Using semantics to scale up evidence-based chemical risk-assessments

Background The manual processes used for risk assessments are not scaling to the amount of data available. Although automated approaches appear promising, they must be transparent in a public policy setting. Objective Our goal is to create an automated approach that moves beyond retrieval to the extraction step of the information synthesis process, where evidence is characterized as supporting, refuting, or neutral with respect to a given outcome. Methods We combine knowledge resources and natural language processing to resolve coordinated ellipses and thus avoid surface level differences between concepts in an ontology and outcomes in an abstract. As with a systematic review, the search criterion, and inclusion and exclusion criterion are explicit. Results The system scales to 482K abstracts on 27 chemicals. Results for three endpoints that are critical for cancer risk assessments show that refuting evidence (where the outcome decreased) was higher for cell proliferation (45.9%), and general cell changes (37.7%) than for cell death (25.0%). Moreover, cell death was the only end point where supporting claims were the majority (61.3%). If the number of abstracts that measure an outcome was used as a proxy for association there would be a stronger association with cell proliferation than cell death (20/27 chemicals). However, if the amount of supporting evidence was used (where the outcome increased) the conclusion would change for 21/27 chemicals (20 from proliferation to death and 1 from death to proliferation). Conclusions We provide decision makers with a visual representation of supporting, neutral, and refuting evidence whilst maintaining the reproducibility and transparency needed for public policy. Our findings show that results from the retrieval step where the number of abstracts that measure an outcome are reported can be misleading if not accompanied with results from the extraction step where the directionality of the outcome is established.

Forecasting oil and gas saturation of the section based on the results of seismic survey interpretation using innovative methods on the territory of the Republic of Kazakhstan

Seismoacoustic entropy analysis (SAE-analysis) and the method of frequency compositions (MFC) are methods of seismic exploration aimed at solving problems of direct search for hydrocarbons based on the results of seismic exploration in promising areas. Both methods use the seismoacoustic response of a hydrocarbon deposit when interacting with the incident wave front as a search criterion. The location of the deposit is determined through dynamic processing and statistical analysis of the spectral characteristics of the wave field. The article presents the results of the forecast of oil saturation by the methods of MFC and SAE-analysis on the territory of Kazakhstan.

Neuronutrition in the perspective of the prevention and treatment of depressive disorder / Neuronutrição na perspectiva da prevenção e tratamento da desordem depressiva

The father of medicine was a pioneer in suggesting the healing power of food nutrients, however it took a long time for science to recognize that food has functional properties and the ability to interfere with mood and brain health. Currently, neuroscience is showing research results, demonstrating the effectiveness of nutritional bioactive compounds with neuroprotective potential. Some metabolic changes are the basis of common neuropsychiatric diseases, such as depressive disorder, characterized by mood dysregulation, cognitive dysfunction, sleep disorders, appetite, fatigue and metabolic or inflammatory changes. Objective: to describe the potential of dietary and bioactive nutrients that interfere in the neurobiology of depressive disorder. Methodology: This is a systematic review, stratified in a time window of 2012-2021. As a search criterion for the articles, a guiding question was formulated: how does the relationship between food nutrition and its potential connections in the neurobiology of depression appear? DesCs-MESH indexes were pre-established in the English language: food nutrition, bioactive, neurobiology depressive disorders, in the vernacular: food nutrition, brain, bioactive, depressive disorder, allied to Boolean operators, to the StArt resource, to exclude duplicate manuscripts. Results: This short-review included 31 articles that met the criteria and demonstrated nutritional bioactivity involved in the neurobiological process of depressive disorder. Conclusion: the connection between diet and depression emerges with promising perspectives when demonstrating the potential of nutrients and bioactive with a neuroprotective effect. The clinical approach combined with the diet designed to produce antidepressant effects can work as an adjunct to the treatment and prevention of depressive symptoms.

Impact of #ASCO Twitter impressions on the oncology community.

