scholarly journals Cold exposure distinctively modulates parathyroid and thyroid hormones in cold-acclimatized and non-acclimatized humans

2020 ◽  
Author(s):  
Zuzana Kovaničová ◽  
Tímea Kurdiová ◽  
Miroslav Baláž ◽  
Patrik Štefanička ◽  
Lukáš Varga ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Thyroid Hormones ◽  
Cold Exposure ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
Whole Body ◽  
Cross Sectional ◽  
Brown Adipose ◽  
Ice Water

AbstractContextCold-induced activation of thermogenesis modulates energy metabolism, but the role of humoral mediators is not completely understood.ObjectiveTo investigate the role of parathyroid and thyroid hormones in acute and adaptive response to cold in humans.DesignCross-sectional study examining acute response to ice-water swimming and to experimental non-shivering thermogenesis (NST) induction in individuals acclimatized and non-acclimatized to cold. Seasonal variation in energy metabolism of ice-water swimmers and associations between circulating PTH and molecular components of thermogenic program in brown adipose tissue (BAT) of neck-surgery patients were evaluated.SettingClinical Research Center.Patients, ParticipantsIce-water swimmers (winter swim n=15, NST-induction n=6), non-acclimatized volunteers (NST-induction, n=11, elective neck surgery n = 36).Main Outcomes and ResultsIn ice-water swimmers, PTH and TSH increased in response to 15min winter swim, while activation of NST failed to regulate PTH and lowered TSH. In non-acclimatized men, NST-induction decreased PTH and TSH. Positive correlation between systemic levels of PTH and whole-body metabolic preference for lipids as well as BAT 18F-FDG uptake was found across the two populations. Moreover, NST-cooling protocol-induced changes in metabolic preference for lipids correlated positively with changes in PTH. Finally, variability in circulating PTH correlated positively with UCP1/UCP1, PPARGC1A and DIO2 in BAT from neck surgery patients.ConclusionsRegulation of PTH and thyroid hormones during cold exposure in humans depends on the cold acclimatization level and/or cold stimulus intensity. Role of PTH in NST is substantiated by its positive relationships with whole-body metabolic preference for lipids, BAT volume and UCP1 content.

scholarly journals Cold Exposure Distinctively Modulates Parathyroid and Thyroid Hormones in Cold-Acclimatized and Non-Acclimatized Humans

Endocrinology ◽  
2020 ◽  
Vol 161 (7) ◽  
Author(s):  
Zuzana Kovaničová ◽  
Tímea Kurdiová ◽  
Miroslav Baláž ◽  
Patrik Štefanička ◽  
Lukáš Varga ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Cold Exposure ◽  
Neck Surgery ◽  
Whole Body ◽  
Free T4 ◽  
Free T3 ◽  
Brown Adipose ◽  
Induced Changes ◽  
Ice Water

Abstract Cold-induced activation of thermogenesis modulates energy metabolism, but the role of humoral mediators is not completely understood. We aimed to investigate the role of parathyroid and thyroid hormones in acute and adaptive response to cold in humans. Examinations were performed before/after 15 minutes of ice-water swimming (n = 15) or 120 to 150 minutes of cold-induced nonshivering thermogenesis (NST) applied to cold-acclimatized (n = 6) or non-acclimatized (n = 11) individuals. Deep-neck brown adipose tissue (BAT) was collected from non-acclimatized patients undergoing elective neck surgery (n = 36). Seasonal variations in metabolic/hormonal parameters of ice-water swimmers were evaluated. We found that in ice-water swimmers, PTH and TSH increased and free T3, T4 decreased after a 15-minute winter swim, whereas NST-inducing cold exposure failed to regulate PTH and free T4 and lowered TSH and free T3. Ice-water swimming-induced increase in PTH correlated negatively with systemic calcium and positively with phosphorus. In non-acclimatized men, NST-inducing cold decreased PTH and TSH. Positive correlation between systemic levels of PTH and whole-body metabolic preference for lipids as well as BAT volume was found across the 2 populations. Moreover, NST-cooling protocol-induced changes in metabolic preference for lipids correlated positively with changes in PTH. Finally, variability in circulating PTH correlated positively with UCP1/UCP1, PPARGC1A, and DIO2 in BAT from neck surgery patients. Our data suggest that regulation of PTH and thyroid hormones during cold exposure in humans varies by cold acclimatization level and/or cold stimulus intensity. Possible role of PTH in NST is indicated by its positive relationships with whole-body metabolic preference for lipids, BAT volume, and UCP1 content.

