Effects of Enrichment with Polyunsaturated Fatty Acids (Omega-3 and Conjugated Linoleic Acid) on Consumer Liking of Beef Aged for 7 or 21 d Evaluated at Different Locations

It was evaluated in this study the effect of the type of the diet on duodenal flow of long-chain fatty acids in steers. The tested diets were the following: conventional (feedlot diet composed of 60% corn silage and 40% of concentrate); winter forage silage - rye grass (Lolium multiflorum, Lam); or tropical forage silage - association of millet (Pennisetum americanum, Leeke + alexander grass, Brachiaria plantaginea). Six Charolais × Nellore crossbred steers with cannulas in duodenum were used in a 3 × 3 double Latin square. Dry material intake was similar among the groups (mean of 4,037 g/day), but the intake of total fatty acids and saturated fatty acids were higher in the group fed tropical pasture silage. On the other hand, the animals which received the conventional diet consumed higher quantity of unsaturated fatty acids. Tropical pasture silage provided higher consumption of vacenic acid (C18:1 t-11) and the winter forage silage offered higher consumption of conjugated linoleic acid. The intake of omega-6 fatty acids was higher in the group fed conventional diet and for omega-3, intake was higher in the group fed tropical pasture diet. The total fatty acid flow in the duodenum was not affected by the diets, but in all treatments it was higher than the consumed one. The animals fed diet with concentrate show the greatest changes on the profile of fatty acids during the ruminal fermentation. Conventional diets provide the highest intake of unsaturated fatty acids and the highest availability of vacenic acid in the small intestine, but they do not increase the supply of intestinal conjugated linoleic acid.

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MODULATION OF FASTED AND POSTPRANDIAL PLASMA LIPIDS IN HEALTHY VOLUNTEERS BY A DIETARY MIXTURE OF OMEGA-3 FATTY ACIDS AND CONJUGATED LINOLEIC ACID

Journal of Food Lipids ◽

10.1111/j.1745-4522.2009.01162.x ◽

2009 ◽

Vol 16 (4) ◽

pp. 499-513 ◽

Cited By ~ 2

Author(s):

FOTINI TSOFLIOU ◽

CLAIRE L. FYFE ◽

IAN MATHESON ◽

DIANE M. JACKSON ◽

GRAHAM W. HORGAN ◽

...

Keyword(s):

Fatty Acids ◽

Linoleic Acid ◽

Healthy Volunteers ◽

Conjugated Linoleic Acid ◽

Plasma Lipids ◽

Omega 3 Fatty Acids ◽

Omega 3

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Bioavailability and metabolic effects in humans of n-3 polyunsaturated fatty acids and conjugated linoleic acid after consumption of naturally enriched cow milk

http://isrctn.org/> ◽

10.1186/isrctn16004121 ◽

2012 ◽

Author(s):

Emilio Ros

Keyword(s):

Fatty Acids ◽

Linoleic Acid ◽

Polyunsaturated Fatty Acids ◽

Conjugated Linoleic Acid ◽

Metabolic Effects ◽

Cow Milk

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Changes in delayed type hypersensitivity, egg antibody content and immune cell fatty acid composition of layer birds fed conjugated linoleic acid, n-6 or n-3 fatty acids

Canadian Journal of Animal Science ◽

10.4141/a03-058 ◽

2004 ◽

Vol 84 (2) ◽

pp. 221-228 ◽

Cited By ~ 10

Author(s):

R. K. Selvaraj ◽

G. Cherian

Keyword(s):

