Early Initiation of 17OHPC Does Not Increase Risk for Gestational Diabetes in Women With Prior Preterm Birth [13L]

2017 ◽  
Vol 129 ◽  
pp. S125
Author(s):  
Anju Suhag ◽  
Ritu Dutta ◽  
Manju Monga ◽  
Haleh Sangi-Haghpeykar ◽  
Susan Ramin ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Diabetes ◽  
Early Initiation ◽  
Increase Risk

scholarly journals Reference Values of D-Dimers and Fibrinogen in the Course of Physiological Pregnancy: the Potential Impact of Selected Risk Factors—A Pilot Study

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Aldona Siennicka ◽  
Magdalena Kłysz ◽  
Kornel Chełstowski ◽  
Aleksandra Tabaczniuk ◽  
Zuzanna Marcinowska ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gestational Diabetes ◽  
Reference Values ◽  
Venous Blood ◽  
Fibrinogen Concentration ◽  
Reference Ranges ◽  
Second Trimester ◽  
Increase Risk ◽  
Potential Impact ◽  
D Dimer

Pregnancy predisposes to thrombotic hemostasis, reflected in the laboratory as, e.g., increased levels of D-Dimers and fibrinogen, but in physiological pregnancy, the risk of venous thrombosis does not increase. Risk may increase if gestational diabetes mellitus (GDM) or nicotinism coexists. Study aims were to determine reference values ​​for D-Dimers and fibrinogen concentrations in each trimester of pregnancy, corrected for GDM and nicotinism. Subjects and Methods. The study involved 71 pregnant women aged 25-44 y. Venous blood was collected three times: in the first (11-14 weeks), second (20-22 weeks), and third (30-31 weeks) trimesters. D-Dimer concentrations were determined by an enzyme-linked fluorescence assay, fibrinogen concentrations by a coagulation method according to Clauss. Results. Significant increases in D-Dimers and fibrinogen concentrations were observed, increasing with successive trimesters (p ANOVA<0.0001). Furthermore, a positive correlation between D-Dimers and fibrinogen was detected in the second trimester of pregnancy (r=0.475; p<0.0001). In addition, a significantly higher fibrinogen concentration was found in women with GDM compared to without GDM (p=0.0449). Reference ranges for D-Dimers were established, in trimester order, as follows: 167-721 ng/mL, 298-1653 ng/mL, and 483-2256 ng/mL. After adjusting for risk factors, significantly higher D-Dimer values ​​(mainly second and third trimesters) were obtained: 165-638 ng/mL, 282-3474 ng/mL, and 483-4486 ng/mL, respectively. Reference ranges for fibrinogen were, in trimester order, 2.60-6.56 g/L, 3.40-8.53 g/L, and 3.63-9.14 g/L and, after adjustment for risk factors, 3.34-6.73 g/L, 3.40-8.84 g/L, and 3.12-9.91 g/L. Conclusions. We conclude that the increase in D-Dimers and fibrinogen levels in women with physiological pregnancy was compounded by gestational diabetes (GDM) and nicotinism. Therefore, D-Dimers and fibrinogen pregnancy reference values require correction for these risk factors.

Effects of Prepregnancy Body Mass Index, Weight Gain, and Gestational Diabetes Mellitus on Pregnancy Outcomes: A Population-Based Study in Xiamen, China, 2011–2018

2019 ◽  
Vol 75 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Wei-juan Su ◽  
Yin-ling Chen ◽  
Pei-ying Huang ◽  
Xiu-lin Shi ◽  
Fang-fang Yan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Weight Gain ◽  
Preterm Birth ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnancy Outcomes ◽  
Population Based ◽  
Population Based Study ◽  
Prepregnancy Body Mass Index

Background: It is unclear that how prepregnancy body mass index (BMI), gestational weight gain (GWG), and gestational diabetes mellitus (GDM) affect pregnancy outcomes in ­China. Thus, we explored how BMI, GWG, and GDM affect the risks of adverse pregnancy outcomes. Methods: We performed a retrospective, population-based study included all births in Xiamen, China, 2011–2018. Demographic data and pregnancy outcomes of 73,498 women were acquired from the Medical Birth Registry of Xiamen. Women were categorized into groups on prepregnancy BMI and GWG in order to assess the risk of pregnancy outcomes. Multivariable logistic regression was performed to evaluate risk factors. Results: Overall, 6,982 (9.37%) women were obese, and 8,874 (12.07%) women were overweight. Obese women are more vulnerable to cesarean delivery, preterm birth, large-for-gestational age (LGA), and macrosomia (crude OR [cOR] 2.00, 1.89–2.12; 1.35, 1.20–1.51; 2.12, 1.99–2.26; 2.53, 2.25–2.86, respectively, adjusted ORs 1.73, 1.62–1.84; 1.25, 1.10–1.42; 2.03, 1.90–2.18; 2.77, 2.44–3.16, respectively). Similar results were observed in overweight women (cORs 1.49, 1.42–1.57; 1.02, 0.91–1.15; 1.60, 1.50–1.70; 2.01, 1.78–2.26, respectively). Furthermore, women who gain weight in excessive group were 1.43, 2.06, and 2.16 times to deliver cesarean, LGA, and macrosomia, respectively. Additionally, GDM women were easily subjected to cesarean section, preterm birth, LGA, low birth weight, and macrosamia (cORs 1.52, 1.55, 1.52, 1.37, 1.27, respectively). Conclusions: Obesity prior to pregnancy, excessive GWG, and GDM were all associated with increased odds of cesarean, LGA, and macrosomia. Blood glucose and weight control before and during pregnancy are needed that may reduce the complications of pregnancy.

