Low Frequency of Severe Hepatotoxicity and Association With HCV Coinfection in HIV-Positive Patients Treated With HAART

Epilepsia partialis continua manifests as low-frequency, rhythmic involuntary movements of a focal body part. We report a young man, HIV-positive and with syphilis, who developed right-hand epilepsia partialis continua associated with a small left-sided cortico-subcortical frontal lesion. A pen and paper test provided ‘mechanographic’ data on frequency, amplitude and rhythmicity of the hand movements, helping distinguish it from other causes of low-frequency repetitive hand movements.

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Frequency of HIV in Obstructive Lung Disease Patients

The International Journal of Frontier Sciences ◽

10.37978/tijfs.v2i2.38 ◽

2018 ◽

Vol 2 (2) ◽

pp. 18-25

Author(s):

Waqas Ahmed ◽

Qudrat Ullah ◽

Mughees Ahmed ◽

Asif Hanif

Keyword(s):

Lung Disease ◽

Sample Size ◽

Obstructive Lung Disease ◽

Low Frequency ◽

Smooth Muscle Contraction ◽

Hiv Positive ◽

Mortality And Morbidity ◽

Causes Of Mortality ◽

Low Prevalence ◽

Very High

AbstractBackground: Obstructive lung disease (OLD) is one of the main causes of mortality and morbidity worldwide. Obstructive lung disease is the narrowing of bronchioles mainly due to excessive smooth muscle contraction. The objective of this study is to evaluate the Frequency of HIV in obstructive lung disease patients.Methodology: Samples were collected randomly, and study was completed in almost six months. 100 samples were taken with an informed consent taken from all the patients. EDTA and Clotted blood was collected for HIV ELISA and HIV screening.Results: In this study, 69% Males and 31%Females, 34% Smokers, 26% patients were Hypertensive, 10% patients were diabetic, 3% patients were diagnosed HIV positive by screening and ELISA.Conclusion: The frequency of HIV in obstructive lung disease patients in this research is not very high as compared to the previous researches, showing high frequency and relationship between HIV and obstructive lung disease patients. The reason behind low frequency is due to low sample size so by increasing the sample size we can get better understanding of frequency of HIV in obstructive lung disease patients. Another reason of insignificant results is low prevalence of HIV in Pakistan as compared to the previous researches in certain countries.

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Liver Damage in Patients with HCV/HIV Coinfection Is Linked to HIV-Related Oxidative Stress

Oxidative Medicine and Cellular Longevity ◽

10.1155/2016/8142431 ◽

2016 ◽

Vol 2016 ◽

pp. 1-11 ◽

Cited By ~ 6

Author(s):

Xiangbo Huang ◽

Hua Liang ◽

Xueying Fan ◽

Liyan Zhu ◽

Tao Shen

Keyword(s):

Oxidative Stress ◽

Hiv Infection ◽

Liver Damage ◽

Central China ◽

Hiv Positive ◽

Liver Ultrasound ◽

Hiv Coinfection ◽

Chronic Hcv ◽

Hcv Coinfection ◽

Hiv Negative

HIV infection aggravates the progression of liver damage in HCV-coinfected patients, with the underlying pathogenesis being multifactorial. Although high level of oxidative stress has been observed frequently in patients infected with HIV or HCV, the status of oxidative stress in HIV/HCV coinfection and its contribution to HCV liver damage have not been determined. This study involved 363 HBsAg-negative, anti-HCV-positive former blood donors recruited from a village in central China in July 2005; of these, 140 were positive for HIV. Of these 363 subjects, 282 were successfully followed up through July 2009. HIV/HCV-coinfected subjects had higher rates of end-stage liver disease-related death than those monoinfected with HCV. Liver ultrasound manifestations were poor in HIV-positive than in HIV-negative individuals, in both chronic HCV carriers and those with resolved HCV. Serum concentrations of total glutathione (tGSH), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), GSSG, and reduced GSH were higher in HIV-positive than HIV-negative subjects. GSSG concentrations were higher in HIV-infected subjects with abnormal ALT/AST levels than in those with normal ALT/AST levels and were associated with poorer liver ultrasound manifestations. These finding indicated that HIV infection accelerated HCV-associated liver damage in HIV/HCV-coinfected individuals. Increased oxidative stress, induced primarily by HIV coinfection, may contribute to aggravated liver damage.

