Wound Healing Potential of Polyherbal Formulation in Rats

2021 ◽  
pp. 2195-2199
Author(s):  
Rohit Kumar ◽  
Reena Gupta ◽  
Bimlesh Kumar ◽  
Bhupinder Kapoor
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Albino Rats ◽  
Wound Infections ◽  
Burn Wound ◽  
Polyherbal Formulation ◽  
Medicinal Plant Extracts ◽  
Healing Property ◽  
Wistar Albino Rats ◽  
Conventional Antibiotics

Chronic wound infections are significant medical burden as the patients have to go through severe discomfort and distress. Invasion of various pathogenic microorganisms at the injured site further leads to damage of tissue which may results in resection of the organ. Appropriate wound healing is necessary to regain the functional and anatomical status of the damaged tissue that got disturbed due to wound. Conventional antibiotics used for the treatment of infections are associated with various drawbacks such as high cost and high incidence of resistance. Moreover, the dressing used for wounds are also unable to provide adequate moisture to the injured tissue. All these factors emphasise on the development of new advanced technologies for wound care. Polyherbal formulations, which comprise of various medicinal plant extracts, exhibit antioxidant and anti-inflammatory properties and can be much better alternative to commercial antibiotics for treatment of wound infections. In the present study, wound healing potential of “Septaheal” (a Polyherbal formulation) was evaluated in Wistar albino rats using incision, excision and burn wound models. The formulation exhibited wound healing property due to its angiogenic and mitogenic potential.

scholarly journals BURN WOUND HEALING POTENTIAL OF RUBIA CORDIFOLIA LINN ON WISTAR ALBINO RATS

2017 ◽  
Vol 5 (2) ◽  
pp. 17-20
Author(s):  
Shilji Devassy ◽  
Ravi Mundugaru ◽  
Poornima Solapure ◽  
S K Hiremath ◽  
P A Patil
Keyword(s):  
Wound Healing ◽  
Albino Rats ◽  
Burn Wound ◽  
Rubia Cordifolia ◽  
Burn Wound Healing ◽  
Wistar Albino Rats

An in vitro study on the burn wound healing activity of cotton fabrics incorporated with phytosynthesized silver nanoparticles in male Wistar albino rats

2017 ◽  
Vol 100 ◽  
pp. 187-196 ◽  
Author(s):  
Balashanmugam Pannerselvam ◽  
Mukesh Kumar Dharmalingam Jothinathan ◽  
Murugan Rajenderan ◽  
Palani Perumal ◽  
Kalaichelvan Pudupalayam Thangavelu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
In Vitro Study ◽  
Cotton Fabrics ◽  
Albino Rats ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Wistar Albino Rats ◽  
Wound Healing Activity

Wound healing potential of naturally synthesized silver nano-particles

2020 ◽  
Vol 9 (1) ◽  
pp. 1-5
Author(s):  
Krishna Reddy BV ◽  
Avinash Kumar Reddy G ◽  
Nageswara Rao G
Keyword(s):  
Wound Healing ◽  
Large Scale ◽  
Uv Spectroscopy ◽  
The Body ◽  
Nano Particles ◽  
Albino Rats ◽  
Practical Applications ◽  
Wound Model ◽  
Healing Property ◽  
Wistar Albino Rats

Nanoparticles have been in raising demand in many fields of science and biotechnology and extends its applications in biomedical and pharmaceutical areas. Out of all the metals silver leads the way in this technology in view of its practical applications. They are used to preserve, diagnose many diseases and mainly used in external applications on the body emphasizing their antimicrobial and healing abilities. On the other hand, the synthesis of nano particles has been a very serious concern due to its huge cost of production, toxicity and dosing issues. Bio synthesis or green synthesis using herbals and microbes to synthesize nano particles showed a path to overcome the above hurdles and make the synthesis of silver nanoparticles more commercial and can be adopted on large scale. In this research silver nano particles were synthesized using purified extracts of leaves of Lannea coromandelica and were confirmed using UV spectroscopy. The produced nanoparticles exhibited surface plasmon resonance at 420nm in UV spectroscopy. They were investigated for their wound healing activity in excision wound model in wistar albino rats for a 16 day study. These nano particles were found to be very successful and showed wound healing property. Thus produced nano particles showed similar activity competent enough with that of the standard, Betanidine. These silver nano particles can be used efficiently in therapies that target infections and wounds that are provoked and delayed healing due to infections.

scholarly journals Evaluation of burn wound healing activity of novel fusidic acid loaded microemulsion based gel in male Wistar albino rats

