scholarly journals Physics of blastocoel formation by hydro-osmotic lumen coarsening

2020 ◽  
Author(s):  
Mathieu Le Verge–Serandour ◽  
Hervé Turlier
Keyword(s):  
Scaling Law ◽  
Dynamic Scaling ◽  
Scaling Exponent ◽  
Spatial Bias ◽  
Blastula Stage ◽  
Early Embryos ◽  
Minor Influence ◽  
Self Similar ◽  
A Minor ◽  
Single Cavity

The blastocoel is a fluid-filled cavity characterizing early embryos at blastula stage. It is commonly described as the result of cell division patterning, but in tightly compacted embryos the mechanism underlying its emergence remains unclear. Based on experimental observations, we discuss an alternative physical model by which a single cavity forms by growth and coarsening of myriad of micrometric lumens interconnected through the intercellular space. Considering explicitly ion and fluid exchanges, we find that cavity formation is primarily controlled by hydraulic fluxes, with a minor influence of osmotic heterogeneities on the dynamics. Performing extensive numerical simulations on 1-dimensional chains of lumens, we show that coarsening is self-similar with a dynamic scaling exponent reminiscent of dewetting films over a large range of ion and water permeability values. Adding active pumping of ions to account for lumen growth largely enriches the dynamics: it prevents from collective collapse and leads to the emergence of a novel coalescence-dominated regime exhibiting a distinct scaling law. Finally, we prove that a spatial bias in pumping may be sufficient to position the final cavity, delineating hence a novel mode of symmetry breaking for tissue patterning. Providing generic testable predictions our hydro-osmotic coarsening theory highlights the essential roles of hydraulic and osmotic flows in development, with expected applications in early embryogenesis and lumenogenesis.

scholarly journals A hydro-osmotic coarsening theory of biological cavity formation

2021 ◽  
Vol 17 (9) ◽  
pp. e1009333
Author(s):  
Mathieu Le Verge-Serandour ◽  
Hervé Turlier
Keyword(s):  
Scaling Law ◽  
Minor Role ◽  
Dynamic Scaling ◽  
Scaling Exponent ◽  
Cavity Formation ◽  
Collective Dynamics ◽  
Water Permeation ◽  
Early Embryos ◽  
A Minor ◽  
Ion Pumping

Fluid-filled biological cavities are ubiquitous, but their collective dynamics has remained largely unexplored from a physical perspective. Based on experimental observations in early embryos, we propose a model where a cavity forms through the coarsening of myriad of pressurized micrometric lumens, that interact by ion and fluid exchanges through the intercellular space. Performing extensive numerical simulations, we find that hydraulic fluxes lead to a self-similar coarsening of lumens in time, characterized by a robust dynamic scaling exponent. The collective dynamics is primarily controlled by hydraulic fluxes, which stem from lumen pressures differences and are dampened by water permeation through the membrane. Passive osmotic heterogeneities play, on the contrary, a minor role on cavity formation but active ion pumping can largely modify the coarsening dynamics: it prevents the lumen network from a collective collapse and gives rise to a novel coalescence-dominated regime exhibiting a distinct scaling law. Interestingly, we prove numerically that spatially biasing ion pumping may be sufficient to position the cavity, suggesting a novel mode of symmetry breaking to control tissue patterning. Providing generic testable predictions, our model forms a comprehensive theoretical basis for hydro-osmotic interaction between biological cavities, that shall find wide applications in embryo and tissue morphogenesis.

scholarly journals Stellar Flares: Observations and Theory

1989 ◽  
Vol 104 (2) ◽  
pp. 49-52
Author(s):  
Suzanne L. Hawley
Keyword(s):  
Scaling Law ◽  
Dynamic Scaling ◽  
X Ray ◽  
Temperature Distributions ◽  
Photometric And Spectroscopic Observations ◽  
Stellar Flares ◽  
Consistent Model ◽  
Self Consistent ◽  
Flare Model ◽  
Large Flare

AbstractPhotometric and spectroscopic observations of a very large flare on AD Leo are presented. A self consistent model of a flare corona, transition region and chromosphere is developed; in particular the chromospheric temperature distributions resulting from X-ray and EUV irradiation by coronae of various temperatures are determined. The predicted line fluxes in Hγ are compared to the observed line fluxes to find the coronal temperature as a function of time during the flare. This run of temperature with time is then compared with the predictions of an independent theoretical flare model based on a dynamic scaling law (see paper by Fisher and Hawley, these proceedings).

