scholarly journals Metabolic Perceptrons for Neural Computing in Biological Systems

2019 ◽  
Author(s):  
Amir Pandi ◽  
Mathilde Koch ◽  
Peter L Voyvodic ◽  
Paul Soudier ◽  
Jerome Bonnet ◽  
...  

AbstractSynthetic biological circuits are promising tools for developing sophisticated systems for medical, industrial, and environmental applications. So far, circuit implementations commonly rely on gene expression regulation for information processing using digital logic. Here, we present a new approach for biological computation through metabolic circuits designed by computer-aided tools, implemented in both whole-cell and cell-free systems. We first combine metabolic transducers to build an analog adder, a device that sums up the concentrations of multiple input metabolites. Next, we build a weighted adder where the contributions of the different metabolites to the sum can be adjusted. Using a computational model trained on experimental data, we finally implement two four-input “perceptrons” for desired binary classification of metabolite combinations by applying model-predicted weights to the metabolic perceptron. The perceptron-mediated neural computing introduced here lays the groundwork for more advanced metabolic circuits for rapid and scalable multiplex sensing.

Author(s):  
Rajit Gadh ◽  
Fritz B. Prinz

Abstract The current paper discusses a fundamentally new approach to defining and finding interactions in computer-aided design (CAD) forms or features. The paper provides a classification of the various interactions found among CAD forms. The paper also illustrates a robust approach to defining and recognizing stand-alone as well as interacting forms. The problem of generic form definition is resolved using a set of high-level abstract entities called loops and links. The computational difficulty in finding the forms is resolved using a mathematically defined geometric filter called the Differential Depth Filter.


Author(s):  
Oleksandr Ostrohliad

Purpose. The aim of the work is to consider the novelties of the legislative work, which provide for the concept and classification of criminal offenses in accordance with the current edition of the Criminal Code of Ukraine and the draft of the new Code developed by the working group and put up for public discussion. Point out the gaps in the current legislation and the need to revise individual rules of the project in this aspect. The methodology. The methodology includes a comprehensive analysis and generalization of the available scientific and theoretical material and the formulation of appropriate conclusions and recommendations. During the research, the following methods of scientific knowledge were used: terminological, logical-semantic, system-structural, logical-normative, comparative-historical. Results In the course of the study, it was determined that despite the fact that the amendments to the Criminal Code of Ukraine came into force in July of this year, their perfection, in terms of legal technology, raises many objections. On the basis of a comparative study, it was determined that the Draft Criminal Code of Ukraine needs further revision taking into account the opinions of experts in the process of public discussion. Originality. In the course of the study, it was established that the classification of criminal offenses proposed in the new edition of the Criminal Code of Ukraine does not stand up to criticism, since other elements of the classification appear in subsequent articles, which are not covered by the existing one. The draft Code, using a qualitatively new approach to this issue, retains the elements of the previous classification and has no practical significance in law enforcement. Practical significance. The results of the study can be used in law-making activities to improve the norms of the current Criminal Code, to classify criminal offenses, as well as to further improve the draft Criminal Code of Ukraine.


Author(s):  
P.L. Nikolaev

This article deals with method of binary classification of images with small text on them Classification is based on the fact that the text can have 2 directions – it can be positioned horizontally and read from left to right or it can be turned 180 degrees so the image must be rotated to read the sign. This type of text can be found on the covers of a variety of books, so in case of recognizing the covers, it is necessary first to determine the direction of the text before we will directly recognize it. The article suggests the development of a deep neural network for determination of the text position in the context of book covers recognizing. The results of training and testing of a convolutional neural network on synthetic data as well as the examples of the network functioning on the real data are presented.


Author(s):  
Saliha Zahoor ◽  
Ikram Ullah Lali ◽  
Muhammad Attique Khan ◽  
Kashif Javed ◽  
Waqar Mehmood

: Breast Cancer is a common dangerous disease for women. In the world, many women died due to Breast cancer. However, in the initial stage, the diagnosis of breast cancer can save women's life. To diagnose cancer in the breast tissues there are several techniques and methods. The image processing, machine learning and deep learning methods and techniques are presented in this paper to diagnose the breast cancer. This work will be helpful to adopt better choices and reliable methods to diagnose breast cancer in an initial stage to survive the women's life. To detect the breast masses, microcalcifications, malignant cells the different techniques are used in the Computer-Aided Diagnosis (CAD) systems phases like preprocessing, segmentation, feature extraction, and classification. We have been reported a detailed analysis of different techniques or methods with their usage and performance measurement. From the reported results, it is concluded that for the survival of women’s life it is essential to improve the methods or techniques to diagnose breast cancer at an initial stage by improving the results of the Computer-Aided Diagnosis systems. Furthermore, segmentation and classification phases are challenging for researchers for the diagnosis of breast cancer accurately. Therefore, more advanced tools and techniques are still essential for the accurate diagnosis and classification of breast cancer.


2020 ◽  
Vol 14 ◽  
Author(s):  
Lahari Tipirneni ◽  
Rizwan Patan

Abstract:: Millions of deaths all over the world are caused by breast cancer every year. It has become the most common type of cancer in women. Early detection will help in better prognosis and increases the chance of survival. Automating the classification using Computer-Aided Diagnosis (CAD) systems can make the diagnosis less prone to errors. Multi class classification and Binary classification of breast cancer is a challenging problem. Convolutional neural network architectures extract specific feature descriptors from images, which cannot represent different types of breast cancer. This leads to false positives in classification, which is undesirable in disease diagnosis. The current paper presents an ensemble Convolutional neural network for multi class classification and Binary classification of breast cancer. The feature descriptors from each network are combined to produce the final classification. In this paper, histopathological images are taken from publicly available BreakHis dataset and classified between 8 classes. The proposed ensemble model can perform better when compared to the methods proposed in the literature. The results showed that the proposed model could be a viable approach for breast cancer classification.


2021 ◽  
Vol 11 (4) ◽  
pp. 1855
Author(s):  
Franco Guzzetti ◽  
Karen Lara Ngozi Anyabolu ◽  
Francesca Biolo ◽  
Lara D’Ambrosio

In the construction field, the Building Information Modeling (BIM) methodology is becoming increasingly predominant and the standardization of its use is now an essential operation. This method has become widespread in recent years, thanks to the advantages provided in the framework of project management and interoperability. Hoping for its complete dissemination, it is unthinkable to use it only for new construction interventions. Many are experiencing what happens with the so-called Heritage Building Information Modeling (HBIM); that is, how BIM interfaces with Architectural Heritage or simply with historical buildings. This article aims to deal with the principles and working methodologies behind BIM/HBIM and modeling. The aim is to outline the themes on which to base a new approach to the instrument. In this way, it can be adapted to the needs and characteristics of each type of building. Going into the detail of standards, the text also contains a first study regarding the classification of moldable elements. This proposal is based on current regulations and it can provide flexible, expandable, and unambiguous language. Therefore, the content of the article focuses on a revision of the thinking underlying the process, also providing a more practical track on communication and interoperability.


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mustafa B. Al-Deen ◽  
Mazin Ali A. Ali ◽  
Zeyad A. Saleh

Abstract This paper presents a new approach to discover the effect of depth water for underwater visible light communications (UVLC). The quality of the optical link was investigated with varying water depth under coastal water types. The performance of the UVLC with multiple input–multiple output (MIMO) techniques was examined in terms of bit error rate (BER) and data rate. The theoretical result explains that there is a good performance for UVLC system under coastal water.


Sign in / Sign up

Export Citation Format

Share Document