Vasovagal reactions in blood donors during or immediately after blood donation

Introduction: A crucial component of the effort to meet the growing demand for blood is the recruitment and retention of young novice blood donors. Reducing postdonation syncopal reactions could have a beneficial impact on donor convenience, safety, and desire to donate again. Aim: To evaluate the effectiveness of predonation hydration over standard blood donation in the prevention or decrease in severity of postdonation Vasovagal Reactions (VVR) in hydrated blood donors in comparison with the non hydrated group. Materials and Methods: The randomised controlled trial was conducted on 953 first time voluntary blood donors. Donors in the intervention arm drank 250 mL water 30 minutes before blood donation, while those in the control group did not receive any intervention. Blood was collected by standard protocol. Outcome, VVR, if present was graded as mild, moderate, and severe. Analysis of results were done using Statistical Package for the Social Sciences (SPSS) version 16.0. A sensitivity analysis was also done to consider the dropouts from the study. Results: A total of 900 participants were included in the study, of which 443 were controls and 457 were cases. An effect size of 6.1%, a Relative Risk (RR) of 0.54 {95% Confidence Interval (CI)=0.36-0.81} and a risk reduction of 45% was arrived at, pointing to a protective role for predonation hydration in preventing VVR. There was a significant reduction in the severity of VVR in the predonation hydration group compared to the standard blood donation group (p-value=0.002). The protective effect of hydration on decreasing the occurrence and severity of VVR had statistical support in males in the moderate and severe grades (p-value=0.017). A similar statistical significance was not established in females (p-value=0.173). Sensitivity analysis did not reveal a difference in the statistical significance of variables between compared groups. Conclusion: Predonation hydration was found to be effective in preventing and decreasing the severity of VVR in novice blood donors.

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Donor Hemovigilance Programme in managing Blood Transfusion Needs: Complications of Whole Blood Donation

Journal of Pathology of Nepal ◽

10.3126/jpn.v3i6.8993 ◽

2013 ◽

Vol 3 (6) ◽

pp. 459-463 ◽

Cited By ~ 1

Author(s):

S Mangwana

Keyword(s):

Blood Transfusion ◽

Adverse Effects ◽

Adverse Events ◽

Whole Blood ◽

Blood Donors ◽

Blood Donation ◽

Tertiary Care ◽

Care Hospital ◽

Blood Donations ◽

Vasovagal Reactions

Background: Hemovigilance like quality systems and audits have become an integral part of Blood Transfusion Services in the developed countries and has contributed greatly to its development. Hemovigilance begins with donors and must enable the collection of information on reactions occurring during the donation of blood, selections of donors and to prevent such incidents. The aim of study was to help identify the trends of adverse events , occurring in blood donors at a tertiary-care hospital, to recommend best practices to improve donor care and safety Materials and Methods: This record-based study was conducted on all adverse events related to allogenic whole blood donations performed over 24 months. All whole blood donations were analyzed. All adverse events occurring during or at the end of the donation were noted using a standardized format and analyzed determining significance at p<0.05. Results: Overall rate was 0.3% with vasovagal reactions constituting 82%, and 18% mild syncopal reactions (p<0.001). Immediate vasovagal reaction with injury was very rare (0.007%). Vasovagal reactions showed a significant association with young age, female gender, first time donation status. Mean age of persons recording adverse effects was 30.23 ± 7.49 years as compared to those without adverse effects, 31.14 ± 8.56 years. Conclusion: Donor safety is an essential perquisite to increase voluntary blood donation. AE analysis helps in identifying the blood donors at risk of AE, applying appropriate motivational strategies, predonation counseling, care during and after donation, developing guidelines and hemovigilance programme in countries with limited resources. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8993 Journal of Pathology of Nepal (2013) Vol. 3, 459-463

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Incidence of Vasovagal Reaction among the Blood Donors Attending at Transfusion Medicine Department of Dhaka Medical College Hospital

Bangladesh Journal of Medicine ◽

10.3329/bjmed.v22i2.13589 ◽

2013 ◽

Vol 22 (2) ◽

pp. 47-50

Author(s):

FS Chowdhury ◽

MAE Siddiqui ◽

KGM Rahman ◽

HA Begum ◽

...

