scholarly journals Explore the Possible Impact of BCG Vaccination Policy on the Morbidity, Mortality, and Recovery Rates due to COVID-19 Infection

2020 ◽  
Author(s):  
Chuan-Hsin Chang ◽  
Yue-Cune Chang
Keyword(s):  
Odds Ratio ◽  
Randomized Clinical Trials ◽  
Vaccination Policy ◽  
Bacille Calmette Guerin ◽  
Recovery Rates ◽  
Bcg Vaccination ◽  
The World ◽  
New Form ◽  
The Relationship ◽  
Disease Specific

ABSTRACTBACKGROUNDThe Coronavirus Disease-19 (COVID-19) is the new form of an acute infectious respiratory disease and has quickly spread over most continents in the world. Recently, it has been shown that Bacille Calmette-Guerin (BCG) might protect against COVID-19. This study aims to investigate the possible correlation between BCG vaccination and morbidity/mortality/recovery rate associated with COVID-19 infection.METHODSData of COVID-19 confirmed cases, deaths, recoveries, and population were obtained from https://www.worldometers.info/coronavirus/ (Accessed on 12 June, 2020). To have meaningful comparisons among countries’ mortality and recovery rates, we only choose those countries with COVID-19 infected cases at least 200. The Poisson regression and logistic regression were used to explore the relationship between BCG vaccination and morbidity, mortality and recovery rates.RESULTSAmong those 158 countries with at least 200 COVID-19 infected cases, there were 141 countries with BCG vaccination information available. The adjusted rates ratio of COVID-19 confirmed cases for Current BCG vaccination vs. non-Current BCG vaccination was 0.339 (with 95% CI= (0.338,0.340)). Moreover, the adjusted odds ratio (OR) of death and recovery after coronavirus infected for Current BCG vaccination vs. non-Current BCG vaccination were 0.258 (with 95% CI= (0.254,0.261)) and 2.151 (with 95% CI= (2.140,2.163)), respectively.CONCLUSIONSThat data in this study show the BCG might provide the protection against COVID-19, with consequent less COVID-19 infection and deaths and more rapid recovery. BCG vaccine might bridge the gap before the disease-specific vaccine is developed, but this hypothesis needs to be further tested in rigorous randomized clinical trials.

Explore the Possible Impact of BCG Vaccination Policy on the Morbidity, Mortality, and Recovery Rates due to COVID-19 Infection. (Preprint)

2020 ◽  
Author(s):  
Yue-Cune Chang
Keyword(s):  
Odds Ratio ◽  
Randomized Clinical Trials ◽  
Vaccination Policy ◽  
Bacille Calmette Guerin ◽  
Recovery Rates ◽  
Bcg Vaccination ◽  
The World ◽  
New Form ◽  
The Relationship ◽  
Disease Specific

BACKGROUND The Coronavirus Disease-19 (COVID-19) is the new form of an acute infectious respiratory disease and has quickly spread over most continents in the world. Recently, it has been shown that Bacille Calmette-Guerin (BCG) might protect against COVID-19. This study aims to investigate the possible correlation between BCG vaccination and morbidity/mortality/recovery rate associated with COVID-19 infection. OBJECTIVE Our findings confirm that the BCG vaccination might protect against COVID-19 virus infection. METHODS Data of COVID-19 confirmed cases, deaths, recoveries, and population were obtained from https://www.worldometers.info/coronavirus/ (Accessed on 12 June, 2020). To have meaningful comparisons among countries’ mortality and recovery rates, we only choose those countries with COVID-19 infected cases at least 200. The Poisson regression and logistic regression were used to explore the relationship between BCG vaccination and morbidity, mortality and recovery rates. RESULTS Among those 158 countries with at least 200 COVID-19 infected cases, there were 141 countries with BCG vaccination information available. The adjusted rates ratio of COVID-19 confirmed cases for Current BCG vaccination vs. non-Current BCG vaccination was 0.339 (with 95% CI= (0.338,0.340)). Moreover, the adjusted odds ratio (OR) of death and recovery after coronavirus infected for Current BCG vaccination vs. non-Current BCG vaccination were 0.258 (with 95% CI= (0.254,0.261)) and 2.151 (with 95% CI= (2.140,2.163)), respectively. CONCLUSIONS That data in this study show the BCG might provide the protection against COVID-19, with consequent less COVID-19 infection and deaths and more rapid recovery. BCG vaccine might bridge the gap before the disease-specific vaccine is developed, but this hypothesis needs to be further tested in rigorous randomized clinical trials. INTERNATIONAL REGISTERED REPORT RR2-https://doi.org/10.1101/2020.06.14.20131268

