scholarly journals A Systematic Review of the Cardiovascular Manifestations and Outcomes in the Setting of Coronavirus-19 Disease

2020 ◽  
Author(s):  
Samarthkumar Thakkar ◽  
Shilpkumar Arora ◽  
Ashish Kumar ◽  
Rahul Jaswaney ◽  
Mohammed Faisaluddin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Case Series ◽  
Inclusion Criteria ◽  
Mortality And Morbidity ◽  
Future Studies ◽  
Treatment And Prevention ◽  
Wide Range ◽  
Myocardial Infection ◽  
The Impact

The impact of coronavirus disease, 2019 (COVID-19), has been profound. Though COVID-19 primarily affects the respiratory system, it has also been associated with a wide range of cardiovascular (CV) manifestations portending extremely poor prognosis. The principal hypothesis for CV involvement is through direct myocardial infection and systemic inflammation. We conducted a systematic review of the current literature to provide a foundation for understanding the CV manifestations and outcomes of COVID-19. PubMed and EMBASE databases were electronically searched from the inception of the databases through April 27th, 2020. A second literature review was conducted to include major trials and guidelines that were published after the initial search but before submission. The inclusion criteria for studies to be eligible were case reports, case series, and observation studies reporting CV outcomes among patients with COVID-19 infection. This review of the current COVID-19 disease and CV outcomes literature revealed a myriad of CV manifestations with potential avenues for treatment and prevention. Future studies are required to understand on a more mechanistic level the effect of COVID-19 on the myocardium and thus provide avenues to improve mortality and morbidity.

scholarly journals A Systematic Review of the Cardiovascular Manifestations and Outcomes in the Setting of Coronavirus-19 Disease

2020 ◽  
Vol 14 ◽  
pp. 117954682097719
Author(s):  
Samarthkumar Thakkar ◽  
Shilpkumar Arora ◽  
Ashish Kumar ◽  
Rahul Jaswaney ◽  
Mohammed Faisaluddin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Case Series ◽  
Inclusion Criteria ◽  
Mortality And Morbidity ◽  
Future Studies ◽  
Treatment And Prevention ◽  
Wide Range ◽  
Myocardial Infection ◽  
The Impact

The impact of coronavirus disease, 2019 (COVID-19), has been profound. Though COVID-19 primarily affects the respiratory system, it has also been associated with a wide range of cardiovascular (CV) manifestations portending extremely poor prognosis. The principal hypothesis for CV involvement is through direct myocardial infection and systemic inflammation. We conducted a systematic review of the current literature to provide a foundation for understanding the CV manifestations and outcomes of COVID-19. PubMed and EMBASE databases were electronically searched from the inception of the databases through 27 April 2020. A second literature review was conducted to include major trials and guidelines that were published after the initial search but before submission. The inclusion criteria for studies to be eligible were case reports, case series, and observation studies reporting CV outcomes among patients with COVID-19 infection. This review of the current COVID-19 disease and CV outcomes literature revealed a myriad of CV manifestations with potential avenues for treatment and prevention. Future studies are required to understand on a more mechanistic level the effect of COVID-19 on the myocardium and thus provide avenues to improve mortality and morbidity.

scholarly journals Myocarditis associated with Covid-19 disease: a systematic review of published Case reports and Case series

2021 ◽  
Author(s):  
Sawai Singh Rathore ◽  
Gianpier Alonzo Rojas ◽  
Manush Sondhi ◽  
Suveenkrishna Pothuru ◽  
Reshma Pydi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Acute Myocarditis ◽  
Case Series ◽  
Cardiac Biomarkers ◽  
Pulmonary Tissue ◽  
Mortality And Morbidity ◽  
Presenting Symptoms ◽  
St Segment ◽  
Inflammatory Infiltrates

