scholarly journals An experimental study into the acousto-mechanical effects of invading the cochlea

2006 ◽  
Vol 3 (9) ◽  
pp. 561-571 ◽  
Author(s):  
Wei Dong ◽  
Nigel P Cooper
Keyword(s):  
Auditory Nerve ◽  
High Frequency ◽  
Transfer Functions ◽  
Low Frequency ◽  
Mechanical Processing ◽  
Nerve Fibres ◽  
Nonlinear Mechanical ◽  
Optically Transparent ◽  
Mechanical Tuning ◽  
Laser Interferometric

The active and nonlinear mechanical processing of sound that takes place in the mammalian cochlea is fundamental to our sense of hearing. We have investigated the effects of opening the cochlea in order to make experimental observations of this processing. Using an optically transparent window that permits laser interferometric access to the apical turn of the guinea-pig cochlea, we show that the acousto-mechanical transfer functions of the sealed (i.e. near intact) cochlea are considerably simpler than those of the unsealed cochlea. Comparison of our results with those of others suggests that most previous investigations of apical cochlear mechanics have been made under unsealed conditions, and are therefore likely to have misrepresented the filtering of low-frequency sounds in the cochlea. The mechanical filtering that is apparent in the apical turns of sealed cochleae also differs from the filtering seen in individual auditory nerve fibres with similar characteristic frequencies. As previous studies have shown the neural and mechanical tuning of the basal cochlea to be almost identical, we conclude that the strategies used to process low frequency sounds in the apical turns of the cochlea might differ fundamentally from those used to process high frequency sounds in the basal turns.

scholarly journals Spatiotemporal Developmental Upregulation of Prestin Correlates With the Severity and Location of Cyclodextrin-Induced Outer Hair Cell Loss and Hearing Loss

2021 ◽  
Vol 9 ◽  
Author(s):  
Dalian Ding ◽  
Haiyan Jiang ◽  
Senthilvelan Manohar ◽  
Xiaopeng Liu ◽  
Li Li ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cells ◽  
Auditory Nerve ◽  
High Frequency ◽  
Spiral Ganglion ◽  
Low Frequency ◽  
Nerve Fibers ◽  
Spiral Ganglion Neurons ◽  
Auditory Nerve Fibers ◽  
Ganglion Neurons

2-Hyroxypropyl-beta-cyclodextrin (HPβCD) is being used to treat Niemann-Pick C1, a fatal neurodegenerative disease caused by abnormal cholesterol metabolism. HPβCD slows disease progression, but unfortunately causes severe, rapid onset hearing loss by destroying the outer hair cells (OHC). HPβCD-induced damage is believed to be related to the expression of prestin in OHCs. Because prestin is postnatally upregulated from the cochlear base toward the apex, we hypothesized that HPβCD ototoxicity would spread from the high-frequency base toward the low-frequency apex of the cochlea. Consistent with this hypothesis, cochlear hearing impairments and OHC loss rapidly spread from the high-frequency base toward the low-frequency apex of the cochlea when HPβCD administration shifted from postnatal day 3 (P3) to P28. HPβCD-induced histopathologies were initially confined to the OHCs, but between 4- and 6-weeks post-treatment, there was an unexpected, rapid and massive expansion of the lesion to include most inner hair cells (IHC), pillar cells (PC), peripheral auditory nerve fibers, and spiral ganglion neurons at location where OHCs were missing. The magnitude and spatial extent of HPβCD-induced OHC death was tightly correlated with the postnatal day when HPβCD was administered which coincided with the spatiotemporal upregulation of prestin in OHCs. A second, massive wave of degeneration involving IHCs, PC, auditory nerve fibers and spiral ganglion neurons abruptly emerged 4–6 weeks post-HPβCD treatment. This secondary wave of degeneration combined with the initial OHC loss results in a profound, irreversible hearing loss.

