Revisiting the impact of ejaculatory abstinence on semen quality and intracytoplasmic sperm injection outcomes

Among infertile couples, 25% involve both male and female factors, while male factor alone accounts for another 25% due to oligo-, astheno-, teratozoospermia, a combination of the three, or even a complete absence of sperm cells in the ejaculate and can lead to a poor prognosis even with the help of assisted reproductive technology (ART). Intracytoplasmic sperm injection (ICSI) has been with us now for a quarter of a century and in spite of the controversy generated since its inception, it remains in the forefront of the techniques utilized in ART. The development of ICSI in 1992 has drastically decreased the impact of male factor, resulting in millions of pregnancies worldwide for couples who, without ICSI, would have had little chance of having their own biological child. This review focuses on the state of the art of ICSI regarding utility of bioassays that evaluate male factor infertility beyond the standard semen analysis and describes the current application and advances in regard to ICSI, particularly the genetic and epigenetic characteristics of spermatozoa and their impact on reproductive outcome.

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The impact of obesity on oocytes: evidence for lipotoxicity mechanisms

Reproduction Fertility and Development ◽

10.1071/rd11904 ◽

2012 ◽

Vol 24 (1) ◽

pp. 29 ◽

Cited By ~ 31

Author(s):

Linda L.-Y. Wu ◽

Robert J. Norman ◽

Rebecca L. Robker

Keyword(s):

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Stress ◽

Mitochondrial Dysfunction ◽

Intracytoplasmic Sperm Injection ◽

Oocyte Quality ◽

Early Embryo ◽

Pregnancy Rates ◽

Clinical Literature ◽

The Impact

Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality.

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What Is the Impact of Excessive Iodine and Semen Quality in Fertile Men of China: An Association Study

10.21203/rs.3.rs-243767/v1 ◽

2021 ◽

Author(s):

Ning Wang ◽

Fang Lv ◽

Ge Yu ◽

Cuige Shi ◽

Shangming Wang ◽

...

Keyword(s):

Semen Quality ◽

Sperm Count ◽

Sperm Concentration ◽

Urinary Iodine ◽

Iodine Concentration ◽

Male Reproduction ◽

Semen Parameters ◽

Human Thyroid ◽

Urinary Iodine Concentration ◽

The Impact

Abstract Background: Iodine is an essential element for hormones synthesized by the human thyroid gland. Thyroid hormone deficiency affects all body tissues, including multiple endocrine changes that alter growth hormones, corticotrophin, glucocorticoids, and gonadal function. In many countries, subfertility is an important problem affecting about 10–15% of all couples trying to conceive. Male subfertile factors have accounted for 25–30% of all cases in their studies. The aim of this study was to study the correlation between urinary iodine concentration (UIC) and semen quality of fertile male in China.Methods: semen and urine samples were collected from males who attended a survey for the reproductive physiological constants of male and female in China. All participants were fertile and they should be free from diseases of male reproductive system and thyroid related diseases. We studied the correlation between UIC and semen quality parameters in fertile males and the effect of iodine concentration on male reproduction. Participants were divided into six groups based on UIC. We measured semen parameters and UIC. Semen parameters or time-to-pregnancy (TTP) were analyzed by Spearman correlation, linear regression and multivariable logistic regression. Results: 1089 men were recruited in the study. The mean and median age of participants were 27.46±0.12 and 27±3.88 years, respectively. UIC of 274 (25.16%) men was lower than the UIC of WHO recommended. UIC of 405 men located in the region of WHO recommended. 62.35% of them were not located in the optimal region. Semen concentration and total sperm count were found to decrease when UIC increases when the UIC≥100 ug/L. Conclusions: A male with deficient UIC or excessive UIC has more risk of lower semen quality such as sperm concentration and total sperm count. In addition, if a male with deficient UIC or excessive UIC, his wife has longer TTP than the males who had normal UIC. Deficient UIC associated with lower semen quality and TTP than excessive UIC.

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Evaluating bull fertility based on non-return method

Veterinarski glasnik ◽

10.2298/vetgl1202027p ◽

2012 ◽

Vol 66 (1-2) ◽

pp. 27-40

Author(s):

Igor Prka ◽

Dragan Vukovic ◽

Stevan Perkovic

Keyword(s):

Semen Quality ◽

Sperm Quality ◽

Quality Parameters ◽

Semen Parameters ◽

Service Period ◽

Microscopic Evaluation ◽

Live Sperm ◽

Return Method ◽

The Impact ◽

First Time

In order to evaluate the results of reproductive cows and heifers, different parameters of fertility are used, such as the service period, insemination index, intercalving time and others, and of the breeding bulls the values obtained through non-return. An ejaculate is taken up for further processing by veterinary centres only provided it meets the prescribed quality parameters. Rating semen parameters includes a macroscopic (volume, colour, consistency, smell and pH) and a microscopic evaluation (mobility, density, percentage of live sperm and abnormal and damaged sperm). In addition to sperm quality and the fertility of the female animal, the results of the non-return method are also influenced by a number of exogenous causes (season, age, race, insemination techniques) that have no small impact on the end result of insemination - pregnancy. In order to obtain more objective results of the fertility of bulls the following tasks were undertaken, namely: 1. to calculate with the non-return method the fertility of bulls in over 10,000 cows inseminated for the first time during a period of 6 years; and 2. to analyze the impact of semen quality, season, age of cow and bull, and the bull breed on the results of fertility.

