Phenol poisoning in three dogs

2000 ◽  
Vol 36 (4) ◽  
pp. 317-321 ◽  
Author(s):  
TL Gieger ◽  
SS Correa ◽  
J Taboada ◽  
AM Grooters ◽  
AJ Johnson
Keyword(s):  
Oral Administration ◽  
Supportive Care ◽  
Coal Tar ◽  
Endoscopic Examination ◽  
Gastric Ulceration ◽  
The Internet ◽  
Muscle Enzymes ◽  
Hematological Abnormalities ◽  
Mucosal Necrosis

Three adult dogs were evaluated following oral administration of phenol by the owner. All three dogs experienced severe oral and gastric ulceration. Hematological abnormalities included neutropenia with the presence of toxic neutrophils, thrombocytopenia, and increased muscle enzymes. Endoscopic examination was performed, and biopsies yielded a diagnosis of gastric mucosal necrosis in two of the dogs. Following supportive care, the dogs recovered completely. Phenol is a caustic, highly poisonous derivative of coal tar. The dogs of this report were poisoned inadvertently by their owner who received misinformation concerning the use of this chemical via the Internet.

scholarly journals Expectations and preferences of patients with primary and relapsed ovarian cancer to maintenance therapy: A NOGGO/ENGOT-ov22 and GCIG survey (Expression IV)

2020 ◽  
Vol 30 (4) ◽  
pp. 509-514
Author(s):  
Irena Rohr ◽  
Sara Alavi ◽  
Rolf Richter ◽  
Maren Keller ◽  
Radoslav Chekerov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ovarian Cancer ◽  
Adverse Effects ◽  
Maintenance Therapy ◽  
Oral Administration ◽  
Epithelial Ovarian Cancer ◽  
Recurrent Disease ◽  
The Internet ◽  
Primary Epithelial Ovarian Cancer

BackgroundMaintenance therapy induces remission and prolongs disease free interval in primary and recurrent ovarian disease. For the treatment decision making process, aspects of quality of life and patients′ preferences are crucial, despite the fact that scientific data are lacking. Therefore, we conducted this European-wide study in patients with ovarian cancer.MethodsA 25 item questionnaire was provided to ovarian cancer patients via the internet or as a paper version in 10 European countries (Austria, Belgium, France, Germany, Italy, Romania, Slovenia, Finland, Turkey, and Spain). Data recorded were demographics, tumor stage, therapy after firstline and recurrent disease, preferences for administration, and expectations concerning maintenance therapy.ResultsOverall, 1954 patients participated from September 2013 to March 2016; 42% had recurrent disease. Most patients (98%) with primary epithelial ovarian cancer underwent surgery followed by chemotherapy (91%). Almost one-third of participants (29%) were receiving maintenance therapy whereas 45% had only heard of it. For 70% of patients with primary epithelial ovarian cancer, they heard about maintenance therapy from their doctor, 10% heard about maintenance therapy from other patients, and 8% from the internet. The main source of information about maintenance therapy in patients with epithelial ovarian cancer relapse was from the treating physician (72%), from other patients (8%), and from the internet (7%). For patients undergoing maintenance therapy, the four most disturbing adverse effects were polyneuropathy (37%), nausea (36%), hair loss (34%), and vomiting (34%). The main objective of maintenance treatment, as perceived by patients, was to increase the chances of cure (73%), improvement in quality of life (47%), and delay in tumor growth (37%). Many patients were willing to undergo maintenance therapy until tumor progression (38%) and 39% would prefer oral administration. No significant differences were detected in the cross country subanalysis regarding expectations of maintenance therapy and patients with primary or relapsed ovarian cancer.ConclusionPatients with ovarian cancer were willing to accept maintenance therapy of prolonged duration and preferred oral administration. There is still a gap between the efficacy of maintenance therapy and patient expectations. Patients need more information on the adverse effects and treatment goals of maintenance therapy to avoid misunderstandings.

scholarly journals Esophago-gastroduodenal ulceration complicated by duodenal perforation in a three year old Thoroughbred colt: a case report