Quality Assessment Techniques Applied to Surface Radial Velocity Maps Obtained from High-Frequency Radars

2015 ◽  
Vol 32 (10) ◽  
pp. 1915-1927 ◽  
Author(s):  
Sung Yong Kim
Keyword(s):  
Quality Assessment ◽  
Radial Velocity ◽  
High Frequency ◽  
Transfer Functions ◽  
Driving Forces ◽  
Partial Information ◽  
Spatial Coherence ◽  
Low Frequency ◽  
Velocity Data ◽  
Radial Velocity Data

AbstractThis paper presents examples of the data quality assessment of surface radial velocity maps obtained from shore-based single and multiple high-frequency radars (HFRs) using statistical and dynamical approaches in a hindcast mode. Since a single radial velocity map contains partial information regarding a true current field, archived radial velocity data embed geophysical signals, such as tides, wind stress, and near-inertial and low-frequency variance. The spatial consistency of the geophysical signals and their dynamic relationships with driving forces are used to conduct the quality assurance and quality control of radial velocity data. For instance, spatial coherence, tidal amplitudes and phases, and wind-radial transfer functions are used to identify a spurious range and azimuthal bin. The uncertainty and signal-to-noise ratio of radial data are estimated with the standard deviation and cross correlation of paired radials sampled at nearby grid points that belong to two different radars. This review paper can benefit HFR users and operators and those who are interested in analyzing HFR-derived surface radial velocity data.

Seismic source characteristics from explosion-generated P waves

1968 ◽  
Vol 58 (6) ◽  
pp. 1833-1848 ◽  
Author(s):  
Lynn D. Trembly ◽  
Joseph W. Berg
Keyword(s):  
High Frequency ◽  
Transfer Functions ◽  
Low Frequency ◽  
Seismic Energy ◽  
Seismic Source ◽  
Propagation Path ◽  
P Waves ◽  
Nuclear Explosions ◽  
Source Characteristics ◽  
The Earth

ABSTRACT Signals from nuclear explosions were used to calibrate seismograph stations (near-regional, regional, and teleseismic ranges) by determining the transfer functions of the lumped source-propagation path-receiver systems. Recorded signals other than those used for calibration purposes were used to derive the characteristics of the sources. It was found that source functions could be derived from distant signals when the frequencies of the output signals were reliably related to the source. For the output data used in this research, the low-frequency cutoff was 0.2 cps at all stations and the high-frequency cutoffs were 4.0, 3.0, and 2.0 cps at the near-regional, regional, and teleseismic distances, respectively. The low-frequency cutoff was due mainly to the recording instruments, and the high-frequency cutoffs were due to the attentuation of the seismic energy by the Earth. The most reliable results were obtained when three half-cycles of the observed output signals (first arrivals) were used. When explosions in granite were used as calibration sources, the energies derived for explosions in tuff, alluvium, and dolomite media were 88, 65, and 12 per cent of the respective “observed” source energies.

Acoustic reflex frequency selectivity in single stapedius motoneurons of the cat

1992 ◽  
Vol 68 (3) ◽  
pp. 807-817 ◽  
Author(s):  
J. B. Kobler ◽  
J. J. Guinan ◽  
S. R. Vacher ◽  
B. E. Norris
Keyword(s):  
Auditory Nerve ◽  
High Frequency ◽  
Low Frequency ◽  
Nerve Fibers ◽  
Main Function ◽  
Acoustic Reflex ◽  
Tuning Curves ◽  
Acoustic Reflexes ◽  
Auditory Nerve Fibers ◽  
Decerebrate Cats

1. The sound frequency selectivities of single stapedius motoneurons were investigated in ketamine anesthetized and in decerebrate cats by recording from axons in the small nerve fascicles entering the stapedius muscle. 2. Stapedius motoneuron tuning curves (TCs) were very broad, similar to the tuning of the overall acoustic reflexes as determined by electromyographic recordings. The lowest thresholds were usually for sound frequencies between 1 and 2 kHz, although many TCs also had a second sensitive region in the 6- to 12-kHz range. The broad tuning of stapedius motoneurons implies that inputs derived from different cochlear frequency regions (which are narrowly tuned) must converge at a point central to the stapedius motoneuron outputs, possibly at the motoneuron somata. 3. There were only small differences in tuning among the four previously described groups of stapedius motoneurons categorized by sensitivity to ipsilateral and contralateral sound. The gradation in high-frequency versus low-frequency sensitivity across motoneurons suggests there are not distinct subgroups of stapedius motoneurons, based on their TCs. 4. The thresholds and shapes of stapedius motoneuron TCs support the hypothesis that the stapedius acoustic reflex is triggered by summed activity of low-spontaneous-rate auditory nerve fibers with both low and high characteristic frequencies (CFs). Excitation of high-CF auditory nerve fibers by sound in their TC “tails” is probably an important factor in eliciting the reflex. 5. In general, the most sensitive frequency for stapedius motoneurons is higher than the frequency at which stapedius contractions produce the greatest attenuation of middle ear transmission. We argue that this is true because the main function of the stapedius acoustic reflex is to reduce the masking of responses to high-frequency sounds produced by low-frequency sounds.