Keyword(s):

Blood Donors ◽

Adverse Reactions ◽

Blood Donation ◽

Medical College Hospital ◽

Transfusion Medicine ◽

College Hospital ◽

Medicine Department ◽

Medical College ◽

Vasovagal Reactions ◽

New Donors

Introduction: Without blood there may be no blood transfusion. Without donors there may not any blood. During vasovagal reaction there is chance of accidental fall and injury to blood donor. So improving the safety of the blood donation experience will reduce the donor injuries and increase the blood donation, donation frequency and donor satisfaction. Objective: This study was done to find out the incidence of blood donor reaction- vasovagal reactions among the blood donors attending at transfusion medicine department of Dhaka Medical College Hospital and to improve the donors safety. Methodology: This study was done at Transfusion Medicine Department of Dhaka Medical College Hospital in the period between January 2010 to December 2010. Total 21815 donors of 18 to 55 years of both sexes were selected after reviewing the questionnaire, physical and medical examination and written consent. Donors were observed for 30 minutes after donation. The needle site was covered with a bandage and the donor was directed to keep the bandage on for several hours. Result: In this study, out of 21815 donors 163(8.7%) developed reaction. In163 reactions, 72(44.18%) were in male and 91 (55.82%) were in female donors. Within 20179 male donors, adverse reactions occurred in 72 (0.35%) and within 1636 female donors, adverse reactions occurred in 91 (5.56%) The symptoms were agitation 23 (14.12%), pallor 31 (19.02%), sweating 29 (17.79%), nausea 21 (12.88%), vomiting 38 (23.21%), cold feeling 12(7.36%), loss of consciousness 9(5.52%),i.e. severe reactions were 9(5.53%) and mild to moderate reactions were154 (94.47%). Among the reactions 127 (0.89%) occurred in new donors, 32 (0.49%) occurred in occasional donors and 4 (0.37%) in periodic donors. Conclusion: Vasovagal reactions are more common in female and new donors. DOI: http://dx.doi.org/10.3329/bjmed.v22i2.13589 Bangladesh J Medicine 2011; 22: 47-50

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F.VIII R:Ag in Hepatitis

10.1055/s-0038-1665838 ◽

1979 ◽

Author(s):

R. Kotitschke ◽

J. Scharrer

Keyword(s):

Chronic Hepatitis ◽

Blood Donors ◽

Blood Donation ◽

Normal Population ◽

Rabbit Antiserum ◽

Two Dimensional ◽

Plastic Plate ◽

Significant Difference ◽

Acute Hepatitis B ◽

The One

F.VIII R:Ag was determined by quantitative immunelectrophoresis (I.E.) with a prefabricated system. The prefabricated system consists of a monospecific f.VIII rabbit antiserum in agarose on a plastic plate for the one and two dimensional immunelectrophoresis. The lognormal distribution of the f.VIII R:Ag concentration in the normal population was confirmed (for n=70 the f.VIII R:Ag in % of normal is = 95.4 ± 31.9). Among the normal population there was no significant difference between blood donors (one blood donation in 8 weeks; for n=43 the f.VIII R:Ag in % of normal is = 95.9 ± 34.0) and non blood donors (n=27;f.VIII R:Ag = 94.6 ± 28.4 %). The f.VIII R:Ag concentration in acute hepatitis B ranged from normal to raised values (for n=10, a factor of 1.8 times of normal was found) and was normal again after health recovery (n=10, the factor was 1.0). in chronic hepatitis the f.VIII R:Ag concentration was raised in the majority of the cases (for n=10, the factor was 3.8). Out of 22 carrier sera 20 showed reduced, 2 elevated levels of the f.VIII R:Ag concentration. in 5 sera no f.VIII R:Ag could be demonstrated. The f.VIII R:Ag concentration was normal for n=10, reduced for n=20 and elevated for n=6 in non A-non B hepatitis (n=36). Contrary to results found in the literature no difference in the electrophoretic mobility of the f.VIII R:Ag was found between hepatitis patients sera and normal sera.

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RISKS OF ANEMIA DEVELOPMENT IN DONORS ACCORDING TO INHERITED PREDISPOSITION AND REGULARITY OF BLOOD DONATION

Ulyanovsk Medico-biological Journal ◽

10.34014/2227-1848-2020-1-72-83 ◽

2020 ◽

pp. 72-83

Author(s):

I.M. Vorotnikov ◽

V.A. Razin ◽

I.M. Lamzin ◽

M.N. Sokolova ◽

M.E. Khapman ◽

...