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Unexpected low frequency of respiratory symptoms in an HIV-positive urban sub-Saharan population compared to an HIV-negative control group

Southern African Journal of HIV Medicine ◽

10.4102/sajhivmed.v20i1.1010 ◽

2019 ◽

Vol 20 (1) ◽

Author(s):

Maren Kummerow ◽

Erica J. Shaddock ◽

Kerstin Klipstein-Grobusch ◽

Roos B. Barth ◽

Diederick E. Grobbee ◽

...

Keyword(s):

Respiratory Symptoms ◽

Low Frequency ◽

Negative Control Group ◽

Negative Control ◽

Hiv Positive ◽

Control Group ◽

Sub Saharan ◽

Hiv Negative

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SEROPREVALENCE OF HIV, HBV, AND HCV AMONG INDIVIDUALS ATTENDING ICTC OF A TERTIARY CARE HOSPITAL IN NORTHERN INDIA.

10.36106/ijsr/2503186 ◽

2021 ◽

pp. 14-16

Author(s):

Seema Aleem ◽

Anjum Farhana ◽

Humaira Bashir

Keyword(s):

Tertiary Care ◽

Cross Sectional Study ◽

Hiv Positive ◽

Hcv Rna ◽

Care Hospital ◽

Cross Sectional ◽

Treatment Services ◽

Northern India ◽

Relevant Variables ◽

Hcv Coinfection

Introduction: Hepatitis B and Hepatitis C share common transmission routes with HIV and coinfection with either can lead to adverse clinical outcomes in patients. This study planned to estimate confections with HBV and HCV among HIV positive subjects at a single Integrated Testing and Counselling Center (ICTC) in Kashmir valley. Methods: The study employed a cross-sectional study design from 2017 to 2019. After pretest counselling all subjects underwent HIV testing as per National AIDS Control guidelines. HIV positive subjects were included in this study. Samples of HIV positive subjects were then tested for HBV by ELISA detecting HbsAg whereas HCV was diagnosed by Anti HCV antibodies and HCV-RNA. Data was entered in excel and analyzed using SPSS. Means and percentages were calculated for relevant variables. Results:Atotal of 20070 subjects were tested during the study period of which 34 (0.169%) were HIVpositive. Around 60% positive subjects were males. Co-infection with HBV was detected in 11.7% subjects whereas 8.8% had an HCV coinfection. One subject had coinfection with both HBV and HCV. There was no signicant association of coinfection with gender or age Conclusion:Considering the adverse impact of coinfection on disease course and outcome, screening for HBVand HCVshould be a component in diagnostic workup of all HIVpositive subjects followed by linkage with specialized treatment services

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Association between Hlaantigens and Progression of HIV Infection in Greek Haemophiliacs

Disease Markers ◽

10.1155/1993/674362 ◽

1993 ◽

Vol 11 (2-3) ◽

pp. 131-137 ◽

Cited By ~ 4

Author(s):

Chr. Papasteriades ◽

J. Economidou ◽

H. Pappas ◽

K. Psarra ◽

V. Kapsimali ◽

...

Keyword(s):

Hiv Infection ◽

Disease Progression ◽

High Frequency ◽

Disease Susceptibility ◽

Hla Antigens ◽

Low Frequency ◽

Stage Iv ◽

Hiv Positive ◽

Rapid Decline ◽

Hiv Seropositive

The frequencies of HLA antigens in 33 HIV seronegative and in 88 HIV seropositive haemophiliacs, who have been followed for at least 6 years since seroconversion or first HIV positive test. were evaluated in relation to disease susceptibility and disease progression. A high frequency of HLA-A2 and -DR2 antigens and a low frequency of HLA-A9 were found to characterize HIV seropositive patients (p<0.05). Progressors to symptomatic CDC stage IV had a higher frequency of HLA-A9 (p<0.01) and DR3. Rapid decline of CD4+ T cells in these patients was associated with HLA-A9, -DR I and DR3. Our data suggest that HLA antigens may contribute to susceptibility to HIV infection and disease progression in Greek haemophiliacs.

