scholarly journals Effects of date fruit (Phoenix dactylifera) on sperm cell morphology and reproductive hormonal profiles in cypermethrin-induced male infertility

2020 ◽  
Author(s):  
Ubah Simon Azubuike ◽  
Agbonu Oluwa Adikpe ◽  
Columbus Philemon Kwinjoh ◽  
Abah Kenneth Owoicho ◽  
Chibuogwu Ijeoma Chika ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Male Infertility ◽  
Phoenix Dactylifera ◽  
Second Phase ◽  
Fruit Extract ◽  
Fruit Extracts ◽  
Date Fruit ◽  
Significant Difference ◽  
Mass Activity ◽  
Date Fruits

AbstractDate fruits are endowed with medicinal values, including boosting the male fertility status, but with meagre empirical evidence. Thus, the current study was designed to assess the ameliorative and potential adverse effects of date fruit extracts (Phoenix dactylifera) on cypermethrin-induced male infertility. The study was conducted in two phases using adult male Wistar rats (n = 42, 180 – 220 g and aged 14 - 16 weeks). The first phase was a single oral dose toxicity study to ascertain the suitability of date fruit extract and cypermethrin administered at 250 mg/kg and 60 mg/kg, respectively. The second phase, which included four treatment groups of six animals per group, assessed the effects of date fruits on cypermethrin-induced infertility. At the termination of the experiment, semen was collected by epididymal extraction for the assessment of sperm abnormalities, motility, mass activity, semen pH, and percentage live. Serum samples were also collected for testosterone and follicle stimulating hormone (FSH) profiling, and the collected data was subjected to statistical analysis. The group administered only cypermethrin showed a decrease in percentage motility, live, mass activity and an increase in total abnormalities over the control group while the group exposed to only date fruits extracts showed increased percentage motility, live, mass activity and a decrease in total abnormalities over the control. The results of a combined administration of date fruit extracts and cypermethrin on a separate group showed a consistently reduced percentage of anatomically abnormal sperm cells and a general improvement of sperm motility and mass activity. There was no significant difference in the weight of the Wister rats in all the groups (p > 0.05). However, testosterone and FSH levels were significantly reduced (p < 0.05) by date fruit extract treatment. The current report provides evidence of the potential ameliorative effects of date fruit extracts in cypermethrin-induced male infertility and cautions excessive use or abuse since some adverse effects were observed.

scholarly journals Microbiological and Organoleptic Quality Characteristics of Laboratory Produced Date Fruit-based Kunun-zaki

2021 ◽  
Vol 2 (3) ◽  
pp. 97-104
Author(s):  
J. O. Egbere ◽  
C. E. Odu ◽  
I. A. Onyimba ◽  
A. C. Ngene ◽  
A. E. Yusuf ◽  
...  
Keyword(s):  
Sensory Quality ◽  
Control Sample ◽  
Phoenix Dactylifera ◽  
Lactobacillus Species ◽  
Sterile Water ◽  
Microbial Succession ◽  
Market Control ◽  
Date Fruit ◽  
The Mean ◽  
Date Fruits

In the quest to produce an acceptable local beverage that could serve as an alternative variety to kunun-zaki for many millions of Nigerians who take the cereal-based beverage as their most preferred and affordable drink a study was undertaken to assess the microbial and sensory quality attributes of laboratory-produced Date fruit-based kunun-zaki. Different blends of dry date fruits (Phoenix dactylifera) and sorghum (Sorghum bicolor) formulated as follows; F1 (100:0), F2 (70:30), F3 (50:50), and F4 (30:70%) of date fruits/sorghum were soaked overnight in water, drained and were wet-milled with ginger and cloves using an equal volume of sterile water, F5 (0:100) was market (Control) sample. The microbial succession study included the identification of organisms at various critical stages of the production of the beverage. The results of the study showed the mean pH, and TTA (%) values for the respective formulated Kunun-dabino product were F1 (4.87 and 0.3870), F2 (4.66 and 0.4508), F3 (4.29 and 0.4600), F4 (4.04 and 0.4690), F5/Control (4.32 and 0.4589) respectively. The mean Total bacterial, coliform and fungal loads of the four experimental products were 2.58 x 104, NIL, and 3.56 x 103 CFU/ml respectively which fall within W.H.O’s recommended standards for ready-to-eat foods. Species of Bacillus, Enterobacter, Shigella, Lactobacillus, Aspergillus, Penicillium Mucur, and Candida were present at the initial production stage while Bacillus and Lactobacillus species persisted right through to the final stage of production. The results of the sensory evaluation showed that while F1 was the least liked, F3 was significantly preferred over the other samples (P < 0.05). The study has shown that ‘Kunun dabino’ produced under the laboratory conditions in this study provides a new brand of beverage that is both microbiologically safe and organoleptically more acceptable to taste panelists.

