0.4 kg DM reduction in pasture intake for each kg DM of concentrates consumed, and this was not affected (P>0.05) by the length of time for which the cows were supplemented. Milk yield declined from November to March and concentrates increased production, but the interaction between period of the year and use of supplements was not significant (P>0.05). However, the milk responses associated with length of time under supplementation appeared to be different in March relative to the other periods. Although the marginal returns to concentrates in March were 0.9 and 1.3 kg milk/kg DM for short- and long-term supplementation, the marginal returns to feeding concentrates for short or long periods during November and January were the same (0.9 kg/kg DM). However, in terms of total DM intake, the average marginal response was lower (1.4 v. 1.9 kg milk/kg of additional total DM) for the short-term treatments. The trends in body condition for the long-term treatments through the experiment indicated that divergence between unsupplemented and supplemented cows occurred consistently throughout, resulting in 0.8 units difference in body condition score after the 6 months of treatment. It is suggested that it was the differences in body condition that were responsible for the variation in milk response towards the end of the experiment. It was concluded that, while the length of time under supplementation had no effect on intake variables or substitution, marginal responses to the long term use of concentrates eventually diverged from those obtained from their use for short periods, principally due to changes in the body condition of animals in the long-term treatments.


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