scholarly journals Influence of Artificial Sweetener on Human Blood Glucose Concentration

2007 ◽  
Vol 7 ◽  
pp. 1618-1621 ◽  
Author(s):  
Ilse Skokan ◽  
P. Christian Endler ◽  
Beatrix Wulkersdorfer ◽  
Dieter Magometschnigg ◽  
Heinz Spranger
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Time Frame ◽  
Test Solution ◽  
Artificial Sweeteners ◽  
Control Group ◽  
Artificial Sweetener ◽  
Blood Sugar Concentration

Artificial sweeteners, such as saccharin or cyclamic acid are synthetically manufactured sweetenings. Known for their low energetic value they serve especially diabetic and adipose patients as sugar substitutes. It has been hypothesized that the substitution of sugar with artificial sweeteners may induce a decrease of the blood glucose. The aim of this study was to determine the reliability of this hypothesis by comparing the influence of regular table sugar and artificial sweeteners on the blood glucose concentration. In this pilot-study 16 patients were included suffering from adiposity, pre-diabetes and hypertension. In the sense of a cross-over design, three test trials were performed at intervals of several weeks. Each trial was followed by a test free interval. Within one test trial each patient consumed 150 ml test solution (water) that contained either 6 g of table sugar (“Kandisin”) with sweetener free serving as control group. Tests were performed within 1 hr after lunch to ensure conditions comparable to patients having a desert. Every participant had to determine their blood glucose concentration immediately before and 5, 15, 30 and 60 minutes after the intake of the test solution. For statistics an analysis of variance was performed. The data showed no significant changes in the blood glucose concentration. Neither the application of sugar (F4;60= 1.645; p = .175) nor the consumption of an artificial sweetener (F2.068;31.023= 1.551; p > .05) caused significant fluctuations in the blood sugar levels. Over a time frame of 60 minutes in the control group a significant decrease of the blood sugar concentration was found (F2.457;36.849= 4.005; p = .020) as a physiological reaction during lunch digestion.

Effects of GYDENPHY caspules on streptozotocin-induced type 1 diabetic in Swiss mouse model

2021 ◽  
Vol 25 (2) ◽  
pp. 24-32
Author(s):  
Trinh Thach Thi Nguyen ◽  
Duy Tuan Nguyen ◽  
Thanh Ha Tuan Nguyen ◽  
Thi Huong Lan Do ◽  
Hoang Ngan Nguyen
Keyword(s):  
Blood Glucose ◽  
Mouse Model ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Insulin Injection ◽  
Swiss Mouse ◽  
Hypoglycemic Effect ◽  
Control Group ◽  
Water Control

Objective: Evaluation the hypoglycemic effect of Gydenphy capsules on Streptozotocin-induced type 1 diabetic in Swiss mouse model. Methods: The type 1 diabetic model was established by intraperitoneal injections of Streptozocin 150mg/kg in Swiss mouse. Then, the Gydenphy were orally administered daily at a dose of 576 mg/kg/day or 1152 mg/kg/day in 10 days. Blood glucose concentration in the Gydenphy oral groups with that of water control group and the intraperitoneal insulin injection group was compared. Results: Blood glucose concentration in the groups using Gydenphy (dose576 mg/kg/24h and dose 1152 mg/kg/24h) significal decreased compared to the distilled water group at (p <0.05 at the time of 4 hours, 8 hours; p <0.01 at the time of 3, 10 days). The hypoglycemic effect of Gydenphy at 576mg/kg/day and 1152 mg/kg/day at 4 hours, 8 hours and 3 days were inferior to insulin 0.1 UI/kg/day for glycemic control. However, the hypoglycemic effect ofGydenphy were equivalent to insulin after 10 consecutive days on treatment. Conclusion: Gydenphy capsules have hypoglycemic effects onStreptozotocin-induced type 1 diabetes in Swiss mouse model.