Structure-activity relations and β-lactamase resistance

1980 ◽  
Vol 289 (1036) ◽  
pp. 197-205 ◽  
Keyword(s):  
Broad Spectrum ◽  
Product Inhibition ◽  
Sulphur Atom ◽  
Chemical Modifications ◽  
Gram Negative ◽  
Structure Activity ◽  
Broad Spectrum Resistance ◽  
Structure Activity Relations ◽  
Minor Influence ◽  
A Minor

β-Lactam antibiotics resistant to β-lactamase degradation can be produced by many chemical modifications, but often at the expense of antibacterial activity. Substitution onto several positions in the molecule produces different and often selective resistance; for instance, heavily sterically hindered acyl groups give staphylococcal P-lactamase resistance to penicillins, and resistance to some enzymes from Gram-negative pathogens to both penicillins and cephalosporins. 6-α- or 7-α-substituents respectively confer a broad spectrum of resistance (e.g. cefoxitin), but changes at positions 2 or 3 have only a minor influence on enzyme susceptibility. Changes in the ring condensed with the β-lactam, such as changing ceph-3-em to ceph-2-em may greatly enhance stability. Small improvements can occur when the nuclear sulphur atom is oxidized, but a much better effect is obtained when it is replaced by another atom such as oxygen, as in clavulanic acid. This compound appears to have broad spectrum resistance which is actually due to susceptibility and subsequent product inhibition.

Lubrication Properties of Aqueous Solutions with Polyethoxylated Ether (PEOE) Added

2011 ◽  
Vol 239-242 ◽  
pp. 1359-1363
Author(s):  
Chao Hui Zhang ◽  
Si Si Liu ◽  
Yue Tao Sun ◽  
Jun Ming Liu
Keyword(s):  
Aqueous Solution ◽  
Aqueous Solutions ◽  
Metal Working ◽  
Functional Additives ◽  
Film Forming ◽  
Minor Influence ◽  
Forming Characteristics ◽  
Aqueous Surfactants ◽  
A Minor ◽  
Lubrication Properties

Aqueous solutions have found broad usages as lubricants, in conjunction with other possible utilizations, such as in metal working and other industries. Due to the inferior lubricity, functional additives are needed to improve their tribological performances among which aqueous surfactants are exclusively included. The film forming property of aqueous solution with polyethoxylated ether added (PEOE) is measured, taking consideration of the influences of the temperature and the concentration. The addition of PEOEs into aqueous solutions will largely increase the film forming capacity. But the concentration has only a minor influence on the lubrication property of the aqueous solutions with PEOEs. The cloud point will strongly alter the film forming characteristics.

scholarly journals Influence of Different Commercial Yeasts on Volatile Fraction of Sparkling Wines

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 247
Author(s):  
Valeriu V. Cotea ◽  
Mihai Cristian Focea ◽  
Camelia Elena Luchian ◽  
Lucia Cintia Colibaba ◽  
Elena Cristina Scutarașu ◽  
...  
Keyword(s):  
International Organization ◽  
Volatile Fraction ◽  
Chemical Parameters ◽  
Physical Chemical ◽  
Organoleptic Characteristics ◽  
Mass Spectrometry Technique ◽  
Minor Influence ◽  
Spectrometry Technique ◽  
A Minor ◽  
Aging Stage

The occurrence of aroma constituents in sparkling wines, with direct impact on their organoleptic characteristics, is affected by several factors, for example the base-wine particularities, grapes cultivar conditions, inoculated yeasts, the aging stage, and wine-making practices. This study evaluated the influence of different four commercial yeasts (IOC FIZZ™, IOC DIVINE™, LEVULIA CRISTAL™, and IOC 18-2007™) on the volatile composition of experimental sparkling wines. For this, five sparkling wines variants from the Muscat Ottonel grape variety were obtained. The base-wine was obtained through reverse osmosis and had a predetermined alcoholic concentration (10.5% vol.). In order to fulfill the proposed purpose, the experimental sparkling wines were characterized by the physical–chemical parameters (according to International Organization of Vine and Wine methods of analysis), volatile fraction (using gas-chromatography coupled with mass spectrometry technique), and sensory descriptors. Data showed a key impact on the concentration of the volatile constituents (p < 0.05), depending on the type of inoculated yeast for the second fermentation. Regarding the sensory analysis, important differences can be observed due to the type of inoculated yeast. Only a minor influence on the physical–chemical parameters was registered.