Keyword(s):

Blood Donors ◽

Blood Donation ◽

Hla Antigens ◽

Hla Typing ◽

Main Role ◽

Inherited Predisposition ◽

Group 2 ◽

Student’S T ◽

A Prospective Study ◽

Group 1

Anemia is one of the most common complications of blood donation. Thus, the objective of the paper was to assess the risks of anemia development in donors according to the regularity of donation and inherited predisposition. Materials and Methods. The authors carried out a prospective study, which included 241 blood donors, using random sampling and case-control techniques. Depending on blood donation frequency, the donors were divided into 2 groups: Group 1 consisted of 122 people (51.5 %) frequently donating blood; Group 2 included 119 people (48. 5 %) rarely donating blood. We studied the initial indicators of a general blood test and the same indicators a year after the first blood donation. Additionally, we performed HLA typing of donors. Statistica v. 8.0 software package (Stat Soft Inc., USA) was used for statistical analysis. To compare two independent samples, we used a nonparametric Mann-Whitney U-test and a parametric Student’s t-test (depending on the type of distribution). To assess anemia risks, the odds ratio was calculated. Results. One year after the first blood donation, anemia was diagnosed in 13 people (10.6 %) in Group 1 and in 7 people (5.9 %) in Group 2 (p=0.179). A11 and B7 HLA antigens did not increase anemia risks in group 1 (OS=1.257 (95 % CI 0.318–4.973) and OS=0.240 (95 % CI 0.051–1.134, respectively). HLA-antigens A11 and B7 did not increase anemia risks in Group 1 (OR=1.257 (95 % CI 0.318-4.973) and OR=0.240 (95 % CI 0.051–1.134), respectively). In group 2, antigen-A11 was also an insignificant factor (OS=2.902 (95 % CI 0.606-13.889)) for anemia development. Whereas, antigen-B7 increased anemia risks by 14 times (OS=14.364 (95 % CI 1.644-124.011)). Conclusion. In rare blood donors, it is the genetic factor that plays the main role in anemia development. High prevalence rates of anemia in frequent blood donors are probably determined by other factors. Keywords: anemia, blood donors, HLA typing. Механизмы развития анемий и факторы, их индуцирующие, остаются до конца не изученными. Целью исследования стало изучение риска развития анемии у доноров крови в зависимости от частоты донации и наличия наследственной предрасположенности к развитию анемии. Материалы и методы. Проведено проспективное исследование, выполненное методами случайной выборки и «случай-контроль», в которое вошел 241 донор крови. В зависимости от частоты сдачи доноры были поделены на 2 группы: группу 1 составили 122 чел. (51,5 %), часто сдающие кровь; группу 2 – 119 чел. (48,5 %), редко сдающих кровь. Изучались исходные показатели общего анализа крови и через год от начала донации. Дополнительно проводилось HLA-типирование доноров. Статистический анализ осуществлялся с применением программы Statistica v. 8.0 (Stat Soft Inc., США). Для сравнения двух независимых выборок использовался непараметрический U-критерий Манна–Уитни и параметрический t-критерий Стьюдента (в зависимости от типа распределения). Для оценки риска возникновения анемии рассчитывалось отношение шансов. Результаты. Через год с момента первой сдачи крови в группе 1 выявлено 13 чел. (10,6 %) с анемией, в группе 2 – 7 чел. (5,9 %) (р=0,179). Наличие HLA-антигенов А11 и B7 не повышало риск развития анемии в группе 1 (ОШ=1,257 (95 % ДИ 0,318–4,973) и ОШ=0,240 (95 % ДИ 0,051–1,134 соответственно). В группе 2 наличие гена А11 также являлось незначимым фактором (ОШ=2,902 (95 % ДИ 0,606–13,889), присутствие гена В7 в 14 раз повышало риск развития анемии (ОШ=14,364 (95 % ДИ 1,664–124,011). Выводы. Высокий риск развития анемии у редко сдающих кровь доноров обусловливается генетическими факторами. Высокая распространённость анемии у часто сдающих кровь доноров, вероятно, определяется другими факторами. Ключевые слова: анемия, доноры крови, HLA-типирование.

