Biallelic ZNFX1 variants are associated with a spectrum of immuno‐hematological abnormalities

2021 ◽  
Author(s):  
Salem Alawbathani ◽  
Ana Westenberger ◽  
Natalia Ordonez‐Herrera ◽  
Mariam Al‐Hilali ◽  
Homoud Al Hebby ◽  
...  
Keyword(s):  
Hematological Abnormalities

scholarly journals Hematological Indices in Portal Hypertension: Cirrhosis versus Noncirrhotic Portal Hypertension

2018 ◽  
Vol 7 (8) ◽  
pp. 196 ◽  
Author(s):  
Abdurrahman Sahin ◽  
Hakan Artas ◽  
Nurettin Tunc ◽  
Mehmet Yalniz ◽  
Ibrahim Bahcecioglu
Keyword(s):  
Portal Hypertension ◽  
Retrospective Study ◽  
Radiological Findings ◽  
Hematological Indices ◽  
Noncirrhotic Portal Hypertension ◽  
End Stage Liver Disease ◽  
Cirrhotic Patients ◽  
Hematological Abnormalities ◽  
End Stage ◽  
Cirrhotic Group

Portal hypertension (PHT) leads to several alterations on hematological indices (HI). The aim of the study is to investigate the differences in HI between cirrhotic subjects and subjects who have noncirrhotic PHT (NCPHT). This retrospective study included 328 patients with PHT (239 cirrhosis and 89 NCPHT). Demographic and clinical features, endoscopic and radiological findings, and HI including neutrophil to lymphocyte ratio (NLR) at the time of PHT diagnosis were recorded. Severity of cirrhosis was assessed according to the Child–Turcotte–Pugh (CTP) classification and Model for End-Stage Liver Disease (MELD) scores. Hematological abnormalities were found in 92.5% of cirrhotic patients and in 55.1% of patients with NCPHT (p < 0.001). While thrombocytopenia was the most common HI in patients with cirrhosis, anemia was the most prevalent HI in NCPHT group. In the cirrhotic group, the NLR was the only parameter to differentiate each CTP group from two others. The NLR value increased with the severity of cirrhosis (2.28 ± 0.14 in CTP-A, 2.85 ± 0.19 in CTP-B and 3.26 ± 0.37 in CTP-C). The AUROC of NLR was 0.692 for differentiating compensated cirrhotic patients from decompensated. Hematological abnormalities are more prevalent and more severe in cirrhotic patients compared to patients with NCPHT. NLR may be used to assess the severity of cirrhosis.

Detection of Bartonella spp. in neotropical felids and evaluation of risk factors and hematological abnormalities associated with infection

2010 ◽  
Vol 142 (3-4) ◽  
pp. 346-351 ◽  
Author(s):  
A.M.S. Guimaraes ◽  
P.E. Brandão ◽  
W. Moraes ◽  
S. Kiihl ◽  
L.C. Santos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hematological Abnormalities

scholarly journals Hematological abnormalities in patients with malaria and typhoid in Tamale Metropolis of Ghana

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Nsoh Godwin Anabire ◽  
Paul Armah Aryee ◽  
Gideon Kofi Helegbe
Keyword(s):  
Tamale Metropolis ◽  
Hematological Abnormalities

scholarly journals Hematological abnormalities in HIV infected individuals in correlation to CD4 counts and ART status

2016 ◽  
Vol 7 (4) ◽  
pp. 14-18 ◽  
Author(s):  
R Raman Thulasi ◽  
D Manimaran ◽  
G Hemanathan ◽  
Tameem Afroz ◽  
Radha Sagar
Keyword(s):  
Opportunistic Infections ◽  
Hematological Parameters ◽  
Cd4 Count ◽  
Health Concern ◽  
Medical Sciences ◽  
Cd4 Counts ◽  
Medical Centers ◽  
Hematological Abnormalities ◽  
Set Up ◽  
One Year

Background: HIV is pandemic and remains as a public health concern for many decades. This infection though associated with many opportunistic infections and neoplasms, it is further complicated with marked hematological abnormalities. The aim of this study is to determine the magnitude & severity of hematological abnormalities in HIV infected individuals and also to analyze these abnormalities in correlation with the CD4 counts. We also compared these hematological abnormalities in patients on ART and those not on ART.Materials and Methods: The study was conducted for a period of one year, on 120 HIV positive cases including both patients on ART & not on ART. Controls with similar age and sex distribution was set up. The blood samples were collected and processed in an automated cell counter. The parameters were tabulated and analyzed with respect to CD4 count & ART status.Results: Among the total of 120 HIV cases, 77% had anemia, 21% had leucopenia and 5% had thrombocytopenia. The magnitude and severity of anemia, leucopenia, thrombocytopenia and other parameters was found to be more in patients not on ART, when compared to patients on ART. Similarly, the magnitude and severity of most of hematological abnormalities were inversely proportional to the CD4 count in non-ART cases but not with cases on ART.Conclusion: The basic hematological parameters can be used as a prospective screening test to assess the severity and progression of HIV infection when CD4 count is not available. These parameters can also be used to assess the response to anti-retroviral treatment. Therefore, these basic hematological investigations readily available at all medical centers are of great use while treating HIV infected patients.Asian Journal of Medical Sciences Vol.7(4) 2016 14-18 

