scholarly journals Effectiveness of the BNT162b2 vaccine in preventing COVID-19 in the working age population – first results from a cohort study in Southern Sweden

Author(s):  
Jonas Björk ◽  
Malin Inghammar ◽  
Mahnaz Moghaddassi ◽  
Magnus Rasmussen ◽  
Ulf Malmqvist ◽  
...  

AbstractBackgroundVaccine effectiveness against COVID-19 needs to be assessed in diverse real-world population settings.MethodsA cohort study of 805 741 residents in Skåne county, Southern Sweden, aged 18-64 years, of whom 26 587 received at least one dose of the BNT162b2 vaccine. Incidence rates of COVID-19 were estimated in sex- and age-adjusted analysis and stratified in two-week periods with substantial community spread of the disease.ResultsThe estimated vaccine effectiveness in preventing infection ≥7 days after second dose was 86% (95% CI 72-94%) but only 42% (95% CI 14-63%) ≥14 days after a single dose. No difference in vaccine effectiveness was observed between females and males. Having a prior positive test was associated with 91% (95% CI 85 to 94%) effectiveness against new infection among the unvaccinated.ConclusionA satisfactory effectiveness of BNT162b2 after the second dose was suggested, but with possibly substantially lower effect before the second dose.

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e043276
Author(s):  
Juhani Juhola ◽  
J P A Arokoski ◽  
Jenni Ervasti ◽  
Mika Kivimäki ◽  
Jussi Vahtera ◽  
...  

ObjectivesTo assess the internal consistency and construct validity of the Finnish translation of the Jenkins Sleep Scale (JSS) in a large healthy working-age population with diverse work characteristics.DesignSurvey-based cross-sectional cohort study.SettingSurvey conducted by an institute of occupational health.ParticipantsEmployees of 10 towns and 6 hospital districts.Primary and secondary outcome measuresThe internal consistency defined by a Cronbach’s alpha. Exploratory and confirmatory factor analyses to evaluate the construct structure of the JSS.ResultsOf 81 136 respondents, 14 890 (18%) were men and 66 246 (82%) were women. Their average age was 52.1 (13.2) years. Of the respondents, 41 823 (52%) were sleeping 7 or less hours per night. The mean JSS total score was 6.4 (4.8) points. The JSS demonstrated high internal consistency with an alpha of 0.80 (lower 95% confidence limit 0.80). Exploratory factor analysis supported a one-factor solution with eigenvalue of 1.94. Confirmatory factor analysis showed that all four items were positively correlated with a single common factor explaining 44%–61% of common factor’s variance.ConclusionsThe Finnish translation of JSS was found to be a unidimensional scale with good internal consistency. As such, the scale may be recommended as a practicable questionnaire when studying sleep difficulties in a healthy working-age population.


Author(s):  
AS Shastin ◽  
VG Gazimova ◽  
OL Malykh ◽  
TS Ustyugova ◽  
TM Tsepilova

Introduction: In the context of a decreasing size of the working-age population, monitoring of the health status and disease incidence in this cohort shall be one of the most important tasks of public and occupational health professionals. Health risk management for the working population in the Russian Federation requires complete and reliable data on its morbidity, especially in view of the fact that its average age demonstrates a stable growth. It is, therefore, crucial to have precise and consistent information about the morbidity of the working-age population. Objective: The study aimed to assess incidence rates of diseases with temporary incapacity for work in the constituent entities of the Ural Federal District of the Russian Federation. Materials and methods: We reviewed data on disease incidence rates published by the Federal State Statistics Service in the Common Interdepartmental System of Statistical Information, Section 15.12, Causes of Temporary Disability, and Section 2.9.I.4, Federal Project for Public Health Promotion. The constituent entities under study were ranked according to the number of cases and days of temporary incapacity per 100 workers and E.L. Notkin scale was used to determine grade the incidence. The statistical analysis was performed using STATISTICA 10 software. Long-term average values of certain indicators, median values, standard deviation (σ) and coefficients of variation were estimated. The difference in the indices was assessed using the Mann-Whitney test. Results: Compared to 2010, incidence rates of diseases with temporary incapacity for work in the constituent entities of the Ural Federal District in 2019 demonstrated a significant decline. The sharp drop was observed in 2015. We also established that the Common Interdepartmental System of Statistical Information contains contradictory information on disease incidence. Conclusion: It is expedient to consider the issue of revising guidelines for organization of federal statistical monitoring of morbidity with temporary incapacity for work and to include this indicator in the system of public health monitoring.


PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237617
Author(s):  
Nobuhiro Ooba ◽  
Rira Iwahashi ◽  
Akiko Nogami ◽  
Toshimitsu Nakayama ◽  
Atsushi Kanno ◽  
...  

2013 ◽  
Vol 24 (2) ◽  
pp. 244-248 ◽  
Author(s):  
A. H. Entonen ◽  
S. B. Suominen ◽  
K. Korkeila ◽  
P. T. Mantyselka ◽  
L. H. Sillanmaki ◽  
...  

Author(s):  
VG Gazimova ◽  
AS Shastin ◽  
OL Malykh ◽  
TM Tsepilova ◽  
TS Ustyugova

Background: Achievement of the national goals to increase life expectancy and ensure sustained population growth in the Russian Federation largely depends on the health status and mortality rates in the working-age population. Health risk management for this cohort is impossible without effective disease incidence data, the lack of which impedes the development and implementation of optimal solutions in health maintenance. Objective: To assess rates and features of disease incidence in the working-age population of the Ural Federal District. Materials and methods: We acquired data on disease incidence in the Russian Federation from statistical yearbooks published on the website of the Federal Research Institute for Health Organization and Informatics of the Russian Ministry of Health and on the size of the working-age population from the Federal State Statistics Service. We estimated age-specific incidence rates (per 100,000) in the working-age population of the Russian Federation, the Ural Federal District and its administrative territories for 2015–2019 using MS Excel. The statistical data analysis was performed using the Statistica 10 software. The incidence structure by ICD-10 disease categories was determined. Results: We were first to establish absolute and relative incidence rates, incidence structure by ICD-10 disease categories, and regional features of disease incidence in the working-age population residing in the Ural Federal District. We found significant differences between district and federal average incidence rates. Conclusions: The incidence in the Ural Federal District was significantly higher than the national average. Incidence rates differed significantly between certain territories of the district. Incidence rates in the working-age population shall be included in the system of public health monitoring and taken into account when developing local programs of governmental guarantees of free medical services to citizens.


2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
E.K. Rosendahl ◽  
N. Carlson ◽  
K. Kragholm ◽  
G. Gislason ◽  
C. Torp-Pedersen ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fabian Tetzlaff ◽  
Jelena Epping ◽  
Juliane Tetzlaff ◽  
Heiko Golpon ◽  
Siegfried Geyer

Abstract Background Lung Cancer (LC) is one of the most prevalent cancer diseases. Due to the lack of databases which allow the combination of information on individual socioeconomic status (SES) and cancer incidence, research on social inequalities in LC among the German population is rare. The aim of the study is to analyse time trends in social inequalities in LC in Germany. Methods The analyses are based on data of a large statutory health insurance provider. The data contain information on diagnoses, occupation and education (working age), and income (full age range) of the insurance population. Trends were analysed for two subpopulations (retirement age and working age) and stratified by sex. The analyses are based on incidence rates and proportional hazard models spanning the periods 2006–2009, 2010–2013 and 2014–2017. Results Incidence rates declined in men but increased in women. For men, inequalities were strongest in terms of income and the decline in incidence was most pronounced in middle- and higher-income men. Among women at retirement age, a reversed income gradient was found which disappeared in the second period. The educational gradient among the working-age population decreased over time due to the trend towards increasing incidence among individuals with higher education. Declining gradients were also found for occupational position. Conclusion The findings reveal considerable inequalities in LC and that trends vary with respect to SES, sex and age. Widening income inequalities were found in the retired population, while educational and occupational inequalities tend to narrow among the working-age population.


1999 ◽  
Author(s):  
IJmert Kant ◽  
Helga J. van den Elzen ◽  
Anna J. H. M. Beurskens ◽  
Ute Bultmann ◽  
Gerard M. H. Swaen

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