scholarly journals Effects of date fruit (Phoenix dactylifera) on sperm cell morphology and reproductive hormonal profiles in cypermethrin-induced male infertility in Wister rats

2021 ◽  
Vol 11 ◽  
pp. e00713
Author(s):  
Simon Azubuike Ubah ◽  
Oluwa Adikpe Agbonu ◽  
Philemon Kwinjoh Columbus ◽  
Kenneth Owoicho Abah ◽  
Ijeoma Chika Chibuogwu ◽  
...  
Keyword(s):  
Male Infertility ◽  
Cell Morphology ◽  
Sperm Cell ◽  
Phoenix Dactylifera ◽  
Date Fruit ◽  
Hormonal Profiles

scholarly journals Phytochemical and Biological Screening of Leaf, Bark and Fruit Extracts from Ilex dipyrena Wall.

Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 837
Author(s):  
Amjad Ali ◽  
Atif Ali Khan Khalil ◽  
Fazli Khuda ◽  
Nausheen Nazir ◽  
Riaz Ullah ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Phytochemical Analysis ◽  
Second Phase ◽  
Mice Model ◽  
Fruit Extract ◽  
Biological Screening ◽  
Fruit Extracts ◽  
Ms Analysis ◽  
Phytochemical Profile ◽  
Different Parts

The Aquifoliaceae is an important family and has been used traditionally for some time. One of the members of this family is the Ilex dipyrena wall, which itself possesses a potential medicinal importance. This plant is traditionally used for the treatment of various ailments including pain, swelling, burns, and fever. The current study was designed to screen out the antioxidant and analgesic potential of this plant and to verify its traditional uses, along with its phytochemical profile. Extracts were subjected to antioxidant, analgesic, and phytochemical analysis using DPPH, chemical-induced (acetic acid and formalin) nociception models and GC-MS analysis, respectively. The leaf, bark, and fruit extracts showed significant antioxidant activity compared to that of standard. Likewise, all the extracts demonstrated significant (p < 0.01) analgesic activity in a mice model. In acetic acid induced analgesia, the leaf, bark, and fruit extracts caused 51.64, 56.13 and 59.52% inhibition, respectively at a dose of 100 mg/kg while at 200 mg/kg it showed 83.01, 71.69 and 75.47% inhibition, respectively. In Formalin-induced paw-licking assay, fruit extract showed 59.42 and 64.19% inhibition at 200 mg/kg dose in the first and second phase, respectively. The GC-MS analysis revealed the presence of cathinone, phenylpropanolamine, dl-phenylephrine, amphetamine, myristic acid, and palmitic acid. Results of the study suggest that crude extracts from different parts of this plant may be a useful source for the development of novel analgesics. However, further investigation in terms of isolation of bioactive compounds and their toxicological evaluations are needed to validate the observed results.

scholarly journals ANTI-INFERTILITY EFFECTS TEST OF DATE PALM FRUIT EXTRACT (PHOENIX DACTYLIFERA L.) IN FEMALE MICE (MUS MUSCULUS) COMPARED WITH PROPOLIS

2018 ◽  
Vol 11 (11) ◽  
pp. 433
Author(s):  
Dwisari Dillasamola ◽  
Almahdy A ◽  
Ria Anggraini ◽  
Skunda Diliarosta ◽  
Biomechy Oktomalio P ◽  
...  
Keyword(s):  
Corpus Luteum ◽  
Date Palm ◽  
Endometrial Thickness ◽  
Ethanol Extract ◽  
Phoenix Dactylifera ◽  
Ovarian Follicles ◽  
Fruit Extract ◽  
Palm Fruit ◽  
Date Fruit ◽  
Phoenix Dactylifera L

Objective: The date palm (Phoenix dactylifera L) is one of the plants empirically used to increase fertility. The aim of this study was to compare the effect of ethanol extract of date palm fruit and propolis on fertility in female mice.Methods: 5 groups were assigned to 1 control and 4 experimental groups. The experimental group treated by oral administration of 100, 200 and 400 mg/kgBW of khalal date fruit extract and 200 mg/kgBW of propolis for 5, 10 and 15 days. Control groups received no extract. After 5, 10 and 15 days the mice were deeply anesthetized with anesthetic ether and sacrificed. Histological changes in ovary and uterine were measured. The data was analyzed by using two way ANOVA and Duncan test.Results: The results of the study of the effect of the dose and duration of the ethanol extract of khalal date fruit on the histology of ovaries and uterine mice showed that there was an increase in the number of primary, secondary, tertiary, degraaf, and corpus luteum follicles but did not affect the follicle of atresia and myometrial and endometrial thickness. in Propolis a dose of 100mg / kgBW increase occurs only in primary, secondary and corpus luteum follicles.Conclusion: Ethanol extract of khalal date fruit and Propolis can increase the number of ovarian follicles. Ethanol extract of khalal date fruit dose can increase the number of ovarian follicles higher than propolis.

