scholarly journals Interoception of breathing and its relationship with anxiety

2021 ◽  
Author(s):  
Olivia K. Harrison ◽  
Laura Nanz ◽  
Stephanie Marino ◽  
Roger Lüchinger ◽  
Franciszek Hennel ◽  
...  

AbstractInteroception, the perception of bodily states, is thought to be inextricably linked to affective qualities such as anxiety. While interoception spans sensory to metacognitive processing, it is not clear whether anxiety is differentially related to these processing levels. Here we investigated this question in the domain of breathing, using computational modelling and high-field (7 Tesla) fMRI to assess brain activity relating to dynamic changes in respiratory resistance of varying predictability. Notably, the anterior insula was associated with both interoceptive prediction certainty and prediction errors, suggesting an important role in representing and updating models of the body. Individuals with low vs. moderate anxiety traits showed differential anterior insula activity for prediction certainty. Multimodal analyses of data from fMRI, computational assessments of metacognition, and questionnaires demonstrated that anxiety-interoception links span all levels, from perceptual sensitivity to metacognition, with the largest effects seen at higher levels of interoceptive processes.

2019 ◽  
Author(s):  
Zina-Mary Manjaly ◽  
Sandra Iglesias

Mindfulness Based Cognitive Therapy (MBCT) was developed to combine methods from cognitive behavioural therapy and meditative techniques, with the specific goal of preventing relapse in recurrent depression. While supported by empirical evidence from multiple clinical trials, the cognitive mechanisms behind the effectiveness of MBCT are not well understood in computational (information processing) or biological terms.This article introduces a testable theory about the computational mechanisms behind MBCT that is grounded in “Bayesian brain” concepts of perception from cognitive neuroscience, such as predictive coding. These concepts regard the brain as embodying a model of its environment (including the external world and the body) which predicts future sensory inputs and is updated by prediction errors, depending on how precise these error signals are.This article offers a concrete proposal how core concepts of MBCT – the being mode, decentring, and reactivity – could be understood in terms of perceptual and metacognitive processes that draw on specific computational mechanisms of the “Bayesian brain”. Importantly, the proposed theory can be tested experimentally, using a combination of behavioural paradigms, computational modelling, and neuroimaging. The novel theoretical perspective on MBCT described in this paper may offer opportunities for finessing the conceptual and practical aspects of MBCT.


2016 ◽  
Vol 1 (45) ◽  
Author(s):  
Bruno Pires Miranda

Resumo O osso é um tecido conjuntivo especializado, vascularizado e dinâmico que se modifica ao longo do organismo. Quando lesado, possui uma capacidade única de regeneração e reparação sem a presença de cicatrizes, mas em algumas situações devido tamanho do defeito ósseo não se regenera por completo. Assim, se faz necessária a realização de procedimentos de regeneração óssea guiada. Para isso, o implantodontista deve conhecer as bases biológicas da regeneração óssea guiada alveolar e suas indicações. Nesta revisão foram abordadas indicações, vantagens e tipos de biomateriais utilizados para preenchimento do alvéolo dentário imediatamente após a extração dentária sempre que o objetivo for à reabilitação através da instalação de implantes. Mesmo este, biomateriais, apresentando inúmeras qualidades, estudos ainda devem ser feitos a fim de obter a cada dia, um material sintético compatível com o tecido ósseo perdido em quantidades adequadas sem necessitar de cirurgias extra-bucais.ABSTRACT Bone is a specialized vascularized connective tissue that dynamic changes throughout the body. When injured, it has a unique ability to regenerate and repair without the presence of scars, but in some situations due to size of the bone defect does not regenerate completely. Thus, it is necessary to perform guided bone regeneration procedures. For this, the implant dentistry must know the biological bases of alveolar guided bone regeneration and its indications. In this review were addressed indications, advantages and types of biomaterials used for filling the tooth socket immediately after the tooth extraction whenever the goal is rehabilitation through implants installation. Even this, biomaterials, having several qualities, further studies must be done to obtain each day, a synthetic material compatible with the bone tissue lost in proper amounts without the need of extra-oral surgery.


2021 ◽  
Vol 11 (7) ◽  
pp. 946
Author(s):  
Won-Mo Jung ◽  
In-Seon Lee ◽  
Ye-Seul Lee ◽  
Yeonhee Ryu ◽  
Hi-Joon Park ◽  
...  

Emotional perception can be shaped by inferences about bodily states. Here, we investigated whether exteroceptive inferences about bodily sensations in the chest area influence the perception of fearful faces. Twenty-two participants received pseudo-electrical acupuncture stimulation at three different acupoints: CV17 (chest), CV23 (chin), and PC6 (left forearm). All stimuli were delivered with corresponding visual cues, and the control condition included visual cues that did not match the stimulated body sites. After the stimulation, the participants were shown images with one of five morphed facial expressions, ranging from 100% fear to 100% disgust, and asked to classify them as fearful or disgusted. Brain activity was measured using functional magnetic resonance imaging during the facial expression classification task. When the participants expected that they would receive stimulation of the chest (CV17), the ratio of fearful to non-fearful classifications decreased compared to the control condition, and brain activities within the periaqueductal gray and the default mode network decreased when they viewed fearful faces. Our findings suggest that bodily sensations around the chest, but not the other tested body parts, were selectively associated with fear perception and that altering external inferences inhibited the perception of fearful faces.


