Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus of the coronavirus family that causes coronavirus disease-19 (COVID-19) in humans and a number of animal species. COVID-19 has rapidly propagated in the world in the past 2 years, causing a global pandemic. Here, we performed proteomic analysis of plasma samples from COVID-19 patients compared to healthy control donors in an exploratory study to gain insights into protein-level changes in the patients caused by SARS-CoV-2 infection and to identify potential proteomic and posttranslational signatures of this disease. Our results suggest a global change in protein processing and regulation that occurs in response to SARS-CoV-2, and the existence of a posttranslational COVID-19 signature that includes an elevation in threonine phosphorylation, a change in glycosylation, and a decrease in arginylation, an emerging posttranslational modification not previously implicated in infectious disease. This study provides a resource for COVID-19 researchers and, longer term, will inform our understanding of this disease and its treatment.

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Understanding the Motivations Influencing Ecological Boycott Participation: An Exploratory Study in Viet Nam

Sustainability ◽

10.3390/su10124786 ◽

2018 ◽

Vol 10 (12) ◽

pp. 4786

Author(s):

Thanh Nguyen ◽

Hai Ngo ◽

Pham Ngo ◽

Gi-Du Kang

Keyword(s):

Southeast Asia ◽

Exploratory Study ◽

Meaning In Life ◽

Viet Nam ◽

Environmentally Sustainable ◽

The Past ◽

Health Consciousness ◽

The World ◽

Valid Knowledge ◽

Depth Interviews

Over the past years, the world has witnessed the growth of ecological boycotts and its impact is increasing leading to the need to better understand this field. Following this movement, Viet Nam, located in Southeast Asia has also swiftly been paying attention to ecological concerns, which have resulted in a variety of ecological boycotts in recent years. While motivations for economic, religious, social, and political boycotts have previously been investigated, the motivations for participation in ecological boycotts have not yet been considered appropriately. This study highlights that a means-end chain (MEC) theory provides an influential method which helps reveal the motives that drive consumers to participate in the ecological boycott in Viet Nam. Processing several in-depth interviews of 60 Vietnamese boycotters and performing MEC analysis, results have shown five major motivations for participation in ecological boycotts, comprising environmentally sustainable consciousness, health consciousness, self-enhancement, meaning in life, and security. The findings are expected to contribute towards both academic aspects (additional understanding related to ecological boycott) and practical aspects (providing valid knowledge for organizers of boycotts and targeted companies to evaluate the ecological boycott and determine factors that can be modified).

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Consumer perceptions of environmentally friendly products

South African Journal of Business Management ◽

10.4102/sajbm.v25i2.843 ◽

1994 ◽

Vol 25 (2) ◽

pp. 59-64

Author(s):

M. T. Bendixen ◽

M. Sandler ◽

D. Seligman

Keyword(s):

Exploratory Study ◽

Environmentally Friendly ◽

Consumer Perceptions ◽

Environmental Benefits ◽

Green Products ◽

Political Issue ◽

The Past ◽

The World ◽

Developed Nations

During the past decade, concern for the environment has emerged as a major socio-political issue among developed nations throughout the world and the increase in the number of environmentally friendly or 'green' products has been significant. The purpose of this exploratory study was to determine the types of products that are considered to be environmentally friendly as well as establishing consumer perceptions of these products. One of the main findings of the research was that 'green' products have achieved substantial awareness among consumers and they are not regarded as a gimmick or a fad. It was also established that the two main barriers that discouraged consumers from purchasing 'green' products were a perception that such products were not price competitive and scepticism regarding their supposed environmental benefits.

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Global epidemiology of Equine Influenza viruses; “A possible emerging zoonotic threat in future” an extensive systematic review with evidence

Brazilian Journal of Biology ◽

10.1590/1519-6984.246591 ◽

2023 ◽

Vol 83 ◽

Author(s):

A. Khan ◽

M. H. Mushtaq ◽

J. Muhammad ◽

B. Ahmed ◽

E. A. Khan ◽

...

