Multiple cycles of rituximab therapy for pemphigus: a group of patients with difficult‐ to‐treat disease or a consequence of late rituximab initiation?

2021 ◽  
Author(s):  
Kamran Balighi ◽  
Parvaneh Hatami ◽  
Mohammad Javad Sheikh Aboli ◽  
Maryam Daneshpazhooh ◽  
Maryam Ghiasi ◽  
...  
Keyword(s):  
Multiple Cycles

scholarly journals Obsidian pyroclasts in the Yellowstone-Snake River Plain ignimbrites are dominantly juvenile in origin

2021 ◽  
Vol 83 (4) ◽  
Author(s):  
L. R. Monnereau ◽  
B. S. Ellis ◽  
D. Szymanowski ◽  
O. Bachmann ◽  
M. Guillong
Keyword(s):  
Glass Composition ◽  
Snake River Plain ◽  
Explosive Eruptions ◽  
Snake River ◽  
Pyroclastic Deposits ◽  
Volcanic Conduit ◽  
Trace Elemental ◽  
Multiple Cycles ◽  
River Plain ◽  
Glass Compositions

AbstractDense, glassy pyroclasts found in products of explosive eruptions are commonly employed to investigate volcanic conduit processes through measurement of their volatile inventories. This approach rests upon the tacit assumption that the obsidian clasts are juvenile, that is, genetically related to the erupting magma. Pyroclastic deposits within the Yellowstone-Snake River Plain province almost without exception contain dense, glassy clasts, previously interpreted as hyaloclastite, while other lithologies, including crystallised rhyolite, are extremely rare. We investigate the origin of these dense, glassy clasts from a coupled geochemical and textural perspective combining literature data and case studies from Cougar Point Tuff XIII, Wolverine Creek Tuff, and Mesa Falls Tuff spanning 10 My of silicic volcanism. These results indicate that the trace elemental compositions of the dense glasses mostly overlap with the vesiculated component of each deposit, while being distinct from nearby units, thus indicating that dense glasses are juvenile. Textural complexity of the dense clasts varies across our examples. Cougar Point Tuff XIII contains a remarkable diversity of clast appearances with the same glass composition including obsidian-within-obsidian clasts. Mesa Falls Tuff contains clasts with the same glass compositions but with stark variations in phenocryst content (0 to 45%). Cumulatively, our results support a model where most dense, glassy clasts reflect conduit material that passed through multiple cycles of fracturing and sintering with concurrent mixing of glass and various crystal components. This is in contrast to previous interpretations of these clasts as entrained hyaloclastite and relaxes the requirement for water-magma interaction within the eruptive centres of the Yellowstone-Snake River Plain province.

Periodicity of insulin secretion comprises multiple cycles with different duration in perfused rat islets

1992 ◽  
Vol 17 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Koji Yarimizu ◽  
Nagamasa Kawano ◽  
Junko Ono ◽  
Ryosaburo Takaki
Keyword(s):  
Insulin Secretion ◽  
Rat Islets ◽  
Multiple Cycles

scholarly journals Erratum: Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility study

2002 ◽  
Vol 29 (2) ◽  
pp. 181-181
Author(s):  
S García-Rayo ◽  
J Pérez-Calvo ◽  
S Martín-Algarra ◽  
R Martínez-Monge ◽  
O Fernández-Hidalgo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Metastatic Breast Cancer ◽  
Feasibility Study ◽  
Metastatic Breast ◽  
Induction Treatment ◽  
Intensive Chemotherapy ◽  
Stem Cell Support ◽  
Multiple Cycles ◽  
Cell Support

DEVS OS (Discrete Even Visualization and Simulation Operating System)

2018 ◽  
Author(s):  
Adnan Hajar
Keyword(s):  
Operating System ◽  
Operating Systems ◽  
Scheduling Algorithm ◽  
The Novel ◽  
Priority Scheduling ◽  
First Come First Serve ◽  
Multiple Cycles ◽  
Visualization And Simulation ◽  
Traditional Approaches

The use of traditional approaches to teach Operating Systems usually lacks the visual aspect. The following research investigates the novel use of DEVS (Discrete Even Visualization and Simulation) in simulating the operation of an operating system. Cd boost++ was the framework of choice for this project. The simulation successfully mimicked the work of an operating system by simulating multiple cycles of program requests. This simulation is capable of further enhance the explanation of how an operating system works. The cases studied in this work include: 1- two processes running concurrently doing multiple IO’s, 2-four processes running concurrently based on a first come first serve scheduling algorithm, and 3- 20 processes running concurrently using highest priority scheduling algorithm. Output observation of the last case show promising results of successful use of DEVS and cd boost++ as a framework to build an operating system.

