scholarly journals Specific connectivity with Operculum 3 (OP3) brain region in acoustic trauma tinnitus: a seed-based resting state fMRI study

2019 ◽  
Author(s):  
Agnès Job ◽  
Anne Kavounoudias ◽  
Chloé Jaroszynski ◽  
Assia Jaillard ◽  
Chantal Delon-Martin
Keyword(s):  
Hearing Loss ◽  
Auditory Cortex ◽  
Functional Mri ◽  
Resting State ◽  
Primary Auditory Cortex ◽  
Acoustic Trauma ◽  
Control Group ◽  
New Model ◽  
The Veil ◽  
The Right

ABSTRACTTinnitus mechanisms remain poorly understood. Our previous functional MRI (fMRI) studies demonstrated an abnormal hyperactivity in the right parietal operculum 3 (OP3) in acoustic trauma tinnitus and during provoked phantom sound perceptions without hearing loss, which lead us to propose a new model of tinnitus. This new model is not directly linked with hearing loss and primary auditory cortex abnormalities, but with a proprioceptive disturbance related to middle-ear muscles. In the present study, a seed-based resting-state functional MRI method was used to explore the potential abnormal connectivity of this opercular region between an acoustic trauma tinnitus group presenting slight to mild tinnitus and a control group. Primary auditory cortex seeds were also explored because they were thought to be directly involved in tinnitus in most current models. In such a model, hearing loss and tinnitus handicap were confounding factors and were therefore regressed in our analysis. Between-groups comparisons showed a significant specific connectivity between the right OP3 seeds and the potential human homologue of the premotor ear-eye field (H-PEEF) bilaterally and the inferior parietal lobule (IPL) in the tinnitus group. Our findings suggest the existence of a simultaneous premotor ear-eye disturbance in tinnitus that could lift the veil on unexplained subclinical abnormalities in oculomotor tests found in tinnitus patients with normal vestibular responses. The present work confirms the involvement of the OP3 subregion in acoustic trauma tinnitus and provides some new clues to explain its putative mechanisms.

Functional Connectivity in Patients With Sensorineural Hearing Loss Using Resting-State MRI

2015 ◽  
Vol 24 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Bin Liu ◽  
Yuan Feng ◽  
Ming Yang ◽  
Jing-ya Chen ◽  
Jing Li ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Auditory Cortex ◽  
Sensorineural Hearing Loss ◽  
Resting State ◽  
Region Of Interest ◽  
Primary Auditory Cortex ◽  
Sensorineural Hearing ◽  
Control Group ◽  
Resting State Functional Connectivity

Purpose This study was undertaken to evaluate whole-brain functional connectivity changes related to auditory cortex in patients with left-sided sensorineural hearing loss (SNHL) using resting-state functional connectivity magnetic resonance imaging. Method Imaging was performed in 19 patients with left-sided SNHL and 35 individuals in the control group without SNHL. Data were collected and analyzed to map functional connectivity using the left/right primary auditory cortex as the region of interest to identify global differences between patients with SNHL and the control group. Results In comparison to the control group, the SNHL group was found to have significant functional connectivity changes in the auditory system, recognition network, visual cortex, and language network. Conclusion These findings suggest that functional brain alterations in unilateral SNHL patients may indicate reorganizations that occur in response to auditory deficits.

scholarly journals Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pavel Hok ◽  
Lenka Hvizdošová ◽  
Pavel Otruba ◽  
Michaela Kaiserová ◽  
Markéta Trnečková ◽  
...  
Keyword(s):  
Functional Mri ◽  
Resting State ◽  
Cervical Dystonia ◽  
Botulinum Neurotoxin ◽  
Botulinum Toxin Injection ◽  
Clinical Severity ◽  
Before And After ◽  
Positive Correlations ◽  
Using Data ◽  
The Right