2020 ◽  
Vol 28 (3) ◽  
pp. 338-348 ◽  
Author(s):  
Mehmet Evren Okur ◽  
Şule Ayla ◽  
Vildan Yozgatlı ◽  
Neşe Buket Aksu ◽  
Ayşegül Yoltaş ◽  
...  
Keyword(s):  
Wound Healing ◽  
Fusidic Acid ◽  
Albino Rats ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Microemulsion Based Gel ◽  
Wistar Albino Rats ◽  
Wound Healing Activity

scholarly journals Antimicrobial and anti-biofilm potencies of dermcidin-derived peptide DCD-1L against Acinetobacter baumannii: an in vivo wound healing model

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Zahra Farshadzadeh ◽  
Maryam Pourhajibagher ◽  
Behrouz Taheri ◽  
Alireza Ekrami ◽  
Mohammad Hossein Modarressi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Acinetobacter Baumannii ◽  
Biofilm Formation ◽  
Histopathological Examination ◽  
Inhibitory Effect ◽  
Bacterial Attachment ◽  
Burn Wound ◽  
Conventional Antibiotics

Abstract Background The global emergence of Acinetobacter baumannii resistance to most conventional antibiotics presents a major therapeutic challenge and necessitates the discovery of new antibacterial agents. The purpose of this study was to investigate in vitro and in vivo anti-biofilm potency of dermcidin-1L (DCD-1L) against extensively drug-resistant (XDR)-, pandrug-resistant (PDR)-, and ATCC19606-A. baumannii. Methods After determination of minimum inhibitory concentration (MIC) of DCD-1L, in vitro anti-adhesive and anti-biofilm activities of DCD-1L were evaluated. Cytotoxicity, hemolytic activity, and the effect of DCD-1L treatment on the expression of various biofilm-associated genes were determined. The inhibitory effect of DCD-1L on biofilm formation in the model of catheter-associated infection, as well as, histopathological examination of the burn wound sites of mice treated with DCD-1L were assessed. Results The bacterial adhesion and biofilm formation in all A. baumannii isolates were inhibited at 2 × , 4 × , and 8 × MIC of DCD-1L, while only 8 × MIC of DCD-1L was able to destroy the pre-formed biofilm in vitro. Also, reduce the expression of genes involved in biofilm formation was observed following DCD-1L treatment. DCD-1L without cytotoxic and hemolytic activities significantly reduced the biofilm formation in the model of catheter-associated infection. In vivo results showed that the count of A. baumannii in infected wounds was significantly decreased and the promotion in wound healing by the acceleration of skin re-epithelialization in mice was observed following treatment with 8 × MIC of DCD-1L. Conclusions Results of this study demonstrated that DCD-1L can inhibit bacterial attachment and biofilm formation and prevent the onset of infection. Taking these properties together, DCD-1L appears as a promising candidate for antimicrobial and anti-biofilm drug development.

scholarly journals EVALUATION OF WOUND HEALING ACTIVITY OF METHANOLIC EXTRACT OF SMILAX WIGHTII (A. DC.) IN WISTAR ALBINO RATS

2014 ◽  
Vol 1 (1) ◽  
pp. 73-77
Author(s):  
Uma Maheswari P ◽  
Shalimol A ◽  
Arumugasamy A ◽  
Udhaya Sankar M.R
Keyword(s):  
Wound Healing ◽  
Dry Weight ◽  
Wound Contraction ◽  
Albino Rats ◽  
Standard Drug ◽  
Excision Wound ◽  
Wound Model ◽  
Wistar Albino Rats ◽  
Incision Wound ◽  
Wound Healing Activity

The present experimental study was designed to evaluate the wound healing activity of methanolic extract of Smilax wightii A. DC. on incision and excision wound models in Wistar albino rats. The parameters studied were wound breaking strength, wound contraction area, epithelialization period, granulation tissuewet, dry weight and hydroxyproline content in incision wound model, percentage of wound contraction and period of epithelialization in excision wound model. The rats were administered topically with 100mg/kg b.wt. (low dosage), 200mg/kg b.wt. (moderate dosage) and 500mg/kg b.wt. (high dosage) of methanolicextract of Smilax wightii (MESW). The activity of the extract treated groups were compared with that of the control 1% Spirit. Framycetin sulphate 0.2% w/w was used as the standard drug. In incision wound model, there was a significant increase in the wound breaking strength in all the experimental groups treated withMESW than that of the control. Similarly, significant (P<0.001) decrease in wound contraction area and period of epithelialization were also observed in the test group animals treated with MESW and the standard drug treated groups when compared to that of the control. , a significant increase was observed in granulation tissue wet and dry weight and hydroxyproline content in the test groups treated with MESW compared to the control. In exicision wound model, there was a significant increase (P<0.01) in the percentage of wound contraction and decrease in period of epithelialization in the experimental groups treated with 200mg/kgb.wt. (moderate dosage) and 500mg/kgb.wt (high dosage) of MESW. The extract treated groups showed significant improvement in all the wound healing parameters of incision, and excision wound models.

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