A Bayesian precision profile for measuring the quality of immunoassay experiments

Author(s):  
A. James O'Malley

A precision profile, the relationship between the concentration of a substance and its measured precision, is a convenient way of conveying the ability of an immunoassay to accurately measure the concentration of a substance in blood serum. A precision profile is characterized by the definition of precision. Historically, precision has been evaluated as the standard error of an estimator of the concentration in a sample conditional on the true concentration. In this paper, Bayesian predictive inference is used to develop a new measure of precision based on the accuracy with which an assay could infer the concentration in a hypothetical new sample. This leads to a natural procedure for evaluating a precision profile that avoids using approximations such as those inherent in traditional methods.

1968 ◽  
Vol 14 (10) ◽  
pp. 960-966 ◽  
Author(s):  
J van der Honing ◽  
C C Saarloos ◽  
J Stip

Abstract A fully automated method has been developed for the determination of total cholesterol in blood serum, using the AutoAnalyzer system. According to the new method, based on the cholesterol determination of Abell et al. (1), the serum sample is saponified and subsequently extracted with carbon tetrachloride. After treatment with Liebermann-Burchard reagent, the amount of cholesterol is determined at 630 nm. The method can be used for free and esterified cholesterol because saponification is carried out. The relationship between the new method and that of Abell et al. is linear. The correlation coefficient is 0.98 and the standard error 1.5%. According to the new method, 30 samples can be analyzed per hour.


2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Claire L. Donohoe ◽  
Aoife M. Ryan ◽  
John V. Reynolds

Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is associated with poor quality of life, poor physical function, and poor prognosis in cancer patients. It involves multiple pathways: procachectic and proinflammatory signals from tumour cells, systemic inflammation in the host, and widespread metabolic changes (increased resting energy expenditure and alterations in metabolism of protein, fat, and carbohydrate). Whether it is primarily driven by the tumour or as a result of the host response to the tumour has yet to be fully elucidated. Cachexia is compounded by anorexia and the relationship between these two entities has not been clarified fully. Inconsistencies in the definition of cachexia have limited the epidemiological characterisation of the condition and there has been slow progress in identifying therapeutic agents and trialling them in the clinical setting. Understanding the complex interplay of tumour and host factors will uncover new therapeutic targets.


ASALIBUNA ◽  
2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Nur Qomari

Bilingualism in teaching is something to be done to make the quality of teaching more effective especially in the World Class University Like Islamic State Of University Maulana Malik Ibrahim Malang. This Article will be give information about implementation of Bilingulism in teaching. And also give information about the definition of bilingual and what kind of bilingual can be implemented especially in Arabic language teaching for the foreigner. Beside of information about the kind of the suitable bilingual in teaching language, This Article also inform how much of Arabic language acquisition when that language to be tought by bilingual method. And offcourse this give information about the relationship between the bilingual teaching language with the skills of language.


2019 ◽  
Vol 20 (2) ◽  
pp. 151-162
Author(s):  
N. Filipenko ◽  
O. Uhrovetskyi ◽  
O. Sharapova

The article analyzes conceptual foundations, views and ideas concerning the essence of expert prevention. The relationship between the concepts of «prevention» and «prevention», which is in contact with each other, is investigated, because one of the main problems of the criminal investigation of the phenomenon of expert prevention is the ambiguity of both scientific understanding and the practical application of the corresponding conceptual-categorical apparatus. It is emphasized that the essence of expert prevention is the influence of the relevant subjects on crime through the use of special professional knowledge. That is, to the subject of forensic examination, should include studies of circumstances on the basis of which can be and should be developed scientific, organizational and technical measures of preventive nature. Proven that among the tasks of preventive nature, which can be solved by the staff of judicial-expert institutions, the development of aimed at forecasting in criminalistic aspects of circumstances contributing to the commission of crimes, taking into account the possibilities of certain types of expert research, should occupy an important place. It is proved that the preventive activities of forensic institutions of Ukraine should be carried out: in the production of examinations in specific criminal, administrative or civil cases; by summarizing expert, as well as forensic investigative practices; in the process of research on expert prevention; by providing on the basis of special knowledge of scientific and practical assistance to government agencies and public organizations in identifying circumstances conducive to the commission of crimes. In order to improve the quality of expert-preventive activities, the staff of the forensic institutions of Ukraine should pay maximum attention to the promotion of preventive activities among representatives of law enforcement and law enforcement agencies. On the basis of the analysis, the author’s definition of expert prevention is given: the activity of a forensic expert based on the laws and by-laws of normative legal acts, aimed at revealing the circumstances contributing to the commission of a crime, and the development of measures for their elimination with the use of special knowledge.


2019 ◽  
Vol 33 ◽  
pp. 89-115
Author(s):  
Edyta WIĘCŁAWSKA

The author presents data gathered in an online survey questionnaire (https://www.interankiety.pl/i/RGmj5rDv) which is a part of a broader research project related to the quality of translation of English language documents in the field of commercial law that are processed in the judicial registration proceedings in reference to the entities subject to registration at the Register of Entrepreneurs of the National Court Register (RP, KRS). The questions and hypotheses posed by the author relate to the relationship or comparison of nation-wide data concerning cases with foreign element in the context of the documents in translation on file in the National Court Register (source texts and their certified translations).The survey is the first stage of this project and has been ascribed a number of aims: allowing for a definition of the genre profile of the corpus texts; identifying the general sociologically conditioned tendencies in their structure; and – primarily – determining the practically feasible search criterion for compiling a design corpus for further quantitative and qualitative analysis of selected language structures (the ensuing stages of the said project). 


