Erectile dysfunction and associated risk factors in male patients with ischemic stroke

Background: Hemorrhagic transformation (HT) of ischemic stroke can have devastating consequences, leading to longer hospitalizations, increased morbidity and mortality. We sought to identify the rate of HT in stroke patients not treated with tPA within a large, biracial population. Methods: The GCNKSS is a population-based stroke epidemiology study from five counties in the Greater Cincinnati region. During 2015, we captured all hospitalized strokes by screening ICD-9 codes 430-436 and ICD-10 codes I60-I68, and G45-46. Study nurses abstracted all potential cases and physicians adjudicated cases, including classifying the degree of HT. Patients treated with thrombolytics were excluded. Incidence rates per 100,000 and associated 95% confidence intervals (CI) were estimated for HT cases, age and sex adjusted to the 2000 US population. Multiple logistic regression was used to examine risk factors associated with HT. Results: In 2015, there were 2301 ischemic strokes included in the analysis. Of these 104 (4.5%) had HT; 23 (22.1%) symptomatic, 55 (52.9%) asymptomatic and 26 (25%) unknown. Documented reasons for not receiving tPA in these patients were: time (71, 68.3%), anticoagulant use (1, 1.0%), other (18,17.3%) and unknown (14, 13.5%), which were not significantly different compared to those without HT. Only 29/104 (18.3%) had HT classified as PH-1 or PH-2. The age, sex and race-adjusted rate of HT was 9.8 (7.9, 11.6) per 100,000. The table shows rates of potential risk factors and the adjusted odds of developing HT. 90 day all-cause case fatality for patients with HT was significantly higher, 27.9% vs. 15.7%, p<0.0001. Conclusion: We found that 4.5% of non-tPA treated IS patients had HT. These patients had more severe strokes, were more likely to have abnormal coagulation tests or anticoagulant use, and were more likely to die within 90 days. We also report the first population-based incidence rate of HT in non-tPA treated of 9.8/100,000, a rate similar to the incidence of SAH.

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Risk Factors for Perinatal Arterial Ischemic Stroke

Cell Medicine ◽

10.1177/2155179018785341 ◽

2018 ◽

Vol 10 ◽

pp. 215517901878534 ◽

Cited By ~ 2

Author(s):

Daniela Munoz ◽

María José Hidalgo ◽

Fernanda Balut ◽

Mónica Troncoso ◽

Susana Lara ◽

...

Keyword(s):

Risk Factors ◽

Ischemic Stroke ◽

Cesarean Section ◽

Apgar Score ◽

Birth Asphyxia ◽

Arterial Ischemic Stroke ◽

Emergency Cesarean Section ◽

Emergency Cesarean ◽

Associated Risk Factors ◽

Perinatal Arterial Ischemic Stroke

Introduction: Arterial ischemic stroke in newborns is an important cause of neonatal morbidity and mortality. Its pathophysiology and associated risk factors are not yet clearly understood and defined. Objective: The aim of this retrospective study was to investigate possible risk factors in diagnosed cases of PAIS (perinatal arterial ischemic stroke). Materials and methods: Case–control study. Clinical data of patients with PAIS diagnosis were analyzed. Two healthy controls were selected for each PAIS case, matched for gestational age. Risk factors were explored using univariable and multivariable analysis. Outcome: 40 patients were included in the study, 24 males and 16 females; 52.5% of cases were diagnosed within the first month of birth, and 47.5% were retrospectively diagnosed. The results showed a male predominance (66.7%). The distribution of cerebral ischemic injury was predominantly medial cerebral artery (87.5%) and occurred more commonly in the left cerebral hemisphere (62.5%). Significant risk factors in the univariate analysis (P < 0.05) were primiparity, stillbirth, neonatal sepsis, asphyxia, twin pregnancy, placenta abruption, emergency cesarean section, Apgar score ≤7 after 5 min, breech presentation, and hyperbilirubinemia. In the multivariate analysis, primiparity (OR 11.74; CI 3.28–42.02), emergency cesarean section (OR 13.79; CI 3.51–54.13), birth asphyxia (OR 40.55; CI 3.08–532.94) and Apgar score ≤7 after 5 min (OR 13.75; CI 1.03–364.03) were significantly associated factors with PAIS. Only five (16.6%) patients had an abnormal thrombophilia study. Conclusion: Risk factors of primiparity, emergency cesarean section, birth asphyxia, and Apgar score ≤7 after 5 min were significantly associated with perinatal stroke. More studies with a larger number of patients and with prolonged follow up are required to establish more clearly the associated risk factors involved in this pathology.

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Erectile dysfunction: prevalence and determinants among T2DM men attending a tertiary care hospital in northern India

International Surgery Journal ◽

10.18203/2349-2902.isj20191128 ◽

2019 ◽

Vol 6 (4) ◽

pp. 1115 ◽

Cited By ~ 2

Author(s):

Raja Langer ◽

Elias Sharma ◽

Bhavna Langer ◽

Rajiv K. Gupta ◽

Rashmi Kumari ◽

...

