Clinicopathological characteristics of patients with esophageal squamous papilloma in Turkey and comparison with the literature data: the largest case series ever reported from Turkey

Background: Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) represent a rare tumor composed of adenocarcinoma and neuroendocrine carcinoma components. This study reports a case series of gastric MiNEN and discusses issues related to its diagnosis, management, and outcomes. Methods: We retrospectively analyzed data from patients with gastric MiNEN who underwent surgical resection at our service from 2009 to 2020. Patients with gastric adenocarcinoma served as a comparison group. Clinical, pathologic, and surgical characteristics were compared. Results: During the selected period, 5 gastric MiNEN patients and 597 patients with gastric adenocarcinoma were included. Among the clinical variables, age, sex, BMI, and laboratory exams were similar between the two groups. Only ASA classification was different (p = 0.015). Pathological variables such as tumor size, lymphovascular invasion, number of retrieved lymph nodes, and pTNM staging were also similar between both groups. Lastly, early surgical outcomes and long-term survival did not differ between gastric MiNEN and adenocarcinoma patients. Conclusion: A MiNEN is a rare tumor that represents less than 1% of GC patients undergoing curative treatment, and demonstrated clinicopathological characteristics and outcomes similar to gastric adenocarcinoma.

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Endoscopic submucosal dissection in management of colorectal tumors near or involving a diverticulum: a retrospective case series

Endoscopy International Open ◽

10.1055/a-0848-8048 ◽

2019 ◽

Vol 07 (05) ◽

pp. E664-E671 ◽

Cited By ~ 3

Author(s):

Victoria Jimenez-Garcia ◽

Masayoshi Yamada ◽

Hiroaki Ikematsu ◽

Hiroyuki Takamaru ◽

Seiichiro Abe ◽

...

Keyword(s):

Endoscopic Submucosal Dissection ◽

Case Series ◽

Clinicopathological Characteristics ◽

R0 Resection ◽

Incomplete Resection ◽

Colorectal Tumors ◽

Resection Rate ◽

Retrospective Case ◽

En Bloc ◽

Submucosal Dissection

Abstract Background and study aims Surgery is the standard treatment for colon tumors associated with diverticulum. Use of endoscopic submucosal dissection (ESD) to treat such tumors is controversial. The aim of this study was to assess the safety and feasibility of ESD in treating superficial colorectal tumors situated near or involving diverticulum. Patients and methods Consecutive patients from two referral centers who had colorectal tumors near or involving diverticulum treated by ESD were retrospectively studied. Clinicopathological characteristics and clinical outcomes were analyzed. Results Of the 12 patients studied, six had tumors near diverticulum and six had tumors involving diverticulum. The overall en-bloc R0 resection rate, median tumor size and procedure time were 67 %, 26.5 mm (range, 15 – 80 mm) and 110 minutes (range, 50 – 220 minutes), respectively. For tumors near diverticulum group, the en-bloc R0 resection rate was 100 % and no adverse events (AEs) or residual/recurrent tumors were observed. In contrast, for intradiverticular tumors group, the en-bloc R0 resection rate was low at 33 %, and one AE (perforation) was observed. The diverticula were ≥ 6 mm in diameter in the patients with incomplete resection. However, all but one diverticulum was unrecognized before ESD. Two residual tumors were detected at the 12-month surveillance and one required surgery. Conclusions This case series indicates that ESD is safe and feasible for treating colorectal tumors near a diverticulum and might be feasible for tumors involving a diverticulum smaller than 6 mm. Selection for smaller diverticulum size may contribute to higher en-bloc R0 resection rates.

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Changes in the Demographic and Clinicopathological Characteristics of Thyroid Cancer: A Population-Based Investigation in Algeria, 1993-2013

Journal of Cancer Epidemiology ◽

10.1155/2020/7812791 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Houda Boukheris ◽

Arslan Bettayeb ◽

Lesley Ann Anderson ◽

Zineb Achour ◽

Fatma Zohra Benbachir ◽

...

Keyword(s):