Ononis natrix L. Lowers the Blood Glucose Concentration in Wistar Rats with Streptozotocin-induced Diabetes Mellitus

2020 ◽  
Vol 20 ◽  
Author(s):  
Baker F. Mubideen ◽  
Ala-Aldeen Ahmad Al-Serhan ◽  
Justin Z. Amarin ◽  
Arwa Al-Dweikat ◽  
Ra'ad Z. Al-Muhaisen ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Wistar Rats ◽  
Blood Glucose Concentration ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
High Dose ◽  
Dose Treatment ◽  
Streptozotocin Induced Diabetes

Background: Practitioners of traditional medicine use the decoction of Ononis natrix L. to treat hyperglycemia. The literature offers no evidence to support the use. Objective: To investigate the effect of the decoction of Ononis natrix L. on the blood glucose concentration in Wistar rats (Rattus norvegicus) with streptozotocin-induced diabetes mellitus. Methods: We obtained 35 Wistar rats from the animal colony of The University of Jordan School of Medicine. We induced diabetes by a single intraperitoneal injection of streptozotocin (60 mg/kg body weight) and 23 rats (66%) survived to allocation. We randomly assigned the rats to one of four groups: negative control (1% Tween 80 in distilled water), positive control (100 mg/kg metformin), high-dose treatment (7.5 mL of the decoction), and low-dose treatment (3.5 mL of the decoc-tion). We administered the doses twice daily by oral gavage for two weeks and measured the tail-blood glucose concentration twice daily, once before the first dose and another time after the second dose. We used linear mixed-effects regression to model the change in blood glucose concentration as a function of the experimentation groups, with adjustments for pseu-doreplication and temporal variation. Results: The estimated mean change was 1 mmol/L (−30 to 31 mmol/L) for the negative control group, −26 mmol/L (−56 to 5 mmol/L) for the positive control group, −75 mmol/L (−108 to −42) for the low-dose treatment group, and −82 mmol/L (−111 to −53 mmol/L) for the high-dose treatment group. Conclusion: In conclusion, we demonstrate, for the first time, the hypoglycemic effect of Ononis natrix L. in an animal model of diabetes.

scholarly journals Effect of Artificial Sweeteners on the Blood Glucose Concentration

2018 ◽  
Vol 1 (2) ◽  
pp. 81-85
Author(s):  
Seema Saraswathy ◽  
Bishamber D Toora ◽  
Manju M ◽  
Sasmita Mishra
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Artificial Sweeteners

scholarly journals Carbohydrate utilization in the pre-ruminant calf

1969 ◽  
Vol 23 (2) ◽  
pp. 333-341 ◽  
Author(s):  
R. C. Siddons ◽  
R. H. Smith ◽  
M. J. Henschel ◽  
W. B. Hill ◽  
J. W. G. Porter
Keyword(s):  
Blood Glucose ◽  
Linear Relationship ◽  
Blood Sugar ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Reducing Sugar ◽  
Carbohydrate Utilization ◽  
Proximal Duodenum ◽  
Preferential Uptake ◽  
Sugar Levels

1. Changes in blood sugar levels after giving carbohydrates have been used to assess carbohydrate utilization in pre-ruminant calves aged between 10 and 50 days.2. Glucose, galactose and lactose were readily utilized by all calves; the utilization of glucose and galactose increased with age, whereas that of lactose remained constant.3. Maltose and fructose utilization was low in young calves and increased slightly with age.4. Sucrose and starch were not utilized.5. Studies with three older pre-ruminant calves (aged 53, 88 and 106 days) in which the carbohydrates were infused into the proximal duodenum showed that glucose, galactose, lactose and xylose all caused marked increases in the level of blood reducing sugar, whereas fructose and sucrose caused no increase, and maltose was intermediate. Xylose and galactose caused very little change in the blood glucose concentration.6. It appeared that preferential uptake occurred of glucose from a glucose-galactose mixture.7. A non-linear relationship was found between the concentration of glucose or galactose infused and the increase in the level of blood reducing sugar.

scholarly journals Effects of Silymarin on Blood Glucose Concentration, Hepatic Histopathological Changes and FOXA2 and FOXA3 Gene Expression in Streptozotocin-Induced Diabetic Male Wistar Rats

2021 ◽  
Vol 5 (2) ◽  
pp. 17
Author(s):  
Sajad Nikkhah ◽  
Rahman Jafari Hafshejan ◽  
Farshid Gheibi Hajivar ◽  
Khalil Khashei ◽  
Sara Afzali
Keyword(s):  
Gene Expression ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Histopathological Changes ◽  
Diabetic Control Group ◽  
Male Wistar Rats