Keyword(s):

Erectile Dysfunction ◽

Diabetic Complications ◽

Family Income ◽

Tertiary Care ◽

Cross Sectional Study ◽

Care Hospital ◽

Cross Sectional ◽

Northern India ◽

Male Patients ◽

Associated Risk Factors

Background: Erectile dysfunction (ED), though an important complication of T2DM is grossly under reported in this part of the world. The present study aimed to determine the prevalence and associated risk factors of ED in T2DM men in northern India.Methods: A cross-sectional study was conducted from January to August 2018 among male patients with T2DM in the medical OPD of a tertiary care teaching hospital in Jammu. IIEF- international index of erectile function was the tool used in the present study.Results: ED prevalence was 62.08%. Among socio-demographic variables, age was significantly associated with ED (p<0.05) while no association was found with education, occupation and family income. Smoking as a life style and hypertension as a co-morbid condition were significantly associated with ED (p<0.05). Duration of diabetes and type of diabetic complications were also found to be statistically significant.Conclusions: Prevalence of ED in T2DM men was quiet high in this region of India. Preventive interventions, early diagnosis and detection of T2DM along with treatment adherence to prevent diabetic complications is strongly recommended. Further research is recommended to establish temporal causality of ED in T2DM.

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Chronic pancreatitis: Risk Factors and Clinico-Radiological Profile

Nepal Medical College Journal ◽

10.3126/nmcj.v23i2.38526 ◽

2021 ◽

Vol 23 (2) ◽

pp. 153-158

Author(s):

Jiwan Thapa ◽

Ramila Shrestha ◽

Ram Krishna Tamang ◽

Shankar Baral ◽

Bhuwneshwer Yadav

Keyword(s):

Risk Factors ◽

Computed Tomography ◽

Chronic Pancreatitis ◽

Structural Changes ◽

Clinical Presentation ◽

Pain Abdomen ◽

Disease Condition ◽

Radiological Changes ◽

Male Patients ◽

Associated Risk Factors

Chronic pancreatitis is a disease condition characterized by progressive inflammation and fibrosis of pancreas. It manifests with pain abdomen, endocrine and exocrine dysfunction. Diagnosis is often difficult and is relied mostly on radiological examination. The aim of this study was to identify associated risk factors and correlate the clinical presentation with various radiological changes of the pancreas.We conducted a prospective hospital based observational study in patients presenting with abdominal pain and evaluated the etiology, clinical presentation and radiological changes of pancreas among 68 chronic pancreatitis patients visiting Gastroenterology Unit, Department of Medicine, National Academy of Medical Sciences, Bir Hospital during 1 year period (November 2019 to October 2020 AD). The results showed mean age of 35.75 ± 11.43 years with predominant male patients (76.4%). Pain abdomen was present in all patients with mean duration of 16.5 months, followed by diabetes in 27.9%. Alcohol was the major risk (n=42, 61.8%) and no cause was identified in 22 (32.3%) patients. Pancreatic parenchymal calcification in 65 (95.6%), duct dilation in 61 (89.7%) and gland atrophy in 39 (57.3%) were major structural changes detected in computed tomography scan, more reliably than ultrasonography. One third of patients had diabetes mellitus, which was significantly higher in female (63.2%) and had major radiological changes of chronic pancreatitis at diagnosis. Alcohol was the common risk of chronic pancreatitis. Structural changes suggestive of disease was demonstrated better by computed tomography.

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C-Reactive Protein - A Predictable Biomarker in Ischemic Stroke

Revista de Chimie ◽

10.37358/rc.19.6.7325 ◽

2019 ◽

Vol 70 (6) ◽

pp. 2290-2293 ◽

Cited By ~ 2

Author(s):

Maria Totan ◽

Elisabeta Antonescu ◽

Maria Gabriela Catana ◽

Maria Mihaela Cernusca-Mitariu ◽

Lavinia Duica ◽

...

Keyword(s):

Risk Factors ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Inflammatory Marker ◽

Protein A ◽

Motor Deficit ◽

Motor Deficits ◽

C Reactive Protein ◽

Reactive Protein ◽

Associated Risk Factors

C-reactive protein (CRP) is a non-specific inflammatory marker, correlated with the severity and prognosis of ischemic stroke. We performed a retrospective study in which were included 81 patients diagnosed with acute ischemic stroke admitted between January and July 2017 in the Department of Neurology, Sibiu Emergency Clinical Hospital. CRP values were classified on three levels (0 - 5 mg / L, 5 - 50 mg / l and] 50 mg / l). We examined the correlation between CRP levels according to the type of ischemic (lacunar / territorial) stroke, the degree of motor deficit (quantified by the mRC scale), the associated risk factors and the mortality rate. PCR values above 50 mg / L were found in patients with territorial stroke (15%). Moderate motor deficits predominate, with PCR values ranging from 5-50 mg / L. The most important risk factors found in the patients included in our study were hypertension and atherosclerosis. We made correlations between these risk factors and the PCR values. In most cases with these two risk factors were recorded a mean PCR value (5-50 mg / L).For atherosclerosis the results were statistically significant, p = 0.021. Most patients (56%) had CRP levels ranging from 5 to 50 mg / L. These values recorded highest death rates. PCR it is an important marker of inflammation and it is important to be determined in all patients with acute ischemic stroke, especially which is thought to be correlated with the prognosis of these patients.

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