Phenol poisoning in three dogs

2000 ◽  
Vol 36 (4) ◽  
pp. 317-321 ◽  
Author(s):  
TL Gieger ◽  
SS Correa ◽  
J Taboada ◽  
AM Grooters ◽  
AJ Johnson
Keyword(s):  
Oral Administration ◽  
Supportive Care ◽  
Coal Tar ◽  
Endoscopic Examination ◽  
Gastric Ulceration ◽  
The Internet ◽  
Muscle Enzymes ◽  
Hematological Abnormalities ◽  
Mucosal Necrosis

Three adult dogs were evaluated following oral administration of phenol by the owner. All three dogs experienced severe oral and gastric ulceration. Hematological abnormalities included neutropenia with the presence of toxic neutrophils, thrombocytopenia, and increased muscle enzymes. Endoscopic examination was performed, and biopsies yielded a diagnosis of gastric mucosal necrosis in two of the dogs. Following supportive care, the dogs recovered completely. Phenol is a caustic, highly poisonous derivative of coal tar. The dogs of this report were poisoned inadvertently by their owner who received misinformation concerning the use of this chemical via the Internet.

scholarly journals Association between IPTA Gene Polymorphisms and Hematological Abnormalities in Hepatitis C Virus-Infected Patients Receiving Combination Therapy

Gut and Liver ◽  
2015 ◽  
Vol 9 (2) ◽  
pp. 214-223 ◽  
Author(s):  
Jow-Jyh Hwang ◽  
Ching-Chu Lo ◽  
Chien-Hung Lin ◽  
Hsu-Sheng Cheng ◽  
I-Wen Hung ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Combination Therapy ◽  
Gene Polymorphisms ◽  
Hematological Abnormalities

Hematological alteration among visceral leishmaniasis patients attending in Western Tigrai, Ethiopia, 2018/2019: A cross-sectional study

2020 ◽  
Author(s):  
Gebremedhin Gebremichail ◽  
Brhane Tesfanchal ◽  
Getachew Belay ◽  
Gebreslassie Gebremariam ◽  
Gebreyohans Teklehaymanot ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Blood Cell ◽  
Hematological Parameters ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Control Groups ◽  
Cross Sectional ◽  
Red Cell Indices ◽  
Hematological Abnormalities

Abstract Background: Hematological abnormalities are common in visceral leishmaniasis patients, which is one of the main public health problems worldwide. The most common hematological abnormalities are anemia, leucopenia and thrombocytopenia. Therefore, this study aimed to assess the hematological alteration among visceral leishmaniasis patients attending Western Tigrai, Ethiopia, 2019. Method: Hospital based comparative cross sectional study was conducted from November 2018 to March 2019 in Western Tigrai, Ethiopia. A total of 100 Visceral Leishmaniasis patients and 100 control groups were included in this study. Blood was collected and analyzed by mindray BC-5800 hematology analyzer. Data was entered and analyzed using Statistical package for social science version 23. Student independent t-test was used for data analysis. P value <0.05 was considered as statistically significant at 95% confidence level. Result: From the total 100 visceral leishmaniasis patients the following abnormalities were reported: 96(96%) anemia, 95(95%) leucopenia, 92(92%) neutropenia, 73(73%) Lymphopenia, 45(45%) eosinopenia and 97(97%) had thrombocytopenia. Red blood cell, hemoglobin, hematocrit, red cell indices and platelet were significantly lower (p<0.05) in visceral leishmaniasis patients compared with the control groups. Similarly the total White blood cell, neutrophil, lymphocyte, eosinophil and basophil count were significantly lower (p<0.05) in visceral leishmaniasis patients compared with the control groups. Conclusion: The major changes in peripheral blood of patient with visceral leishmaniasis are reduced number of red blood cells, reduction in leukocytes and decreased platelet count. Visceral leishmaniasis patients presented with anemia, leucopenia and thrombocytopenia. So this finding indicates that visceral leishmaniasis causes alterations of hematological parameters. Key words: Amastigote, Anemia, Hematological Parameters, Promastigote, Visceral leishmaniasis, Ethiopia .

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