EFFECT OF POST-EXERCISE ETHANOL INTOXICATION ON THE FREE TESTOSTERONE RESPONSE TO RESISTANCE EXERCISE IN MEN.

2003 ◽  
Vol 35 (Supplement 1) ◽  
pp. S330 ◽  
Author(s):  
J L. Vingren ◽  
L P. Koziris ◽  
V Ben-Ezra ◽  
W J. Kraemer
Keyword(s):  
Resistance Exercise ◽  
Free Testosterone ◽  
Ethanol Intoxication ◽  
Post Exercise

scholarly journals High-Load Resistance Exercise Augments Androgen Receptor–DNA Binding and Wnt/β-Catenin Signaling without Increases in Serum/Muscle Androgens or Androgen Receptor Content

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3829
Author(s):  
Thomas D. Cardaci ◽  
Steven B. Machek ◽  
Dylan T. Wilburn ◽  
Jeffery L. Heileson ◽  
Darryn S. Willoughby
Keyword(s):  
Androgen Receptor ◽  
Dna Binding ◽  
Resistance Exercise ◽  
Repeated Measures ◽  
Free Testosterone ◽  
High Load ◽  
Total Testosterone ◽  
Post Exercise ◽  
Bonferroni Adjustment ◽  
Full Body

The purpose of this study was (1) to determine the effect of single bouts of volume- and intensity-equated low- (LL) and high-load (HL) full-body resistance exercise (RE) on AR-DNA binding, serum/muscle testosterone and dihydrotestosterone, muscle androgen receptor (AR), and AR-DNA binding; and, (2) to determine the effect of RE on sarcoplasmic and nucleoplasmic β-catenin concentrations in order to determine their impact on mediating AR-DNA binding in the absence/presence of serum/muscle androgen and AR protein. In a cross-over design, 10 resistance-trained males completed volume- and intensity-equated LL and HL full-body RE. Blood and muscle samples were collected at pre-, 3 h-, and 24 h post-exercise. Separate 2 × 3 factorial analyses of variance (ANOVAs) with repeated measures and pairwise comparisons with a Bonferroni adjustment were used to analyze the main effects. No significant differences were observed in muscle AR, testosterone, dihydrotestosterone, or serum total testosterone in either condition (p > 0.05). Serum-free testosterone was significantly decreased 3 h post-exercise and remained significantly less than baseline 24 h post-exercise in both conditions (p < 0.05). In response to HL, AR-DNA binding significantly increased at 3 h post-exercise (p < 0.05), whereas no significant differences were observed at any time in response to LL (p > 0.05). Moreover, sarcoplasmic β-catenin was significantly greater in HL (p < 0.05) without significant changes in nucleoplasmic β-catenin (p > 0.05). In conclusion, increases in AR-DNA binding in response to HL RE indicate AR signaling may be load-dependent. Furthermore, despite the lack of increase in serum and muscle androgens or AR content following HL RE, elevations in AR-DNA binding with elevated sarcoplasmic β-catenin suggests β-catenin may be facilitating this response.

scholarly journals Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christina M. Dieli-Conwright ◽  
Nathalie Sami ◽  
Mary K. Norris ◽  
Junxiang Wan ◽  
Hiroshi Kumagai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Repeated Measures ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Care Group ◽  
Post Exercise ◽  
Increased Risk ◽  
Hispanic White

AbstractMOTS-c is a mitochondrial derived peptide with exercise mimetic activity that elicits beneficial effects on metabolism and exercise capacity. Furthermore, MOTS-c effects in humans are affected by race, potentially via ethnic-specific mtDNA variations. Women treated for breast cancer are at an increased risk for cardiovascular disease, diabetes and obesity, due to side effects of cancer-treatments. We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS). BCS (Stage I–III) were randomized to exercise or standard care. The intervention promoted aerobic and resistance exercise for 16 weeks. MOTS-c was analyzed in fasting plasma using an in-house ELISA. Within and between group differences were assessed by paired t-test and repeated measures ANOVA. Pearson’s correlation was computed to assess the association between MOTS-c and metabolic biomarkers at baseline and post-exercise. Twenty-five Hispanic-BCS and 24 non-Hispanic White BCS were included. Hispanic BCS were younger, of greater adiposity, had higher stage cancers, and had worse metabolic profiles at baseline compared to non-Hispanic White BCS (p < 0.001). Post-exercise, MOTS-c levels significantly increased when compared to baseline and the usual care group among non-Hispanic White BCS (p < 0.01) but not among Hispanic breast cancer survivors (p > 0.01). Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01). A 16-week aerobic and resistance intervention increased MOTS-c levels among non-Hispanic White BCS. Trial registration: This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010. https://clinicaltrials.gov/ct2/show/NCT01140282.