Explore the Possible Impact of BCG Vaccination Policy on the Morbidity, Mortality, and Recovery Rates due to COVID-19 Infection. (Preprint)

2020 ◽  
Author(s):  
Chuan-Hsin Chang ◽  
Yue-Cune Chang
Keyword(s):  
Odds Ratio ◽  
Randomized Clinical Trials ◽  
Vaccination Policy ◽  
Bacille Calmette Guerin ◽  
Recovery Rates ◽  
Bcg Vaccination ◽  
The World ◽  
New Form ◽  
The Relationship ◽  
Disease Specific

UNSTRUCTURED BACKGROUND The Coronavirus Disease-19 (COVID-19) is the new form of an acute infectious respiratory disease and has quickly spread over most continents in the world. Recently, it has been shown that Bacille Calmette-Guerin (BCG) might protect against COVID-19. This study aims to investigate the possible correlation between BCG vaccination and morbidity/mortality/recovery rate associated with COVID-19 infection. METHODS Data of COVID-19 confirmed cases, deaths, recoveries, and population were obtained from https://www.worldometers.info/coronavirus/ (Accessed on 12 June, 2020). To have meaningful comparisons among countries mortality and recovery rates, we only choose those countries with COVID-19 infected cases at least 200. The Poisson regression and logistic regression were used to explore the relationship between BCG vaccination and morbidity, mortality and recovery rates. RESULTS Among those 158 countries with at least 200 COVID-19 infected cases, there were 141 countries with BCG vaccination information available. The adjusted rates ratio of COVID-19 confirmed cases for Current BCG vaccination vs. non-Current BCG vaccination was 0.339 (with 95% CI= (0.338,0.340)). Moreover, the adjusted odds ratio (OR) of death and recovery after coronavirus infected for Current BCG vaccination vs. non-Current BCG vaccination were 0.258 (with 95% CI= (0.254,0.261)) and 2.151 (with 95% CI= (2.140,2.163)), respectively. CONCLUSIONS That data in this study show the BCG might provide the protection against COVID-19, with consequent less COVID-19 infection and deaths and more rapid recovery. BCG vaccine might bridge the gap before the disease-specific vaccine is developed, but this hypothesis needs to be further tested in rigorous randomized clinical trials. INTERNATIONAL REGISTERED REPORT RR2-https://doi.org/10.1101/2020.06.14.20131268

scholarly journals Association of national Bacille Calmette-Guérin vaccination policy with COVID-19 epidemiology: an ecological study in 78 countries

2020 ◽  
Author(s):  
Norifumi Kuratani
Keyword(s):  
Protective Mechanism ◽  
Vaccination Policy ◽  
Bacille Calmette Guerin ◽  
Mixed Effect ◽  
Bcg Vaccination ◽  
Risk Of Death ◽  
Effect Model ◽  
Increase Rate ◽  
A Current ◽  
Country Specific

A possible association between national Bacille Calmette-Guérin (BCG) vaccination policy and lower COVID-19 incidence has been suggested in some preprint papers. Using publicly accessible databases, I explored associations of national BCG vaccination policy with COVID-19 epidemiology in 78 countries. Data collection was conducted from April 25 to May 5, 2020. I compared countries that have a current universal BCG vaccination policy (BCG countries), with countries that currently lack such a policy (non-BCG countries). The mixed effect model revealed national BCG policy decreases in the country-specific risk of death by COVID-19, correspond to odds ratio of 0.446 (95% confidence intervals 0.323 - 0.614, P =1×10-5). In BCG countries, the case increase rate was attenuated marginally by 25.4% (95% CI 3.0 to 42.7, P=0.029) as compared with those of the non-BCG countries. Although the protective mechanism of BCG vaccination against COVID-19 remains unknown, further laboratory and clinical research should be warranted.

BCG Vaccination Program mitigates COVID19 Related Mortality: A Reality check

2021 ◽  
Vol 22 ◽  
Author(s):  
Archana Pandita ◽  
Audesh Bhat ◽  
Anita Koul ◽  
Shashank K Singh
Keyword(s):  
Potential Role ◽  
Respiratory Infections ◽  
Cross Protection ◽  
Childhood Vaccination ◽  
Vaccination Program ◽  
Vaccination Policy ◽  
Bcg Vaccination ◽  
Reality Check ◽  
The World ◽  
Related Mortality

