PurposeThe purpose of this paper is to identify the critical factors influencing the cloud computing adoption (CCA) in the manufacturing micro, small and medium enterprises (MSMEs) by employing a decision-making trial and evaluation laboratory (DEMATEL) methodology.Design/methodology/approachThrough literature review and expert opinions, 30 significant factors were identified, and then a DEMATEL approach was applied for exploring the cause–effect relationship between the factors.FindingsThe results of study highlighted that five factors, namely, “hardware scalability and standardisation”, “cost (subscription fees, maintenance cost and implementation cost (CS1)”, “innovation”, “installation and up gradation (CS28)”, and “quality of service” were the most significant factors influencing the CCA in the case sector.Research limitations/implicationsThe DEMATEL model was developed by considering expert inputs, and these inputs could be biased which can influence the reliability of the model. This study guides the organisational managers, cloud service providers and governmental organisations in formulating the new policies/strategies or modifying the existing ones for the effective CCA in the case sector.Originality/valueFor the first time. interdependency between the critical factors influencing CCA was discussed by employing the DEMATEL approach in the Indian manufacturing MSMEs context.