scholarly journals Efficacy of Sodium Valproate in the Treatment of Photosensitive Epilepsy (PSE) and the Probable Reasons for the Persistence of Occipital Spikes

2004 ◽  
Vol 4 ◽  
pp. 521-530 ◽  
Author(s):  
Ebere C. Anyanwu ◽  
John E. Ehiri ◽  
Andrew W. Campbell

Intermittent photic stimulation (IPS) in patients with photosensitive epilepsy (PSE) leads to EEG abnormalities, which include generalized discharges with spike and wave activity. This paper investigates 33 PSE patients, 14 (42%) males and 19 (58%) females. The age range was between 8 and 45 years. After the treatment of the patients with sodium valproate (VPA), the EEG examinations showed that the generalized discharges disappeared, while the occipital spikes persisted. The mechanism of action of VPA was re-evaluated in order to ascertain whether or not the persistent occipital was due to a failure in inhibitory postsynaptic potential (IPSP). It was concluded that the possible causes of VPA's inefficacy in abolishing occipital spikes in PSE was not necessarily due to a failure in IPSP, but rather it could be due to a time-dependent failure of certain cells of the visual system to respond positively to the VPA's modulatory activity, probably involving the ionic channels, neurotransmitters, and the second messenger systems. The relationship between occipital spikes and visual evoked response is discussed. The extent to which metabolic processes and neurotransmitters are involved is also evaluated.

2004 ◽  
Vol 4 ◽  
pp. 159-166 ◽  
Author(s):  
Ebere C. Anyanwu ◽  
John Ehiri

Patients with photosensitive epilepsy are susceptible to seizures due to photoparoxysmal response (PPR). This response adversely precipitates factors that modify the functional status of the visual system. Such factors may or may not be evident superficially, but may lead to ocular defects due to trauma, hormonal imbalance, abnormal intraocular pressure (IOP), or any other reflex-inducing stimuli. The extent to which photosensitive epileptic patients suffer from PPR-related ocular defects has not been documented fully. In this investigation, ocular defects in patients with photosensitive epilepsy are studied using visual-evoked response (VER). A total of 212 photosensitive epileptic patients were studied to ascertain the magnitude and distribution of ocular defects using the changes in EEG and visual-evoked potential (VEP); 51% of the patients were female, the age range was 1–46 years. The major ocular defects and complications found were visual field defects, optic nerve abnormalities, nystagmus, cataracts, amblyopia, and migraine. These findings were analyzed according to age and sex. The relationship between the ocular abnormalities and the interpretations of the changes in the characteristics of the VEP indicated that optic-related atrophies, visual defects, optic neuritis, chiasmal compression, nystagmus, migraine headache, cataracts, and amblyopia were prevalent in photosensitive epileptic patients at varying degrees. The results showed that although ocular defects in photosensitive epilepsy may not be obvious differentially, VEP can be used in their diagnosis, contrary to earlier studies reporting that VEP is not of much value in epilepsy diagnosis.


1983 ◽  
Vol 26 (1) ◽  
pp. 2-9 ◽  
Author(s):  
Vincent J. Samar ◽  
Donald G. Sims

The relationship between the latency of the negative peak occurring at approximately 130 msec in the visual evoked-response (VER) and speechreading scores was investigated. A significant product-moment correlation of -.58 was obtained between the two measures, which confirmed the fundamental effect but was significantly weaker than that previously reported in the literature (-.90). Principal components analysis of the visual evoked-response waveforms revealed a previously undiscovered early VER component, statistically independent of the latency measure, which in combination with two other components predicted speechreading with a multiple correlation coefficient of S4. The potential significance of this new component for the study of individual differences in speechreading ability is discussed.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 449-449
Author(s):  
Victoria Chen ◽  
Alysson Light

Abstract Possible selves are defined as “personalized representations of one’s self in future states” (Cross & Markus, 1991). Research has also found that thinking frequently about possible selves predicts lower well-being, whereas thinking clearly about possible selves is associated with higher well-being (McElwee & Haugh, 2010). However, possible selves differ across the lifespan (Hooker & Kaus, 1994; Cross & Markus, 1991) and life stages can impact exploration of possible identities (Arnett, 2000). Thus we hypothesize that the relationship between thought about possible selves and well-being differs across the lifespan. In a cross-sectional survey, 240 participants (age range: 18-92) reported on frequency and clarity of possible selves, as well as general self-clarity (Campbell et al., 1996). Results indicate curvilinear moderation by age of the link between possible self-clarity and well-being, with the association being stronger among midlife adults than among younger adults and older adults. Also, as clarity of feared possible selves increases, self-concept clarity decreases. Similarly, frequency of thinking about feared possible selves was negatively correlated with self-concept clarity. However, clarity and frequency of thought about hoped-for positive possible selves had no correlation with self-concept clarity.