scholarly journals Cold tolerance, cold-induced hyperphagia, and nonshivering thermogenesis are normal in α1-AMPK−/− mice

2011 ◽  
Vol 301 (2) ◽  
pp. R473-R483 ◽  
Author(s):  
Jake D. Bauwens ◽  
Eric G. Schmuck ◽  
Christopher R. Lindholm ◽  
Rebecca L. Ertel ◽  
Jacob D. Mulligan ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cold Exposure ◽  
Whole Body ◽  
Nonshivering Thermogenesis ◽  
Wild Type ◽  
Brown Adipose ◽  
Ampk Activity ◽  
Amp Activated Protein Kinase ◽  
Established Role

Recent studies indicate that a substantial amount of metabolically active brown adipose tissue (BAT) exists in adult humans. Given the unique ability of BAT to convert calories to heat, there is intense interest in understanding the regulation of BAT metabolism in hopes that its manipulation might be an effective way of expending excess calories. Because of the established role of AMP-activated protein kinase (AMPK) as a “metabolic master switch” and its extremely high levels of activity in BAT, it was hypothesized that AMPK might play a central role in regulating BAT metabolism. To test this hypothesis, whole body α1-AMPK−/− (knockout) and wild-type mice were studied 1) under control (room temperature) conditions, 2) during chronic cold exposure (14 days at 4°C), and 3) during acute nonshivering thermogenesis (injection of a β3-adrenergic agonist). Under control conditions, loss of α1-AMPK resulted in downregulation of two important prothermogenic genes in BAT, thyrotropin-releasing hormone (−9.2-fold) and ciliary neurotrophic factor (−8.7-fold). Additionally, it caused significant upregulation of α2-AMPK activity in BAT, white adipose tissue, and liver, but not cardiac or skeletal muscle. During acute nonshivering thermogenesis and chronic cold exposure, body temperature was indistinguishable in the α1-AMPK−/− and wild-type mice. Similarly, the degree of cold-induced hyperphagia was identical in the two groups. We conclude that α1-AMPK does not play an obligatory role in these processes and that adaptations to chronic loss of α1-AMPK are able to compensate for its loss via several mechanisms.

scholarly journals Causative Factors of Ludwig’s Angina

2017 ◽  
Vol 26 (1) ◽  
pp. 3-7
Author(s):  
Dipali Biswas ◽  
Mashuque Mahamud ◽  
Sharfuddin Mahmud ◽  
Md Shaikhul Islam ◽  
DGM Akaiduzzaman ◽  
...  
Keyword(s):  
Systemic Disease ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
Odontogenic Infection ◽  
Cross Sectional ◽  
Medical College ◽  
Causative Factors ◽  
Poor Nutritional Status ◽  
Improve Patient

Introduction: Ludwig’s angina is a rapidly progressive, potentially fulminant cellulitis involving the sub-lingual, submental and sub-mandibular spaces. It typically originates from an infected or recently extracted tooth, most commonly the lower second and third molars. Besides, poor nutritional status, lack of proper medical supports are still major predisposing factors in developing Ludwig’s angina in countries like Bangladesh.Aim: Our study aimed to observe the role of odontogenic infection in development of Ludwig’s Angina.Method: We carried out a cross sectional study among 26 patients with Ludwig’s angina admitted in the department of ENT and Head-neck surgery in SSMC &Mitford Hospital from January-December-2014.Results: In this study we found that males are predominantly affected than females (21 males and 5 females, ratio-4.2:1) with odontogenic infection (18, 69%) as source. We found historyof recent tooth extraction in 6 cases (23%) & organism was isolated from pus culture,Klebsiella in 10 cases (19.2%) out of 26 cases. We elicited underlying systemic disease mainly is Diabetes Mellitus in 9 cases (35%) that predisposes to Ludwig’s angina.\Conclusion: Our study suggests that prompt and thorough clinical evaluation and definitivecare will considerably improve patient condition and reduce morbidity and mortality.J Dhaka Medical College, Vol. 26, No.1, April, 2017, Page 3-7