AbstractIn cervical dystonia, functional MRI (fMRI) evidence indicates changes in several resting state networks, which revert in part following the botulinum neurotoxin A (BoNT) therapy. Recently, the involvement of the cerebellum in dystonia has gained attention. The aim of our study was to compare connectivity between cerebellar subdivisions and the rest of the brain before and after BoNT treatment. Seventeen patients with cervical dystonia indicated for treatment with BoNT were enrolled (14 female, aged 50.2 ± 8.5 years, range 38–63 years). Clinical and fMRI examinations were carried out before and 4 weeks after BoNT injection. Clinical severity was evaluated using TWSTRS. Functional MRI data were acquired on a 1.5 T scanner during 8 min rest. Seed-based functional connectivity analysis was performed using data extracted from atlas-defined cerebellar areas in both datasets. Clinical scores demonstrated satisfactory BoNT effect. After treatment, connectivity decreased between the vermis lobule VIIIa and the left dorsal mesial frontal cortex. Positive correlations between the connectivity differences and the clinical improvement were detected for the right lobule VI, right crus II, vermis VIIIb and the right lobule IX. Our data provide evidence for modulation of cerebello-cortical connectivity resulting from successful treatment by botulinum neurotoxin.

scholarly journals Protective effect of Nigella sativa oil on acoustic trauma induced hearing loss in rats

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Belde Culhaoglu ◽  
Selim S. Erbek ◽  
Seyra Erbek ◽  
Evren Hizal
Keyword(s):  
Hearing Loss ◽  
Protective Effect ◽  
Nigella Sativa ◽  
Acoustic Trauma ◽  
Female Rats ◽  
Auditory Brainstem Responses ◽  
Control Group ◽  
Study Group ◽  
Intensity Level ◽  
Hearing Thresholds

Acoustic trauma is a common reason for hearing loss. Different agents are used to prevent the harmful effect of acoustic trauma on hearing. The aim of this study was to evaluate the potential preventive effect of <em>Nigella sativa</em> (black cumin) oil in acoustic trauma. Our experimental study was conducted with 20 Sprague Downey female rats (mean age, 12 months; mean weight 250 g). All of the procedures were held under general anesthesia. Following otoscopic examinations, baseline-hearing thresholds were obtained using auditory brainstem responses (ABR). To create acoustic trauma, the rats were then exposed to white band noise of 4 kHz with an intensity level of 107 dB in a soundproof testing room. On Day 1 following acoustic trauma, hearing threshold measurements were repeated. The rats were divided into two groups as the study group (n: 10) and the controls (n: 10). 2 mL/kg/day of <em>Nigella sativa</em> oil was given to the rats in the study group orally. On Day 4 following acoustic trauma, ABR measurements were repeated again. There was no difference between the baseline hearing thresholds of the rats before acoustic trauma (P&gt;0.005). After the acoustic trauma, hearing thresholds were increased and there was no significant statistically difference between the hearing thresholds of the study and control groups (P=0.979). At the 4<sup>th</sup> day following acoustic trauma, hearing thresholds of the rats in control group were found to be higher than those in the study group (P=0.03). Our results suggest that <em>Nigella sativa</em> oil has a protective effect against acoustic trauma in early period. This finding should be supported with additional experimental and clinical studies, especially to determine the optimal dose, duration and frequency of potential <em>Nigella sativa</em> oil therapy.

scholarly journals STUDY OF PREVALENCE AND PATTERN OF HEARING LOSS IN PATIENTS OF HEPATITIS B

2019 ◽  
Vol 3 (12) ◽  
Author(s):  
Kapildev Mondal ◽  
Poulomi Saha
Keyword(s):  
Hearing Loss ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Pure Tone ◽  
Control Group ◽  
Hepatitis B Infection ◽  
Cellular Carcinoma ◽  
The Right ◽  
Hep B