11039 Background: The oncology community is embracing social media (SM) platforms like Twitter to gain exposure to research, to network, and to engage in real-time discussions. The emergence of SM activity around the ASCO annual meetings has dramatically increased over the past 5 years, with factors such as the COVID-19 pandemic further accelerating use of digital platforms. This growth in SM engagement within the oncology community has previously been presented by totaling the quantity of tweets within a given time frame. Here, we explore the impact of specific trends through impression data. Methods: To evaluate activity trends among certain oncology stakeholders, we utilized an SM analytics platform, Symplur, to conduct a content analysis around ASCO conferences (2016-2020) using hashtags (#ASCOyy) as the search criterion. We focused our analysis on trends in impressions , defined by the theoretical maximum number of Twitter users a given tweet could have directly reached in a follower's timeline. We gathered impressions data to quantitatively assess overall ASCO engagement and evaluate topics of interest, and to discover common ASCO themes and reach within specific stakeholder groups. Results: Our results show the largest increase in impressions was during #ASCO20, despite a plateauing effect seen in the actual number of tweets (Table). The cumulative number of impressions for #ASCO16 was 468.2 million compared with approximately 1.12 billion for #ASCO20. Differentiating this result from the number of tweets related to ASCO, there was stabilization in the absolute number from #ASCO17 onward. When compiling impressions by doctors and by patient advocates, a similar trend emerged, with the most impressions captured during #ASCO20 (Table). Conclusions: As SM use continues to expand in the oncology community, stakeholders have turned to their digital voice to express views and opinions. The impact of impressions versus absolute number of tweets will continue to grow with a stakeholder’s follower count, thus building on the digital presence in oncology.[Table: see text]

Criteria for Determining the Genesis of Placers and Their Different Sources Based on the Morphological Features of Placer Gold

Based on the identified typomorphic features of placer gold, a set of determined morphogenetic criteria is proposed to identify the genesis of placer gold content and different sources in the platform areas, which allow more correctly selecting search methods and improving the efficiency of forecasting ore and placer gold deposits.Goldparticles larger than 0.25 mm with signs of wind-worn processing indicate the formation of autochthonous aeolian placers.Gold particles with signs of wind-worn processing with a size of 0.1–0.25 mm, forming an extensive halo of dispersion, indicate the formation of allochthonous placers in Quaternary deposits.Deflationary (autochthonous) placers of native gold can be found by the halo of its distribution of toroidal and sphericalhollow forms, which, of course, are the search morphogenetic criterion of aeolian placers.The presence of disc-shaped and lamellar gold particles with ridgelike edges in alluvial placers is typical for placers of heterogeneous origin, formed due to deflation of proluvialplacers.The discovery of pseudo-ore gold in alluvial placers indicates the arrival of gold from intermediate gold-bearing sources of different ages and not from primary sources, which is a morphogenetic criterion for determining different sources of the placer.In modern gold placers, the presence of gold of a pseudo-ore appearance can serve as a search criterion for the discovery of gold-bearing conglomerates with high gold content. The developed method for diagnosing the genotype of placer gold by its morphological characteristics (alluvial, aeolian, pseudo-ore) can be successfully used by industrial geological organizations to search and explore ore and placer gold deposits.

Routine Postoperative Management of Blepharoplasty: A Review of Current Evidence-Based Practice

Introduction Advances in blepharoplasty have resulted in an improved understanding of preoperative risk factors, intraoperative hemostasis, and wound closure. This has reduced the risk of severe adverse events. The aim of this review is to determine the current evidence base for routine postblepharoplasty management. Method A literature review was performed using MEDLINE, PUBMED, and EMBASE databases. Expanded search criterion “bleph*” was combined with individual terms assessing postoperative management. Articles were assessed and qualified as per Oxford Centre of Evidence-Based Medicine levels 1 to 5 (1 = highest level of evidence). Results A total of 47 unique articles matched our search strategy. Most articles were a description of individual expert opinion, surveys of practice, or case series (level 4–5 evidence). Few randomized controlled trials were performed (level 2). Conclusion Many articles describe the clinical experience of senior facial plastic surgeons. Our review found some evidence for postoperative cooling and preincision antisepsis to be effective. This review highlights the need for higher-quality studies to improve the evidence base for routine postoperative management.

