scholarly journals Deep Learning-based Pipeline to Recognize Alzheimer′s Disease using fMRI Data

2016 ◽  
Author(s):  
Saman Sarraf ◽  
Ghassem Tofighi

Over the past decade, machine learning techniques and in particular predictive modeling and pattern recognition in biomedical sciences, from drug delivery systems to medical imaging, have become one of the most important methods of assisting researchers in gaining a deeper understanding of issues in their entirety and solving complex medical problems. Deep learning is a powerful machine learning algorithm in classification that extracts low- to high-level features. In this paper, we employ a convolutional neural network to distinguish an Alzheimer′s brain from a normal, healthy brain. The importance of classifying this type of medical data lies in its potential to develop a predictive model or system in order to recognize the symptoms of Alzheimer′s disease when compared with normal subjects and to estimate the stages of the disease. Classification of clinical data for medical conditions such as Alzheimer′s disease has always been challenging, and the most problematic aspect has always been selecting the strongest discriminative features. Using the Convolutional Neural Network (CNN) and the famous architecture LeNet-5, we successfully classified functional MRI data of Alzheimer′s subjects from normal controls, where the accuracy of testing data reached 96.85%. This experiment suggests that the shift and scale invariant features extracted by CNN followed by deep learning classification represents the most powerful method of distinguishing clinical data from healthy data in fMRI. This approach also allows for expansion of the methodology to predict more complicated systems.

Author(s):  
Dr. Abhay E Wagh

Abstract: Now a day, with the rapid advancement in the digital contents identification, auto classification of the images is most challenging job in the computer field. Programmed comprehension and breaking down of pictures by framework is troublesome when contrasted with human visions. A Several research have been done to defeat issue in existing classification system,, yet the yield was limited distinctly to low even out picture natives. Nonetheless, those approach need with exact order of pictures. This system uses deep learning algorithm concept to achieve the desired results in this area like computer. Our framework presents Convolutional Neural Network (CNN), a machine learning algorithm is used for automatic classification the images. This system uses the Digit of MNIST data set as a bench mark for classification of gray-scale images. The gray-scale images are used for training which requires more computational power for classification of those images. Using CNN network the result is near about 98% accuracy. Our model accomplishes the high precision in grouping of images. Keywords: Convolutional Neural Network (CNN), deep learning, MINIST, Machine Learning.


Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 652 ◽  
Author(s):  
Carlo Augusto Mallio ◽  
Andrea Napolitano ◽  
Gennaro Castiello ◽  
Francesco Maria Giordano ◽  
Pasquale D'Alessio ◽  
...  

Background: Coronavirus disease 2019 (COVID-19) pneumonia and immune checkpoint inhibitor (ICI) therapy-related pneumonitis share common features. The aim of this study was to determine on chest computed tomography (CT) images whether a deep convolutional neural network algorithm is able to solve the challenge of differential diagnosis between COVID-19 pneumonia and ICI therapy-related pneumonitis. Methods: We enrolled three groups: a pneumonia-free group (n = 30), a COVID-19 group (n = 34), and a group of patients with ICI therapy-related pneumonitis (n = 21). Computed tomography images were analyzed with an artificial intelligence (AI) algorithm based on a deep convolutional neural network structure. Statistical analysis included the Mann–Whitney U test (significance threshold at p < 0.05) and the receiver operating characteristic curve (ROC curve). Results: The algorithm showed low specificity in distinguishing COVID-19 from ICI therapy-related pneumonitis (sensitivity 97.1%, specificity 14.3%, area under the curve (AUC) = 0.62). ICI therapy-related pneumonitis was identified by the AI when compared to pneumonia-free controls (sensitivity = 85.7%, specificity 100%, AUC = 0.97). Conclusions: The deep learning algorithm is not able to distinguish between COVID-19 pneumonia and ICI therapy-related pneumonitis. Awareness must be increased among clinicians about imaging similarities between COVID-19 and ICI therapy-related pneumonitis. ICI therapy-related pneumonitis can be applied as a challenge population for cross-validation to test the robustness of AI models used to analyze interstitial pneumonias of variable etiology.


Vibration ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 341-356
Author(s):  
Jessada Sresakoolchai ◽  
Sakdirat Kaewunruen

Various techniques have been developed to detect railway defects. One of the popular techniques is machine learning. This unprecedented study applies deep learning, which is a branch of machine learning techniques, to detect and evaluate the severity of rail combined defects. The combined defects in the study are settlement and dipped joint. Features used to detect and evaluate the severity of combined defects are axle box accelerations simulated using a verified rolling stock dynamic behavior simulation called D-Track. A total of 1650 simulations are run to generate numerical data. Deep learning techniques used in the study are deep neural network (DNN), convolutional neural network (CNN), and recurrent neural network (RNN). Simulated data are used in two ways: simplified data and raw data. Simplified data are used to develop the DNN model, while raw data are used to develop the CNN and RNN model. For simplified data, features are extracted from raw data, which are the weight of rolling stock, the speed of rolling stock, and three peak and bottom accelerations from two wheels of rolling stock. In total, there are 14 features used as simplified data for developing the DNN model. For raw data, time-domain accelerations are used directly to develop the CNN and RNN models without processing and data extraction. Hyperparameter tuning is performed to ensure that the performance of each model is optimized. Grid search is used for performing hyperparameter tuning. To detect the combined defects, the study proposes two approaches. The first approach uses one model to detect settlement and dipped joint, and the second approach uses two models to detect settlement and dipped joint separately. The results show that the CNN models of both approaches provide the same accuracy of 99%, so one model is good enough to detect settlement and dipped joint. To evaluate the severity of the combined defects, the study applies classification and regression concepts. Classification is used to evaluate the severity by categorizing defects into light, medium, and severe classes, and regression is used to estimate the size of defects. From the study, the CNN model is suitable for evaluating dipped joint severity with an accuracy of 84% and mean absolute error (MAE) of 1.25 mm, and the RNN model is suitable for evaluating settlement severity with an accuracy of 99% and mean absolute error (MAE) of 1.58 mm.