2009 ◽  
Vol 54 (No. 8) ◽  
pp. 374-378 ◽  
Author(s):  
B. Bezdekova
Keyword(s):  
Duodenal Ulcer ◽  
Delayed Gastric Emptying ◽  
Endoscopic Examination ◽  
Gastric Ulceration ◽  
Exercise Intolerance ◽  
Duodenal Perforation ◽  
Endoscopic Appearance ◽  
Blood Examination ◽  
Septic Peritonitis ◽  
Gastroduodenal Ulceration

: A three year old Thoroughbred colt was admitted to our clinic because of chronic inapetence, weight loss and exercise intolerance. Clinical examination, blood examination and endoscopy were carried out. The endoscopic appearance of the distal esophagus was characterized by extensive and severe ulceration. Gastroscopy revealed severe diffuse ulceration of the entire nonglandular mucosa. A diagnosis of esophago-gastric ulceration and delayed gastric emptying was made. Shortly after endoscopic examination the colt developed acute severe colic with profuse diarrhea and was euthanized. Necropsy and histopathology were performed. The most notable abnormalities were severe and extensive esophageal, gastric and duodenal ulcerations. One duodenal ulcer was perforated and acute septic peritonitis developed. The diagnosis was thus confirmed and extended – esophago-gastroduodenal ulceration with complication of duodenal perforation.

Tularemia

2016 ◽  
Author(s):  
Alida Gertz
Keyword(s):  
Health Care ◽  
Antibiotic Resistance ◽  
Oral Administration ◽  
Supportive Care ◽  
Health Care System ◽  
Francisella Tularensis ◽  
Small Mammals ◽  
Clinical Symptoms ◽  
Gram Negative ◽  
Route Of Transmission

Tularemia, caused by the gram-negative coccobacillus Francisella tularensis, is an extremely infectious bacterial zoonosis. Symptoms depend on site of exposure; they can be nonspecific and may include fever, lymphadenopathy, ulcer or papule, and nausea/vomiting. Natural transmission occurs via small mammals, such as rabbits, or arthropod bites. IV or IM antibiotics are preferred over oral forms. Supportive care is also critical; some patients may require respiratory support. If used as a biological weapon, aerosolized F. tularensis would be the most likely route of transmission. Clinical symptoms would include those of pneumonic tularemia. In the event of a bioterrorist attack, oral administration antibiotics can be used, as the health care system may not be able to accommodate intravenous or intramuscular treatment. Antibiotic resistance should also be considered if patients deteriorate despite use of recommended antibiotics.

Primary Gastrointestinal Lymphosarcoma with Epitheliotropism in Three Shar-Pei and One Boxer Dog

1995 ◽  
Vol 32 (4) ◽  
pp. 423-426 ◽  
Author(s):  
H. Steinberg ◽  
R. R. Dubielzig ◽  
J. Thomson ◽  
G. Dzata
Keyword(s):  
Weight Loss ◽  
Endoscopic Examination ◽  
Gastric Ulceration ◽  
Intestinal Lymphoma ◽  
Epithelial Basement Membrane ◽  
Hepatic Involvement ◽  
Mesenteric Lymph ◽  
Small Intestinal ◽  
Neoplastic Lymphocytes ◽  
Epithelial Basement

Three male Shar-pei dogs and one female spayed Boxer dog ranging in age from 4 years, 4 months to 7 years, 8 months had 4-7-week histories of diarrhea, progressive anorexia, weight loss, and vomiting. The dogs were depressed, lethargic, and hypoalbuminemic, with losses of 23-39% of body weight. Endoscopic examination revealed gastric ulceration with areas of mucosal hyperemia and pallor. Small nodules with occasional central depressions were present in three dogs. Gastric and proximal duodenal mucosal biopsies showed neoplastic lymphocytes infiltrating the lamina propria, with invasion of the superficial and glandular epithelial basement membrane. Immunohistochemical evaluation of two dogs was negative for anti-canine IgG and positive for anti-CD3. Necropsy of the Boxer and two Shar-peis confirmed epitheliotropic gastric and small intestinal lymphoma in all three dogs, with mesenteric lymph node and hepatic involvement in two and one dog, respectively.