Fatty Acids ◽

Immune Response ◽

Fatty Acid ◽

Linoleic Acid ◽

Polyunsaturated Fatty Acids ◽

Conjugated Linoleic Acid ◽

Oxidation Products ◽

Thigh Muscle ◽

Delayed Type Hypersensitivity ◽

Lipid Oxidation Products

The effects of polyunsaturated fatty acids on delayed type hypersensitivity (DTH), egg yolk antibody content, immune tissue fatty acid profile and lipid oxidation products of layer birds were investigated. One hundred and twenty layer birds were fed diets containing conjugated linoleic acid (CLA) + animal fat (Diet I), sunflower oil (Diet II), canola + flax oil (Diet III) or fish oil (Diet IV). The total added lipid content of the diet was 3%. Birds fed Diets III and IV had higher content of n-3 fatty acids in lymphocyte and splenocytes. Thiobarbituric reactive substances were higher (P < 0.05) in the breast and thigh muscle of Diet IV fed birds. Serum and yolk anti-BSA antibody contents were higher (P < 0.05) in birds fed Diets III and IV. DTH was decreased (P < 0.05) in birds fed Diets IV and III. The number of lymphocyte CD4+ and CD8+ cells and spleen mononuclear cell CD4+, CD8+ and IgM+ cells did not differ (P > 0.05) between treatment groups. Feeding n-3 fatty acids increased antibody-mediated immune response, while n-6 fatty acids and CLA increased cell-mediated immune response. Key words: Conjugated linoleic acid, polyunsaturated fatty acids, delayed type hypersensitivity, immunoglobulins

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Conjugated linoleic acid or omega 3 fatty acids increase mitochondrial biosynthesis and metabolism in skeletal muscle cells

Lipids in Health and Disease ◽

10.1186/1476-511x-11-142 ◽

2012 ◽

Vol 11 (1) ◽

Cited By ~ 66

Author(s):

Roger A Vaughan ◽

Randi Garcia-Smith ◽

Marco Bisoffi ◽

Carole A Conn ◽

Kristina A Trujillo

Keyword(s):

Skeletal Muscle ◽

Fatty Acids ◽

Linoleic Acid ◽

Conjugated Linoleic Acid ◽

Muscle Cells ◽

Skeletal Muscle Cells ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Mitochondrial Biosynthesis

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Leukocyte telomere length and serum polyunsaturated fatty acids, dietary habits, cardiovascular risk factors and features of myocardial infarction in elderly patients

BMC Geriatrics ◽

10.1186/s12877-019-1383-9 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Are A. Kalstad ◽

Sjur Tveit ◽

Peder L. Myhre ◽

Kristian Laake ◽

Trine B. Opstad ◽

...

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Fatty Acids ◽

Cardiovascular Risk ◽

Linoleic Acid ◽

Elderly Patients ◽

Polyunsaturated Fatty Acids ◽

Telomere Length ◽

Leukocyte Telomere Length ◽

Omega 3

Abstract Background Telomeres are non-coding sequences at the end of eukaryote chromosomes, which in complex with associated proteins serve to protect subtelomeric DNA. Telomeres shorten with each cell division, are regarded as a biomarker for aging and have also been suggested to play a role in atherosclerosis and cardiovascular disease (CVD). The aim of the present study was to explore the associations between leukocyte telomere length and serum polyunsaturated fatty acids, diet, cardiovascular risk factors and features of myocardial infarction (MI) in elderly patients. Methods The material is based upon the first 299 included patients in the OMEMI trial, where patients aged 70–82 years of age are randomized to receive omega-3 supplements or corn oil (placebo) after MI. Patients were included 2–8 weeks after the index MI. DNA was extracted from whole blood, and leukocyte telomere length (LTL) was analyzed by qPCR and reported as a number relative to a reference gene. Serum long chain polyunsaturated fatty acid (LCPUFA) content was analyzed by gas chromatography. Diet was evaluated with the validated SmartDiet food frequency questionnaire. Medical records, patient interviews and clinical examination provided previous medical history and anthropometric data. Non-parametric statistical tests were used. Results Median (25, 75 percentile) LTL was 0.55 (0.42, 0.72). Patients had a median age of 75 years, 70.2% were male and 45.2% used omega-3 supplements. There was a weak, but significant correlation between LTL and linoleic acid (r = 0.139, p = 0.017), but not with other LCPUFAs. There was a trend towards longer telomeres with a healthier diet, but this did not reach statistical significance (p = 0.073). No associations were found between LTL and CVD risk factors or features of MI. Conclusions In our population of elderly with a recent myocardial infarction LTL was associated with linoleic acid concentrations, but not with other LCPUFAs. Patients with a healthy diet tended to have longer telomeres. The limited associations may be due to age and the narrow age-span in our population. Further studies, designed to detect longitudinal changes should be performed to explore the role of telomeres in cardiovascular aging. Trial registration Clinical trials no. NCT01841944, registration date April 29, 2013.

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