Background: Covid-19 is an extremely contagious illness caused by the severe acute respiratory syndrome (SARS-CoV-2) virus. Although this disease primarily involves pulmonary tissue, rapidly advancing research has established cardiac involvement in Covid-19 patients. Objective: This systematic review article aimed to compile and illustrate clinical characteristics, diagnostic findings, management, and outcomes manifesting in myocarditis linked with Covid-19. Methods: A literature search was accomplished for published eligible articles with MEDLINE/PubMed and Embase databases. All eligible case reports and case series were included from around the world without any language restrictions. For this review, inclusion criteria were laboratory-confirmed SARS-CoV-2 infection cases reporting a diagnosis of acute myocarditis. Results: Data from 41 studies describing myocarditis in 42 Covid-19 patients was obtained. The median age of these patients was 43.4 years, with 71.4% of them being male. Fever was the most prevalent presenting symptoms seen in 57% of patients. Hypertension was the most pervasive comorbidity accompanying these patients. Cardiac biomarkers troponin and Brain natriuretic peptide (BNP) were raised in almost 90% and 87% of patients, respectively. Electrocardiogram findings were Non-specific and included ST-segment and T-wave changes. The most prevalent histopathological feature appreciated was diffuse lymphocytic inflammatory infiltrates. Antivirals and corticosteroids were the most frequently used medications. About 38% of patients also needed vasopressor assistance. Out of 42 patients, 67% recovered, and eight died. Conclusion: Due to the risk of a sudden worsening of patients conditions and myocarditis association with considerable mortality and morbidity, a knowledge of this cardiac complication of Covid-19 disease is crucial for healthcare professionals.

scholarly journals Coronavirus infection in neonates: a systematic review

2020 ◽  
pp. fetalneonatal-2020-319837
Author(s):  
Daniele Trevisanuto ◽  
Francesco Cavallin ◽  
Maria Elena Cavicchiolo ◽  
Martina Borellini ◽  
Serena Calgaro ◽  
...  
Keyword(s):  
Systematic Review ◽  
Spontaneous Breathing ◽  
Respiratory Infections ◽  
Case Reports ◽  
Gastrointestinal Symptoms ◽  
Case Series ◽  
Final Analysis ◽  
Good Prognosis ◽  
Cochrane Database ◽  
The Impact

ObjectiveTo summarise currently reported neonatal cases of SARS-CoV-2 infection.MethodsA search strategy was designed to retrieve all articles published from 1 December 2019 to 12 May 2020, by combining the terms ‘coronavirus’ OR ‘covid’ OR ‘SARS-CoV-2’) AND (‘neonat*’ OR ‘newborn’) in the following electronic databases: MEDLINE/Pubmed, Scopus, Web of Science, MedRxiv, the Cochrane Database of Systematic Review and the WHO COVID-19 database, with no language restrictions. Quality of studies was evaluated by using a specific tool for assessment of case reports and/or case series.ResultsTwenty-six observational studies (18 case reports and 8 case series) with 44 newborns with confirmed SARS-CoV-2 infection were included in the final analysis. Studies were mainly from China and Italy. Half of neonates had a documented contact with the infected mother and one out of three infected neonates was admitted from home. Median age at diagnosis was 5 days. One out of four neonates was asymptomatic, and the remaining showed mild symptoms typical of acute respiratory infections and/or gastrointestinal symptoms. The majority of neonates were left in spontaneous breathing (room air) and had good prognosis after a median duration of hospitalisation of 10 days.ConclusionsMost neonates with SARS-CoV-2 infection were asymptomatic or presented mild symptoms, generally were left in spontaneous breathing and had a good prognosis after median 10 days of hospitalisation. Large epidemiological and clinical cohort studies, as well as the implementation of collaborative networks, are needed to improve the understanding of the impact of SARS-CoV-2 infection in neonates.

scholarly journals Intranasal corticosteroids do not affect intraocular pressure or lens opacity: a systematic review of controlled trials

2015 ◽  
Vol 53 (4) ◽  
pp. 290-302
Author(s):  
N. Ahmadi ◽  
K. Snidvongs ◽  
L. Kalish ◽  
R. Sacks ◽  
K. Tumuluri ◽  
...  
Keyword(s):  
Systematic Review ◽  
Intraocular Pressure ◽  
Case Reports ◽  
Case Series ◽  
Upper Airway ◽  
Lens Opacity ◽  
Systemic Absorption ◽  
Intranasal Corticosteroids ◽  
Reported Data ◽  
The Impact