Keyword(s):

Animal Species ◽

Influenza Viruses ◽

Human Beings ◽

Virus Infections ◽

Equine Influenza Virus ◽

Equine Influenza ◽

The Past ◽

Global Epidemiology ◽

The World ◽

Recent Developments

Abstract There are different opinions around the World regarding the zoonotic capability of H3N8 equine influenza viruses. In this report, we have tried to summarize the findings of different research and review articles from Chinese, English, and Mongolian Scientific Literature reporting the evidence for equine influenza virus infections in human beings. Different search engines i.e. CNKI, PubMed, ProQuest, Chongqing Database, Mongol Med, and Web of Knowledge yielded 926 articles, of which 32 articles met the inclusion criteria for this review. Analyzing the epidemiological and Phylogenetic data from these articles, we found a considerable experimental and observational evidence of H3N8 equine influenza viruses infecting human being in different parts of the World in the past. Recently published articles from Pakistan and China have highlighted the emerging threat and capability of equine influenza viruses for an epidemic in human beings in future. In this review article we have summarized the salient scientific reports published on the epidemiology of equine influenza viruses and their zoonotic aspect. Additionally, several recent developments in the start of 21st century, including the transmission and establishment of equine influenza viruses in different animal species i.e. camels and dogs, and presumed encephalopathy associated to influenza viruses in horses, have documented the unpredictable nature of equine influenza viruses. In sum up, several reports has highlighted the unpredictable nature of H3N8 EIVs highlighting the need of continuous surveillance for H3N8 in equines and humans in contact with them for novel and threatening mutations.

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Rapid Development and Deployment of Respiratory Evaluation Clinics in Response to the COVID-19 Pandemic to Keep Staff and Patients Safe

Osteopathic Family Physician ◽

10.33181/13025 ◽

2021 ◽

pp. 38-42

Author(s):

Charles Haddad ◽

Christopher Scuderi ◽

Judelle Haddad-Lacle ◽

Reetu Grewal ◽

Jeffrey Jacqmein ◽

...

Keyword(s):

Infectious Disease ◽

Rapid Development ◽

Lessons Learned ◽

The Novel ◽

Global Pandemic ◽

Vulnerable Patients ◽

The World ◽

Novel Coronavirus ◽

Geographical Locations ◽

The U.S

The world as we knew it changed at the beginning of 2020 with the explosion of the global pandemic caused by SARS-CoV-2, a.k.a. COVID-19. As of January 10, 2021, the novel coronavirus has infected over 89 million people worldwide and killed over 1.9 million. In the U.S., there have been 22 million people infected and 373,000 deaths. It has never been more important to protect our vulnerable patients and staff from infectious disease, especially during the time they spend in our offices and clinics. It quickly became apparent that there was a need for a dedicated location where patients could be seen that were too ill to be evaluated via telemedicine, but not ill enough to be sent to the Emergency Department (ED). To fill this need, our primary care network developed the Respiratory Evaluation Clinic (REC) concept. These were two geographical locations where the outlying clinics could send potentially infectious patients to evaluate and test COVID-19. Some recommendations, adaptations, lessons learned and the REC clinics' expansions to other locations throughout our network are discussed.

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COVID-19 Exposes Warped Global Health Power: The System Needs a Course Correction

Business and Human Rights Journal ◽

10.1017/bhj.2021.38 ◽

2021 ◽

pp. 1-8

Author(s):

Aruna KASHYAP ◽

Kyle KNIGHT ◽

Margaret WURTH

Keyword(s):

Global Health ◽

World Health Organization ◽

World Health ◽

Arundhati Roy ◽

The Past ◽

Global Pandemic ◽

The World ◽

Health Organization

Just three weeks after the World Health Organization (WHO) recognized COVID-19 as a global pandemic, novelist Arundhati Roy wrote: ‘Historically, pandemics have forced humans to break with the past and imagine their world anew. This one is no different. It is a portal, a gateway between one world and the next.’1

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Infectious Disease, Endangerment, and Extinction

International Journal of Evolutionary Biology ◽

10.1155/2013/571939 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 35

Author(s):

Ross D. E. MacPhee ◽

Alex D. Greenwood

Keyword(s):

Infectious Disease ◽

Animal Species ◽

Species Level ◽

Primary Factor ◽

The Past ◽

Population Fitness

Infectious disease, especially virulent infectious disease, is commonly regarded as a cause of fluctuation or decline in biological populations. However, it is not generally considered as a primary factor in causing the actual endangerment or extinction of species. We review here the known historical examples in which disease has, or has been assumed to have had, a major deleterious impact on animal species, including extinction, and highlight some recent cases in which disease is the chief suspect in causing the outright endangerment of particular species. We conclude that the role of disease in historical extinctions at the population or species level may have been underestimated. Recent methodological breakthroughs may lead to a better understanding of the past and present roles of infectious disease in influencing population fitness and other parameters.