Thyroid Cancer ◽

Case Series ◽

Population Based ◽

Clinicopathological Characteristics ◽

Nutrition Status ◽

Iodine Nutrition ◽

Molecular Features ◽

International Trends ◽

Histologic Types ◽

Over Time

Over the last three decades, the incidence of thyroid cancer has increased worldwide. The reasons for this increase remain controversial. In Algeria, however, to date, information on thyroid cancer has been limited to a hospital-based case series. We analyzed data from a population-based cohort study in Oran District, Algeria, to describe demographic and clinicopathological characteristics of patients diagnosed with thyroid cancer between 1993 and 2013. Medical records and pathology reports of thyroid cancer patients who had surgery were reviewed. Changes in demographic and clinicopathological features over the 21-year period are described. During the study period, thyroid cancer was diagnosed in 1248 women (86.5%, mean age 43.7±15.2 years) and 195 men (23.4%, mean age 48.1±15.9 years). Most cases (83.1% for women and 69.8% for men) sought a diagnosis following a self-neck check. The most common histologic types were papillary (58.3%), follicular (29.7%), anaplastic (4.1%), and medullary (0.8%) carcinomas. The incidence of papillary carcinomas significantly increased (p<0.001) while the incidence of other histologic types significantly decreased over time. Tumor size overall significantly decreased (p<0.001) while the frequency of small (≤20 mm) and larger (>20 mm) carcinomas significantly increased (p<0.05). The frequency of thyroid cancers with capsular effractions and angioinvasions also decreased over time. Thyroid cancer incidence in Algeria has increased substantially in line with international trends with changes in clinical practice being a possible contributing factor. However, the increasing papillary-to-follicular cancer ratio may be due to changes in iodine nutrition status in Algeria. Further research, including exploration of biological and molecular features of thyroid cancer, will enable a better understanding of risk factors and etiopathogenetic mechanisms.

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Upper limb soft tissue metastasis in post mastectomy patient

International Surgery Journal ◽

10.18203/2349-2902.isj20184105 ◽

2018 ◽

Vol 5 (10) ◽

pp. 3433

Author(s):

Janani S. Reddy ◽

Surya Rao Rao Venkata Mahipathy ◽

Alagar Raja Durairaj ◽

Narayanamurthy Sundaramurthy

Keyword(s):

Soft Tissue ◽

Breast Carcinoma ◽

World Literature ◽

Soft Tissues ◽

Case Series ◽

Anterior Chest Wall ◽

Clinicopathological Characteristics ◽

Soft Tissue Metastasis ◽

Primary Malignancy ◽

Chest Wall Recurrence

Soft tissue metastasis from any primary malignancy is considered very rare and a breast carcinoma metastasizing to soft tissue is still rarer. To the best of our knowledge, carcinoma breast with soft tissue metastasis to upper extremity is very uncommon with only seven cases been reported in world literature till date and our case is the eighth such case in an elderly female, a known case of carcinoma left breast operated 7 years back. Only few case series and isolated cases reports have been published regarding any primary malignancy or breast carcinoma metastasizing to soft tissues. PET CT done showed features suggestive of left anterior chest wall recurrence with contralateral axillary lymphnodal metastasis and with soft tissue metastases in the left arm. We hereby present this case with review of literature to highlight its extreme rarity, unusual presentation, clinicopathological characteristics and its overall prognosis.

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Polyneuropathy in Young Siberian Huskies Caused by Degenerative and Inflammatory Diseases

Veterinary Pathology ◽

10.1177/0300985820934112 ◽

2020 ◽

Vol 57 (5) ◽

pp. 666-674

Author(s):

Hanne Jahns ◽

Karen M. Vernau ◽

Catherine M. Nolan ◽

Emma J. O’Neill ◽

Robert E. Shiel ◽

...

Keyword(s):

Axonal Degeneration ◽

Inflammatory Diseases ◽

Age At Onset ◽

Case Series ◽

Clinicopathological Characteristics ◽

Autonomic Nerve ◽

Laryngeal Paralysis ◽

Immune Mediated ◽

Large Fiber ◽

Inherited Neuropathies

Polyneuropathy is defined as the simultaneous dysfunction of several peripheral nerves. In dogs, a number of breeds are predisposed to a variety of immune-mediated and/or degenerative inherited forms of polyneuropathy, with laryngeal paralysis and/or megaesophagus as important clinical features of many of these conditions. This case series describes degenerative and inflammatory polyneuropathies in 7 young Siberian huskies that were categorized based on clinicopathological characteristics as follows: (1) slowly progressive laryngeal paralysis and megaesophagus caused by primary axonal degeneration with large fiber loss (n = 2); (2) slowly progressive polyneuropathy without megaesophagus or laryngeal paralysis caused by primary axonal degeneration with large fiber loss (n = 2); (3) acute inflammatory demyelinating neuropathy causing sensory, motor and autonomic nerve deficits (n = 2); and (4) ganglioradiculitis (sensory neuronopathy; n = 1). Based on the predominantly young age at onset, slow progression, relatedness of affected dogs, and clinical and pathological similarities with inherited neuropathies reported in other dog breeds, a hereditary basis for the degenerative polyneuropathies in Siberian huskies is suspected. However, 5 different mutations in 3 genes known to cause polyneuropathy in other dog breeds ( NDRG1, ARHGEF10, or RAB3GAP1) were not detected in the affected Siberian huskies suggesting that more genetic variants remain to be identified. This study highlights the varied underlying lesions of polyneuropathies in young Siberian huskies.