scholarly journals Effect of acute postexercise ethanol intoxication on the neuroendocrine response to resistance exercise

2000 ◽  
Vol 88 (1) ◽  
pp. 165-172 ◽  
Author(s):  
L. Perry Koziris ◽  
William J. Kraemer ◽  
Scott E. Gordon ◽  
Thomas Incledon ◽  
Howard G. Knuttgen
Keyword(s):  
Resistance Exercise ◽  
Ethanol Concentration ◽  
Pooled Analysis ◽  
Cortisol Concentration ◽  
Neuroendocrine System ◽  
Sympathoadrenal System ◽  
Ethanol Intoxication ◽  
Blood Ethanol Concentration ◽  
Neuroendocrine Response ◽  
Prolonged Effect

This investigation was conducted to determine the effect of postexercise ethanol intoxication (21.97 ± 1.09 mmol/l blood) on the response of selected aspects of the neuroendocrine system to a resistance exercise (Ex) session. Nine resistance-trained men (25.0 ± 1.4 yr, 179.4 ± 3.4 cm, 79.7 ± 3.3 kg) were used to compare three 3-day treatments: control, Ex, and ethanol after exercise (ExEt). Blood was collected serially from an antecubital vein before exercise, immediately after exercise, and for pooled analysis at 20–40 (2 samples), 60–120 (4 samples), and 140–300 (9 samples) min after exercise on day 1 and in the morning (2 samples each) on days 2 and 3. Ethanol did not increase circulating epinephrine, norepinephrine, or cortisol concentration (Cort) above Ex elevations. At 60–120 min, only ExEt Cort was greater than control Cort. Concentrations of testosterone, luteinizing hormone, and corticotropin were not affected by either treatment. It is concluded that, although this blood ethanol concentration is insufficient to acutely increase Cort above that caused by Ex alone, it appears that ethanol may have a prolonged effect beyond the Ex response. This blood ethanol concentration does not further stimulate the sympathoadrenal system during the postexercise response.

scholarly journals Ultrafast Ultrasound-Derived Muscle Strain Measure Correlates with Carotid Local Pulse Wave Velocity in Habitual Resistance-Trained Individuals

2021 ◽  
Vol 11 (18) ◽  
pp. 8783
Author(s):  
Hsin-Fu Lin ◽  
Yi-Hung Liao ◽  
Pai-Chi Li
Keyword(s):  
Pulse Wave Velocity ◽  
Resistance Exercise ◽  
Strain Rate ◽  
Wave Velocity ◽  
Exercise Intensity ◽  
Pulse Wave ◽  
Muscle Stiffness ◽  
Ultrasound Elastography ◽  
Muscle Strain ◽  
Post Exercise

Purpose: this study investigated the effects of the intensity of machine-based bicep curl resistance exercise on ultrafast ultrasound-derived muscle strain rate and carotid ultrafast pulse wave velocity (ufPWV), and examined the association between muscle strain rate, ufPWV, and established carotid function measures in habitual resistance-trained individuals. Methods: twenty-three young habitual resistance-trained males (age: 24 ± 1 year, body mass index = 24 ± 1 kg/m2) were recruited to participate in two bouts of acute bicep curl exercise. After one-repetition maximum determination (1RM), the participants were randomly assigned to engage in bicep curls at 40 or 80%1RM intensity (10 reps × five sets) by a crossover study design. The muscle strain rate of bicep muscle, carotid ufPWV during systole(ufPWV-sys), and diastole (ufPWV-dia) were obtained pre- and post-exercise. In addition, carotid function measures were calculated by obtained carotid diameter and central blood pressure changes. Results: compared with pre-exercise, the reduction in post-exercise muscle strain rate and its area under the curve of 80%1RM was greater than those of 40%1RM. Both ufPWV-sys and ufPWV-dia increased regardless of exercise intensity. Baseline bicep muscle strain rate correlated not only with ufPWV-sys (r = −0.71, p = 0.001), ufPWV-dia (r = −0.74, p = 0.001), but also carotid compliance (r = 0.49, p = 0.02), distensibility (r = 0.54, p = 0.01) and ß stiffness (r= −0.84, p < 0.0001). The ufPWVs also correlated with ß stiffness (r = 0.64–0.76, p = 0.01). Conclusion: muscle stiffness measured by ultrafast ultrasound elastography increases positively with resistance exercise intensity, and it appears to correlate with carotid ufPWV and established carotid function measures in habitual resistance-trained individuals.

