Moderate-intensity exercise with blood flow restriction on cardiopulmonary kinetics and efficiency during a subsequent high-intensity exercise in young women

Introduction: Patients with hypertrophic cardiomyopathy (HCM) are excluded from high intensity activities due to perceived fear of sudden cardiac death. Observational data from athletes with HCM suggest that engaging in high intensity exercise (HIE) may be safe and is associated with higher cardiorespiratory fitness. Whether HIE can safely elicit a superior increase in fitness compared to moderate intensity exercise in patients with HCM is unclear. Methods: Nine HCM patients (49 ± 7 years, 3 female) were assessed for maximal oxygen uptake (VO 2 max, Douglas Bag method), cardiac output (Q c , acetylene rebreathing), and peripheral oxygen extraction (av-O 2 diff, Fick equation) before randomization and after 5 months of MIE or HIE training. Patients completed 3-4 sessions of MIE each week, while the HIE group also incorporated 1-2 supervised high intensity interval training sessions/week from month 3 onwards. Arrhythmias were monitored via pre-existing implantable cardiac defibrillators or implantable loop recorders placed prior to training. Results: Five months of MIE increased absolute VO 2 max by 3% and relative VO 2 max by 4%, while HIE consistently increased absolute VO 2 max by 6% and relative VO 2 max by 5% (Figure). Maximal Q c did not change after MIE but increased in all HIE patients (+1.2L/min, 95% CI -1.4 to 3.9), while maximal av-O 2 diff remained stable in both groups. Training compliance was 84 ± 15% in HIE and 93 ± 11% in MIE. There were no serious exercise-related adverse events in either group though two HIE subjects had arrhythmias at rest: 1) 14-beat run of wide complex tachycardia of uncertain mechanism given underlying conduction disease prior to a training session, and 2) 11 beats of non-sustained ventricular tachycardia prior to post exercise testing. Conclusions: Preliminary findings show that five months of HIE safely and consistently increased cardiorespiratory fitness in patients with HCM, though overall the improvements were comparable to MIE.

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Acute Muscular Responses To High Intensity And Low Intensity With Blood Flow Restriction Cycling

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000496149.09951.88 ◽

2014 ◽

Vol 46 ◽

pp. 883

Author(s):

Daeyeol Kim ◽

Jeremy P. Loenneke ◽

Robert S. Thiebaud ◽

Xin Ye ◽

Grant Mouser ◽

...

Keyword(s):

Blood Flow ◽

High Intensity ◽

Blood Flow Restriction ◽

Flow Restriction ◽

Low Intensity ◽

Muscular Responses

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Moderate Intensity Treadmill Running Relieves Motion-Induced Post-Traumatic Osteoarthritis Mice by up-Regulating the Expression of lncRNA H19

10.21203/rs.3.rs-600744/v1 ◽

2021 ◽

Author(s):

Xuchang Zhou ◽

Hong Cao ◽

Miao Wang ◽

Jun Zou ◽

wei wu

Keyword(s):

Knee Joint ◽

High Intensity ◽

High Intensity Exercise ◽

Treadmill Running ◽

Moderate Intensity ◽

Control Group ◽

Mrna Levels ◽

Knee Cartilage ◽

Moderate Intensity Exercise ◽

Post Traumatic

Abstract Background The purpose of this study was to explore whether moderate-intensity exercise can alleviate motion-induced post-traumatic osteoarthritis (PTOA) and the expression change of lncRNA H19 during this progression.Methods Twenty-week-old male C57BL/6 mice were randomly divided into five groups: model control group (CM group, n = 6), treadmill model group (M group, n = 6), rehabilitation control group (CK group, n = 6), treadmill model + rehabilitation training group (K group, n = 6) and treadmill model + rest group (J group, n = 6). Paraffin sections were used to observe the pathological changes in the mouse knee joint in each group. A micro-CT was used to scan the knee joint to obtain the morphological indexes of tibial plateau bone. Real-time PCR was used to detect the mRNA levels of inflammatory factors, synthetic and catabolic factors in cartilage. Results After high-intensity exercise for four weeks, the inflammation and catabolism of the mouse knee cartilage were enhanced, and the anabolism was weakened. Further study showed that these results were partially reversed after four-week moderate-intensity training. The results of hematoxylin-eosin staining confirmed this finding. Meanwhile, high-intensity exercise reduced the expression of lncRNA H19 in cartilage, while the expression of lncRNA H19 increased after four weeks of moderate-intensity exercise.Conclusion High-intensity treadmill running can cause injury to the knee cartilage in C57BL/6 mice which leads to PTOA and an decrease of lncRNA H19 expression in cartilage. Moderate-intensity exercise can relieve PTOA and partially reverse lncRNA H19 expression.

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Resistance Training with Blood Flow Restriction Compared to Traditional Resistance Training on Strength and Muscle Mass in Non-Active Older Adults: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph182111441 ◽

2021 ◽

Vol 18 (21) ◽

pp. 11441

Author(s):

Darío Rodrigo-Mallorca ◽

Andrés Felipe Loaiza-Betancur ◽

Pablo Monteagudo ◽

Cristina Blasco-Lafarga ◽

Iván Chulvi-Medrano

Keyword(s):