2012 ◽  
Vol 17 (1) ◽  
pp. 5-26
Author(s):  
Hans Goller

Neuroscientists keep telling us that the brain produces consciousness and consciousness does not survive brain death because it ceases when brain activity ceases. Research findings on near-death-experiences during cardiac arrest contradict this widely held conviction. They raise perplexing questions with regard to our current understanding of the relationship between consciousness and brain functions. Reports on veridical perceptions during out-of-body experiences suggest that consciousness may be experienced independently of a functioning brain and that self-consciousness may continue even after the termination of brain activity. Data on studies of near-death-experiences could be an incentive to develop alternative theories of the body-mind relation as seen in contemporary neuroscience.


2019 ◽  
Author(s):  
A. Wiehler ◽  
K. Chakroun ◽  
J. Peters

AbstractGambling disorder is a behavioral addiction associated with impairments in decision-making and reduced behavioral flexibility. Decision-making in volatile environments requires a flexible trade-off between exploitation of options with high expected values and exploration of novel options to adapt to changing reward contingencies. This classical problem is known as the exploration-exploitation dilemma. We hypothesized gambling disorder to be associated with a specific reduction in directed (uncertainty-based) exploration compared to healthy controls, accompanied by changes in brain activity in a fronto-parietal exploration-related network.Twenty-three frequent gamblers and nineteen matched controls performed a classical four-armed bandit task during functional magnetic resonance imaging. Computational modeling revealed that choice behavior in both groups contained signatures of directed exploration, random exploration and perseveration. Gamblers showed a specific reduction in directed exploration, while random exploration and perseveration were similar between groups.Neuroimaging revealed no evidence for group differences in neural representations of expected value and reward prediction errors. Likewise, our hypothesis of attenuated fronto-parietal exploration effects in gambling disorder was not supported. However, during directed exploration, gamblers showed reduced parietal and substantia nigra / ventral tegmental area activity. Cross-validated classification analyses revealed that connectivity in an exploration-related network was predictive of clinical status, suggesting alterations in network dynamics in gambling disorder.In sum, we show that reduced flexibility during reinforcement learning in volatile environments in gamblers is attributable to a reduction in directed exploration rather than an increase in perseveration. Neuroimaging findings suggest that patterns of network connectivity might be more diagnostic of gambling disorder than univariate value and prediction error effects. We provide a computational account of flexibility impairments in gamblers during reinforcement learning that might arise as a consequence of dopaminergic dysregulation in this disorder.


2019 ◽  
Author(s):  
Paddy Ross ◽  
Beatrice de Gelder ◽  
Frances Crabbe ◽  
Marie-Hélène Grosbras

AbstractEmotions are strongly conveyed by the human body and the ability to recognize emotions from body posture or movement is still developing through childhood and adolescence. To date, there are very few studies exploring how these behavioural observations are paralleled by functional brain development. Furthermore, there are currently no studies exploring the development of emotion modulation in these areas. In the current study, we used functional magnetic resonance imaging (fMRI) to compare the brain activity of 25 children (age 6-11), 18 adolescents (age 12-17) and 26 adults while they passively viewed short videos of angry, happy or neutral body movements. We observed that when viewing bodies generally, adults showed higher activity than children bilaterally in the body-selective areas; namely the extra-striate body area (EBA), fusiform body area (FBA), posterior superior temporal sulcus (pSTS) and amygdala (AMY). Adults also showed higher activity than adolescents, but only in right hemisphere body-selective areas. Crucially, however, we found that there were no age differences in the emotion modulation of activity in these areas. These results indicate, for the first time, that despite activity selective to body perception increasing across childhood and adolescence, emotion modulation of these areas in adult-like from 7 years of age.Conflict of InterestThe author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.


2021 ◽  
Vol 22 (1) ◽  
pp. 78-83
Author(s):  
Jonas Gonçalves Coelho

Many neuroscientific experiments, based on monitoring brain activity, suggest that it is possible to predict the conscious intention/choice/decision of an agent before he himself knows that. Some neuroscientists and philosophers interpret the results of these experiments as showing that free will is an illusion, since it is the brain and not the conscious mind that intends/chooses/decides. Assuming that the methods and results of these experiments are reliable the question is if they really show that free will is an illusion. To address this problem, I argue that first it is needed to answer three questions related to the relationship between conscious mind and brain: 1. Do brain events cause conscious events? 2. Do conscious events cause brain events? 3. Who is the agent, that is, who consciously intends/chooses/ decides, the conscious mind, the brain, or both? I answer these questions by arguing that the conscious mind is a property of the brain due to which the brain has the causal capacity to interact adaptively with its body, and trough the body, with the physical and sociocultural environment. In other words, the brain is the agent and the conscious mind, in its various forms - cognitive, volitional and emotional - and contents, is its guide of action. Based on this general view I argue that the experiments aforementioned do not show that free will is an illusion, and as a starting point for examining this problem I point out, from some exemplary situations, what I believe to be some of the necessary conditions for free will.Key-words: Agent brain, conscious mind, free will, Libet-style experiments.


