Predictive value of serum uric acid levels for adverse perinatal outcomes in preeclampsia

Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.

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Doppler measurements of both umbilical arteries do not improve predictive value for adverse perinatal outcomes in small-for-gestational age fetuses

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2018.10.040 ◽

2018 ◽

Vol 231 ◽

pp. 169-173

Author(s):

Charlotte A. Vollgraff Heidweiller-Schreurs ◽

Ninieck E. van Maasakker ◽

Peter M. van de Ven ◽

Christianne J.M. de Groot ◽

Caroline J. Bax ◽

...

Keyword(s):

Gestational Age ◽

Small For Gestational Age ◽

Predictive Value ◽

Perinatal Outcomes ◽

Adverse Perinatal Outcomes ◽

Umbilical Arteries

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The predictive value of serum uric acid, roll-over test, and body mass index in pre-eclampsia

International Journal of Gynecology & Obstetrics ◽

10.1016/j.ijgo.2005.10.017 ◽

2005 ◽

Vol 92 (2) ◽

pp. 133-134 ◽

Cited By ~ 4

Author(s):

F. Kaypour ◽

H. Masomi Rad ◽

N. Ranjbar Novin

Keyword(s):

Body Mass Index ◽

Uric Acid ◽

Serum Uric Acid ◽

Body Mass ◽

Predictive Value

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Assessing the Role of Uric Acid as a Predictor of Preeclampsia

Frontiers in Physiology ◽

10.3389/fphys.2021.785219 ◽

2022 ◽

Vol 12 ◽

Author(s):

Ana I. Corominas ◽

Yollyseth Medina ◽

Silvia Balconi ◽

Roberto Casale ◽

Mariana Farina ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Predictive Value ◽

Gestational Hypertension ◽

Low Cost ◽

High Sensitivity ◽

Use Of Resources ◽

Before And After ◽

High Negative Predictive Value ◽

Group A

We assessed the diagnostic utility of uric acid for the prediction of preeclampsia. An observational prospective approach was carried out during 2014. Preeclamptic women were classified into 4 groups accordingly to the onset of preeclampsia and the presence of intrauterine growth restriction (IUGR). Serum uric acid levels, urea, and creatinine were measured. Receiver operating curves (ROC) of the uric acid levels ratio (UAr) between a dosage before and after the 20th week of gestation were performed. One thousand two hundred and ninety-third pregnant women were enrolled in this study. Eight hundred ten had non-complicated pregnancies, 40 preeclampsia, 33 gestational hypertension, and 20 IUGR without preeclampsia. Uric acid significantly raised after 20 weeks of gestation in women who develop preeclampsia before 34 weeks (Group A) or in those who develop preeclampsia after 37 weeks associated with IUGR (Group C). In women who develop preeclampsia after 34 weeks without IUGR (Groups B and D), uric acid increased after the 30th week of gestation. In all groups, UAr was greater than 1.5. In gestational hypertension, UAr was superior to 1.5 toward the end of gestation, while in IUGR without preeclampsia, the behavior of serum uric acid was similar to non-complicated pregnancies. In all cases, urea and creatinine showed normal values, confirming that patients had no renal compromise. ROC area was 0.918 [95% confidence interval (CI): 0.858–0.979) for the preeclampsia group and 0.955 (95% CI: 0.908–1.000) for Group A. UAr at a cut-off point ≥1.5 had a very low positive predictive value, but a high negative predictive value of 99.5% for preeclampsia and it reached 100% for Group A. Thus, a UAr less than 1.5 may be a helpful parameter with a strong exclusion value and high sensitivity for those women who are not expected to develop preeclampsia. Additionally, this low-cost test would allow for better use of resources in developing countries.

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Predictive Value of Estimated Serum Uric Acid in Patients with Acute Coronary Syndrome in AL-Diwaniyah Teaching Hospital

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.12.04.397 ◽

2020 ◽

Vol 12 (04) ◽

Keyword(s):

Acute Coronary Syndrome ◽

Uric Acid ◽

Serum Uric Acid ◽

Teaching Hospital ◽

Predictive Value ◽

Coronary Syndrome

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Neck Circumference Is a Reliable Predictor for Hyperuricemia in Women With Polycystic Ovary Syndrome: a Case Control Study

10.21203/rs.3.rs-545759/v1 ◽

2021 ◽

Author(s):

Haiyan Yang ◽

Chang Liu ◽

Congcong Jin ◽

Rong Yu ◽

Lin Ding ◽

...