2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Peter M. Maloca ◽  
Philipp L. Müller ◽  
Aaron Y. Lee ◽  
Adnan Tufail ◽  
Konstantinos Balaskas ◽  
...  

AbstractMachine learning has greatly facilitated the analysis of medical data, while the internal operations usually remain intransparent. To better comprehend these opaque procedures, a convolutional neural network for optical coherence tomography image segmentation was enhanced with a Traceable Relevance Explainability (T-REX) technique. The proposed application was based on three components: ground truth generation by multiple graders, calculation of Hamming distances among graders and the machine learning algorithm, as well as a smart data visualization (‘neural recording’). An overall average variability of 1.75% between the human graders and the algorithm was found, slightly minor to 2.02% among human graders. The ambiguity in ground truth had noteworthy impact on machine learning results, which could be visualized. The convolutional neural network balanced between graders and allowed for modifiable predictions dependent on the compartment. Using the proposed T-REX setup, machine learning processes could be rendered more transparent and understandable, possibly leading to optimized applications.


Sensors ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 210 ◽  
Author(s):  
Zied Tayeb ◽  
Juri Fedjaev ◽  
Nejla Ghaboosi ◽  
Christoph Richter ◽  
Lukas Everding ◽  
...  

Non-invasive, electroencephalography (EEG)-based brain-computer interfaces (BCIs) on motor imagery movements translate the subject’s motor intention into control signals through classifying the EEG patterns caused by different imagination tasks, e.g., hand movements. This type of BCI has been widely studied and used as an alternative mode of communication and environmental control for disabled patients, such as those suffering from a brainstem stroke or a spinal cord injury (SCI). Notwithstanding the success of traditional machine learning methods in classifying EEG signals, these methods still rely on hand-crafted features. The extraction of such features is a difficult task due to the high non-stationarity of EEG signals, which is a major cause by the stagnating progress in classification performance. Remarkable advances in deep learning methods allow end-to-end learning without any feature engineering, which could benefit BCI motor imagery applications. We developed three deep learning models: (1) A long short-term memory (LSTM); (2) a spectrogram-based convolutional neural network model (CNN); and (3) a recurrent convolutional neural network (RCNN), for decoding motor imagery movements directly from raw EEG signals without (any manual) feature engineering. Results were evaluated on our own publicly available, EEG data collected from 20 subjects and on an existing dataset known as 2b EEG dataset from “BCI Competition IV”. Overall, better classification performance was achieved with deep learning models compared to state-of-the art machine learning techniques, which could chart a route ahead for developing new robust techniques for EEG signal decoding. We underpin this point by demonstrating the successful real-time control of a robotic arm using our CNN based BCI.


2021 ◽  
Author(s):  
Aria Abubakar ◽  
Mandar Kulkarni ◽  
Anisha Kaul

Abstract In the process of deriving the reservoir petrophysical properties of a basin, identifying the pay capability of wells by interpreting various geological formations is key. Currently, this process is facilitated and preceded by well log correlation, which involves petrophysicists and geologists examining multiple raw log measurements for the well in question, indicating geological markers of formation changes and correlating them with those of neighboring wells. As it may seem, this activity of picking markers of a well is performed manually and the process of ‘examining’ may be highly subjective, thus, prone to inconsistencies. In our work, we propose to automate the well correlation workflow by using a Soft- Attention Convolutional Neural Network to predict well markers. The machine learning algorithm is supervised by examples of manual marker picks and their corresponding occurrence in logs such as gamma-ray, resistivity and density. Our experiments have shown that, specifically, the attention mechanism allows the Convolutional Neural Network to look at relevant features or patterns in the log measurements that suggest a change in formation, making the machine learning model highly precise.


2021 ◽  
Vol 9 ◽  
Author(s):  
Ashwini K ◽  
P. M. Durai Raj Vincent ◽  
Kathiravan Srinivasan ◽  
Chuan-Yu Chang

Neonatal infants communicate with us through cries. The infant cry signals have distinct patterns depending on the purpose of the cries. Preprocessing, feature extraction, and feature selection need expert attention and take much effort in audio signals in recent days. In deep learning techniques, it automatically extracts and selects the most important features. For this, it requires an enormous amount of data for effective classification. This work mainly discriminates the neonatal cries into pain, hunger, and sleepiness. The neonatal cry auditory signals are transformed into a spectrogram image by utilizing the short-time Fourier transform (STFT) technique. The deep convolutional neural network (DCNN) technique takes the spectrogram images for input. The features are obtained from the convolutional neural network and are passed to the support vector machine (SVM) classifier. Machine learning technique classifies neonatal cries. This work combines the advantages of machine learning and deep learning techniques to get the best results even with a moderate number of data samples. The experimental result shows that CNN-based feature extraction and SVM classifier provides promising results. While comparing the SVM-based kernel techniques, namely radial basis function (RBF), linear and polynomial, it is found that SVM-RBF provides the highest accuracy of kernel-based infant cry classification system provides 88.89% accuracy.


2021 ◽  
Author(s):  
Wael Alnahari

Abstract In this paper, I proposed an iris recognition system by using deep learning via neural networks (CNN). Although CNN is used for machine learning, the recognition is achieved by building a non-trained CNN network with multiple layers. The main objective of the code the test pictures’ category (aka person name) with a high accuracy rate after having extracted enough features from training pictures of the same category which are obtained from a that I added to the code. I used IITD iris which included 10 iris pictures for 223 people.


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