scholarly journals Antioxidant Capacity and Phenolic and Sugar Profiles of Date Fruits Extracts from Six Different Algerian Cultivars as Influenced by Ripening Stages and Extraction Systems

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 503
Author(s):  
Malika Tassoult ◽  
Djamel Edine Kati ◽  
María África Fernández-Prior ◽  
Alejandra Bermúdez-Oria ◽  
Juan Fernandez-Bolanos ◽  
...  
Keyword(s):  
Sugar Content ◽  
Antioxidant Properties ◽  
Dry Weight ◽  
Natural Antioxidants ◽  
Antioxidant Power ◽  
Fruit Extracts ◽  
Ripening Stages ◽  
Date Fruit ◽  
Ferric Reducing Antioxidant Power ◽  
First Time

The study investigated the phenols, sugar and the antioxidant capacities of date fruit extracts obtained by organic solvents and by hydrothermal treatment from six different Algerian cultivars at two ripening stages for the first time. The analyzed cultivars exhibited potent antioxidant properties (ferric reducing antioxidant power (FRAP), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) scavenging capacities) and different phenols regardless of the solvents and the maturity stages. About 18 phenols were identified and quantified, mainly in the hydrothermal extracts. The earlier stages were characterized by high amounts of o-coumaric acid, cinnamic acid and luteolin, with a noticeable absence of quercetin. The tamr stage presented the highest sugar content (78.15–86.85 mg/100 mg dry weight (DW)) with an abundance of glucose. Galactose was present only in some cultivars from the kimri stage (tamjouhert). Uronic acids were mostly detected at the tamr stage (4.02–8.82 mg gallic acid equivalent/100 mg dried weight). The obtained results highlight the potential of using date fruit extracts as natural antioxidants, especially at industrial scales that tend use hydrothermal extraction.

scholarly journals Sex-dependent liver cancer xenograft models for predicting clinical data in the evaluation of anticancer drugs

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Sungryong Oh ◽  
Joohee Jung
Keyword(s):  
Liver Cancer ◽  
Adverse Effects ◽  
Anticancer Drugs ◽  
Clinical Data ◽  
Xenograft Model ◽  
In Vitro Test ◽  
Incidence And Mortality ◽  
Significant Difference ◽  
Xenograft Models

Abstract Background The incidence and mortality of liver cancer show a great difference between the sexes. We established sex-dependent liver cancer xenograft models and investigated whether such sex-dependent models could be used to simultaneously evaluate the therapeutic and adverse effects of anticancer drugs for drug screening. Results In the in-vitro test, the cytotoxicity of anticancer drugs (cisplatin, 5-fluorouracil, and doxorubicin) was compared between male- and female-derived liver cancer cell lines. Cisplatin and 5-fluorouracil exhibited cytotoxicity without sex-difference, but doxorubicin showed dose-dependently significant cytotoxicity only in male-derived cells. Our results showed a strong correlation between preclinical and clinical data with the use of sex-dependent liver cancer xenograft models. Moreover, the male-derived Hep3B-derived xenograft model was more sensitive than the female-derived SNU-387-derived xenograft model against doxorubicin treatment. Doxorubicin showed more severe cardiotoxicity in the male xenograft model than in the female model. We investigated the occurrence frequency of doxorubicin-related cardiotoxicity using data obtained from the Korea Institute of Drug Safety & Risk Management Database, but no significant difference was observed between the sexes. Conclusions Our results suggest that sex-dependent xenograft models are useful tools for evaluating the therapeutic and adverse effects of anticancer drugs, because sex is an important consideration in drug development.

scholarly journals Effects of date fruit (Phoenix dactylifera L.) on labor and delivery outcomes: a systematic review and meta-analysis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Alireza Bagherzadeh Karimi ◽  
Asghar Elmi ◽  
Mojgan Mirghafourvand ◽  
Roghaiyeh Baghervand Navid
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Phoenix Dactylifera ◽  
Labor And Delivery ◽  
Date Fruit ◽  
Delivery Outcomes ◽  
Phoenix Dactylifera L
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