Режимы взаимодействия намагниченных стопок ВТСП-лент

On the basis of the critical state model, the interaction force of a pair of magnetic lines, which are sets of magnetized stacks of second-generation HTSC tapes, is calculated. The modes of magnetization of interacting rulers by an external magnetic field and the origin of the magnetization reversal of the stacks of tapes during multiple cycles of approaching - moving the rulers away from each other are considered. The force of interaction of the rulers is determined depending on the distance between them and the number of the cycle.

From Egg to Organism

How an egg turns into an organism continues to baffle the imagination. We can describe how it happens and many of the particulars, but still struggle to comprehend how events at the levels of genes and cells produce a fruit fly, a sea urchin, or a baby. The fertilized egg, at bottom a single cell, undergoes multiple cycles of division with concurrent differentiation and transformations of shape, resulting in a multicellular embryo whose several regions are committed to develop into distinct organs. Differentiation relies on elaborate networks of control on gene expression that promote certain genes and silence others. Spatial organization of the embryo commonly involves diffusible “morphogens,” hormone-like substances that instruct cells as to their developmental fate. Chemical gradients are supplemented by diverse processes that draw on active transport, mechanical forces, and cell migration. Genes do not hold a comprehensive blueprint for development. They operate in the context of cells that are directed by both genes and self-organization, and there is no plan separable from its execution. How an egg turns into an organism may no longer be mysterious or miraculous, but it remains as wondrous as ever that an assemblage of lifeless molecules can build a butterfly.

Relationship between the Formation of PM2.5 and Meteorological Factors in Northern China: The Periodic Characteristics of Wavelet Analysis

China’s rapid urbanisation and industrialisation have led to frequent haze in China in recent years. Although many measures to control haze have been implemented, no significant improvement has been observed, and haze still exists. In this study, we used wavelet transform to investigate the changes in PM2.5 on the time scale, the relationship amongst meteorological factors, and the causes and changes in haze formation and take measures to prevent haze. Results indicated the following: (1) The peak of PM2.5 changes in winter in the past three years primarily occurred in the range from 11:00 to 13:00 and 20:00 to 22:00. (2) Multiple cycles of daily average PM2.5 concentrations existed in 3–5 d, 6–14 d, 6–21 d, and 16–27 d, with a significant oscillation in 6–14 d and stable cycle characteristics. (3) The meteorological factors promoted the formation of haze to a certain extent. When haze occurred, the near-surface wind speed was only 1 m/s, which was not conducive to the spread of pollutants. (4) The formation of haze was affected by the interaction of various factors; the photochemical reactions of NO2 and O3 also exacerbated the formation of pollutants. This study provided a clear direction for the prevention and prediction of haze. Furthermore, the government must take relevant measures to reduce pollutant emissions and ensure the air quality of cities in winter.

Synthesis, Characterization and Enhanced Visible Light Photocatalytic Performance of ZnWO4-NPs@rGO Nanocomposites

ZnWO4 nanoparticles on reduced graphene oxide (ZnWO4-NPs@rGO) nanocomposites were synthesized using the hydrothermal method. Structural, morphological, optical, and photocatalytic studies of the ZnWO4-NPs@rGO nanocomposites were successfully investigated. Photo-catalytic performances of the ZnWO4-NPs@rGO nanocomposites were examined for the degradation of hazardous methylene blue dye (HMBD) in a neutral medium. ZnWO4-NPs@rGO nanocomposites show superior photo-catalytic performances over pure ZnWO4 nanoparticles. ZnWO4-NPs@rGO nanocomposites degrade ~98% dye while pure ZnWO4 nanoparticles degrade ~53% dye in 120 min. The prepared nanocomposites also show excellent recycled photo-catalytic efficiencies over multiple cycles.