Background: Intranasal corticosteroids (INCS) are prescribed for the long-term prophylactic treatment of inflammatory upper airway conditions. Although some systemic absorption can occur via topical routes, the clinical relevance is controversial. The effects of orally administered corticosteroids on intraocular pressure (IOP) and lens opacity (LO) are well established, but the impact of the INCS is less well defined. This study aims to systematically review the literature for evidence of adverse occular events with INCS use. Methodology: A systematic review of literature from Medline and Embase databases (January 1974 to 21st of November 2013) was performed. Using the PRISMA guidelines, all controlled clinical trials of patients using INCS, that reported original measures of IOP, LO, glaucoma or cataract incidences were included. Studies with adjuvant administration of oral, inhaled and intravenous steroids were excluded. Results: 665 articles were retrieved with 137 were considered for full-text review. Of these, 116 (85%) were literature reviews and two were case reports. 19 studies (10 RCTs, 1 case-control, 8 case series) were included for the qualitative review, of which 18 reported data on IOP and 10 on cataract/LO. None (n=0) of the 10 RCT reporting data on glaucoma or IOP demonstrated changes in IOP compared to control. Also none (n=0) of the 6 RCTs reporting cataract or lens opacity demonstrated changes compared to control. Conclusion: Data from studies with low levels of bias, do not demonstrate a clinically relevant impact of INCS on neither ocular pressure, glaucoma, lens opacity nor cataract formation.

scholarly journals Smartphone Addiction and Associated Health Outcomes in Adult Populations: A Systematic Review

2021 ◽  
Vol 18 (22) ◽  
pp. 12257
Author(s):  
Zubair Ahmed Ratan ◽  
Anne-Maree Parrish ◽  
Sojib Bin Zaman ◽  
Mohammad Saud Alotaibi ◽  
Hassan Hosseinzadeh
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Health Outcomes ◽  
Mental Health Outcomes ◽  
Smartphone Addiction ◽  
Inclusion Criteria ◽  
Physical And Mental Health ◽  
Cross Sectional ◽  
Wide Range ◽  
The Impact

Background: Smartphones play a critical role in increasing human–machine interactions, with many advantages. However, the growing popularity of smartphone use has led to smartphone overuse and addiction. This review aims to systematically investigate the impact of smartphone addiction on health outcomes. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to carry out the systematic review. Five electronic databases including Medline, Web of Science, PsycINFO, PubMed, and Scopus were searched to identify eligible studies. Eligible studies were screened against predetermined inclusion criteria and data were extracted according to the review questions. This review is registered in PROSPERO (CRD42020181404). The quality of the articles was assessed using the National Institutes of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Results: A total of 27 of 2550 articles met the inclusion criteria. All of the studies were cross-sectional and focused on physical, mental, and neurological health outcomes. The majority of the studies focused on mental health outcomes and consistent associations were observed between smartphone addiction and several mental health outcomes. Anxiety and depression were commonly found to mediate mental health problems. A wide range of physical health sequelae was also associated with smartphone addiction. Furthermore, there was an association between smartphone addiction and neurological disorders. Conclusions: Our findings suggest that there are consistent associations between smartphone addiction and physical and mental health, especially mental health. Social awareness campaigns about smartphone addiction and its impact on physical and mental health are needed. Further studies, especially randomized controlled trials, are warranted to validate the impacts of smartphone addiction.

scholarly journals A systematic review of the neglect of non-COVID patients amidst COVID pandemic

2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Priyanka Mishra ◽  
◽  
Amborish Nath ◽  
Surbhi Sharma ◽  
Ajit Kumar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Case Series ◽  
Communicable Diseases ◽  
Health Concern ◽  
Health Priorities ◽  
P Value ◽  
Non Communicable Diseases ◽  
Adverse Pregnancy ◽  
The Impact