Advancing Translational Research by Enabling Collaborative Teamwork: The TRACT Approach

2012 ◽  
Vol 2 (3) ◽  
Author(s):  
Nedal H. Arar ◽  
Divya Nandamudi
Keyword(s):  
Content Analysis ◽  
Translational Research ◽  
Research Work ◽  
Structured Interviews ◽  
Team Collaboration ◽  
Team Members ◽  
Effective Strategies ◽  
Multiple Cycles ◽  
And Function ◽  
Collaborative Activities

Background: The work of multidisciplinary research teams (MDRTs) is vital for translational research. The objectives of this study were 1) to understand the structure and function of MDRTs, and 2) to develop effective strategies to enhance collaboration among team members. Methods and Findings: Semi-structured interviews were conducted with 23 participants involved in multidisiplinary research work at two San Antonio, Texas, institutions. Interview materials were tape-recorded, transcribed, and content analyzed using qualitative methods.Themes that emerged from the content analysis were used to develop and refine strategies to enhance the work of MDRTs. The findings showed that MDRTs operate through multiple cycles of: 1) team formation, 2) team collaboration, 3) sustainable collaborative activities, and 4) team maturity. Content analysis identified four interrelated basic elements within the MDRT tract that facilitate team cycles: 1) shared interest/vision among agreeable team leader and members, 2) viable means of communication, 3) available resources, and 4) perceived gain/benefit of teamwork.Conclusions: Our findings highlighted several opportunities and challenges in the formation, dynamics, and growth of MDRTs. Effective strategies to enhance teamwork should levearge these opportunities and address challenges, taking into consideration the interdependent aspects of the basic elements within the MDRTs tract.

Further Characterization of the Potent and Prolonged Inhibition of Herpes Simplex Virus Replication in Human Cell Lines by Penciclovir

1996 ◽  
Vol 7 (3) ◽  
pp. 128-137 ◽  
Author(s):  
T.H. Bacon ◽  
B.A. Howard
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cell Lines ◽  
Virus Replication ◽  
Human Cell ◽  
Human Cell Lines ◽  
Potent Inhibition ◽  
Multiple Cycles ◽  
Simplex Virus ◽  
Hsv 1

The replication of herpes simplex virus type 1 (HSV-1) or HSV-2 in MRC-5 cells infected at 0.01 pfu cell−1 treated continuously for 72 h, was inhibited more efficiently by penciclovir than aciclovir ( p = 0.0001). However, multiple cycles of replication were required in order to distinguish the compounds. Virus from cultures treated for 72 h with either compound, at 3 or 10 μg ml−1 was resistant to penciclovir and aciclovir (50% effective concentrations > 10 μg ml−1), but infectivity titres of supernatants from these aciclovirtreated cultures were higher than for penciclovir. Increased production of resistant virus in aciclovirtreated cultures may be the consequence of the less potent inhibition of virus replication by aciclovir. Penciclovir caused prolonged inhibition of HSV-1 and HSV-2 replication in three human cell lines infected at 1 pfu cell−1 following treatment for 18 h, whereas virus replication resumed rapidly after withdrawal of aciclovir. Neither compound showed prolonged activity after 18 h treatment, when the multiplicity of infection was reduced to 0.01 pfu cell−1. This surprising observation prompted experiments testing the effect of repeated pulse treatment in cultures infected at low multiplicity. Penciclovir inhibited HSV-1 replication significantly more effectively than aciclovir in MRC-5 cells infected at 10−4 pfu cell−1 treated daily for 6 h ( p < 0.001, n = 5) but only a trend was observed for HSV-2 ( p = 0.06, n = 6).

scholarly journals Gene Transfer to the Desiccation-Tolerant CyanobacteriumChroococcidiopsis

2001 ◽  
Vol 183 (7) ◽  
pp. 2298-2305 ◽  
Author(s):  
Daniela Billi ◽  
E. Imre Friedmann ◽  
Richard F. Helm ◽  
Malcolm Potts
Keyword(s):  
High Efficiency ◽  
Genetic Manipulation ◽  
Recipient Cell ◽  
Conjugative Transfer ◽  
Lower Efficiency ◽  
Genetic Studies ◽  
Variable Regions ◽  
Multiple Cycles ◽  
Experimental Strain

ABSTRACT The coccoid cyanobacterium Chroococcidiopsisdominates microbial communities in the most extreme arid hot and cold deserts. These communities withstand constraints that result from multiple cycles of drying and wetting and/or prolonged desiccation, through mechanisms which remain poorly understood. Here we describe the first system for genetic manipulation ofChroococcidiopsis. Plasmids pDUCA7 and pRL489, based on the pDU1 replicon of Nostoc sp. strain PCC 7524, were transferred to different isolates of Chroococcidiopsisvia conjugation and electroporation. This report provides the first evidence that pDU1 replicons can be maintained in cyanobacteria other than Nostoc and Anabaena. Following conjugation, both plasmids replicated inChroococcidiopsis sp. strains 029, 057, and 123 but not in strains 171 and 584. Both plasmids were electroporated into strains 029 and 123 but not into strains 057, 171, and 584. Expression of P psbA-luxAB on pRL489 was visualized through in vivo luminescence. Efficiencies of conjugative transfer for pDUCA7 and pRL489 into Chroococcidiopsissp. strain 029 were approximately 10−2 and 10−4 transconjugants per recipient cell, respectively. Conjugative transfer occurred with a lower efficiency into strains 057 and 123. Electrotransformation efficiencies of about 10−4electrotransformants per recipient cell were achieved with strains 029 and 123, using either pDUCA7 or pRL489. Extracellular deoxyribonucleases were associated with each of the five strains. Phylogenetic analysis, based upon the V6 to V8 variable regions of 16S rRNA, suggests that desert strains 057, 123, 171, and 029 are distinct from the type species strain Chroococcidiopsis thermalis PCC 7203. The high efficiency of conjugative transfer of Chroococcidiopsis sp. strain 029, from the Negev Desert, Israel, makes this a suitable experimental strain for genetic studies on desiccation tolerance.

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