scholarly journals Does Adipose Tissue Thermogenesis Play a Role in Metabolic Health?

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Craig Porter ◽  
Elisabet Børsheim ◽  
Labros S. Sidossis
Keyword(s):  
Adipose Tissue ◽  
Energy Metabolism ◽  
Brown Adipose Tissue ◽  
Metabolic Diseases ◽  
Oxidative Capacity ◽  
Whole Body ◽  
Research Strategies ◽  
Brown Adipocytes ◽  
Brown Adipose

The function ascribed to brown adipose tissue in humans has long been confined to thermoregulation in neonates, where this thermogenic capacity was thought lost with maturation. Recently, brown adipose tissue depots have been identified in adult humans. The significant oxidative capacity of brown adipocytes and the ability of their mitochondria to respire independently of ATP production, has led to renewed interest in the role that these adipocytes play in human energy metabolism. In our view, there is a need for robust physiological studies determining the relationship between molecular signatures of brown adipose tissue, adipose tissue mitochondrial function, and whole body energy metabolism, in order to elucidate the significance of thermogenic adipose tissue in humans. Until such information is available, the role of thermogenic adipose tissue in human metabolism and the potential that these adipocytes may prevent or treat obesity and metabolic diseases in humans will remain unknown. In this article, we summarize the recent literature pertaining to brown adipose tissue function with the aims of drawing the readers’ attention to the lack of data concerning the role of brown adipocytes in human physiology, and to the potential limitations of current research strategies.

scholarly journals Role of Contact with Tuberculous Patients in Cases of Tuberculous Cervical Lymphadenitis.

2004 ◽  
Vol 43 (152) ◽  
pp. 79-82
Author(s):  
D K Baskota ◽  
RCM Amatya ◽  
RP Shrivastav ◽  
BK Sinha
Keyword(s):  
Communicable Disease ◽  
Disease Process ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Cervical Lymphadenitis ◽  
Cross Sectional ◽  
History Of ◽  
One Year

A prospective, analytical and cross-sectional study to find out the role of contact with tuberculous patientsduring the process of development of Tuberculous Cervical Lymphadenitis was currently carried out in theDepartment of ENT- Head & Neck Surgery of Tribhuvan University Teaching Hospital Kathmandu, Nepal.Altogether 103 cases of histopathologically confirmed cases of Tuberculous Cervical Lymphadenitis of morethan six weeks of duration were included in the study during the period of one year from March, 2000 toFebruary, 2001.History of contact with tuberculous patients in the past during the development of the disease process wasfound to be positive in 19(18.4%) of the 103 cases. In rest of the 84 cases history of contact with tuberculouspatients was found to be negative (81.6%).The result of this study so far indicates that there is a minimal role of contact with tuberculous patients forthe development of tuberculous cervical lymphadenitis. Although tuberculosis is known as a chroniccommunicable disease, in our study majority cases of Tuberculous Cervical Lymphadenitis did not give anyhistory of contact with tuberculous patients in the past.Key Words: Tuberculous cervical lymphadenitis, tuberculous patients, communicable disease.

scholarly journals Role of Hum Test in Diagnosis of Hearing Loss

2020 ◽  
Vol 4 (3) ◽  
pp. 782-785
Author(s):  
Ashish Dhakal ◽  
Bikash Lal Shrestha ◽  
Sameer Karmacharya ◽  
Aakash Pradhan
Keyword(s):  
Hearing Loss ◽  
Gold Standard ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Sectional Study ◽  
Cross Sectional