LH secretion and testosterone concentrations are blunted after resistance exercise in men

2001 ◽  
Vol 91 (3) ◽  
pp. 1251-1258 ◽  
Author(s):  
Bradley C. Nindl ◽  
William J. Kraemer ◽  
Daniel R. Deaver ◽  
Jana L. Peters ◽  
James O. Marx ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Production Rate ◽  
Exercise Bout ◽  
Pulse Amplitude ◽  
Free Testosterone ◽  
Pulse Frequency ◽  
Deconvolution Analysis ◽  
Exercise Condition ◽  
Heavy Resistance Exercise ◽  
Exercise Induced

This study examined the hypothesis that exercise-induced changes in circulating testosterone would be centrally mediated via hypothalamic-pituitary release of luteinizing hormone (LH). We tested this hypothesis by examining overnight LH, total and free testosterone (TT and FT), and cortisol (C) concentrations in 10 young healthy men (21 ± 1 yr) during two experimental sessions: a control and an acute heavy-resistance exercise bout (50 total sets consisting of squats, bench press, leg press, and latissimus dorsi pull-down). Exercise was performed from 1500 to 1700, and blood sampling began at 1700 and continued until 0600 the next morning. Blood was sampled every 10 min for LH and every hour for TT, FT, and C. Hormonal concentrations were determined via RIA, and the secretion characteristics of LH were analyzed with deconvolution analysis. When overnight postexercise concentrations were compared with control concentrations, no statistically significant ( P ≤ 0.05) differences were observed for LH half-life, LH pulse frequency, interpulse interval, pulse amplitude, or pulse mass. Significant differences were observed for LH production rate (13.6 ± 4 and 17.9 ± 5 IU · l distribution volume−1 · day−1 for exercise and control, respectively, a 24% reduction). For the ANOVA marginal main effect means due to condition, C was significantly elevated (5.9 ± 0.7 vs. 4.0 ± 0.4 μg/dl), while TT (464 ± 23 vs. 529 ± 32 ng/dl) and FT (15.6 ± 0.7 vs. 18.3 ± 0.9 pg/ml) were significantly decreased for the exercise condition. These data demonstrate that the decline in overnight testosterone concentrations after acute heavy-resistance exercise is accompanied by a blunted LH production rate and elevated C concentrations.

Effect of High-velocity Resistance Exercise on 24-h Blood Pressure in Hypertensive Older Women

2020 ◽  
Vol 42 (01) ◽  
pp. 41-47
Author(s):  
Filipe Fernandes Oliveira-Dantas ◽  
Rodrigo Alberto Vieira Browne ◽  
Ricardo Santos Oliveira ◽  
Ludmila Lucena Pereira Cabral ◽  
Luiz Fernando de Farias Junior ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Resistance Exercise ◽  
Older Women ◽  
Ambulatory Blood Pressure ◽  
High Velocity ◽  
Moderate Intensity ◽  
Exercise Session ◽  
Control Session ◽  
Post Exercise ◽  
Resistance Exercise Session

AbstractThis study investigated the acute post-exercise effect of high-velocity resistance exercise on ambulatory blood pressure in hypertensive older women. Fourteen volunteers (67.9±5.1 years) performed a high-velocity resistance exercise session (8 exercises using Thera-Band, 3 sets of 6 repetitions as fast as possible in the concentric phase with moderate intensity) and a control session, separated by a 7–10-day period. Ambulatory blood pressure was monitored following 12-h post-sessions and compared between conditions at 1 to 4-h, 5 to 8-h, and 9 to 12-h. Average 24-h ambulatory blood pressure, awake, asleep periods, and blood pressure load were also analyzed. There was a condition by time interaction for systolic ambulatory blood pressure over 12-h post-sessions (P=0.043). It was observed a lower systolic ambulatory blood pressure in the first 4-h period following the high-velocity resistance exercise session compared to the control session (−6.7 mmHg, 95% CI  − 11.6 to −1.8 mmHg; P=0.011). No changes were observed for diastolic ambulatory blood pressure over 12-h post-sessions as well as for the other variables analyzed (P>0.05). In summary, a single high-velocity resistance exercise session elicits a post-exercise antihypertensive effect and may be considered as a strategy to acutely improve blood pressure control in hypertensive older women.