1997 ◽  
Vol 170 (6) ◽  
pp. 511-514 ◽  
Author(s):  
R. J. Howard ◽  
C. Graham ◽  
P. Sham ◽  
J. Dennehey ◽  
D. J. Castle ◽  
...  

BackgroundThe relationship between those schizophrenia-like conditions that have their onset in late life and early-onset schizophrenia is unclear. Very few family history studies of patients with late-onset psychosis have been reported, and it is not known whether their relatives have an increased risk of psychosis.MethodInformation was collected on the psychiatric morbidity of 269 first-degree relatives of patients with schizophrenia or delusional disorder with an onset after the age of 60 (late paraphrenia), and 272 first-degree relatives of healthy elderly control subjects, using a research diagnostic instrument.ResultsWith a narrow age range (15–50 years) at risk, the estimated lifetime risk of schizophrenia was 1.3% in the relatives of both cases and controls. With a wider age range (15–90 years) at risk, estimated lifetime risk of schizophrenia was 2.3% for the relatives of cases, and 2.2% for the relatives of controls. However, depression was significantly more common among the relatives of cases than controls.ConclusionThose schizophrenia-like psychoses with onset in late life are not genetically associated with schizophrenia.


2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Dr. Seena M. Mathai ◽  
Debolina Chatterjee ◽  
Bhuvaneswari Mohanraj

Parents and siblings play a major role in influencing the self-esteem of an individual. The parents’ relationship with the child, their responses to the child’s academic performance which includes motivation as well as encouragement plays a huge role in building up a positive self-esteem which further helps them to develop a better personality; better career along with that self-esteem also helps one to solve their problems in life. In this research, data from 112 participants were collected through an online survey focusing on the relationship between parenting styles and self-esteem across a specific age range. Parenting styles were assessed using 20 question model(What questions, while self-esteem was evaluated using Rosenberg self-esteem scale. Through this research the effect of native place on one’s self esteem was determined along with the effect of other factors such as relationship with siblings, academic performance on self-esteem was analysed


2019 ◽  
Vol 8 (9) ◽  
pp. 214-225
Author(s):  
Nongmeikapam Premika Devi

The present study examines the relationship of depression and the neuropsychologicalfunction of attention, planning and auditory verbal learning and memory among individualswith HIV/AIDS. 200 subjects who were HIV/AIDS positive (100 males and 100 females) andwere within age range of 20 to 50 years and minimum education level of 8th standard weretaken. The result indicates that Depression slows down the performance of attention; alsodepression most likely decreases the function of auditory verbal learning and memory


2020 ◽  
Vol 1 (2) ◽  
pp. 53-61
Author(s):  
Naveed Sultan ◽  
Zainab Javed

Suicide is described as death caused by self-directed injurious behavior with any intent to die as a result of the behavior. Adolescence is a period of marked risk for suicide. This study was carried out to find out the relationship of parenting style and suicidal ideation of adolescents. A sample of (N= 200) with age range of 13 to 19 years from different schools of Khyber Pakhtun Khwa, Pakistan was selected. Two instruments were used in study:  Parental Authority Questionnaire (PAQ), and Suicidal Risk Scale (SRS). Pearson partial correlation was applied to analyze the data. The findings shows permissive mother parenting style is significantly positively correlated with authoritarian mother parenting, permissive father parenting, authoritarian father parenting, and suicidal ideation. Whereas, authoritarian mother parenting style significantly positively correlated with permissive father parenting, authoritarian father parenting, and suicidal ideation. Meanwhile authoritative/flexible mother parenting style is significantly negatively correlated with permissive father parenting, authoritarian father parenting, and suicidal ideation.


Author(s):  
Biranchi Adhikari ◽  
◽  
Ajay Behera ◽  
Rabindra Mahapatra ◽  
Harish Das ◽  
...  

The effects of cell phone use on motorcycle riders’ behaviour are studied in smart city, Bhubaneswar, capital of state odisha, India. Most of motorcycle riders confess using cell phone devices while driving. Moreover, relationship between near miss and accidents has been found with the use of cell phone, reflecting a risk factor for motorcycle riders.“ This study examines the relationship between such type of behaviours, comprising calling and manipulating the screen, and the frequency of near miss and actual accidents among motorcycle riders. We conducted a web based survey measuring cell phone-specific violations, human errors, near miss and accident to motorcycle riders (N=289; age range; 18-60). We hypothesized that the relationship between cell phone use and near miss would be explained by an increase in the number of human errors committed, thus increasing the likelihood of being involved in near miss. Moreover, we hypothesized that near miss will predict actual accidents. Outcomes of path analysis showed that cell phone-specific violations predicted accidents throughout their consecutive effects on human errors and near miss only in the subsample of men. These findings offer an explanation of how cell phone use contributes to increase the likelihood of getting involved in near miss and actual accidents. The current study builds a path model explaining how cell phone-specific violations lead to more near miss among motorcycle riders.


Sign in / Sign up

Export Citation Format

Share Document