The rapidly evolving health concern for COVID-19 has considerably overshadowed the non-COVID ailments. Ranging from delays in diagnosis and treatment, neglect of mild-moderate diseases resulting into their progression, adverse pregnancy outcomes and many others, an array of the collateral damage of this pandemic is still evolving. We have performed this systematic review about the impact of COVID pandemic on patients suffering from other ailments. Our search was conducted through PubMed, Cochrane and Google scholar databases. We included systematic reviews and meta- analysis, and randomized controlled trials, observational studies, case series and case reports to ensure comprehensiveness of our search. We excluded abstract only articles, news articles, the non-scientific commentaries and reports from the review. Primary outcome was assessment of the impact of COVID pandemic on non-COVID diseases and management strategies for tackling the same. This review showed that this crisis has resulted into a significant delay in routine diagnostic procedures and workup with p value < 0.00001 (OR of 0.36; 95% CI, 0.24 to 0.55). The highest impacts will be seen with preexisting major health priorities like HIV, tuberculosis, malignancy, various non-communicable diseases, reproductive and child health. The chief culprits for this include inadequate supplies of medicines, healthcare staff, diagnostics and other technologies. Expansion of the health care workforce, enhanced health financing and supply chain resilience can help us override this pandemic. Hence, the intersection of COVID-19 with other non- COVID ailments can have drastic effects. To minimize this surplus morbidity and mortality, we need to adopt comprehensive strategies and maintain the momentum even after this pandemic is surpassed. Keywords: COVID-19; neglect; non-COVID; non-communicable diseases; communicable diseases; management.

scholarly journals RESPIRATORY MUSCLES TRAINING (RMT) TO DYSPNEA SCALE OF COPD: A SYSTEMATIC REVIEW

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Imron Rosyadi ◽  
Shinta Dewi Kasih Bratha
Keyword(s):  
Systematic Review ◽  
Respiratory Muscle ◽  
Randomized Clinical Trials ◽  
Respiratory Muscles ◽  
Inclusion Criteria ◽  
Future Studies ◽  
Lung Capacity ◽  
Considerable Impact ◽  
The Impact ◽  
Function Activity

SummaryBackground: COPD can decrease patients' activity because of dyspneaObjectives: To critically evaluate the effect of RMT as a treatment of COPD.Method: Five databases were found from 2008, a randomized clinical trials (RCTs) research will be a reference if they evaluated RMT against any type of control in patients with any form of respiratory muscle weakness.Result: Five trials met the inclusion criteria. One journal has the good of sampling technic by using the COPD patient from 3 hospitals. Only four journals show the significant effect of RMT to decrease dyspnea of COPD. The impact of RMT is going to increase the lung capacity, lung function, activity, respiratory muscle straightness, and minimize the effort of breathing. Only one journal does this intervention for 12 weeks.Conclusion: The evidence for the effect of RMT to decrease the dyspnea scale has a significant impact. For future studies, it will be better to use RMT longer to get a more considerable impact.  

scholarly journals Cost of Oral Cancer: Protocol for a Systematic Review

2020 ◽  
Author(s):  
REJANE FARIA RIBEIRO-ROTTA ◽  
Eduardo Antônio Rosa ◽  
Vanessa Milani ◽  
Nadielle Rodrigues Dias ◽  
Daniele Masterson Tavares Pereira Ferreira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Cancer ◽  
Economic Burden ◽  
Case Reports ◽  
Evaluation Studies ◽  
Productivity Loss ◽  
Case Series ◽  
Cost Utility ◽  
Rehabilitation Care ◽  
The Impact

Abstract Background: Cancer care is among the costliest in the social sphere. Oral cancer (OC) is a chronic disease whose incidence has been growing worldwide. The lack of economic evaluation studies assessing the economic impact of OC, as well as the need to search for evidence of the economic burden of OC motivated this investigation. This study aims to collect evidence on the cost of OC (lip cancer - LC, oral cavity cancer - OCC and oropharyngeal cancer - OPC) worldwide. Methods: A systematic review will be conducted take into consideration any perspective. The primary outcome will be the costs related to oral cancer in patients, reported in monetary units. Specific breakdown of costs will be reported (direct hospital costs, rehabilitation care costs, direct non-healthcare costs, indirect costs and productivity loss, and intangible costs). SCOPUS, WEB OF SCIENCE, COCHRANE and BVS databases will be searched. Original studies on cost of OC that assess its cost based on components as: hospital and/or outpatient, promotion and prevention will be included. It will be excluded types of study such as: editorial, letters, reviews, case reports, case series, clinical trials, studies that address specific analysis, such as cost-effectiveness, cost-utility, cost-benefit, cost-minimization. A systematic meta-narrative synthesis will be presented. Data on quantities of health and social resource consumption, currencies used and whether studies show total or incremental costs will be collected.Discussion: The identification of evidence on the economic burden of LC, OCC and OPC will allow the determination of the contribution share of each sector of society in the total economic burden of oral cancer. Also, this evidence will favour the estimate of the impact that the reduction of the OC burden would have on its associated costs and better guide the choice decision, to optimize the benefits. Systematic review registration: PROSPERO ID number 172471.

