scholarly journals Superficial Granulomatous Pyoderma Gangrenosum of the Penis: A Case Report

2006 ◽  
Vol 6 ◽  
pp. 2426-2429
Author(s):  
Shyamala S. Gopi ◽  
Alan T. Evans ◽  
Asif Raza ◽  
Derek J. Byrne
Keyword(s):  
Case Report ◽  
Pyoderma Gangrenosum ◽  
Correct Diagnosis ◽  
External Genitalia ◽  
Skin Lesions ◽  
Underlying Disease ◽  
Sinus Tract ◽  
Systemic Diseases ◽  
Histological Features ◽  
Penile Ulceration

Classic type of pyoderma gangrenosum (PG) is an uncommon ulceronecrotic cutaneous disease of uncertain aetiology characterised by broad zones of confluent ulceration with violaceous undermined margins. Some 50% of cases are associated with systemic diseases. The superficial granulomatous variant of pyoderma gangrenosum (SGPG) of the external genitalia is extremely rare Patients with this condition develop single or multiple ulcerated skin lesions often with sinus tract formation. The majority of these lesions were found on the trunk and limbs. SGPG is less likely to be associated with underlying disease processes than classic PG. We present a 58 year-old with recalcitrant penile ulceration demonstrated to be SGPG on biopsy. Although rare and poorly recognised, the histological features are sufficiently typical to allow the correct diagnosis to be established.

scholarly journals A case report: 46 XY-disorder of sexual development

2019 ◽  
Vol 8 (3) ◽  
pp. 1200
Author(s):  
Tejal Kansara ◽  
Tushar Shah ◽  
Yesha Umbharatwala
Keyword(s):  
Case Report ◽  
Sexual Development ◽  
Multidisciplinary Approach ◽  
Correct Diagnosis ◽  
External Genitalia ◽  
Peripheral Blood Lymphocytes ◽  
Dysmorphic Features ◽  
Disorder Of Sexual Development ◽  
The Family ◽  
Male Karyotype

Authors report a case of a 6-year-old child with syndromic 46, XY disorder of sexual development. From the birth patient was assigned female. Physical examination showed dysmorphic features and ambiguous external genitalia. Cytogenetic analysis of cultured peripheral blood lymphocytes revealed a male karyotype. The result of the chromosomal investigation showing male genetic sex, together with the ambivalent aspect of the external genitalia and gonads that are exclusively testes led to the diagnosis of 46, XY disorder of sexual development. The clinical management will help the child and the family deal effectively with this condition A multidisciplinary approach to this problem involving pediatricians, specialists in the field of endocrinology, genetics, surgery and psychiatry is necessary in order to reach a prompt and correct diagnosis and treatment.

scholarly journals Multicentric Cutaneous Crohn's Disease: A Case Report and Review of Literature

1990 ◽  
Vol 4 (2) ◽  
pp. 59-63 ◽  
Author(s):  
Robert Prokopetz ◽  
J Barrie Ross ◽  
Peter Smith ◽  
Joseph J Sidorov
Keyword(s):  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Erythema Nodosum ◽  
Skin Lesions ◽  
Review Of Literature ◽  
Histological Features ◽  
The Past ◽  
Common Skin ◽  
Skin Conditions

A patient presented with skin lesions at sites not contiguous with Crohn's disease of the bowel and with specific histological features of Crohn's disease occurring two weeks from the onset of bowel symptoms. Currently a number of nonspecific skin conditions such as erythema nodosum, pyoderma gangrenosum and erythema multiforme are accepted as being the most common skin manifestations of Crohn's disease. It is likely, however, that specific lesions of Crohn's disease in the skin have been underdiagnosed either because of lack of biopsy or misinterpretation of the histology. Twenty-three cases with specific Crohn's disease in the skin have been recorded in the past 25 years, since the condition has been recognized. Sarcoidosis has been a common misdiagnosis. The literature relating to multicentric Crohn's disease is reviewed and attention drawn to its protean and masquerading features. An argument is made for the use of the term 'multicentric' rather than 'metastatic' in relation to cutaneous Crohn's disease.

scholarly journals Grover’s disease in a patient with atopic dermatitis - a case report

2021 ◽  
Vol 74 (1-2) ◽  
pp. 33-37
Author(s):  
Sanja Jakovljevic ◽  
Ljuba Vujanovic ◽  
Dejan Ogorelica ◽  
Aleksandra Fejsa-Levakov ◽  
Jasmina Sekulic
Keyword(s):  
Case Report ◽  
Immunoglobulin E ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Elevated Serum ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Complete Regression ◽  
Laboratory Findings ◽  
Topical Corticosteroids