: Since its origin in the Wuhan province of China in December 2019, Coronavirus disease 19 (COVID-19) has spread to most parts of the world and has infected millions of people. However, the significant variability in the mortality rate across the world indicates some underlying factors, especially the immunity factors that may have a potential role in this variability. One such factor that is being discussed and tested is the Bacillus Calmette-Guerin (BCG) vaccine. The available evidence suggests that BCG vaccination provides broad protection against respiratory infections as well as other infections. Therefore, BCG may prove to be a barrier for COVID-19 infection and may offer a ray of hope. In this review, we contrasted BCG vaccination program with COVID-19 mortality and analyzed trained immunity and cross protection against unrelated pathogens due to BCG vaccination. On analyzing the available data, we observed that countries without universal BCG vaccination policy are severely affected, while countries having universal BCG policies are less affected. Based on these data, we propose that the SARS-CoV-2 related qualified immunity, cross protection against unrelated pathogens and COVID-19 impact variations could be partly explained by the different national policies regarding BCG childhood vaccination. The combination of reduced morbidity and mortality may make BCG vaccination a potential new tool in the fight against COVID-19.

scholarly journals Recent changes in tuberculosis control and BCG vaccination policy in France

2007 ◽  
Vol 12 (37) ◽  
Author(s):  
D Lévy-Bruhl ◽  
M C Paty ◽  
D Antoine ◽  
D Bessette
Keyword(s):  
Control Program ◽  
Vaccination Policy ◽  
Tuberculosis Control ◽  
Bacille Calmette Guerin ◽  
Bcg Vaccination ◽  
National Tuberculosis Control Program ◽  
Tuberculosis Control Program ◽  
National Tuberculosis ◽  
National Tuberculosis Control

On 11 July 2007, the French Minister of Health launched the National Tuberculosis Control Program and a new policy on Bacille Calmette-Guérin (BCG) vaccination.

scholarly journals Worldwide inverse correlation between Bacille Calmette-Guérin immunization and COVID-19 mortality

2020 ◽  
Author(s):  
Willis X. Li
Keyword(s):  
Inverse Correlation ◽  
Poverty Rate ◽  
Vaccination Rate ◽  
Bacille Calmette Guerin ◽  
Multivariate Statistical ◽  
Per Capita Gdp ◽  
Bcg Vaccination ◽  
The World ◽  
Per Capita ◽  
Using Data

Abstract The coronavirus disease 2019 (COVID-19) pandemic has spread to all countries in the world after more than half a year since it was first reported in late 2019, and different countries have been impacted differently. Multivariate statistical analyses were used to evaluate COVID-19 deaths and cases relative to nine other demographic and socioeconomic factors in all countries and regions of the world using data as of August 1, 2020. The factors analyzed in the study include a country’s total COVID-19 deaths and cases per million population, per capita gross domestic product (GDP), population density, virus tests per million population, median age, government response stringency index, hospital beds availability per thousand population, extreme poverty rate, Bacille Calmette-Guérin (BCG) vaccination rate, and diphtheria-tetanus-pertussis (DTP3) immunization rate. The study reveals that COVID-19 deaths per million population in a country most significantly correlates, inversely, with the country’s BCG vaccination rate, and also significantly correlates a country’s per capita GDP and median age, while COVID-19 cases per million population significantly correlate with per capita GDP and tests per thousand population. This study contributes to a growing body of evidence supporting the notion that BCG vaccination may be protective against COVID-19 mortality.

scholarly journals Bacille Calmette-Guérin Osteomyelitis of the Distal Radius in a Toddler

2020 ◽  
Vol 25 (2) ◽  
pp. 134-139
Author(s):  
Ji-Young Kim ◽  
Ji-In Jeon ◽  
Hak Chang
Keyword(s):  
Side Effects ◽  
Early Diagnosis ◽  
Clinical Features ◽  
Distal Radius ◽  
Rare Case ◽  
Proper Treatment ◽  
Bacille Calmette Guerin ◽  
Bcg Vaccination ◽  
The World

BCG (Bacille Calmette-Guérin) vaccine has been administered safely to billions of people all over the world. The Tokyo-172 strain has reported to have a lower virulence and side effects than other strains. BCG osteomyelitis of distal radius is a very rare but serious complication due to generalized dissemination of BCG. We report a rare case of BCG osteomyelitis of the distal radius in a 21-month-old girl who had no underlying disorders. Although uncommon, BCG osteomyelitis should be considered a possible complication of BCG vaccination under certain clinical features for early diagnosis and proper treatment.