Hepatitis B has been documented to cause various extra hepatic manifestations along with known hepatic complications. It has been reported that hepatitis-B patients are more susceptible to inner ear damage and hearing loss. The aim of this study is to evaluate hearing loss among patients of   hepatitis B {all 6 categories Hepatitis B infection: chronic Hepatitis B  infection , hepatitis B cirrhosis ,Hepatitis B virus carriers , occult chronic Hepatitis B and Hepatitis B infection with poly arthritis nodosa, hepato cellular carcinoma with hepatitis B}compared with healthy subjects. METHOD: In this case control study 100 Hepatitis B positive patients and 100 age and gender-matched healthy individuals were included over the period of 5 years. All of them were known cases of chronic hepatitis B positive for   HBsAg at least for 18 months. All   patients were aged 18 to 50 years to exclude presence of presbycusis. After base line investigations, they were subjected for all cases and controls were subjected otoscopic examination and hearing assessment using standard pure tone audiometry. Descriptive statistical analysis has been carried out in this study. RESULT: In patients of Hepatitis B (94 patients,6 patients had of  natural death ) pure tone average (mean thresholds 250,500, 1000,2000,4000 &8000 Hz) was 28.4 dB in the right ear and 27.3 dB in the left (hearing loss).In the control group(96 patients,4 patients dropped out), PTA average was 9.9 dB in the right ear and 9.3dB in the left (normal hearing). In both groups, Speech Discrimination score (SDS) was100% in both ears. The percentage of hearing loss in the right and left ear over the total of six frequencies differed significantly in the two groups. Out of 94 patients of control group, 38 patients (40.4%) patients presented with Chronic Liver Disease (CLD), 14 patients (14.8%) patients presented with cirrhosis with Hepatitis B, 6 (6.3%) patients had Poly arthritis Nodosa with Hep-B, 18(19.1%) patients were diagnosed as carrier of Hepatitis-B , 11(11.7%) patients had occult Hepatitis-B and 7(7.4%) patients were diagnosed with hepato cellular carcinoma. Hearing loss was maximum in patients of   PAN with Hep-B. Second highest mean SNHL was seen in patients of Hep-B with cirrhosis .Third highest mean hearing loss was noted in patients with HCC .Forth highest mean hearing loss was noted in patients with occult Hep-B. Fifth highest mean hearing loss was noted in carriers of Hep-B.Lowest group with SNHL was chronic liver disease. CONCLUSION: Regular audiometric tests are recommended for patients with HBV infection to assess their hearing ability and enable the earlier detection of SNHL. We also suggest that HBV presenting with the sudden onset of hearing loss should be examined for the possibility of acute exacerbation of chronic HBV infection. KEYWORDS: Mean, Sensorineural, Hearing loss, Cirrhosis.

scholarly journals Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study

2021 ◽  
Vol 15 ◽  
Author(s):  
Pingping Guo ◽  
Siyuan Lang ◽  
Muliang Jiang ◽  
Yifeng Wang ◽  
Zisan Zeng ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Prefrontal Cortex ◽  
Sensorineural Hearing Loss ◽  
Resting State ◽  
Regional Homogeneity ◽  
Sensorineural Hearing ◽  
Parahippocampal Gyrus ◽  
Control Group ◽  
Precentral Gyrus ◽  
Healthy Controls

Background: Brain functional alterations have been observed in children with congenital sensorineural hearing loss (CSNHL). The purpose of this study was to assess the alterations of regional homogeneity in children with CSNHL.Methods: Forty-five children with CSNHL and 20 healthy controls were enrolled into this study. Brain resting-state functional MRI (rs-fMRI) for regional homogeneity including the Kendall coefficient consistency (KCC-ReHo) and the coherence-based parameter (Cohe-ReHo) was analyzed and compared between the two groups, i.e., the CSNHL group and the healthy control group.Results: Compared to the healthy controls, children with CSNHL showed increased Cohe-ReHo values in left calcarine and decreased values in bilateral ventrolateral prefrontal cortex (VLPFC) and right dorsolateral prefrontal cortex (DLPFC). Children with CSNHL also had increased KCC-ReHo values in the left calcarine, cuneus, precentral gyrus, and right superior parietal lobule (SPL) and decreased values in the left VLPFC and right DLPFC. Correlations were detected between the ReHo values and age of the children with CSNHL. There were positive correlations between ReHo values in the pre-cuneus/pre-frontal cortex and age (p &lt; 0.05). There were negative correlations between ReHo values in bilateral temporal lobes, fusiform gyrus, parahippocampal gyrus and precentral gyrus, and age (p &lt; 0.05).Conclusion: Children with CSNHL had RoHo alterations in the auditory, visual, motor, and other related brain cortices as compared to the healthy controls with normal hearing. There were significant correlations between ReHo values and age in brain regions involved in information integration and processing. Our study showed promising data using rs-fMRI ReHo parameters to assess brain functional alterations in children with CSNHL.