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Feline blood donation adverse reactions: classification and description of acute and delayed reactions in a donor population

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x211020295 ◽

2021 ◽

pp. 1098612X2110202

Author(s):

Tiago AM Abreu ◽

Andreia ST Oliveira ◽

Rui RF Ferreira ◽

Sandrina MV Correia ◽

Mafalda SSQ Morais ◽

...

Keyword(s):

Blood Donors ◽

Adverse Reactions ◽

Blood Donation ◽

Animal Blood ◽

Veterinary Practitioner ◽

Donor Programme ◽

Donor Population ◽

Delayed Reactions ◽

Low Incidence ◽

High Level

Objectives This article aims to analyse the safety of feline blood donation by describing the frequency and nature of any adverse reactions and their causes, as well as propose measures to decrease the incidence of adverse reactions. Methods In this prospective study, any blood donor adverse reactions detected by the clinical staff during and immediately after donation were recorded. The owners of the cats were also surveyed by a veterinary practitioner or veterinary nurse 5 days after donation, using a predefined questionnaire to assess for any clinical or behavioural changes. Data were collected between January 2019 and March 2020 from blood donors enrolled in an animal blood bank programme. Results Of 3690 blood donations from 1792 feline donors assessed, post-donation reactions were reported in 1.14% (n = 42): 0.22% (n = 8) were acute reactions, which included weakness, pallor, tachypnoea and open-mouth breathing; and 0.92% (n = 34) were delayed post-donation reactions, with 0.16% involving cutaneous (haematomas and skin rashes, n = 6), 0.68% involving behavioural (n = 25) and 0.08% involving digestive (emesis and inappetence, n = 3) signs. Conclusions and relevance The low incidence of post-donation reactions in this study is encouraging, suggesting that a well-established protocol and competent staff can help to ensure a high level of safety in a feline donor programme and, in turn, increase the confidence of cat owners.

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Seroprevalence of SARS-Coronavirus 2 among asymptomatic healthy blood donors from healthcare and non-healthcare settings: Implications for safety of blood donors and blood collection staff during blood donation

Transfusion and Apheresis Science ◽

10.1016/j.transci.2021.103118 ◽

2021 ◽

pp. 103118

Author(s):

Hem Chandra Pandey ◽

Yashaswi Dhiman ◽

Chippy CS ◽

Poonam Coshic ◽

Pankaj Jain

Keyword(s):

Blood Donors ◽

Blood Donation ◽

Blood Collection ◽

Sars Coronavirus ◽

Healthcare Settings

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Cardiovascular risk in 159 934 frequent blood donors while addressing the healthy donor effect

Heart ◽

10.1136/heartjnl-2018-314138 ◽

2019 ◽

Vol 105 (16) ◽

pp. 1260-1265 ◽

Cited By ~ 1

Author(s):

Karlijn Peffer ◽

Martin den Heijer ◽

Wim L A M de Kort ◽

André L M Verbeek ◽

Femke Atsma

Keyword(s):

Cardiovascular Risk ◽

High Frequency ◽

Healthy Donor ◽

Blood Donors ◽

Cox Regression ◽

Blood Donation ◽

Low Frequency ◽

Sensitivity Analyses ◽

Hospital Data ◽

Dutch Hospital

ObjectiveTo investigate whether regular blood donation decreases cardiovascular risk.MethodsAll 159 934 Dutch whole-blood donors with an active donation career of at least 10 years were categorised into sex-specific donation tertiles based on the number of donations during this 10-year qualification period. Cardiovascular endpoints were based on hospital discharge diagnoses and death certificates from Dutch Hospital Data and Statistics Netherlands and occurring after the 10-year qualification period. Cox regression was used to estimate the age-adjusted and starting year-adjusted hazard rate ratio (HRR).ResultsFemale high-frequency blood donors had a reduced cardiovascular morbidity (HRR=0.91, 95% CI 0.85 to 0.98) compared with low-frequency blood donors. No effect was observed in men (HRR=1.00, 95% CI 0.95 to 1.05). To rule out a residual healthy donor effect (HDE), additional sensitivity analyses using a 5-year qualification period were conducted. The results supported the absence of a residual HDE.ConclusionsThis study showed a protective effect of long-term, high-frequency blood donation against cardiovascular disease. This effect was only observed in women and not in men.

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