Appropriate electrode sites and electrical characteristics for TENS

2014 ◽  
Keyword(s):  
Social Factors ◽  
High Intensity ◽  
High Frequency ◽  
Low Frequency ◽  
Electrical Characteristics ◽  
Nerve Fibres ◽  
Low Intensity ◽  
Factors Influencing ◽  
Electrode Positioning ◽  
Low Threshold

The success of TENS treatment depends on the use of safe and appropriate TENS technique. Uncertainty about optimal TENS technique is due in part to the variety of possible electrode positions and electrical characteristics that can be chosen for treatment. Conventional TENS uses low-intensity, high-frequency currents to activate low-threshold afferent nerve fibres in the skin. AL-TENS uses high-intensity, low-frequency currents to generate non-painful phasic muscle contractions (twitching). The purpose of this chapter is to discuss the principles that underpin the use of safe and appropriate electrode sites and electrical characteristics during TENS. The chapter covers how to choose between conventional and AL-TENS, the appropriate electrode positioning for conventional TENS and AL-TENS including instances where AL-TENS may be more beneficial than conventional TENS, appropriate choice of electrical characteristics for stimulation, and biological, psychological, and social factors influencing response to TENS

Forced Flame Response of a Lean Premixed Multi-Nozzle Can Combustor

2011 ◽  
Author(s):  
Michael T. Szedlmayer ◽  
Bryan D. Quay ◽  
Janith Samarasinghe ◽  
Alex De Rosa ◽  
Jong Guen Lee ◽  
...  
Keyword(s):  
Heat Release ◽  
High Frequency ◽  
Transfer Functions ◽  
Low Frequency ◽  
Forced Response ◽  
Operating Conditions ◽  
Velocity Fluctuations ◽  
Lean Premixed ◽  
Flame Response ◽  
Rate Of Heat Release

An experimental investigation was conducted to determine the air-forced flame response of a five-nozzle, 250 kW, lean premixed gas turbine can combustor. Operating conditions were varied over a range of inlet temperatures, inlet velocities, and equivalence ratios, while the forcing frequency was varied from 100 to 450 Hz with constant normalized velocity fluctuations of approximately 5%. The response of the flame’s rate of heat release to inlet velocity fluctuations is expressed in terms of the phase and gain of a flame transfer function. In addition, chemiluminescence imaging is used to characterize the time-averaged and phase-averaged spatial distribution of the flame’s heat release. The resulting flame transfer functions and chemiluminescence flame images are compared to each other to determine the effects of varying the operating conditions. In addition, they are compared to data obtained from a single-nozzle combustor with the same injector. The forced response of the multi-nozzle flame demonstrates a similar pattern to those obtained in a single-nozzle combustor with the same injector. An exception occurs at high frequency where the multi-nozzle flame responds to a greater degree than the single-nozzle flame. At low frequency the multi-nozzle flame dampens the perturbations while the single-nozzle flame amplifies them. A number of minima and maxima occur at certain frequencies which correspond to the interference of two mechanisms. The frequency of these minima is nearly the same for the single- and multi-nozzle cases. When plotted with respect to Strouhal number instead of frequency there is a degree of collapse that occurs around the first observed minima.

scholarly journals A Diversity Combination Model Incorporating an Inward Bias for Interaural Time-Level Difference Cue Integration in Sound Lateralization