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Efficiency vs. Resilience: Lessons from COVID-19

10.1007/978-3-030-86144-5_38 ◽

2021 ◽

pp. 285-289

Author(s):

Moshe Y. Vardi

Keyword(s):

High Likelihood ◽

Short Term ◽

The Past ◽

Global Pandemic ◽

The World ◽

Economic Goal

AbstractWhy was the world not ready for COVID-19, in spite of many warnings over the past 20 years of the high likelihood of a global pandemic? This chapter argues that the economic goal of efficiency, focused on short-term optimization, has distracted us from resilience, which is focused on long-term optimization. Computing also seems to have generally emphasized efficiency at the expense of resilience. But computing has discovered that resilience is enabled by redundancy and distributivity. These principles should be adopted by society in the “after-COVID” era.

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The familiar places we dream about: Pokémon GO and nostalgia during a global pandemic

10.33767/osf.io/pf2t6 ◽

2021 ◽

Author(s):

Gwyneth Peaty ◽

Tama Leaver

Keyword(s):

The Past ◽

Additional Layer ◽

Global Pandemic ◽

Outdoor Spaces ◽

The World ◽

Pokémon Go ◽

Restricted Mobility ◽

Societal Trauma ◽

The Impact ◽

Player Experiences

This article explores the impact of COVID-19 on the developers and players of Pokémon GO through the lens of nostalgia. Focusing on the game as a nostalgic text that works to remediate physical and social spaces, we examine how gameplay has changed in response to players’ restricted mobility and isolation during the 2020 global pandemic. The release of Pokémon GO in 2016 was a watershed moment in the development of mobile augmented reality games. Building on a popular culture franchise familiar to many, it fused cutting-edge technology with memories of the past. Previous studies suggest playing Pokémon GO is associated with dreamlike nostalgia for childhood adventures. But these experiences were intimately linked with physical movement, proximity to others, and the exploration of outdoor spaces. Confined to their homes during the COVID-19 pandemic, once free-roaming players are now being encouraged to embrace isolated, sedentary play. There is an additional layer of nostalgia in operation as players and developers alike reminisce about socializing and playing in the world outside the home. This article therefore explores how Pokémon GO mediates player experiences and unpacks its role in negotiating both memory and contemporary societal trauma.

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Insights Into the Changing Landscape of Coronavirus Disease 2019

Frontiers in Cellular and Infection Microbiology ◽

10.3389/fcimb.2021.761521 ◽

2022 ◽

Vol 11 ◽

Author(s):

Ruby A. Escobedo ◽

Deepak Kaushal ◽

Dhiraj K. Singh

Keyword(s):

Infectious Disease ◽

Personalized Medicine ◽

Severe Acute Respiratory Syndrome ◽

Clinical Manifestations ◽

World Health ◽

Disease Treatment ◽

Global Pandemic ◽

The World ◽

Dynamic Landscape ◽

Health Organization

Coronavirus disease 2019 (COVID-19) is a highly contagious, infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in late 2019 in Wuhan China. A year after the World Health Organization declared COVID-19 a global pandemic, over 215 million confirmed cases and approximately 5 million deaths have been reported worldwide. In this multidisciplinary review, we summarize important insights for COVID-19, ranging from its origin, pathology, epidemiology, to clinical manifestations and treatment. More importantly, we also highlight the foundational connection between genetics and the development of personalized medicine and how these aspects have an impact on disease treatment and management in the dynamic landscape of this pandemic.

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Preventing the next pandemic

10.38105/spr.a0k8wrx6ma ◽

2021 ◽

pp. 68-75

Author(s):

Michelle Matzko ◽

Marie Floryan ◽

Christian Loyo ◽

Colin O'Leary ◽

Allison Stout

Keyword(s):

Public Health ◽

Pathogen Detection ◽

Pandemic Preparedness ◽

Supply Chain Disruptions ◽

The Past ◽

Global Pandemic ◽

The World ◽

Multi Level ◽

Threat Recognition ◽

Health Messaging

Scientists have increasingly sounded the alarm about insufficient global pandemic preparedness, messaging which has appropriately escalated in the past two decades after the SARS (Severe acute respiratory syndrome), MERS (Middle East respiratory syndrome), and Ebola outbreaks [1]. This global lack of readiness was revealed during the most recent COVID-19 pandemic via slow threat recognition, early mixed public health messaging, supply chain disruptions, and vaccine rollout challenges [2]. This article reviews how pandemic pathogens originate and describes methods of early pathogen detection. It also details how multi-level interventions such as public health messaging, widespread accessible testing, and international cooperation, including funding, are critical tools for mitigating the spread of disease. Finally, we discuss how advancements in biotechnology help counter widespread outbreaks, including the use of early molecular diagnostics, application of therapeutics, and the development of "plug and play" vaccines. The world demands early and strong preparation to prevent the next pandemic.

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