scholarly journals Antibody Responses to 3rd Dose mRNA Vaccines in Nursing Home and Assisted Living Residents

2021 ◽  
Author(s):  
Ali Zhang ◽  
Jessica A Breznik ◽  
Rumi Clare ◽  
Ishac Nazy ◽  
Matthew S Miller ◽  
...  
Keyword(s):  
Nursing Home ◽  
Assisted Living ◽  
Nursing Home Residents ◽  
Humoral Response ◽  
Antibody Responses ◽  
Wild Type ◽  
Neutralization Capacity ◽  
Vaccine Recommendations ◽  
Variant Virus ◽  
Dose Vaccine

A comparison of SARS-CoV-2 wild-type and the beta variant virus neutralization capacity between 2 and 3 mRNA vaccine series in nursing home residents, and between nursing home and assisted living residents strongly supports 3rd dose vaccine recommendations, and equivalent polices for nursing homes and assisted living settings. Findings suggest that residents mount a robust humoral response to a 3rd mRNA vaccination, and have greater neuralization capacity compared to a 2 dose series.

scholarly journals From Micro to Macro: Exploring Preference-Based Person Centered Care from Multiple Perspectives

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 836-836
Author(s):  
Katherine Abbott ◽  
Kristine Williams
Keyword(s):  
Nursing Home ◽  
Assisted Living ◽  
Fixed Effects ◽  
Nursing Home Residents ◽  
Direct Care ◽  
Multiple Perspectives ◽  
Person Centered Care ◽  
Fixed Effects Panel Regression ◽  
Centered Care ◽  
The Impact

Abstract Advancing our knowledge related to honoring nursing home resident preferences is a cornerstone of person-centered care (PCC). While there are multiple approaches to providing PCC, we focus on resident preferences as assessed via the Preferences for Everyday Living Inventory (PELI). The PELI is an evidenced-based, validated instrument that can be used to enhance the delivery of PCC. In this symposium, we explore the perspectives of a variety of stakeholders including nursing home residents, staff, and the impact of preference-based care on provider level regulatory outcomes. First, we present a comparative study of preference importance among n=317 African America and White nursing home residents that found more similarities than differences between the two groups. Second, a content analysis of the responses from n=196 interviews with nursing home residents details the barriers and facilitators connected to their levels of satisfaction with their preferences being fulfilled. Third, perspectives from n=27 direct care workers explore the concept of pervasive risk avoidance to the delivery of PCC. Fourth, systems-level practices, such as shift assignments and provider schedules are identified as barriers to successfully fulfilling resident preferences from the perspectives of n=19 staff within assisted living. Our final presentation utilizes a fixed-effects panel regression analysis with n=551 Ohio nursing home providers to explore the impact of PELI use on regulatory outcomes such as substantiated complaints and deficiency scores reported in the CMS Nursing Home Compare data. Discussant Dr. Kristi Williams will integrate findings, highlighting implications for policy, practice, and future directions. Research in Quality of Care Interest Group Sponsored Symposium.

scholarly journals Antibody Responses to Third-Dose mRNA Vaccines in Nursing Home and Assisted Living Residents

2022 ◽  
Author(s):  
Ali Zhang ◽  
Jessica A. Breznik ◽  
Rumi Clare ◽  
Ishac Nazy ◽  
Matthew S. Miller ◽  
...  
Keyword(s):  
Nursing Home ◽  
Assisted Living ◽  
Antibody Responses

scholarly journals Antibody Responses 3-5 Months Post-Vaccination with mRNA-1273 or BNT163b2 in Nursing Home Residents

2021 ◽  
Author(s):  
Jessica A. Breznik ◽  
Ali Zhang ◽  
Angela Huynh ◽  
Matthew S. Miller ◽  
Ishac Nazy ◽  
...  
Keyword(s):  
Immune Response ◽  
Nursing Home ◽  
Humoral Immune Response ◽  
Type Strain ◽  
Wild Type Strain ◽  
Nursing Home Residents ◽  
Wild Type ◽  
Humoral Immune ◽  
Fold Reduction ◽  
Antibody Levels