scholarly journals Phytoplankton thermal responses adapt in the absence of hard thermodynamic constraints

2018 ◽  
Author(s):  
Dimitrios - Georgios Kontopoulos ◽  
Erik van Sebille ◽  
Michael Lange ◽  
Gabriel Yvon-Durocher ◽  
Timothy G. Barraclough ◽  
...  
Keyword(s):  
Thermal Performance ◽  
Thermal Sensitivity ◽  
Meta Analysis ◽  
Habitat Type ◽  
Performance Curve ◽  
Thermal Environments ◽  
Thermal Performance Curve ◽  
Performance Curves ◽  
Minor Influence ◽  
A Minor

AbstractTo better predict how populations and communities respond to climatic temperature variation, it is necessary to understand how the shape of the response of fitness-related traits to temperature evolves (the thermal performance curve). Currently, there is disagreement about the extent to which the evolution of thermal performance curves is constrained. One school of thought has argued for the prevalence of thermodynamic constraints through enzyme kinetics, whereas another argues that adaptation can—at least partly—overcome such constraints. To shed further light on this debate, we perform a phylogenetic meta-analysis of the thermal performance curves of growth rate of phytoplankton—a globally important functional group—, controlling for environmental effects (habitat type and thermal regime). We find that thermodynamic constraints have a minor influence on the shape of the curve. In particular, we detect a very weak increase of maximum performance with the temperature at which the curve peaks, suggesting a weak “hotter-is-better” constraint. Also, instead of a constant thermal sensitivity of growth across species, as might be expected from strong constraints, we find that all aspects of the thermal performance curve evolve along the phylogeny. Our results suggest that phytoplankton thermal performance curves adapt to thermal environments largely in the absence of hard thermodynamic constraints.

Meiofauna constitute a considerable portion of invertebrate drift among moss-rich patches within a karst hydrosystem

Biologia ◽  
2014 ◽  
Vol 69 (3) ◽  
Author(s):  
Mirela Perić ◽  
Tvrtko Dražina ◽  
Maria Špoljar ◽  
Ines Radanović ◽  
Biserka Primc ◽  
...  
Keyword(s):  
Flow Velocity ◽  
Spatial Scale ◽  
Early Summer ◽  
Small Scale ◽  
Invertebrate Drift ◽  
Flow Conditions ◽  
Small Spatial Scale ◽  
Minor Influence ◽  
Drift Density ◽  
A Minor

AbstractAiming to establish the most frequent invertebrate taxa in drift at the small spatial scale within a moss-rich karst tufa-precipitating hydrosystem, we sampled drift among microhabitats differing in substratum type and flow conditions along a tufa barrier-cascading lotic reach. Additionally, we addressed the question of the contribution and the potential significance of meiofauna within the overall invertebrate drift at the small spatial scale. During the study period, a total of 60 invertebrate taxa were recorded in the drift. Six of these taxa belonged to the annelid/arthropod meiofauna and they represented 35% of total drift density. Macroinvertebrates found in drift were represented mainly by larval insects. The composition of the most abundant taxa in total drift was as follows: Alona spp. (Cladocera 26.7%), Riolus spp. (Coleoptera: Elmidae 13.2%), Simulium spp. (Diptera: Simuliidae 12.2%), Enchytraeidae (Oligochaeta 10.4%), Hydrachnidia (6.3%), Orthocladinae (Diptera: Chironomidae 3.9%) and Naididae (Oligochaeta 3.6%). Faunal drift densities and amounts of transported particulate matter (PM) were highest at the fast-flowing sites located at the barriers and lowest at the slow-flowing sites within pools. Similarly to the seasonal amounts of transported PM, faunal drift was lowest in winter, and peaked in autumn and in late spring/early summer. Correlation between flow velocity and PM-faunal drift densities suggested a significant effect of the dislodged PM, though a minor influence of discharge and flow velocity on faunal drift. We suggest that the small-scale habitat heterogeneity and the respective feeding and refugial strategies of the fauna, as well as faunal passive dislodgement initiated by the shear forces of the flow were the most important drivers of observed drift patterns.