Progestogens for the prevention of preterm birth and risk of developing gestational diabetes mellitus: a meta-analysis

2019 ◽  
Vol 221 (5) ◽  
pp. 429-436.e5 ◽  
Author(s):  
Vasilios Pergialiotis ◽  
Ioannis Bellos ◽  
Erifili Hatziagelaki ◽  
Aris Antsaklis ◽  
Dimitrios Loutradis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Preterm Birth ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis

Does administration of 17 alpha-hydroxyprogesterone caproate for preterm birth prevention alter the incidence of gestational diabetes?

2005 ◽  
Vol 193 (6) ◽  
pp. S182
Author(s):  
Andrei Rebarber ◽  
Niki Istwan ◽  
Karen Russo-Stieglitz ◽  
Larry Rand ◽  
Debbie Rhea ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Diabetes ◽  
Hydroxyprogesterone Caproate

scholarly journals First Trimester Biomarkers in the Prediction of Later Pregnancy Complications

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Stefan C. Kane ◽  
Fabricio da Silva Costa ◽  
Shaun Brennecke
Keyword(s):  
Risk Factors ◽  
Clinical Trials ◽  
Clinical Practice ◽  
Preterm Birth ◽  
High Risk ◽  
Gestational Diabetes ◽  
First Trimester ◽  
Obstetric Outcomes ◽  
High Risk Population ◽  
Maternal History

Adverse obstetric outcomes, such as preeclampsia, preterm birth, gestational diabetes, and fetal growth restriction, are poorly predicted by maternal history and risk factors alone, especially in nulliparae. The ability to predict these outcomes from the first trimester would allow for the early initiation of prophylactic therapies, institution of an appropriate model and location of care, and recruitment of a truly “high risk” population to clinical trials of interventions to prevent or ameliorate these conditions. To this end, development of adequately sensitive and specific predictive tests for these outcomes has become a significant focus of perinatal research. This paper reviews the biomarkers involved in these multiparametric tests and also outlines the performance of these tests and issues regarding their introduction into clinical practice.

Pre-pregnancy obesity compromises obstetric and neonatal outcomes

2015 ◽  
Vol 43 (2) ◽  
Author(s):  
Katharina Hancke ◽  
Theresa Gundelach ◽  
Birgit Hay ◽  
Sylvia Sander ◽  
Frank Reister ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Diabetes ◽  
Cesarean Section ◽  
Neonatal Outcomes ◽  
Elective Cesarean Section ◽  
Obese Women ◽  
Elective Cesarean ◽  
Group A ◽  
Grade Ii ◽  
Group B

AbstractObesity is an important issue among fertile women as it may affect obstetric and neonatal outcomes.Obstetric and neonatal outcomes of primiparous women were retrospectively analyzed in non-obese (n=11387) and obese (n=943) women. A subgroup analysis was performed in obese women divided into three groups: Grade I obesity (Group A, n=654), Grade II obesity (Group B, n=192), and Grade III obesity (Group C, n=97). Odds ratios (OR) were expressed with the corresponding 95% confidence intervals (CI).The incidence of gestational diabetes (non-obese, 1.9%; obese, 7.6%; Group C, 19.6%) and preeclampsia (non-obese, 3.3%; obese, 13.5%; Group C, 17.5%) increased with rising weight. The risk of non-elective cesarean section was significantly higher in obese women than in non-obese women (21.7% vs. 13.2%). The risk of extreme preterm birth (before 28 weeks of gestation) doubled in the Grade I obesity group (OR, 2.1; 95% CI, 1.4–3.2) and nearly tripled in women with body mass index ≥35 kg/mPre-pregnancy obesity is associated with higher incidences of gestational diabetes and preeclampsia. Our study shows that obese women have a higher risk of non-elective cesarean section and preterm birth.

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