Introduction: The Hum Test is used by some otolaryngologists as an alternative to the Weber Test to detect the presence and type of acute hearing change; however, its use has not yet been formally validated. Objective: To compare the diagnostic performance of Hum test with Weber test to detect hearing loss taking pure tone audiometry as the gold standard. Methodology: A prospective, cross-sectional study was conducted in the department of Otorhinolaryngology and Head and Neck surgery, Dhulikhel Hospital- Kathmandu University Hospital, from June 2018 to February 2019. Total of 257 patients were enrolled in the study and were subjected to 3 tests: Weber test, Hum test, and pure tone audiometry. Results: When examining patients with hearing loss, sensitivity of Hum test and weber test were 60.3% and 93.8 % respectively. In patients with CHL, sensitivity of Hum test was 55.7% while Weber test was 94.8%. In SNHL, it was 74.6% for Hum test and 90.5% for Weber test. Likewise, according to laterality of disease, sensitivity of Hum test was 58.6% for unilateral hearing loss and 65.2% for bilateral hearing loss. For Weber test it was 96.3% for unilateral and 86.4% for bilateral disease. Conclusion: Hum test is not as sensitive as Weber test in diagnosis of hearing loss both for conductive and sensorineural hearing loss.

Role of Sildenafil in the Treatment of Persistent Pulmonary Hypertension of Newborn (PPHN) - Should it Be Withdrawn from Market of Bangladesh due to Threat of being Misuses

2020 ◽  
Vol 35 (2) ◽  
pp. 100-104
Author(s):  
Maksudur Rahman ◽  
Mohammad Abdullah Al Mamun ◽  
MAK Azad Chowdhury ◽  
Abu Sayeed Munsi
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cardiac Intensive Care Unit ◽  
Cross Sectional ◽  
Cardiac Intensive Care ◽  
Hospital Protocol

Background: Recently it has been apprehended that sildenafil, a drug which has been successfully using in the treatment of PPHN and erectile dysfunction in adult, is going to be withdrawn from the market of Bangladesh due to threat of its misuses. Objective: The aim of this study was to see the extent of uses of sildenafil in the treatment of PPHN and importance of availability of this drugs in the market inspite of its probable misuses. Methods: This cross sectional study was conducted in neonatal intensive care unit (NICU), special baby care unit (SCABU) and cardiac intensive care unit (CICU) of Dhaka Shishu (Children) Hospital from June, 2017 to May 2018. Neonates with PPHN were enrolled in the study. All cases were treated with oral sildenefil for PPHN along with others management according to hospital protocol. Data along with other parameters were collected and analyzed. Results: Total 320 patients with suspected PPHN were admitted during the study period. Among them 92 (29%) cases had PPHN. Male were 49(53 %) cases and female were 43(47%) cases. Mean age at hospital admission was 29.7±13.4 hours. Based on echocardiography,13(14%) cases had mild, 38 (41%) cases moderate and 41(45%) cases severe PPHN. Mean duration of sildenafil therapy was 11.9±7.1 days. Improved from PPHN were 83 (90%) cases. Mortality was 10% (9). Conclusion: In this study it was found that the incidence of PPHN is 29% among the suspected newborns. Sildenafil is successfull in improving the oxygenation of PPHN and to decrease the mortality of neonates. DS (Child) H J 2019; 35(2) : 100-104

Role of Fibrinolytic Therapy in Empyema Thoracis – A Hospital Based one year Cross Sectional Study

2012 ◽  
Vol 2 (2) ◽  
pp. 345-350
Author(s):  
Dr. Girish.L Dandagi ◽  
◽  
Venkat kalyana kumar. P ◽  
Dr. Dr.Isaac Mathew ◽  
Dr. Dr.G S Gaude Dr. Dr.G S Gaude
Keyword(s):  
Cross Sectional Study ◽  
Fibrinolytic Therapy ◽  
Empyema Thoracis ◽  
Sectional Study ◽  
Cross Sectional ◽  
One Year
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