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Congenital bilateral absence of the vas deferens: the impact of spermatogenesis quality on intracytoplasmic sperm injection outcomes in 108 men

Andrology ◽

10.1111/andr.12019 ◽

2015 ◽

Vol 3 (3) ◽

pp. 473-480 ◽

Cited By ~ 12

Author(s):

M. A. Llabador ◽

A. Pagin ◽

C. Lefebvre-Maunoury ◽

F. Marcelli ◽

B. Leroy-Martin ◽

...

Keyword(s):

Intracytoplasmic Sperm Injection ◽

Vas Deferens ◽

Bilateral Absence ◽

The Impact

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The impact of male infertility or intracytoplasmic sperm injection technique on perinatal outcomes

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767058.2020.1730802 ◽

2020 ◽

pp. 1-7

Author(s):

Shiqiao Hu ◽

Bei Xu ◽

Bo Huang ◽

Lei Jin

Keyword(s):

Male Infertility ◽

Intracytoplasmic Sperm Injection ◽

Perinatal Outcomes ◽

Injection Technique ◽

The Impact

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Canine babesiosis – a disease rarely considered in the context of male infertility

Irish Veterinary Journal ◽

10.1186/s13620-020-00174-y ◽

2020 ◽

Vol 73 (1) ◽

Author(s):

Anna Domosławska ◽

Sławomir Zdunczyk

Keyword(s):

Vitamin E ◽

Semen Quality ◽

Sperm Quality ◽

Babesia Canis ◽

Canine Babesiosis ◽

Case Presentation ◽

The Past ◽

Fertility Problems ◽

The Impact ◽

Treatment Of Infection

Abstract Background Little is known about the impact of babesiosis on semen quality and fertility in dogs. Case presentation Four cases of infertility in male dogs after infection with Babesia canis are described. In all dogs sperm quality was low. Two dogs were castrated pharmacologically or surgically. In two dogs fertility was restored after supplementation with selenium and Vitamin E. As possible causes of spermatogenesis disorders due to the treatment of infection with Babesia canis with imidocarb, fever and disturbed testicular microcirculation are discussed. Conclusions These cases indicate that if males have fertility problems, question about babesiosis infection in the past should be a permanent point in the clinical interview.

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Clinical results from intracytoplasmic sperm injection at monash IVF

Reproduction Fertility and Development ◽

10.1071/rd9950247 ◽

1995 ◽

Vol 7 (2) ◽

pp. 247 ◽

Cited By ~ 4

Author(s):

RI McLachlan ◽

G Fuscaldo ◽

H Rho ◽

C Poulos ◽

J Dalrymple ◽

...

Keyword(s):

Intracytoplasmic Sperm Injection ◽

Oocyte Retrieval ◽

Clinical Results ◽

Fertilization Rate ◽

Vitro Fertilization ◽

Failed Fertilization ◽

Patient Groups ◽

Sperm Antibodies ◽

The Impact

The impact of a modification of the intracytoplasmic sperm injection (ICSI) technique on fertilization and pregnancy rates was examined in a retrospective analysis of 171 consecutive ICSI treatment cycles (156 patients). Patients were selected for ICSI on the basis of severe oligoasthenozoospermia (65 patients) or following conventional in vitro fertilization (IVF) with failed or poor fertilization (70 patients). Seven patients in which epididymal or testicular sperm was used, 10 patients with sperm antibodies and 4 patients with retrograde ejaculation or who required electro-ejaculation were also treated with ICSI. In the first 105 cycles (102 patients), single sperm, rendered immotile, were injected into the ooplasm of 979 metaphase II (M II) oocytes using an established technique (Method 1). In the following 66 cycles (513 M II oocytes injected), the ICSI procedure was modified by increased aspiration of the oolemma to ensure the intracytoplasmic deposition of sperm (Method 2). The patient groups did not differ between the two injection procedures. The normal (two pronuclear) fertilization rate increased significantly (P < 0.001) from 34.3% with Method 1 to 73.1% with Method 2, with no difference in the oocyte degeneration rate (4.3% v. 4.5% respectively). The incidence of failed fertilization was significantly (P < 0.01) reduced from 17.1% (18 cycles) to 1.6% (1 cycle) with the change in technique. As a consequence of the increased fertilization rates with Method 2, more embryos were available for assessment and transfer, and a pregnancy rate per oocyte retrieval of 21.2% was obtained for Method 2. Fertilization, embryo transfer and pregnancies were obtained in all patient groups treated with ICSI.(ABSTRACT TRUNCATED AT 250 WORDS)

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