scholarly journals Scaling properties of gravity-driven sediments

1995 ◽  
Vol 2 (3/4) ◽  
pp. 178-185 ◽  
Author(s):  
D. H. Rothman ◽  
J. P. Grotzinger
Keyword(s):  
Critical Thickness ◽  
Sedimentary Basin ◽  
Scaling Law ◽  
Scaling Exponent ◽  
Power Law Distribution ◽  
Scaling Properties ◽  
Number Of Layers ◽  
Gravity Driven ◽  
Gravity Driven Flow ◽  
Open Question

Abstract. Recent field observations of the statistical distribution of turbidite and debris flow deposits are discussed. In some cases one finds a good fit over 1.5-2 orders of magnitude to the scaling law N(h) α h-B, where N(h) is the number of layers thicker than h. Observations show that the scaling exponent B varies widely from deposit to deposit, ranging from about 1/2 to 2. Moreover, one case is characterized by a sharp crossover in which B increases by a factor of two as h increases past a critical thickness. We propose that the variations in B, either regional or within the same deposit, are indicative of the geometry of the sedimentary basin and the rheological properties of the original gravity-driven flow. The origin of the power-law distribution remains an open question.

scholarly journals Perspective determines the production and interpretation of pointing gestures

2020 ◽  
Author(s):  
Oliver Herbort ◽  
Lisa-Marie Krause ◽  
Wilfried Kunde
Keyword(s):  
Virtual Reality ◽  
Virtual Reality Environment ◽  
Observer Perspective ◽  
Minor Influence ◽  
Pointing Gestures ◽  
A Minor ◽  
The Relationship

Abstract Pointing is a ubiquitous means of communication. Nevertheless, observers systematically misinterpret the location indicated by pointers. We examined whether these misunderstandings result from the typically different viewpoints of pointers and observers. Participants either pointed themselves or interpreted points while assuming the pointer’s or a typical observer perspective in a virtual reality environment. The perspective had a strong effect on the relationship between pointing gestures and referents, whereas the task had only a minor influence. This suggests that misunderstandings between pointers and observers primarily result from their typically different viewpoints.

Gravity currents with residual trapping

2008 ◽  
Vol 611 ◽  
pp. 35-60 ◽  
Author(s):  
M. A. HESSE ◽  
F. M. ORR ◽  
H. A. TCHELEPI
Keyword(s):  
Scaling Law ◽  
Leading Edge ◽  
Power Laws ◽  
Gravity Currents ◽  
Sharp Interface Model ◽  
Current Volume ◽  
Residual Trapping ◽  
Self Similar ◽  
Loss Term ◽  
Structural Closure

Motivated by geological carbon dioxide (CO2) storage, we present a vertical-equilibrium sharp-interface model for the migration of immiscible gravity currents with constant residual trapping in a two-dimensional confined aquifer. The residual acts as a loss term that reduces the current volume continuously. In the limit of a horizontal aquifer, the interface shape is self-similar at early and at late times. The spreading of the current and the decay of its volume are governed by power-laws. At early times the exponent of the scaling law is independent of the residual, but at late times it decreases with increasing loss. Owing to the self-similar nature of the current the volume does not become zero, and the current continues to spread. In the hyperbolic limit, the leading edge of the current is given by a rarefaction and the trailing edge by a shock. In the presence of residual trapping, the current volume is reduced to zero in finite time. Expressions for the up-dip migration distance and the final migration time are obtained. Comparison with numerical results shows that the hyperbolic limit is a good approximation for currents with large mobility ratios even far from the hyperbolic limit. In gently sloping aquifers, the current evolution is divided into an initial near-parabolic stage, with power-law decrease of volume, and a later near-hyperbolic stage, characterized by a rapid decay of the plume volume. Our results suggest that the efficient residual trapping in dipping aquifers may allow CO2 storage in aquifers lacking structural closure, if CO2 is injected far enough from the outcrop of the aquifer.

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