Keyword(s):

Uric Acid ◽

Polycystic Ovary Syndrome ◽

Negative Predictive Value ◽

Serum Uric Acid ◽

Predictive Value ◽

Polycystic Ovary ◽

Neck Circumference ◽

Youden Index ◽

Ovary Syndrome ◽

Increased Risk

Abstract Background: The prevalence of hyperuricemia in the women with polycystic ovary syndrome (PCOS) is almost threefold higher than that in women without PCOS. Both PCOS and hyperuricemia are considered risk factors of metabolic disorders, including hypertension, diabetes and cardiovascular diseases. Previous study has indicated that neck circumference (NC) is a good predictor for insulin resistance in women with PCOS. The present analysis thus aims to assess the predictive value of NC for hyperuricemia in women with PCOS.Methods: This is a cross-sectional study that recruited one hundred ninety women with PCOS from January 2018 to December 2019. PCOS was diagnosed according to the Rotterdam definition. Hyperuricemia was defined as serum uric acid level of at least 357 μmol/L.Results: PCOS females with hyperuricemia had significantly greater values of NC, body mass index (BMI), waist circumference (WC) and hip circumference (HC). NC was positively associated with serum uric acid levels, with a standardized regression coefficient of 0.34 after adjusting for confounding factors. Furthermore, logistic regression analysis showed that NC was significantly associated with an increased risk of hyperuricemia, with an adjusted odds ratio of 1.58. The associations between NC and serum uric acid levels were more evident in those with medium BMI (22.02 kg/m2 ≤ BMI < 25.08 kg/m2), low WC (WC < 85 cm) or medium HC (90 cm ≤ HC < 96 cm). The optimal cutoff point of NC in predicting hyperuricemia was 32.0 cm (Youden index = 0.48), with the sensitivity and negative predictive value of 87.23% and 93.68%, respectively.Conclusions: Neck circumference is positively correlated with hyperuricemia and has a high negative predictive value for hyperuricemia in women with PCOS. Therefore, we suggest NC as a simple, novel, and reliable anthropometric measure to be used in the routine clinical assessment of women with PCOS to screen those at high risk of hyperuricemia.

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Role of umbilical artery Doppler velocimetry in predicting the adverse perinatal outcomes in hypertensive disorder of pregnancy

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20174409 ◽

2017 ◽

Vol 6 (10) ◽

pp. 4382

Author(s):

Jyoti Yadav ◽

Mala Shukla ◽

P. K. Jain ◽

Devender Kumar

Keyword(s):

Predictive Value ◽

Perinatal Outcome ◽

Umbilical Artery ◽

Perinatal Outcomes ◽

Chronic Hypertension ◽

Hypertensive Disorder ◽

Umbilical Artery Doppler ◽

Hypertensive Disorder Of Pregnancy ◽

Adverse Perinatal Outcomes ◽

Group B

Background: Early detection of fetoplacental compromise with Umbilical Artery Doppler indices and to know the predictive value of each indices in predicting perinatal outcome and interventional strategies in these patients.Methods: The present prospective study was conducted on 200 women with hypertensive disorder of pregnancy. Umbilical artery doppler evaluation done in all the patients at (28-32) weeks, (33-36) weeks and (37-40) weeks of gestation and more frequently in those patients having deranged Doppler. Patients divided into two groups women with abnormal Umbilical artery indices (group B) and normal indices (group A). Perinatal outcome of both the groups were compared, analyzed statistically using Chi-square test. Multiple pregnancy, chronic hypertension, fetal congenital anomalies, systemic disease and those lost to follow up till delivery were excluded from study.Results: A total of 200 pregnant women with hypertensive disorder, 64% were primgravida. Abnormal umbilical artery indices seen in 36%. Adverse outcome was seen in 88.88% patients of group B. Statistically significantly higher rate of caeserian section, induction of labour, Preterm delivery, fetal growth restriction, NICU admission, NICU stay >48hrs were seen in group B. In all indices Umbilical artery PI had highest Sensitivity (84.21%), positive predictive value (88.88%) and accuracy (90%).Conclusions: Umbilical artery PI is the most reliable to predict adverse perinatal outcomes and help in appropriate timing of intervention to improve perinatal outcome.

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