Physiological and metabolic responses as function of the mechanical load in resistance exercise

2014 ◽  
Vol 39 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Sebastian Buitrago ◽  
Nicolas Wirtz ◽  
Ulrich Flenker ◽  
Heinz Kleinöder
Keyword(s):  
Resistance Exercise ◽  
Mechanical Load ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Maximum Velocity ◽  
Linear Increase ◽  
Detectable Effect ◽  
Turnover Rates ◽  
Post Exercise ◽  
The Relationship

The present study aimed to investigate the relationship between the mechanical load during resistance exercise and the elicited physiological responses. Ten resistance-trained healthy male subjects performed 1 set of resistance exercise each at 55%, 70%, and 85% of 1 repetition maximum for as many repetitions as possible and in 4 training modes: 4-1-4-1 (4 s concentric, 1 s isometric, 4 s eccentric, and 1 s isometric successive actions), 2-1-2-1, 1-1-1-1, and explosive (maximum velocity concentric). Mean concentric power and total concentric work were determined. Oxygen uptake (V̇O2) was measured during exercise and for 30 min post exercise. Total volume of consumed oxygen (O2 consumed) and excess post-exercise oxygen consumption (EPOC) were calculated. Maximum blood lactate concentration (LAmax) was also determined. V̇O2 exhibited a linear dependency on mean concentric power. Mean concentric power did not have a detectable effect on EPOC and LAmax. An augmentation of total concentric work resulted in significant linear increase of O2 consumed and EPOC. Total concentric work caused a significant increase in LAmax. In general, a higher mechanical load induced a larger physiological response. An increase in mean concentric power elicited higher aerobic energy turnover rates. However, a higher extent of total concentric work augments total energy cost covered by oxidative and (or) glycolytic pathways.

scholarly journals Increased net muscle protein balance in response to simultaneous and separate ingestion of carbohydrate and essential amino acids following resistance exercise

2014 ◽  
Vol 39 (3) ◽  
pp. 329-339 ◽  
Author(s):  
Oliver C. Witard ◽  
Tara L. Cocke ◽  
Arny A. Ferrando ◽  
Robert R. Wolfe ◽  
Kevin D. Tipton
Keyword(s):  
Amino Acids ◽  
Resistance Exercise ◽  
Acute Exercise ◽  
Muscle Protein ◽  
Exercise Bout ◽  
Essential Amino Acids ◽  
Delayed Response ◽  
Protein Balance ◽  
Post Exercise ◽  
Exercise Muscle

Relative to essential amino acids (EAAs), carbohydrate (CHO) ingestion stimulates a delayed response of net muscle protein balance (NBAL). We investigated if staggered ingestion of CHO and EAA would superimpose the response of NBAL following resistance exercise, thus resulting in maximal anabolic stimulation. Eight recreationally trained subjects completed 2 trials: combined (COMB — drink 1, CHO+EAA; drink 2, placebo) and separated (SEP — drink 1, CHO; drink 2, EAA) post-exercise ingestion of CHO and EAA. Drink 1 was administered 1 h following an acute exercise bout and was followed 1 h later by drink 2. A primed, continuous infusion of l-[ring-13C6]-phenylalanine was combined with femoral arteriovenous sampling and muscle biopsies for the determination of muscle protein kinetics. Arterial amino acid concentrations increased following ingestion of EAA in both conditions. No difference between conditions was observed for phenylalanine delivery to the leg (COMB: 167 ± 23 μmol·min−1·(100 mL leg vol)−1 × 6 h; SEP: 167 ± 21 μmol·min−1·(100 mL leg vol)−1 × 6 h, P > 0.05). In the first hour following ingestion of the drink containing EAA, phenylalanine uptake was 50% greater for the SEP trial than the COMB trial. However, phenylalanine uptake was similar for COMB (110 ± 19 mg) and SEP (117 ± 24 mg) over the 6 h period. These data suggest that whereas separation of CHO and EAA ingestion following exercise may have a transient physiological impact on NBAL, this response is not reflected over a longer period. Thus, separation of CHO and EAA ingestion is unnecessary to optimize post-exercise muscle protein metabolism.

scholarly journals Post Exercise Hypotension Following Acute Bouts Of Aerobic Compared To Resistance Exercise

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S217
Author(s):  
Scott R. Collier ◽  
Melissa Tobin ◽  
Erin Kelly ◽  
Kevin Heffernan ◽  
Bo Fernhall
Keyword(s):  
Resistance Exercise ◽  
Post Exercise ◽  
Post Exercise Hypotension
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