scholarly journals Pharmacokinetics and Anti-Gastric Ulceration Activity of Oral Administration of Aceclofenac and Esomeprazole in Rats

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 152 ◽  
Author(s):  
Tae Kim ◽  
Subindra Thapa ◽  
Da Lee ◽  
Seung Chung ◽  
Jun Lim ◽  
...  
Keyword(s):  
Oral Administration ◽  
Plasma Concentrations ◽  
Gastric Ulceration ◽  
Sprague Dawley ◽  
Food Effects ◽  
Concurrent Administration ◽  
Gastrointestinal Complications ◽  
Sprague Dawley Rats ◽  
Liquid Chromatography Tandem Mass ◽  
Lesion Index

This study examined the effects of esomeprazole on aceclofenac pharmacokinetics and gastrointestinal complications in rats. Aceclofenac alone, or in combination with esomeprazole, was orally administered to male Sprague-Dawley rats. Plasma concentrations of aceclofenac, its major metabolite diclofenac, and esomeprazole were simultaneously determined by a novel liquid chromatography-tandem mass spectrometry method. Gastrointestinal damage was determined by measuring ulcer area and ulcer lesion index of the stomach. Oral administration of aceclofenac induced significant gastric ulceration, which was inhibited by esomeprazole administration. Following concurrent administration of aceclofenac and esomeprazole, overall pharmacokinetic profiles of aceclofenac and metabolic conversion to diclofenac were unaffected by esomeprazole. Aceclofenac metabolism and pharmacokinetics were not subject to significant food effects, whereas bioavailability of esomeprazole decreased in fed compared to fasting conditions. In contrast, the pharmacokinetics of aceclofenac and esomeprazole were significantly altered by different dosing vehicles. These results suggest that co-administration of esomeprazole with aceclofenac may reduce aceclofenac-induced gastrointestinal complications without significant pharmacokinetic interactions. The optimal combination and clinical significance of the benefits of the combination of aceclofenac and esomeprazole need to be further evaluated.

Clove Oil Ingestion in an Infant

1991 ◽  
Vol 10 (4) ◽  
pp. 291-294 ◽  
Author(s):  
Brian W. Lane ◽  
Matthew J. Ellenhorn ◽  
Tim V. Hulbert ◽  
Margaret McCarron
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Oral Administration ◽  
Supportive Care ◽  
Gastric Lavage ◽  
Anion Gap ◽  
Clove Oil ◽  
Total Recovery ◽  
Central Nervous System Depression ◽  
Urinary Abnormalities

A case is presented in which a 7-month-old child developed central nervous system depression, urinary abnormalities and a large anion-gap acidosis after the accidental oral administration of clove oil. Supportive care and gastric lavage were sufficient for total recovery of the patient. Possible mechanisms of the depression and acidosis are discussed, and suggestions for treatment are presented.

scholarly journals Effects of Transport Conditions on Behavioural and Physiological Responses of Horses

Animals ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 160 ◽  
Author(s):  
Barbara Padalino ◽  
Sharanne L Raidal
Keyword(s):  
Physiological Responses ◽  
Gastric Ulceration ◽  
Muscle Enzymes ◽  
Physiological Laboratory ◽  
Loss Of Balance ◽  
Before And After ◽  
Transport Stress ◽  
Horse Health ◽  
In Transit ◽  
The Impact