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Metabolic changes associated with antiretroviral therapy in HIV-positive patients

Revista de Saúde Pública ◽

10.1590/s0034-89102009005000005 ◽

2009 ◽

Vol 43 (2) ◽

pp. 283-290 ◽

Cited By ~ 15

Author(s):

Sabrina Esteves de Matos Almeida ◽

Michele Borges ◽

Marilu Fiegenbaum ◽

Cynara Carvalho Nunes ◽

Maria Lucia Rosa Rossetti

Keyword(s):

Antiretroviral Therapy ◽

Total Cholesterol ◽

Protease Inhibitors ◽

Highly Active Antiretroviral Therapy ◽

Repeated Measures ◽

Smoking Habit ◽

Metabolic Changes ◽

Hiv Positive ◽

Glucose Levels ◽

Hcv Coinfection

OBJECTIVE: To evaluate metabolic changes associated with highly active antiretroviral therapy (HAART) in HIV-positive patients, and to identify risk factors associated. METHODS: Retrospective study that included 110 HIV-positive patients who where on HAART in the city of Porto Alegre (Southern Brazil) between January 2003 and March 2004. Data on demographic variables, cigarette smoking, diabetes mellitus, cholesterol and triglyceride levels, stage of HIV infection, antiretroviral therapy and HCV coinfection were collected. General linear models procedure for repeated measures was used to test the interaction between HAART and HCV coinfection or protease inhibitor treatment. RESULTS: Total cholesterol, triglycerides, and glucose levels significantly increased after receiving HAART (p<0.001 for all variables), but no interaction with protease inhibitors was seen for total cholesterol, glucose and triglyceride levels (interaction treatment*protease inhibitors p=0.741, p=0.784, and p=0.081, respectively). An association between total cholesterol levels and HCV coinfection was found both at baseline and follow-up (effect of HCV coinfection, p=0.011). Glucose levels were increased by HAART (treatment effect, p=0.036), but the effect was associated to HCV coinfection (treatment*HCV effect, p=0.018). Gender, smoking habit, intravenous drug use and age were not significantly associated with cholesterol, triglyceride and glucose changes. CONCLUSIONS: HCV-infected patients at baseline were significantly less likely to develop hypercholesterolemia. The results provide further evidence of the role of HAART for the development of metabolic disturbances.

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Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa470 ◽

2020 ◽

Vol 7 (12) ◽

Author(s):

Amanda Mocroft ◽

Jens D Lundgren ◽

Juergen K Rockstroh ◽

Inka Aho ◽

Gilles Wandeler ◽

...

Keyword(s):

Diabetes Mellitus ◽

Hepatitis C ◽

Incidence Rates ◽

Hiv Positive ◽

Hcv Rna ◽

Population Attributable Fractions ◽

Attributable Fractions ◽

Hcv Coinfection

Abstract Background The role of hepatitis C virus (HCV) coinfection and HCV-RNA in the development of diabetes mellitus (DM) in HIV-positive persons remains unclear. Methods Poisson regression was used to compare incidence rates of DM (blood glucose >11.1 mmol/L, HbA1C >6.5% or >48 mmol/mol, starting antidiabetic medicine or physician reported date of DM onset) between current HIV/HCV groups (anti-HCV-negative, spontaneously cleared HCV, chronic untreated HCV, successfully treated HCV, HCV-RNA-positive after HCV treatment). Results A total of 16 099 persons were included; at baseline 10 091 (62.7%) were HCV-Ab-negative, 722 (4.5%) were spontaneous clearers, 3614 (22.4%) were chronically infected, 912 (5.7%) had been successfully treated, and 760 (4.7%) were HCV-RNA-positive after treatment. During 136 084 person-years of follow-up (PYFU; median [interquartile range], 6.9 [3.6–13.2]), 1108 (6.9%) developed DM (crude incidence rate, 8.1/1000 PYFU; 95% CI, 7.7–8.6). After adjustment, there was no difference between the 5 HCV strata in incidence of DM (global P = .33). Hypertension (22.2%; 95% CI, 17.5%–26.2%) and body mass index >25 (22.0%; 95% CI, 10.4%–29.7%) had the largest population-attributable fractions for DM. Conclusions HCV coinfection and HCV cure were not associated with DM in this large study. The biggest modifiable risk factors were hypertension and obesity, and continued efforts to manage such comorbidities should be prioritized.

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