Since the liver is among the primary organs susceptible to the effects of hyperglycaemia, diabetes mellitus (DM) could be a risk factor for the development and progression of liver damage. In present study, since no side-effects from the herbal medicine have been reported, the effect of silymarin on blood glucose concentration, hepatic histopathological changes and FOXA2 and FOXA3 gene expression, which are key genes in liver regeneration, was investigated. In this fundamental with experimental approach study, 40 male Wistar rats weighing 180-220 g were used. Rats were kept under the standard conditions of temperature of 20-22°C and humidity of 50% and consecutive 12-hour periods of light and darkness. Rats were randomly divided into five different groups (n=8 each), including healthy control rats, diabetic control rats, diabetic rats receiving silymarin (50, 100 and 150 mg/kg). Diabetes was induced by injecting streptozotocin (50 mg/kg B.W., i.p.). For 4 weeks silymarin groups received the drug once every three days through gavage and fasting blood glucose concentration measured once every 10 days. At the end of a month experiment, livers were harvested for hepatic histopathological and FOXA2 and FOXA3 gene expression changes analysis. In the diabetic rats treated with silymarin (50, 100 and 150 mg/kg), by comparison with the diabetic control group (p<0.05), glucose levels decreased significantly. Moreover, FOXA2 and FOXA3 expression in diabetic groups treated with silymarin significantly increased compared to diabetic control group (p<0.05). Hepatic histopathological changes were improved in the treated groups.The present study indicates that silymarin significantly decreased blood glucose concentration and increased the FOXA2 and FOXA3 gene products level. Hence, silymarin is able to improve some of the symptoms associated with diabetes and possesses hepatoprotective effects in streptozotocin-induced diabetic rats.

Effects of mixture powder of black rice (Oryza sativa L indica), red beans (Phaseolus vulgaris L), and moringa leaves (Moringa oleifera L) on blood glucose concentration in hyperglycemic Rats

2021 ◽  
Vol 9 (2) ◽  
pp. 136-143
Author(s):  
Lalu Juntra Utama ◽  
Suryana Suryana ◽  
Anita Christina Sembiring
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Oryza Sativa L ◽  
Fasting Blood Glucose ◽  
Female Rats ◽  
Control Group ◽  
Standard Diet ◽  
Black Rice ◽  
Control Group Design

Background: Diabetes mellitus, increased blood glucose or hyperglycemia, is associated with increased oxidative stress and cardiovascular diseases. This condition will further cause carbohydrate and fat metabolism change, resulting in the decreased antioxidant defense system. Black rice, red beans, and moringa leaves contain oleic acid, butyric amino acid, antioxidants, phytic acid, and arginine, which can improve insulin sensitivity, and blood glucose homeostasis.Objective: This study aimed to analyze the effect of betamelor (black rice, red beans, and moringa leaves) on blood glucose in ratsMaterials and Methods: The design of this research was experimental research with pre-and post-control group design. A total of 20 Sprague Dawley female rats were divided into four groups, namely standard feed (PS), 80% feed of betamelor (PB8), 50% feed of betamelor (PB5), and 20% feed of betamelor (PB2). Betamelor intervention was given as much as 5% of weight for 28 days. Fasting Blood Glucose (FBG) levels were measured using the GOD-PAP method. Blood glucose data were analyzed by Analysis of Variance (ANOVA) at a 95% confidence level and using Duncan's test.Results: There were differences in FBG between groups after the intervention of betamelor. The results showed that after 28 days of intervention, betamelor decreased the serum glucose concentration from 122.69 mg / dL to 97.70 mg / dL (20.37%) in the PB8 group and from 123.91 mg / dL to 113.28 mg / dL (8.58%) in the PB5 group, but the standard diet (PS) increased by 5.73%. This result can be applied to reduce blood glucose levels in obese and patients with metabolic syndrome.Conclusions: There was a significant effect of giving a mixture of black rice, red beans, and Moringa leaves on fasting blood sugar in rats.

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