Hedonismo y Fractura de la Modernidad

1998 ◽  
pp. 1-7
Author(s):  
Roberto Dante Flores
Keyword(s):  
New Technologies ◽  
Point Of View ◽  
Media Technologies ◽  
The World ◽  
The Face ◽  
The Subject ◽  
New Form ◽  
Crisis Of Modernity ◽  
The Impact ◽  
The Relationship

This is an analysis of the ethico-cultural crisis of modernity and the emergence of the so-called postmodern aesthetic expressions (and conduct), examined principally from the point of view of Frederic Jameson and its coincidence with other authors (D. Lowe, G. Lipovetsky, and P. Virilio). I also investigate the relationship between the new sensitivities of the end of the century and the notion of justice, and its moral. This is seen by the authors as a consequence of the impact that mass-media technologies have produced in individuals leading to a new form of experience: the aesthetization of life and the fragmentation of the subject. The culture of the image is omnipresent, diluting art into aesthetization and the subject into the objectivization of consumption. We can see that there is a loss of historicity in the postmodern individual-originating from the speed of audiovisual information-upon perceiving, on a screen, the world in an instanct, without references to either a past or a future. The new technologies are the product of a new stage of capitalism, even more so than in the modernity of massive consumption. As a consequence of these three factors (aesthetization, ahistoricity, consumption), there has emerged a hedonistic ethos which differentiates itself from its modern vanguardist antecedents in that it is no longer the transgressor of a religious moral, or the secularism of duty, because pleasure is no longer forbidden. This framework, which is lacking in hard principles and is sustained by 'weak and conviction free' individuals is compatible with the liberal ethic of Rawls. In the face of the contradiction of modernity, we shall reconsider, as factors of socio-political construction, the moral values provided by the world's great religions.

scholarly journals Worldwide inverse correlation between Bacille Calmette-Guérin immunization and COVID-19 morbidity and mortality

2020 ◽  
Author(s):  
Willis X. Li
Keyword(s):  
Confounding Factor ◽  
Inverse Correlation ◽  
Poverty Rate ◽  
Vaccination Rate ◽  
Capita Gross Domestic Product ◽  
Bacille Calmette Guerin ◽  
Vaccination Rates ◽  
Bcg Vaccination ◽  
The World ◽  
Per Capita

Abstract The COVID-19 pandemic has spread to all countries in the world after more than six months since it was first reported in late 2019, and different countries have been impacted differently. Correlation analysis between COVID-19 death numbers and different demographic and socioeconomic factors for all world countries (n=210) as of June 1, 2020, reveals that COVID-19 deaths per million population in a country significantly correlates with the country’s median age (r=0.48, p=4.8e-4) and per capita gross domestic product (GDP) (r=0.55, p=4.14e-5), and inversely correlates with the country’s Bacille Calmette-Guérin (BCG) vaccination rate (r=–0.63, p=9.9e-7). COVID-19 death is found not significantly associated, however, with a country’s policy stringency index, population density, extreme poverty rate, hospital beds availability per thousand people, and diphtheria-tetanus-pertussis (DTP3) immunization. Old age is likely a confounding factor for the correlation between COVID-19 and per capita GDP (r=0.66, p=2.3e-7). To control for possible confounding effects of age, countries with similar median age were grouped and analyzed. The inverse correlation between BCG vaccination rates and COVID-19 case (r=–0.338, p=0.0082) and death (r=–0.411, p=0.0011) remained significant among the top 61 countries with highest median age. The current study suggests that BCG might be protective against SARS-CoV-2 infection.

scholarly journals A Short History of the BCG Vaccine

2021 ◽  
pp. 55-58
Author(s):  
Georgiana Bianca Constantin ◽  
Ionuţ Căluian
Keyword(s):  
Detailed Analysis ◽  
Tuberculin Test ◽  
Bcg Vaccine ◽  
National Program ◽  
Short History ◽  
Bacille Calmette Guerin ◽  
Bcg Vaccination ◽  
The World ◽  
History Of ◽  
And Control

BCG vaccine continues to be controversial, live attenuated BCG is still the only vaccine in use which is able to prevent TB in humans. It is still difficult to determine which strain should be used and further detailed analysis of the genomics and immunogenicity of BCG sub-strains may provide an answer to this important question. The only vaccine available is the BCG (Bacille Calmette-Guerin), that has been used for about 100 years, with remarkable results. The majority of the world followed the lead of Europe and the WHO and introduced routine BCG vaccination according to various schedules. According to the Methodological Guide for the Implementation of the National Program for the Prevention, Surveillance and Control of Tuberculosis, BCG vaccination is indicated for all newborns, at the age of 2-7 days (if there are no contraindications), before discharge from maternity and without preliminary tuberculin test.

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