Plastic Surgery at War: A Scoping Review of Current Conflicts

Introduction The scope of military plastic surgery and location where care is provided has evolved with each major conflict. To help inform plastic surgeon utilization in future conflicts, we conducted a review of military plastic surgery-related studies to characterize plastic surgeon contributions during recent military operations. Materials and Methods Using a scoping review design, we searched electronic databases to identify articles published since September 1, 2001 related to military plastic surgery according to a defined search criterion. Next, we screened all abstracts for appropriateness based on pre-established inclusion/exclusion criteria. Finally, we reviewed the remaining full-text articles to describe the nature of care provided and the operational level at which care was delivered. Results The final sample included 55 studies with most originating in the United States (54.5%) between 2005 and 2019 and were either retrospective cohort studies (81.8%) or case series (10.9%). The breadth of care included management of significant upper/lower extremity injuries (40%), general reconstructive and wound care (36.4%), and craniofacial surgery (16.4%). Microsurgical reconstruction was a primary focus in 40.0% of published articles. When specified, most care was described at Role 3 (25.5%) or Roles 4/5 facilities (62.8%) with temporizing measures more common at Role 3 and definite reconstruction at Roles 4/5. Several lessons learned were identified that held commonality across plastic surgery domain. Conclusions Plastic surgeons continue to play a critical role in the management of wounded service members, particularly for complex extremity reconstruction, craniofacial trauma, and general expertise on wound management. Future efforts should evaluate mechanisms to maintain these skill sets among military plastic surgeons.

Progressive Surface Reconstruction of Cardiac Anatomy from Sparse and Scattered Points for Heart Mapping Procedure

In computer aided radiofrequency catheter ablation of the heart, intraoperative three-dimensional reconstruction of the intracardiac cavity is a very important step. In this paper, we propose a point-by-point surface reconstruction algorithm based on scattered points and guarantee the properties of local reconstruction and surface smoothing. The algorithm firstly builds a generic self-adapted grid model to enclose and approximate to the initial sampled points (at least four points) captured from endocardial surface. Then, the grid model is deformed when adding a newly sampled point. To avoid the linear increase of computation with the increasing of the number of points and unbalanced neighborhood, we propose a local region search criterion based on orthogonal least squares and a neighborhood partition method. Such criterion can guarantee selecting the minimum local balanced points to complete each step of grid deformation. Four normal and six abnormal cardiac computed tomography angiography models specific to the left atrium are used to verify our method. The results show that the surface reconstruction errors as well as the reconstruction time per update are smaller than the state-of-theart methods applied to progressive reconstruction using sparse and scattered points. Furthermore, a cardiac phantom of right ventricle is used to verify the 3D surface reconstruction by our method. The experimental results confirm the feasibility of the proposed algorithm in practical operation.

Quantitative Review of Construction 4.0 Technology Presence in Construction Project Research

The development of technologies associated with the fourth industrial revolution is rapid. Construction 4.0 represents the architecture, engineering, construction and operations industries exploration of new technologies, equivalent to Industry 4.0 for the manufacturing industry. These concepts address multiple perspectives besides the technological, such as management and processes. The purpose of this study was to investigate to what extent research regarding construction projects addresses information and communication, automatisation or industrialisation technologies. A scoping review was the method used to perform a quantitative analysis of over two thousand journal papers published from 2015 onwards. The results show that new technologies are addressed separately, while synergy studies are uncommon. Longitudinal analyses show that there was no significant increase in journal papers concerning new technologies from 2015 to 2019. Information and communication was the search criterion with the least number of papers found. The environmental perspective of new technologies was present but the least common from 2019 to 2020. Hence, this review shows that there is an extensive research gap regarding Construction 4.0 technologies in the context of construction projects. Studies regarding synergy and environmental effects of new technologies should increase to start the progress towards a successful entry into the fourth industrial revolution.

Virtual screening of natural products database

: Constant research with natural products has generated, over time, a large number of compounds with potential to be evaluated in several biological tests and subsequently have been cataloged in databases that allow other researchers perform virtual screenings on activity in various biological systems. This considerably reduces the time for the development of new drugs. This review describes the main databases of Natural Products available for searching for bioactive compounds. It also describes the main features of Virtual Screening strategies for identification of molecules with potential to be used as new drugs. In adittion, a search was made in the Web of Science database, using as search term "Virtual screening of natural products databases" from 2003 to 2018. The search criterion resulted in 230 articles, which had their abstracts evaluated as to the pertinence to the criteria required for this work, which are: a) be a research article; b) performing a virtual screening from databases of natural products or containing natural products; c) works that identified drug candidate molecules. Based on these criteria, the bibliographic review work on the topic was excluded. After this analysis, 104 works were selected for this review. Were selected relevant papers describing the obtaining of potential drug candidates that were distributed in 15 classes, of which the anticancer, antibacterial and anti-inflammatory hits were the most abundant. There are also described works showing efforts to search for new molecules against various other diseases in distinct biological systems. In this way, this work shows an overview of several methodologies and we hope they can help and inspire the development of new research to improve people's quality of life.