AbstractNursing home residents often fail to mount robust responses to vaccinations and recent reports of breakthrough infections, particularly from variants of concern, raise questions about whether vaccination regimens elicit a sufficient humoral immune response or if booster doses are warranted. We examined SARS-CoV-2 antibody levels and neutralizing capacity in nursing home residents 3-5 months after 2 doses of mRNA-1273 or BNT163b2 vaccination as per recommended schedules.Nursing home residents were recruited from eight long-term care homes in Ontario, Canada, between March and July 2021. Antibody levels and neutralization capacity from a previously published convalescent cohort were used as a comparator. Serum SARS-CoV-2 IgA/G/M against spike (S) protein and its receptor-binding domain (RBD) were measured by validated ELISA, with assay cut-off at the mean and 3 standard deviations of a pre-COVID-19 population from the same geographic region. Antibody neutralization was measured against the wild-type strain of SARS-CoV-2 and the beta variant of concern (B.1.351).No neutralizing antibodies were detected in ∼20% of residents to the wild-type virus (30/155; 19%) or beta variant (27/134; 20%). Residents that received BNT163b2 had a ∼4-fold reduction in neutralization to the wild-type strain, and a ∼2-fold reduction in neutralization to the beta variant relative to those who received mRNA-1273.Current mRNA SARS-CoV-2 vaccine regimens may not have equivalent efficacy in nursing home residents. Our findings imply that differences in the humoral immune response may contribute to breakthrough infections, and suggest that consideration of the type of vaccine administered to older adults will have a positive impact on the generation of protective immunity.

scholarly journals Dynamics of the Cellular and Humoral Immune Response After BNT162b2 Messenger Ribonucleic Acid Coronavirus Disease 2019 (COVID-19) Vaccination in COVID-19-Naive Nursing Home Residents

2021 ◽  
Author(s):  
Jens T Van Praet ◽  
Stefaan Vandecasteele ◽  
Anneleen De Roo ◽  
Matthijs Vynck ◽  
An S De Vriese ◽  
...  
Keyword(s):  
Nursing Home ◽  
Ribonucleic Acid ◽  
Cellular Response ◽  
Nursing Home Residents ◽  
Booster Vaccination ◽  
Humoral Response ◽  
Messenger Ribonucleic Acid ◽  
Humoral Immune ◽  
Cellular Immune Responses ◽  
Cellular Immune

Abstract Short-term humoral and cellular immune responses are diminished after BNT162b2 messenger ribonucleic acid coronavirus disease 2019 (COVID-19) vaccination in COVID-19-naive nursing home residents, a population particularly vulnerable to the disease. We found both responses to decline after 4 weeks and remain lower than those of healthcare workers after 24 weeks, with an estimated half-life of the antibody response of 47 days. At 4 weeks, older age was significantly associated with a decreased humoral response, and diabetes mellitus and active malignancy were associated with a decreased cellular response. Our results imply that COVID-19-naive nursing home residents are a target group for booster vaccination trials.

scholarly journals Kinetics of antibody responses dictate COVID-19 outcome

2020 ◽  
Author(s):  
Carolina Lucas ◽  
Jon Klein ◽  
Maria Sundaram ◽  
Feimei Liu ◽  
Patrick Wong ◽  
...  
Keyword(s):  
Disease Severity ◽  
Disease Onset ◽  
Humoral Response ◽  
Neutralizing Antibody ◽  
Antibody Responses ◽  
Delayed Response ◽  
Viral Control ◽  
Cross Sectional ◽  
Neutralization Capacity ◽  
Kinetics Of

SummaryRecent studies have provided insights into innate and adaptive immune dynamics in coronavirus disease 2019 (COVID-19). Yet, the exact feature of antibody responses that governs COVID-19 disease outcomes remain unclear. Here, we analysed humoral immune responses in 209 asymptomatic, mild, moderate and severe COVID-19 patients over time to probe the nature of antibody responses in disease severity and mortality. We observed a correlation between anti-Spike (S) IgG levels, length of hospitalization and clinical parameters associated with worse clinical progression. While high anti-S IgG levels correlated with worse disease severity, such correlation was time-dependent. Deceased patients did not have higher overall humoral response than live discharged patients. However, they mounted a robust, yet delayed response, measured by anti-S, anti-RBD IgG, and neutralizing antibody (NAb) levels, compared to survivors. Delayed seroconversion kinetics correlated with impaired viral control in deceased patients. Finally, while sera from 89% of patients displayed some neutralization capacity during their disease course, NAb generation prior to 14 days of disease onset emerged as a key factor for recovery. These data indicate that COVID-19 mortality does not correlate with the cross-sectional antiviral antibody levels per se, but rather with the delayed kinetics of NAb production.

