2D nonuniform array design for imaging applications

Author(s):  
Marco Moebus ◽  
Abdelhak M. Zoubir
Keyword(s):  
Author(s):  
Krishna Rudraraju Chaitanya ◽  
P. Mallikarjuna Rao ◽  
K. V. S. N. Raju ◽  
G. S. N. Raju

Author(s):  
Poovi Ganesan ◽  
N Damodharan

Background: A better understanding of the biopharmaceutical and physicochemical properties of drugs and the pharmaco-technical factors would be of great help for developing pharmaceutical products. But, it is extremely difficult to study the effect of each variable and interaction among them through the conventional approach Objective: To screen the most influential factors affecting the particle size (PS) of lipid nanoparticle (LNPs) (solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC)) for poorly water-soluble BCS class-II drug like tamoxifen (TMX) to improve its oral bioavailability and to reduce its toxicity to tolerable limits using Taguchi (L12 (2 11)) orthogonal array design by applying computer optimization technique. Results: The size of all LNPs formulations prepared as per the experimental design varied between 172 nm and 3880 μm, polydispersity index between 0.033 and 1.00, encapsulation efficiency between 70.8% and 75.7%, and drug loading between 5.84% and 9.68%. The study showed spherical and non-spherical as well as aggregated and non-aggregated LNPs. Besides, it showed no interaction and amorphous form of the drug in LNPs formulation. The Blank NLCs exhibited no cytotoxicity on MCF-7 cells as compared to TMX solution, SLNs (F5) and NLCs (F12) suggests that the cause of cell death is primarily from the effect of TMX present in NLCs. Conclusions: The screening study clearly showed the importance of different individual factors significant effect for the LNPs formulation development and its overall performance in an in-vitro study with minimum experimentation thus saving considerable time, efforts, and resources for further in-depth study.


Author(s):  
Nicola Anselmi ◽  
Giorgio Gottardi ◽  
Paolo Rocca ◽  
Giacomo Oliveri ◽  
Andrea Massa

Electronics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 415
Author(s):  
Jordan C. Hanson

Phased array radar systems have a wide variety of applications in engineering and physics research. Phased array design usually requires numerical modeling with expensive commercial computational packages. Using the open-source MIT Electrogmagnetic Equation Propagation (MEEP) package, a set of phased array designs is presented. Specifically, one and two-dimensional arrays of Yagi-Uda and horn antennas were modeled in the bandwidth [0.1–5] GHz, and compared to theoretical expectations in the far-field. Precise matches between MEEP simulation and radiation pattern predictions at different frequencies and beam angles are demonstrated. Given that the computations match the theory, the effect of embedding a phased array within a medium of varying index of refraction is then computed. Understanding the effect of varying index on phased arrays is critical for proposed ultra-high energy neutrino observatories which rely on phased array detectors embedded in natural ice. Future work will develop the phased array concepts with parallel MEEP, in order to increase the detail, complexity, and speed of the computations.


2012 ◽  
Vol 549 ◽  
pp. 60-64
Author(s):  
Zhen Huang ◽  
Xiao Han Shi ◽  
Shao Fang Liu ◽  
Wei Juan Jiang

An orthogonal array design was employed for optimizing the supercritical CO2 extraction of Rhizoma Atractylodis Macrocephalae. The extraction was performed at temperature from 40 to 60oC, pressure from 15 to 35MPa, extraction time varying from 30 to 90min and particle size spanning from 20 to 80 mesh. The results reflect that the extraction yield is more significantly influenced by the extraction time, pressure and particle size but less by temperature. The experiments show that the extraction yield obviously increases with increasing pressure, different from the literatures. In terms of the sample origin, a comparison shows that outstanding differences exist among the extraction yields from different sources.


Energies ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 49
Author(s):  
Zheng Yuan ◽  
Jin Jiang ◽  
Jun Zang ◽  
Qihu Sheng ◽  
Ke Sun ◽  
...  

In the array design of the vertical axis wind turbines (VAWT), the wake effect of the upstream VAWT on the downstream VAWT needs to be considered. In order to simulate the velocity distribution of a VAWT wake rapidly, a new two-dimensional numerical method is proposed, which can make the array design easier and faster. In this new approach, the finite vortex method and vortex particle method are combined to simulate the generation and evolution of the vortex, respectively, the fast multipole method (FMM) is used to accelerate the calculation. Based on a characteristic of the VAWT wake, that is, the velocity distribution can be fitted into a power-law function, a new correction model is introduced to correct the three-dimensional effect of the VAWT wake. Finally, the simulation results can be approximated to the published experimental results in the first-order. As a new numerical method to simulate the complex VAWT wake, this paper proves the feasibility of the method and makes a preliminary validation. This method is not used to simulate the complex three-dimensional turbulent evolution but to simulate the velocity distribution quickly and relatively accurately, which meets the requirement for rapid simulation in the preliminary array design.


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