The regulations for minimal space and direction of travel for land transport in horses vary worldwide and there is currently no definitive guidance to promote equine health and welfare. This study evaluated the effects of bay size and direction of travel (forwards/backwards) in horses by comparing the behavioural, physiological, laboratory and gastroscopy parameters between transported and confined horses. A total of twenty-six mares took part in the study; 12 horses were confined for 12 h, and all mares underwent 12 hours’ transportation, travelling in single (n = 18) or wide bays (n = 8), and forward (n = 10) or rear (n = 16) facing. Behaviour was recorded during confinement/transportation and analysed using a behaviour sampling ethogram. Clinical examination, blood samples and gastroscopy were conducted before and after confinement/transportation. The frequency of behaviours relating to stress and balance increased during transport, and horses transported in a rear-facing position and in a wider bay size showed fewer balance-related behaviours. Balance behaviours, particularly loss of balance, were positively associated with the severity of gastric ulceration after transportation and elevated muscle enzymes, while increased stress behaviours correlated with decreased gastrointestinal sounds. Heart rate and rectal temperature after transportation were positively associated with balance and stress behaviours, and with squamous gastric ulcer scores. Transportation was associated with expected increases in cortisol and muscle enzymes, but positioning and space allowance had minimal effects on these analytes. Findings suggest that transportation in a rear-facing position and in wider bays might reduce the impact of transport on horse health and welfare, and monitoring behaviour in transit and physiological measurements after transportation should be recommended. Behavioural and physiological parameters were more sensitive than haematological, biochemical or endocrine analytes to identify horses suffering from transport stress.

scholarly journals How can eHealth enhance adherence to cancer therapy and supportive care?

2016 ◽  
Vol 144 (1-2) ◽  
pp. 116-121 ◽  
Author(s):  
Emma Bateman ◽  
Dorothy Keefe
Keyword(s):  
Cancer Therapy ◽  
Supportive Care ◽  
State Of The Art ◽  
The Internet ◽  
Communications Technology ◽  
Wireless Technology ◽  
Global Expansion ◽  
Related Information ◽  
Current State ◽  
Health Related

eHealth is currently a hot topic, but is certainly not a new one. The use of communications technology to relay health-related information or provide medical services has been around since the advent of this technology. It has been primarily over the last decade that eHealth has seen a global expansion, due to the far-reaching capabilities of the Internet and the widespread use of wireless technology. This paper will outline what eHealth is, what adherence is, and how eHealth can help with adherence, in cancer and supportive care particularly. It will discuss the current state of the art, and project into the future.

scholarly journals Evaluation of the scope, quality, and health literacy demand of Internet-based anal cancer information

2019 ◽  
Vol 107 (4) ◽  
Author(s):  
Rebecca Charow ◽  
Michelle Snow ◽  
Sameera Fathima ◽  
Meredith E. Giuliani ◽  
Kate McEwan ◽  
...  
Keyword(s):  
Health Literacy ◽  
Supportive Care ◽  
Health Information ◽  
Anal Cancer ◽  
Assessment Tool ◽  
Supportive Care Needs ◽  
Cancer Information ◽  
The Internet ◽  
Medical Subject Headings ◽  
Care Needs

Objectives: As there is a dearth of information about anal cancer available at cancer centres, patients often use the Internet to search for information. This is problematic, however, because the quality of information on the Internet is variable, and the health literacy demanded is higher than the average patrons’ capacity. The purposes of this study were to (1) determine the most common websites with anal cancer consumer health information, (2) identify the supportive care needs that each website addresses, and (3) evaluate the websites’ quality and health literacy demand.Methods: Medical Subject Headings (MeSH) entry terms for “Anus Neoplasms” were used in Google Canada to identify websites. Seven domains of supportive care needs were defined using Fitch’s Supportive Care Framework for Cancer Care. Website quality was evaluated using the DISCERN tool. Health literacy demand was assessed using readability calculators, where best practice dictates a grade 6 or lower, and the Patient Education Material Assessment Tool (PEMAT) that computes a percentage score in 2 domains, understandability and actionability, with 80% being an acceptable score.Results: Eighteen unique websites were evaluated. One website met health literacy best practices and had a “good” quality rating. Most websites addressed only 1 supportive care domain (61%), were of “fair” quality (67%), had readability scores higher than grade 6 (89%), and had PEMAT scores ranging from 41%–92% for understandability and 0–70% for actionability.Conclusion: The information gaps on anal cancer websites warrant a need for more health literate anal cancer health information on the Internet.

Sign in / Sign up

Export Citation Format

Share Document