2020 ◽  
Vol 10 (18) ◽  
pp. 6356
Author(s):  
Sina Mojtahedi ◽  
Engin Erzin ◽  
Pekcan Ungan
Keyword(s):  
Sound Source ◽  
High Frequency ◽  
Transfer Functions ◽  
Low Frequency ◽  
Time Level ◽  
Complex Sound ◽  
Combination Model ◽  
Duplex Theory ◽  
The Brain ◽  
Hearing System

A sound source with non-zero azimuth leads to interaural time level differences (ITD and ILD). Studies on hearing system imply that these cues are encoded in different parts of the brain, but combined to produce a single lateralization percept as evidenced by experiments indicating trading between them. According to the duplex theory of sound lateralization, ITD and ILD play a more significant role in low-frequency and high-frequency stimulations, respectively. In this study, ITD and ILD, which were extracted from a generic head-related transfer functions, were imposed on a complex sound consisting of two low- and seven high-frequency tones. Two-alternative forced-choice behavioral tests were employed to assess the accuracy in identifying a change in lateralization. Based on a diversity combination model and using the error rate data obtained from the tests, the weights of the ITD and ILD cues in their integration were determined by incorporating a bias observed for inward shifts. The weights of the two cues were found to change with the azimuth of the sound source. While the ILD appears to be the optimal cue for the azimuths near the midline, the ITD and ILD weights turn to be balanced for the azimuths far from the midline.

Simulations of high-resolution images of amorphous silicon films

1986 ◽  
Vol 44 ◽  
pp. 544-545
Author(s):  
G. Y. Fan ◽  
J. M. Cowley
Keyword(s):  
Electron Microscope ◽  
High Frequency ◽  
Fourier Transformation ◽  
Amorphous Materials ◽  
Low Frequency ◽  
Chromatic Aberration ◽  
Structure Information ◽  
Frequency Components ◽  
High Resolution Images ◽  
Spatial Frequency Spectrum

It is well known that the structure information on the specimen is not always faithfully transferred through the electron microscope. Firstly, the spatial frequency spectrum is modulated by the transfer function (TF) at the focal plane. Secondly, the spectrum suffers high frequency cut-off by the aperture (or effectively damping terms such as chromatic aberration). While these do not have essential effect on imaging crystal periodicity as long as the low order Bragg spots are inside the aperture, although the contrast may be reversed, they may change the appearance of images of amorphous materials completely. Because the spectrum of amorphous materials is continuous, modulation of it emphasizes some components while weakening others. Especially the cut-off of high frequency components, which contribute to amorphous image just as strongly as low frequency components can have a fundamental effect. This can be illustrated through computer simulation. Imaging of a whitenoise object with an electron microscope without TF limitation gives Fig. 1a, which is obtained by Fourier transformation of a constant amplitude combined with random phases generated by computer.

SEM image sharpness analysis

1996 ◽  
Vol 54 ◽  
pp. 142-143
Author(s):  
M. T. Postek ◽  
A. E. Vladar
Keyword(s):  
High Frequency ◽  
Low Frequency ◽  
Quantitative Information ◽  
Primary Electron ◽  
Image Sharpness ◽  
Critical Dimensions ◽  
Sem Image ◽  
Frequency Changes ◽  
Electron Microscopes ◽  
Scanning Electron

Fully automated or semi-automated scanning electron microscopes (SEM) are now commonly used in semiconductor production and other forms of manufacturing. The industry requires that an automated instrument must be routinely capable of 5 nm resolution (or better) at 1.0 kV accelerating voltage for the measurement of nominal 0.25-0.35 micrometer semiconductor critical dimensions. Testing and proving that the instrument is performing at this level on a day-by-day basis is an industry need and concern which has been the object of a study at NIST and the fundamentals and results are discussed in this paper.In scanning electron microscopy, two of the most important instrument parameters are the size and shape of the primary electron beam and any image taken in a scanning electron microscope is the result of the sample and electron probe interaction. The low frequency changes in the video signal, collected from the sample, contains information about the larger features and the high frequency changes carry information of finer details. The sharper the image, the larger the number of high frequency components making up that image. Fast Fourier Transform (FFT) analysis of an SEM image can be employed to provide qualitiative and ultimately quantitative information regarding the SEM image quality.

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