The Women who Heard Folk Portuguese Music in the Right Ear: A Case of Unilateral Musical Hallucinosis

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
P. Ferreira ◽  
S. Simões ◽  
J. Cerqueira ◽  
J. Soares-Fernandes ◽  
Á. Machado
Keyword(s):  
Auditory Cortex ◽  
Classical Music ◽  
Mild Hypertension ◽  
Sensory Deprivation ◽  
Primary Auditory Cortex ◽  
Pet Scan ◽  
Charles Bonnet Syndrome ◽  
History Of ◽  
The Right ◽  
Portuguese Music

Introduction:Although probably undereported, musical hallucinosis is very rare and usually bilateral. It refers to auditory complex hallucinations, for which the patient has full insight, and includes melodies, tunes, rhythms and timbres.Clinical case:A 71-year-old women was seen for a history of hearing music in the right ear. She had mild hypertension and auricular fibrillation, being chronically medicated with aspirine, bisoprolol and hydroclorothiazide. Three months previously she started hearing some popular folk Portuguese songs in the right ear. She could identify the lyrics and sing the songs she heard. Weeks later fado and classical music were added to the repertoire, and later on she started hearing less well-formed sounds like “dlam... dlam” or “uhh... uhh”. There were no other auditory or visual hallucinations. She was seen by an otorhinolaryngologist, and made an audiogram showing bilateral, right-predominant, pre-coclear deafness with normal evoked brainstem auditory potentials. An MRI showed small deep subcortical lacunar lesions. EEG was normal. PET scan showed left temporal hypometabolism. On benzodiazepines she had discrete improvement.Conclusion:Musical hallucinosis has been found mainly in deaf patients, and a similar mechanism to that of Charles-Bonnet syndrome has been proposed. Sensory deprivation of primary auditory cortex would “release” the secondary auditory cortex, to produce complex auditory hallucinations with full insight. In our patient we were able to demonstrate the integrity of the brainstem pathway, supporting a direct link between diminished right ear sound transmission and left temporal lobe diminished activation as ascertained by the pet scan.

Acoustic Trauma: Tinnitus and Vertigo

1984 ◽  
Vol 98 (S9) ◽  
pp. 82-83 ◽  
Author(s):  
Alfred D. Weiss ◽  
Elizabeth R. Weiss
Keyword(s):  
Hearing Loss ◽  
Family History ◽  
High Frequency ◽  
Acoustic Trauma ◽  
Neurologic Disease ◽  
High Frequency Hearing Loss ◽  
History Of ◽  
Word Discrimination ◽  
The Right ◽  
Shipyard Workers

Three hundred ten randomly selected male shipyard workers, with an average age of 56 years, with an average of 19 years with their employer, excluding workers with evidence of other otologic or relevant neurologic disease, were analyzed in terms of hearing loss, tinnitus, vertigo, and family history of hearing loss. The audiograms showed bilateral, symmetrical mid to high frequency hearing loss with SRT of 21 db and 85 per cent PB word discrimination. Eleven per cent had a family history of hearing loss, but this did not correlate with the patients' hearing loss, tinnitus, or vertigo. Fifteen per cent of the patients gave a history of vertigo. Tinnitus occurred in 43 per cent of right ears and in 41 per cent of left ears. Statistical analysis showed that the tinnitus did not correlate with hearing loss at any frequency in the right ear but correlated significantly with hearing loss at 2000 and 3000 HZ in the left ear! These were significant but small. Multiple correlational analysis indicated.

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