Vision Based Indoor Surveillance Patrol Robot Using Extended Dijkstra Algorithm in Path Plannin

Vision based patrol robot has been with great interest nowadays due to its consistency, cost effectiveness and no temperament issue. In recent times, Global positioning system (GPS) has been cooperated with Global Navigation Satellite System (GNSS) to come out with better accuracy quality in positioning, navigation, and timing (PNT) services to locate a device. However, such localization service is yet to reach any indoor facility. For an indoor surveillance vision based patrol robot, such limitation hinders its path planning capabilities that allows the patrol robot to seek for the optimum path to reach the appointed destination and return back to its home position. In this paper, a vision based indoor surveillance patrol robot using sensory manipulation technique is presented and an extended Dijkstra algorithm is proposed for the patrol robot path planning. The design of the patrol robot adopted visual type sensor, range sensors and Inertia Measurement Unit (IMU) system to impulsively update the map’s data in line with the patrol robot’s current path and utilize the path planning features to carry out obstacle avoidance and re-routing process in accordance to the obstacle’s type met by the patrol robot. The result conveyed by such approach certainly managed to complete multiple cycles of testing with positive result.

Living on the Edge and Beyond of Anoxia: Evolutionary Ecological Insights From Inside Crayfish Burrows

Burrowing is a common trait among crayfish thought to help species deal with adverse environmental challenges. Here we used in-vivo experimental data and in-silico modelling of oxygen saturation in a virtual burrow inhabited by crayfish. Except for the entrance 200 mm region, the burrow microenvironment becomes anoxic, on average, within 8 hours, and 12-hour day-night multiple cycles were not sufficient for refreshing the burrow microenvironment even with temporary lack of crayfish. We asked whether the ecological category of crayfish burrowing activity is reflected in the physiological ability to cope with hypoxia and anoxia. As dissolved oxygen declined, respiration patterns of primary burrowers differed from those of secondary and tertiary burrowers, showing also the highest variability in anoxia tolerance. Secondary burrowers showed consistent tolerance with all species exhibiting a mean survival of > 3h anoxic conditions. Tertiary burrowers were variable, exhibiting moderate to zero tolerance of anoxia. The adaptive mechanisms to cope with hypoxia might be a basal legacy from the crayfish monophyletic ancestors – lobsters, traveller crustaceans often reaching deep depths in the ocean. These results challenge the current understanding of crayfish ecology, opening an evolutionary ecological perspective which might be relevant for the next generation of phylogenetical approaches.

Investigation of CO Deactivation of Passive NOx Adsorption on La Promoted Pd/BEA

Passive NOx adsorption (PNA) is a method, in which NOx can be stored at low temperatures and released at higher temperatures where the urea decomposition is functional during selective catalytic reduction (i.e., above 180–200 °C). We have studied the promotion of Pd/BEA with La as a PNA in the presence of high CO concentration. Both the reference and promoted samples exhibited a significant loss of NOx adsorption/desorption capacity after multiple cycles using 4000 ppm CO. However, already after 5 cycles, 99% of the NOx released between 200 and 400 °C was lost for Pd/BEA, compared to only 64% for Pd-La/BEA, which thereafter was stable. XPS and O2-TPD clearly showed that the Pd species were influenced by La. The PNA deactivation in the presence of CO could be related to Pd reduction followed by migration and the formation of more PdOx clusters, as observed by O2-TPD analysis. Interestingly, significantly more PdOx clusters formed on Pd/BEA after 10 cycles compared to Pd-La/BEA.

Translational Development of A Tumor Junction Opening Technology

Our goal is to overcome treatment resistance in ovarian cancer patients, which occurs in most cases after an initial positive response to chemotherapy. A central resistance mechanism is the maintenance of desmoglein-2 (DSG2)-positive tight junctions between malignant cells, which prevents drug penetration into the tumor. We generated JO4, a recombinant protein that binds to DSG2, resulting in the transient opening of junctions in epithelial tumors. Here, we present studies on the clinical translation of JO4 in combination with PEGylated liposomal doxorubicin/Doxil® for ovarian cancer therapy. A manufacturing process for cGMP-compliant production of JO4 was developed. GLP toxicology studies using material from this process in DSG2 transgenic mice and cynomolgus macaques showed no treatment-related toxicities after intravenous injection at doses reaching 24 mg/kg. Multiple cycles of intravenous JO4 plus Doxil® (4 cycles, 4 weeks apart, simulating the treatment regimen in the clinical trial) elicited antibodies against JO4 that increased with each cycle and were accompanied by elevation of pro-inflammatory cytokines IL6 and TNF. Pretreatment with steroids and cyclophosphamide reduced the anti-JO4 antibody response and blunted cytokine release. Our data indicate acceptable safety of our new treatment approach if immune reactions are monitored and counteracted with appropriate immune suppression.