scholarly journals A systems biology approach reveals the physiological origin of hepatic steatosis induced by liver X receptor activation

2014 ◽  
Vol 29 (4) ◽  
pp. 1153-1164 ◽  
Author(s):  
Brenda S. Hijmans ◽  
Christian A. Tiemann ◽  
Aldo Grefhorst ◽  
Marije Boesjes ◽  
Theo H. Dijk ◽  
...  
Keyword(s):  
Systems Biology ◽  
Hepatic Steatosis ◽  
Receptor Activation ◽  
Liver X Receptor

scholarly journals Regulation of Insulin Resistance and Adiponectin Signaling in Adipose Tissue by Liver X Receptor Activation Highlights a Cross-Talk with PPARγ

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e101269 ◽  
Author(s):  
Fenping Zheng ◽  
Saifei Zhang ◽  
Weina Lu ◽  
Fang Wu ◽  
Xueyao Yin ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Cross Talk ◽  
Receptor Activation ◽  
Liver X Receptor

Liver X receptor activation inhibits PC-3 prostate cancer cells via the beta-catenin pathway

2017 ◽  
Vol 213 (3) ◽  
pp. 267-270 ◽  
Author(s):  
Kuang Youlin ◽  
Zhang Li ◽  
He Weiyang ◽  
Kang Jian ◽  
Liang Siming ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Receptor Activation ◽  
Liver X Receptor ◽  
Beta Catenin ◽  
Prostate Cancer Cells

scholarly journals Liver X receptor agonist downregulates growth hormone signaling in the liver

2011 ◽  
Vol 8 (2) ◽  
Author(s):  
Fahad Zadjali ◽  
Ruyman Santana-Farre ◽  
Mercedes Mirecki-Garrido ◽  
Ewa Ellis ◽  
Gunnar Norstedt ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hepatic Steatosis ◽  
Hepatic Metabolism ◽  
Liver X Receptor ◽  
Cytokine Signaling ◽  
Hormone Signaling ◽  
Suppressor Of Cytokine Signaling ◽  
Lxr Agonists ◽  
Liver X Receptor Agonist ◽  
Gh Receptors

AbstractLiver X receptor (LXR) agonists have been shown to influence the development of hyperlipidemia and atherosclerosis in mouse models. It has also been demonstrated that some LXR agonists can cause hepatic steatosis in experimental animals. Growth hormone (GH) is known to regulate hepatic metabolism and the absence of hepatic GH receptors (GHR) leads to hepatic steatosis. In this study, we analyzed whether the actions of LXR agonists could involve interference with GH signaling. We showed that LXR agonists impair GH signaling in hepatocytes. LXR agonist treatment attenuated GH induction of suppressor of cytokine signaling 2 (

scholarly journals Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model

2009 ◽  
Vol 51 (4) ◽  
pp. 763-770 ◽  
Author(s):  
François Briand ◽  
Morgan Tréguier ◽  
Agnès André ◽  
Didier Grillot ◽  
Marc Issandou ◽  
...  
Keyword(s):  
Reverse Cholesterol Transport ◽  
Receptor Activation ◽  
Liver X Receptor ◽  
Cholesterol Transport ◽  
Hamster Model
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