2021 ◽  
Vol 11 (11) ◽  
pp. 1384
Author(s):  
Fabienne Picard ◽  
Peter Bossaerts ◽  
Fabrice Bartolomei

Ecstatic epilepsy is a rare form of focal epilepsy in which the aura (beginning of the seizures) consists of a blissful state of mental clarity/feeling of certainty. Such a state has also been described as a “religious” or mystical experience. While this form of epilepsy has long been recognized as a temporal lobe epilepsy, we have accumulated evidence converging toward the location of the symptomatogenic zone in the dorsal anterior insula during the 10 last years. The neurocognitive hypothesis for the genesis of a mental clarity is the suppression of the interoceptive prediction errors and of the unexpected surprise associated with any incoming internal or external signal, usually processed by the dorsal anterior insula. This mimics a perfect prediction of the world and induces a feeling of certainty. The ecstatic epilepsy is thus an amazing model for the role of anterior insula in uncertainty and surprise.


Author(s):  
Richard Swinburne

For the Greeks, the soul is what gives life to the body. Plato thought of it as a thing separate from the body. A human living on earth consists of two parts, soul and body. The soul is the essential part of the human – what makes me me. It is the part to which the mental life of humans pertains – it is the soul which thinks and feels and chooses. Soul and body interact. Bodily states often cause soul states, and soul states often cause bodily states. This view is known as substance dualism. It normally includes the view that the soul is simple, that it does not have parts. If an object has parts, then one of those parts can have properties which another part does not. But for any experience that I have, an auditory or visual sensation or thought, it happens to the whole me. Plato also held that at death, soul and body are separated; the body decays while the soul departs to live another life. Aristotle, by contrast, thought of the soul simply as a ‘form’, that is, as a way of behaving and thinking; a human having a soul just is the human behaving (by moving parts of the body) and thinking in certain characteristic human ways. And just as there cannot be a dance without people dancing, so there cannot be ways of behaving without embodied humans to behave in those ways. Hence, for Aristotle, the soul does not exist without the body. Christian theology, believing in life after death, found it natural to take over Plato’s conception of the soul. But in the thirteenth century, St Thomas Aquinas sought to develop an Aristotelian conception modified to accommodate Christian doctrine. The soul, Aquinas taught, was indeed a form, but a special kind of form, one which could temporarily exist without the body to which it was naturally fitted. It has always been difficult to articulate this view in a coherent way which makes it distinct from Plato’s. Descartes restated Plato’s view. In more modern times, the view that humans have souls has always been understood as the view that humans have an essential part, separable from the body, as depicted by Plato and Aquinas. The pure Aristotelian view has more normally been expressed as the view that humans do not have souls; humans consist of matter alone, though it may be organized in a very complicated way and have properties that inanimate things do not have. In other words, Aristotelianism is a kind of materialism. If, however, one thinks of the soul as a thing separable from the body, it could still cease to exist at death, when the body ceases to function. Plato had a number of arguments designed to show that the soul is naturally immortal; in virtue of its own nature, because of what it is, it will continue to exist forever. Later philosophers have developed some of these arguments and produced others. Even if these arguments do not show it (and most philosophers think that they do not), the soul may still be naturally immortal; or it may be immortal because God or some other force keeps it in being forever, either by itself or joined to a new body. If there is an omnipotent God, he could keep it in existence forever; and he might have revealed to us that he is going to do so.


Neuroforum ◽  
2018 ◽  
Vol 24 (4) ◽  
pp. A151-A158
Author(s):  
Gundela Meyer

Abstract The human insula is a key node in a neuronal network which integrates interoceptive stimuli from the own body, and exteroceptive stimuli from the environment, and thus maintains the autonomic, emotional and socio-cognitive homeostasis of the body. In the last years, the insula has come into the focus of attention. Comparative anatomical studies showed that in many species the insula forms the lateral edge of the cortex. Very little is known about the prenatal development of the human insula, which is the first cortical region to mature. The origin of the pyramidal neurons for the insula is a small sector of the proliferating ventricular/subventricular zone at the cortico-striatal boundary (CSB). The CSB contains the radial glia cells, which are stem cells and give rise to a dense fascicle of radial glia processes. This fascicle traverses the external capsule and serves as a migration substrate for the neuroblasts on their way from the CSB into the insula. Around the 10/11th week of gestation, the lateral ventricle and its adjacent structures including the CSB bend in a C-shaped fashion. The insula now develops between a dorsal, fronto-parietal and a ventral, temporal CSB, which provide descending and ascending streams of neuroblasts, respectively, migrating along the radial glia fascicle. As a consequence of the ventricular rotation during ontogenesis, the human insula changes its initial position at the lateral edge of the cortex to its final central location, which reflects its integrative functions in brain activity.


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