1997 ◽  
Vol 67 (4) ◽  
pp. 635-658 ◽  
Author(s):  
Kathleen Weiler

In this article, Kathleen Weiler reflects on the historiography of Country Schoolwomen, her recent study of women teachers in rural California. Using a broad definition of feminist research, Weiler summarizes some of the most salient issues currently under debate among feminist scholars. She raises questions about the nature of knowledge, the influence of language in the social construction of gender, and the importance of an awareness of subjectivity in the production of historical evidence. Using several cases from Country Schoolwomen, Weiler discusses the importance of considering the conditions under which testimony is given, both in terms of the dominant issues of the day — for example, the way womanliness or teaching is presented in the authoritative discourse — and the relationship between speaker and audience. She concludes that a feminist history that begins with a concern with the constructed quality of evidence moves uneasily between historical narrative and a self-conscious analysis of texts.


2021 ◽  
Vol 13 (13) ◽  
pp. 7039
Author(s):  
Laurence Pattacini

In a post-industrial world one of the foci of urbanism has been on the regeneration of former industrial sites along urban rivers. This is a contemporary urban design issue that needs further attention, especially in relation to urban forms and design interventions. This paper sets out to contribute to research in design by reviewing past theories and practices in order to inform the formation of conceptual ideas. These are of importance to inform practice and ensure responsive and responsible processes in planning and design. Such a review has hitherto been lacking, but with a renewed interest in urban densification, research in the design of cities is required. Thus, this paper provides a critical assessment of theories, which are identified and categorised in relation to urban riverside regeneration. For this study, urban design is considered as a craft requiring ‘savoir faire’ to ensure the functionality and quality of urban spaces. Transferable principles and ideas are identified in relation to the specific characteristics of riverside locations contributing to the definition of a ‘riverside urbanity’. It provides a theoretical framework identifying types of riverside landscapes, including the relationship between urban forms and river corridors.


2021 ◽  
Vol 4 (27) ◽  
pp. 160-163
Author(s):  
J.D. Murmyilo ◽  

This article analyzes the problems of addi-tional financing of the university and the possibility of considering them as a subject of social responsibility for Russian society. The possibility of improving the quality of education in higher education through the use of endowment assets is substantiated. The definition of endowment assets and funds is given. The level of development of this mechanism by the leading Russian uni-versities is determined. The author analyzes the statistics of successful foreign use of such a tool as endowment funds. This article attempts to establish the relationship be-tween the number of participants in endow-ment funds and the amount of funds raised. Also, the tasks necessary to develop an al-gorithm of actions that allow Russian higher education to use endowment assets have been formulated.


Author(s):  
O. V. Shpyrnya ◽  
E. A. Eremina ◽  
M. V. Koreneva

The article describes the main features of promoting the services of entertainment industry enterprises. The definition of entertainment services is given, a list of enterprises providing such services is indicated. The relationship between entertainment services and the development of the tourism and hospitality industry is revealed. Various options for promoting the services of entertainment industry enterprises are presented. Attention is paid to the importance of the process of branding the business of entertainment industry enterprises and maintaining a high level of quality of customer service. Particular attention was paid to additional elements of the marketing mix in promoting the services of entertainment industry enterprises. The basic methods of promoting services are examined, with particular emphasis on social networks VKontakte, Odnoklassniki, Instagram, Facebook. The prospects of organizing focus groups in social networks while promoting certain services in the entertainment industry are noted. It is concluded that technologies for promoting services in the entertainment industry contribute to expanding the number of potential customers, forming a group of regular customers, increasing interest from consumers, partners, and more.There is no conflict of interests.


2018 ◽  
Vol 7 (4.3) ◽  
pp. 25
Author(s):  
Viktor Vojtov ◽  
Abliatif Biekirov ◽  
Anton Voitov

The purpose of this work was to develop a criterion for estimating the quality factor of the tribosystem and to assess its effect on wear rate, friction coefficient and run-in time. The basis of the methodological approach when developing a criterion for the quality of the tribosystem is the parameters that take into account the construction of the tribosystem, the thermal diffusivity of materials and the loading conditions of the tribosystems.The definition of the quality of the tribosystem has been further developed, which, unlike the known one, takes into account the geometric dimensions and kinematic scheme of the tribosystem, the thermal diffusivity of materials and the rate of propagation of deformation in the surface layers of the triboelement materials during their contact interaction. Theoretical and experimental studies established the relationship between the quality value, wear rate and the friction coefficient in the process of running-in. It is shown that the increase in quality helps to reduce the above-mentioned parameters.The relationship between the running-in time and the quality value is established. It is shown that the process of running-in can be controlled. To reduce the running-in time, it is necessary to reduce the sliding speed during the transient process and to increase the tribological properties of the lubricating medium. The presented theoretical and experimental studies allow us to state that the quality of tribosystems Q can be a measure of the potential ability of the tribosystem to adapt (adapt) to operating conditions, providing the maximum resource.  


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