Introduction. Grover?s disease is characterized by pruriginous polymorphic rash with a variable course and duration. Although the etiology is still unknown, the disease is often associated with other dermatoses, malignant diseases, use of certain medications, as well as immunosuppression. Case Report. We report a case of a 70-year-old male patient who was referred for examination to the Clinic of Dermatovenereology Diseases, Clinical Center of Vojvodina, due to a rash that lasted for nine months. The first lesions on the skin appeared around the nipples as exudative eczematous plaques. A few months later, identical lesions appeared on the lower legs. During treatment with systemic antihistamines and topical corticosteroids, there were episodes of transient improvements and re-exacerbations. In the meantime, erythematous brownish, round and oval papules appeared on the abdomen and the back, accompanied by intense itch. Laboratory findings revealed eosinophilia and elevated serum immunoglobulin E levels. A skin biopsy of the back lesion was performed and the histopathological examination confirmed the diagnosis of Grover?s disease. After the systemic treatment using corticosteroids and antihistamines, with gradual dose reduction and application of topical corticosteroids and emollients, complete regression of the skin lesions was achieved. Conclusion. Since the clinical manifestations of the disease may be nonspecific and discrete, dermatopathological analysis is of crucial importance in making the correct diagnosis. In patients with atopy, the treatment with systemic corticosteroids, antihistamines and topical agents may lead to regression of skin lesions with a significant improvement in the quality of life.

scholarly journals Significance of Correct Diagnosis of Odontogenic Extraoral Sinus: A Report Of Two Cases

2018 ◽  
Vol 1 (11) ◽  
pp. 334-338
Author(s):  
Shweta Bansal ◽  
Ruchi Juneja ◽  
Gyanendra Mishra ◽  
Akshay Nambiar
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Antibiotic Therapy ◽  
Clinical Course ◽  
Correct Diagnosis ◽  
Sinus Tract ◽  
Short Term ◽  
Diagnostic Challenge ◽  
Odontogenic Origin

Cutaneous draining sinus tracts of odontogenic origin often are a diagnostic challenge. A delay in correctly diagnosing these types of lesions can result in unnecessary antibiotic therapy and surgical treatment. This case report presents the clinical course of two cases with extra-oral sinus tract formation, from diagnosis and treatment to short-term follow-up and evaluation. These facial lesions were initially misdiagnosed as lesions of non-odontogenic origin. Later on an odontogenic cause was identified and endodontic intervention resulted in resolution of the problem, confirming the initial misdiagnosis.

scholarly journals Dermatological Aspects of Infections Caused By Endotoxins In Teeth With Necrotic Pulps and Apical Periodontitis

2021 ◽  
Vol 6 (1) ◽  
pp. 01-05
Author(s):  
Daniel Jiménez Zaragoza ◽  
Jorge Paredes Vieyra ◽  
Francisco Javier Jiménez Enríquez
Keyword(s):  
Case Report ◽  
Skin Lesions ◽  
Sinus Tract ◽  
Purulent Discharge ◽  
Radiographic Examination ◽  
Odontogenic Infections ◽  
Facial Region ◽  
Dental Origin ◽  
The Face ◽  
Uncommon Case

Aim: To report an uncommon case of an extraoral sinus tract of the facial region caused by a tooth with an acute apical abscess in the mandible. Case report: Established on oral examination and radiographic examination, an Acute Apical Abscess (cellulitis/phlegmon) of tooth 47 was diagnosed, which had resulted in a cutaneous sinus tract. The continuous purulent discharge of the sinus tract in the facial right region ceased after drainage and extraction of tooth 47. Conclusion: It is challenging to diagnose and identify a cutaneous draining sinus tract of dental origin. Thus, treatment of skin lesions of the face (impetigo), and neck odontogenic infections should always be considered. Clinical and radiographic dental examinations can identify the tooth involved.

scholarly journals Malignant melanoma of the bladder: A case report

2014 ◽  
Vol 8 (1-2) ◽  
pp. 54 ◽  
Author(s):  
Hamide Sayar ◽  
Seyda Erdogan ◽  
Fulya Adamhasan ◽  
Esma Gurbuz ◽  
Mehmet Fatih İnci
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Immunohistochemical Staining ◽  
Correct Diagnosis ◽  
Primary Lesion ◽  
Histological Features ◽  
Malignant Melanomas ◽  
Metastatic Lesions ◽  
S 100 ◽  
Hmb 45

Primary malignant melanoma of the bladder is very rare. Rather than being a primary lesion, malignant melanomas of the bladder are more commonly metastatic lesions. The histopathological appearance largely does not differ from that of melanoma at other body sites. It is often difficult to discriminate whether a bladder melanoma is primary or metastatic. Therefore, a careful review of histological features and performing necessary immunohistochemical staining procedures for S-100 protein and HMB-45 are very important in achieving a correct diagnosis. We report a case of hypomelanotic malignant melanoma of the bladder. Despite the variety of therapies available for primary melanomas of the bladder, the prognosis is still poor.