scholarly journals Anxiety impact during COVID-19: a systematic review

2021 ◽  
Vol 15 (03) ◽  
pp. 320-325
Author(s):  
Patricia Batista ◽  
Vitor Duque ◽  
Ana Luzio-Vaz ◽  
Anabela Pereira
Keyword(s):  
Systematic Review ◽  
Published Data ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Future Studies ◽  
Anxiety Measurement ◽  
Meta Analyses ◽  
The Impact ◽  
Sample Methodology

Introduction: The COVID-19 epidemic has been causing serious physical, but also psychological effects in society. This systematic review sought to identify studies that describe COVID-19 related anxiety, and to understand the impact of anxiety assessment in defining strategies to be implemented in future studies. Methodology: This systematic review included cross-sectional studies with no publication year limit. It was performed a systematic search through three databases, namely, PubMed, Science Direct and Web of Science using the descriptors “COVID-19” and “anxiety”. PRISMA criteria reporting of systematic reviews and meta-analyses were applied. Eligible articles were selected in accordance with inclusion and exclusion criteria. The inclusion criteria were: research articles related with anxiety measurement during the COVID-19 outbreak; interventions to reduce anxiety; and published in English. Results: From 44 references, just four scientific articles were accepted for inclusion within this review. These studies were analyzed regarding their sample, methodology, instruments used, and its results. Conclusions: This systematic review was based on published data at the onset of the pandemic, and it could serve as a basis for the development of implementations plans to improve anxiety disorders. The importance of this theme, the implications and potential directions for future investigations will be discussed.

scholarly journals The impact of the COVID-19 pandemic on self-harm and suicidal behaviour: a living systematic review

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 1097 ◽  
Author(s):  
Ann John ◽  
Chukwudi Okolie ◽  
Emily Eyles ◽  
Roger T. Webb ◽  
Lena Schmidt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Suicidal Behaviour ◽  
Case Reports ◽  
Case Series ◽  
Economic Effects ◽  
Service Utilisation ◽  
Suicidal Thoughts ◽  
Low Middle Income Countries ◽  
Self Harm ◽  
The Impact

Background: The COVID-19 pandemic has caused morbidity and mortality, as well as, widespread disruption to people’s lives and livelihoods around the world. Given the health and economic threats posed by the pandemic to the global community, there are concerns that rates of suicide and suicidal behaviour may rise during and in its aftermath. Our living systematic review (LSR) focuses on suicide prevention in relation to COVID-19, with this iteration synthesising relevant evidence up to June 7th 2020. Method:  Automated daily searches feed into a web-based database with screening and data extraction functionalities. Eligibility criteria include incidence/prevalence of suicidal behaviour, exposure-outcome relationships and effects of interventions in relation to the COVID-19 pandemic. Outcomes of interest are suicide, self-harm or attempted suicide and suicidal thoughts. No restrictions are placed on language or study type, except for single-person case reports. Results: Searches identified 2070 articles, 29 (28 studies) met our inclusion criteria, of which 14 articles were research letters or pre-prints awaiting peer review. All articles reported observational data: 12 cross-sectional; eight case series; five modelling; and three service utilisation studies. No studies reported on changes in rates of suicidal behaviour. Case series were largely drawn from news reporting in low/middle income countries and factors associated with suicide included fear of infection, social isolation and economic concerns.   Conclusions:  A marked improvement in the quality of design, methods, and reporting in future studies is needed. There is thus far no clear evidence of an increase in suicide, self-harm, suicidal behaviour, or suicidal thoughts associated with the pandemic. However, suicide data are challenging to collect in real time and economic effects are evolving. Our LSR will provide a regular synthesis of the most up-to-date research evidence to guide public health and clinical policy to mitigate the impact of COVID-19 on suicide. PROSPERO registration: CRD42020183326 01/05/2020

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