Systematic Review ◽

Older Adults ◽

Blood Flow ◽

Resistance Training ◽

Muscle Mass ◽

High Intensity ◽

Meta Analysis ◽

Small Sample ◽

Blood Flow Restriction ◽

Flow Restriction

Low-intensity training with blood flow restriction (LI-BFR) has been suggested as an alternative to high-intensity resistance training for the improvement of strength and muscle mass, becoming advisable for individuals who cannot assume such a load. The systematic review aimed to determine the effectiveness of the LI-BFR compared to dynamic high-intensity resistance training on strength and muscle mass in non-active older adults. A systematic review was conducted according to the Cochrane Handbook and reportedly followed the PRISMA statement. MEDLINE, EMBASE, Web of Science Core Collection, and Scopus databases were searched between September and October 2020. Two reviewers independently selected the studies, extracted data, assessed the risk of bias and the quality of evidence using the GRADE approach. Twelve studies were included in the qualitative synthesis. Meta-analysis pointed out significant differences in maximal voluntary contraction (MVC): SMD 0.61, 95% CI [0.10, 1.11], p = 0.02, I2 71% p < 0.0001; but not in the repetition maximum (RM): SMD 0.07, 95% CI [−0.25, 0.40], p = 0.66, I2 0% p < 0.53; neither in the muscle mass: SMD 0.62, 95% CI [−0.09, 1.34], p = 0.09, I2 59% p = 0.05. Despite important limitations such as scarce literature regarding LI-BFR in older adults, the small sample size in most studies, the still differences in methodology and poor quality in many of them, this systematic review and meta-analysis revealed a positive benefit in non-active older adults. LI- BFR may induce increased muscular strength and muscle mass, at least at a similar extent to that in the traditional high-intensity resistance training.

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Blood Flow Restriction Compared To High Intensity Interval Training On Power Output And Muscle Strength

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000686680.68851.73 ◽

2020 ◽

Vol 52 (7S) ◽

pp. 1020-1020

Author(s):

Justin Anderson ◽

Kali Morris ◽

Gustavo Almeida ◽

Julie Barnett ◽

Tabitha Castillo ◽

...

Keyword(s):

Blood Flow ◽

Muscle Strength ◽

Power Output ◽

High Intensity ◽

Interval Training ◽

Blood Flow Restriction ◽

High Intensity Interval Training ◽

Flow Restriction ◽

High Intensity Interval

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The effect of moderate versus high intensity exercise on heart rate variability in sedentary office workers

Journal of Bangladesh Society of Physiologist ◽

10.3329/jbsp.v16i1.54348 ◽

2021 ◽

Vol 16 (1) ◽

pp. 16-23

Author(s):

Vibha Gangwar ◽

Manish Kumar Verma ◽

Ritesh Singh Gangwar ◽

Nitin Ashok John ◽

Rajani Bala Jasrotia

Keyword(s):

Heart Rate ◽

Exercise Training ◽

High Intensity ◽

High Intensity Exercise ◽

Office Workers ◽

Moderate Intensity ◽

Moderate Intensity Exercise ◽

Group I ◽

Before And After ◽

Group Ii

Background: Sedentary behavior is one of the leading modifiable risk factors for cardiovascular disease and all-cause mortality. Physical exercise exerts beneficial physiological effects on cardiovascular fitness. Different grades of physical exercise have different effects on cardiovascular health. Objective: To compare the effect of moderate and high intensity exercise training on heart rate variability (HRV) in sedentary office workers. Methods: This study was conducted on 40 healthy sedentary volunteers aged between 20-40 years of both the genders. Participants were distributed into two groups of 20 subjects each. Subjects of group I and group II performed moderate intensity and high intensity exercise respectively on bicycle ergometer for 12 weeks. Their 5- minute ECG recording was done by three channel physiograph, and frequency domain indices of HRV and heart rate (HR) were analyzed and compared before and after exercise training. Their blood pressure was also recorded and compared before and after exercise training. Independent sample t-test and paired sample ttest were used for statistical analysis. Results: HF, systolic and diastolic blood pressure reduced significantly after exercise in group II (p=0.015, 0.005, and 0.015 respectively) while HR and LF/HF ratio reduced in both group I and group II (p=0.000 for HR, and 0.034, 0.001 for LF/HF). The decrease in HR was greater after high intensity exercise than moderate intensity exercise (p= 0.025). Conclusion: Parasympathetic activity improves after moderate and high intensity exercise but improvement is more after high intensity exercise training. Therefore, high intensity exercise training is more beneficial than moderate intensity exercise training. J Bngladesh Soc Physiol 2021;16(1): 16-23

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Blood flow restriction - short insight of the method

Timisoara Physical Education and Rehabilitation Journal ◽

10.2478/tperj-2019-0008 ◽

2019 ◽

Vol 12 (23) ◽

pp. 11-15

Author(s):

Tiberiu Puta ◽

Alexandra Mihaela Stănilă ◽

Remus Datcu

Keyword(s):

Blood Flow ◽

Resistance Exercise ◽

High Intensity ◽

Recovery Process ◽

Load Resistance ◽

Blood Flow Restriction ◽

High Intensity Training ◽

Flow Restriction ◽

Low Intensity ◽

Intensity Training

AbstractIntroduction: The blood flow restriction method is a training method that is based on the partial occlusion of circulation during a workout. This technique combines low-intensity exercise with the occlusion of the bloodstream which produces results similar to high-intensity training.Aim: We aimed to identify the areas in which this method is applicable, its potential benefits and effects, recommendations regarding the rules of use for maximal effects (dosage, intensity, etc.), and also possible contraindications or warnings regarding the use of this method.Methods: We have analyzed a number of 20 articles on this topic from the field literature of the last 10 years, using ”google academic” as a search engine.Results: After this study we concluded that blood flow restriction is a method with wide applicability in the field of sports training, but also in the recovery process; however, it requires attention in choosing the necessary equipment. For healthy individuals, best training adaptations occur when combining low-load blood flow restriction resistance exercise with traditional high-load resistance exercise.Conclusion: Low-intensity resistance exercise with blood flow restriction is as effective as high-intensity training (for strength and muscle mass gains), but only the high-intensity protocol promotes significant hypotensive responses after exercise.

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