Skin and systemic diseases

2010 ◽  
pp. 4715-4723
Author(s):  
Clive B. Archer
Keyword(s):  
Internal Medicine ◽  
Diabetes Mellitus ◽  
Lupus Erythematosus ◽  
Older Patients ◽  
Systemic Disease ◽  
Skin Lesions ◽  
Underlying Disease ◽  
Systemic Diseases ◽  
Systemic Lupus ◽  
General Internal

Dermatology is most interesting where it overlaps with general internal medicine. Skin lesions may be part of a systemic disease (e.g. in sarcoidosis or systemic lupus erythematosus), or they may be a manifestation of an underlying disease or process as in the case of acanthosis nigricans, which can be associated with either an underlying adenocarcinoma in older patients, or with insulin resistance and sometimes overt diabetes mellitus in younger obese patients....

scholarly journals Diagnostic and Therapeutic Approach to HIVKaposi’s Sarcoma Patients-Case Report

2019 ◽  
Vol 23 (3) ◽  
pp. 167-171
Author(s):  
Chari Charis ◽  
Dalampiras Antonios ◽  
Margianou Ioanna ◽  
Zarampouka Katerina ◽  
Michalopoulos Antonios
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Kaposi's Sarcoma ◽  
Rna Virus ◽  
Correct Diagnosis ◽  
Kaposi’S Sarcoma ◽  
Immune Deficiency Syndrome ◽  
Vascular Tumor ◽  
Skin Lesions ◽  
University Hospital

Summary Background/Aim: The Acquired Immune Deficiency Syndrome (AIDS) is an immunologic entity, which is due to an RNA virus. AIDS is relatively easy transmitted and has a poor prognosis. The main mechanism of this Syndrome is characterized by the destruction and diminishing of T4 lymphocytes or helper/suppressor T-cells. Kaposi’s sarcoma is a neoplasm due to human herpes HHV-8. Kaposi’s sarcoma is one of the entities that determines the disease of AIDS. Kaposi’s sarcoma appears as skin lesions and attacks the oral cavity and lymph nodes. Case report: A male patient, with HIV-syndrome, was referred to the Special Infection Clinic of the University Hospital with a chief complaint of having two lesions, in the oral cavity and in the right ear. The histological report revealed the diagnosis of vascular tumor having morphological and immuno-histochemical characteristics compatible with Kaposi’s sarcoma. Conclusions: The doctor must be suspicious when lesions are observed, particularly in the oral cavity. A biopsy must be taken in order to obtain the correct diagnosis and examine the possibility of the presence of Kaposi’s sarcoma or AIDS.

Similar but different: distinguishing between pemphigus vegetans and pyostomatitis-pyodermatitis vegetans

2021 ◽  
Vol 14 (4) ◽  
pp. e242162
Author(s):  
Brendan Stagg ◽  
Anna Simpson ◽  
Shireen Sidhu
Keyword(s):  
Inflammatory Bowel Disease ◽  
Case Report ◽  
Correct Diagnosis ◽  
Direct Immunofluorescence ◽  
Topical Steroids ◽  
Histological Features ◽  
History Of ◽  
Inflammatory Bowel ◽  
Skin Biopsies ◽  
Pemphigus Vegetans

A 51-year-old woman presented with a 4-month history of painful ulcers in the mouth and vulva, and painful vegetative plaques at intertriginous sites. Skin biopsies showed squamous hyperplasia and intraepidermal eosinophilic pustulation. Skin direct immunofluorescence (DIF) revealed intercellular deposition of IgG and C3 in the lower part of the epidermis, while serum indirect immunofluorescence (IIF) confirmed the presence of antiepithelial antibodies. The patient was diagnosed with pemphigus vegetans, and successfully treated with dapsone, prednisolone and topical steroids. Although pemphigus vegetans and pyostomatitis-pyodermatitis vegetans can show identical clinical and histological features, the presence or absence of comorbid inflammatory bowel disease, and the results of both skin DIF and serum IIF can be used to distinguish between these two conditions. This case report explores the challenges in making this distinction, and the implications of establishing the correct diagnosis.

scholarly journals Odontogenic keratocyst: An incidental finding during an orthodontic examination

2020 ◽  
Vol 47 (3) ◽  
pp. 245-250
Author(s):  
Othman Hameed ◽  
Jamie Gwilliam ◽  
Eric Whaites
Keyword(s):  
Case Report ◽  
Clinical Examination ◽  
Incidental Finding ◽  
Treatment Plan ◽  
Correct Diagnosis ◽  
Young Male ◽  
Underlying Disease ◽  
Odontogenic Keratocyst ◽  
Radiographic Examination ◽  
Orthodontic Patients

For all orthodontic patients, a detailed clinical examination is essential to obtain the correct diagnosis before the formulation of an orthodontic treatment plan. Additional information may be required from radiographs in order to supplement this clinical examination. While orthodontists principally prescribe dental panoramic tomographs for orthodontic patients to confirm the presence, position and morphology of unerupted teeth, the absence or presence of disease within the supporting structures may be overlooked. This case report presents one such instance where the pre-orthodontic radiographic examination of a young male patient revealed the presence of an asymptomatic odontogenic keratocyst in the right posterior body of the mandible. This case report discusses how this incidental finding was diagnosed, managed and how its surgical treatment subsequently affected the orthodontic management of the patient. Furthermore, this case highlights the importance of undertaking a thorough and systematic approach when analysing any prescribed radiographs, in order to reduce the risk of overlooking any evidence of underlying disease.

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