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Clinicopathological characteristics of T-cell non-Hodgkin lymphoma arising in patients with immunodeficiencies: a single-center case series of 25 patients and a review of the literature

Haematologica ◽

10.3324/haematol.2017.169987 ◽

2017 ◽

Vol 103 (3) ◽

pp. 486-496 ◽

Cited By ~ 3

Author(s):

Marieke L. Nijland ◽

Lianne Koens ◽

Steven T. Pals ◽

Ineke J.M. ten Berge ◽

Frederike J. Bemelman ◽

...

Keyword(s):

T Cell ◽

Hodgkin Lymphoma ◽

Case Series ◽

Clinicopathological Characteristics ◽

Review Of The Literature ◽

Single Center ◽

Non Hodgkin Lymphoma

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Clinicopathological Characteristics and Prognosis of Retroperitoneal Castleman Disease: a Study of Combined Case Series

10.21203/rs.3.rs-948403/v1 ◽

2021 ◽

Author(s):

Kun LIU ◽

Liang Liu ◽

Xueyi Liang ◽

Heshui Wu ◽

Zhiqiang Liu

Keyword(s):

Survival Data ◽

Case Reports ◽

Demographic Data ◽

Abdominal Mass ◽

Case Series ◽

Disease Free Survival ◽

Clinicopathological Characteristics ◽

Castleman Disease ◽

Cochrane Library ◽

Almost All

Abstract Background: Owing to the sporadic incidence, the clinicopathological features and prognosis of retroperitoneal Castleman disease (CD) are limited. We aimed to investigate the clinicopathological characteristics and prognosis of retroperitoneal CD.Patients and methods: The retroperitoneal CDs were obtained from our center and case reports extracted from Pubmed and Cochrane library from 1975 to 2020. The baseline clinical and demographic data and survival data were analyzed.Results: A total of 110 retroperitoneal CDs were enrolled in the present study. The most common symptoms were abdominal pain (34/110, 30.9%), followed by abdominal mass (22/110, 20.0%) and weight loss (10/110, 9.1%). Most tumors are 5-10 cm in diameter (61/99, 66.7%). 103/110 (93.6%) tumors are unicentric, and hyaline vascular types (93/108, 86.1%) are the most common pathological type in retroperitoneal CD. The five-year disease-free survival (DFS) and disease-specific survival (DSS) were 96.7% and 100%, respectively. Almost all tumors can be removed surgically.Conclusions: The median diameter of retroperitoneal CD is 7.0 cm. The most common type is unicentric hyaline vascular in retroperitoneal CD. Surgical resection seems to be the most effective therapy, and the five-year DFS and DSS were 98.6% and 100%.

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Abstract 32: Lynch syndrome-associated breast cancers: Clinicopathological characteristics of a case series from the Colon CFR

10.1158/1538-7445.am10-32 ◽

2010 ◽

Author(s):

Christophe Rosty ◽

Michael Walsh ◽

Margaret Cummings ◽

Daniel Buchanan ◽

Sven Arnold ◽

...

Keyword(s):

Lynch Syndrome ◽

Case Series ◽

Clinicopathological Characteristics ◽

Breast Cancers

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Tyrosine Kinase Inhibitors as a Treatment of Symptomatic CNS Metastases in Oncogene-Driven NSCLC

Journal of Oncology ◽

10.1155/2020/1980891 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Omer Gal ◽

Elizabeth Dudnik ◽

Ofer Rotem ◽

Inbar Finkel ◽

Idit Peretz ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Case Series ◽

Clinicopathological Characteristics ◽

Leptomeningeal Disease ◽

Next Generation ◽

Cns Metastases ◽

Valuable Treatment ◽

Nsclc Patients

Central nervous system (CNS) metastases occur frequently in oncogene-driven non-small cell lung cancer (NSCLC). Standard treatment approaches can potentially delay systemic treatment (surgical intervention) or result in neurocognitive impairment (radiotherapy). Recently, next-generation tyrosine kinase inhibitors (TKIs) have demonstrated remarkable intracranial activity. However, most clinical trials did not enroll patients suffering neurological symptoms. Our study aimed to assess the CNS activity of targeted therapies in this patient population. We present a case series of nine NSCLC patients with either EGFR mutation or ALK rearrangement and symptomatic CNS metastases that were treated with TKIs. Clinicopathological characteristics, treatment, and outcomes were analyzed. Most patients presented with symptomatic CNS metastases at time of metastatic disease presentation (6/9). Additionally, the majority of patients had leptomeningeal disease (6/9) and multiple parenchymal metastases. Patients presented with a variety of CNS symptoms with the most common being nausea, vomiting, headache, and confusion. Most patients (6/9) responded rapidly both clinically and radiographically to the targeted treatment, with a marked correlation between systemic and intracranial radiographic response. In conclusion, upfront use of next-generation TKIs in patients with oncogene-driven NSCLC with symptomatic CNS metastases is associated with reasonable intracranial activity and represents a valuable treatment option.

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