Families Filling the Gap: Comparing Family Involvement for Assisted Living and Nursing Home Residents With Dementia

2005 ◽  
Vol 45 (Supplement 1) ◽  
pp. 87-95 ◽  
Author(s):  
C. L. Port ◽  
S. Zimmerman ◽  
C. S. Williams ◽  
D. Dobbs ◽  
J. S. Preisser ◽  
...  
Keyword(s):  
Nursing Home ◽  
Family Involvement ◽  
Assisted Living ◽  
Nursing Home Residents

Antibody Response to Influenza Vaccination in Nursing Home Residents and Healthcare Workers During Four Successive Seasons in Niigata, Japan

2005 ◽  
Vol 26 (11) ◽  
pp. 859-866 ◽  
Author(s):  
Mizuho Sato ◽  
Reiko Saito ◽  
Naohito Tanabe ◽  
Makoto Nishikawa ◽  
Asami Sasaki ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Nursing Home ◽  
Antibody Response ◽  
Healthcare Workers ◽  
Geometric Mean ◽  
Nursing Home Residents ◽  
Antibody Responses ◽  
Fourfold Increase ◽  
Almost All ◽  
Underlying Diseases

AbstractObjective:To evaluate the antibody response to influenza vaccines in nursing home residents and healthcare workers (HCWs) and its relation to residents' functional and chronic disease status during four successive seasons.Design:Before-after study.Setting:Nine nursing homes during the 1998-1999 season and two during the 1999-2000, 2000-2001, and 2001-2002 seasons.Participants:Two hundred fifty-nine residents and 79 HCWs during the 1998-1999 season; 180 and 71, respectively, during the 1999-2000 season; 162 and 71, respectively, during the 2000-2001 season; and 153 and 79, respectively, during the 2001-2002 season.Results:Multivariate analysis indicated that the mean fold increase in the geometric mean titers (GMTs) of hemagglutination inhibition (HI) antibodies and the response rate (the proportion of vaccinées resulting in a significant, at least fourfold increase in antibody titer) were good and no significant differences occurred for almost all strains in both residents and HCWs. The GMTs of HI antibodies and the protection rate (the proportion of participants with HI antibody titers & 40) were increased in both residents and HCWs, but were significantly lower for almost all strains in residents than in HCWs. Furthermore, multivariate analysis indicated that subdivision of residents into three groups by level of daily activities and into four groups according to underlying diseases revealed only minor differences in immune responses.Conclusions:Antibody responses to the influenza vaccine were lower in residents than in HCWs. However, residents showed similar antibody responses regardless of their level of daily activity or underlying diseases.

scholarly journals Reduced BNT162b2 mRNA vaccine response in SARS-CoV-2-naive nursing home residents

2021 ◽  
Author(s):  
David H. Canaday ◽  
Lenore Carias ◽  
Oladayo A. Oyebanji ◽  
Debbie Keresztesy ◽  
Dennis Wilk ◽  
...  
Keyword(s):  
Nursing Home ◽  
Healthcare Workers ◽  
Nursing Home Residents ◽  
Antibody Responses ◽  
Control Measures ◽  
Vaccine Response ◽  
Infection Control Measures ◽  
Data Gap ◽  
Antibody Levels ◽  
Care Worker

AbstractThe SARS-CoV-2 pandemic impact on nursing home (NH) residents prompted their prioritization for early vaccination. To fill the data gap for vaccine immunogenicity in NH residents, we examined antibody levels after BNT162b2 mRNA vaccine to spike, receptor binding domain (RBD) and for virus neutralization in 149 NH residents and 111 health care worker controls. SARS-CoV-2-naive NH residents mount antibody responses with nearly 4-fold lower median neutralization titers and half the anti-spike level compared to SARS-CoV-2-naive healthcare workers. By contrast, SARS-CoV-2-recovered vaccinated NH residents had neutralization, anti-spike and anti-RBD titers similar to SARS-CoV-2-recovered vaccinated healthcare workers. NH residents’ blunted antibody responses have important implications regarding the quality and durability of protection afforded by neoantigen vaccines. We urgently need better longitudinal evidence on vaccine effectiveness specific to NH resident populations to inform best practices for NH infection control measures, outbreak prevention and potential indication for a vaccine boost.

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