Idiopathic Transient Normocytic, Normochromic Anaemia of Childhood

1978 ◽  
Vol 14 (1) ◽  
pp. 28-33
Author(s):  
R. G. TOOGOOD ◽  
E. SPEED ◽  
K. C. CHENEY ◽  
M. S. RICE
Keyword(s):  
Normochromic Anaemia ◽  
Normocytic Normochromic Anaemia

scholarly journals UNUSUAL CASE OF ANAEMIA IN ADULT MALE

2020 ◽  
pp. 71-73
Author(s):  
Dnyaneshwar S Cheke ◽  
Isha Desai ◽  
Jitendra Ingole
Keyword(s):  
Bone Marrow ◽  
Marked Reduction ◽  
Unusual Case ◽  
Pure Red Cell Aplasia ◽  
Myeloproliferative Disorder ◽  
Red Cell ◽  
Red Cell Aplasia ◽  
Normochromic Anaemia ◽  
Erythroid Precursors ◽  
Normocytic Normochromic Anaemia

A case of Anaemia which was investigated and found to be a case of Acquired Pure Red Cell Aplasia. Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anaemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. It is commonly due to primary autoimmune or infection and secondary to myeloproliferative disorder. In this discussion we are presenting a case of normocytic normochromic anaemia which was admitted to our hospital after being investigated and treated several times outside. On extensive workup, we diagnosed the case as PRCA secondary to Thymoma and initiated the appropriate management.

Kasabach-Merritt phenomenon with cellulitis in infant

2020 ◽  
Vol 13 (9) ◽  
pp. e235065
Author(s):  
Ariyati Yosi ◽  
Abdullah Afif Siregar ◽  
Yasmine Siregar ◽  
Widyaningsih Oentari
Keyword(s):  
Oral Corticosteroid ◽  
Vascular Lesion ◽  
Severe Thrombocytopenia ◽  
Laboratory Findings ◽  
Blood Examination ◽  
Normochromic Anaemia ◽  
Normocytic Normochromic Anaemia ◽  
Tufted Angioma ◽  
History Of ◽  
D Dimer

Kasabach-Merritt phenomenon (KMP) is consumptive coagulopathy in large vascular lesion. This condition is specific in kaposiform haemangioendothelioma (KHE) and tufted angioma, associated with high mortality rate. This condition often involves the limbs, trunk and retroperitoneum. The clinical features that are usually found are purpura, oedema, induration and ecchymosis. A boy baby aged 9 months presented with a history of violaceous tumour that appeared on his left leg at birth that became enlarged since 6 months ago that caused discrepancy between both of his legs. The patient has his left leg massaged through alternative treatment, causing it became bruised and wounded. Blood examination showed normocytic normochromic anaemia with severe thrombocytopenia and high D-dimer. The patient was diagnosed with KMP with cellulitis and treated with oral corticosteroid, propranolol and antibiotics. Diagnosis of KMP can be made through clinical and laboratory findings. Combination therapy with corticosteroid and propranolol can be considered for KMP treatment.

scholarly journals Structure of anaemic conditions comorbid to alcoholic and non-alcoholic steatohepatitis

2021 ◽  
Vol 11 (5) ◽  
pp. 147-157
Author(s):  
Oksana Khukhlina ◽  
Tetiana Antofiichuk ◽  
Mykola Antofiichuk
Keyword(s):  
Chronic Disease ◽  
Prospective Study ◽  
Vitamin B12 ◽  
Retrospective Analysis ◽  
Medical Records ◽  
Alcoholic Steatohepatitis ◽  
Anaemia Of Chronic Disease ◽  
Normochromic Anaemia ◽  
Normocytic Normochromic Anaemia

The retrospective analysis of 378 medical records of inpatients with steatohepatitis (SH) depending on its etiology was performed to identify and study the type of anaemic conditions (AC). Among patients with SH of mixed (including alcoholic) etiology anaemia was found in 32.2% of cases, in patients with alcoholic (ASH) - in 36.3%, in patients with non-alcoholic SH (NASH) - in 22.0 % of cases. Macrocytic, hyperchromic anaemia prevailed in patients with anaemia of all groups: in patients with SH of mixed etiology - in 47.9%, in patients with ASH - 56.8%, NASH - 71.4%. Normocytic, normochromic anaemia was registered in 52.1% with mixed etiology of SH, in patients with ASH - 43.2%, NASH - 28.6%.The prospective study of 125 patients with SH showed that anaemia was found in 40.0% of patients with ASH, among patients with SH of mixed (including alcoholic) etiology anaemia was found in 32.0%, among patients with NASH the result was 21.7%. The following types of anaemia were found in ASH: vitamin B12 - deficient - in 17.5% of cases, anaemia of chronic disease - in 10.0% of cases and Zieve's syndrome - in 12.5% of cases. Three types of anaemia were found in patients with SH of mixed etiology: vitamin B12 - deficient - in 16.0% of cases, anaemia of chronic disease - in 8.0% and Zieve's syndrome - in 8.0% of patients. The structure of anaemias in patients with NASH accompanied by obesity of I-II degrees is as follows: B12 - deficient anaemia - in 15.0% of cases, anaemia of chronic disease - in 6.7% of people. In patients with NASH, H. pylory contamination was present in 84.6% of patients with anaemic syndrome (AS), including 100% of patients with B12-deficient anaemia. With ASH, H. pylory contamination was present in 80.0% with anaemia, including 100% of patients with B12-deficient anaemia. In patients with SH of mixed etiology, H. pylory contamination was present in 100.0% of people with AS.

scholarly journals Sepsis as a cause of intrahepatic cholestasis

2009 ◽  
Vol 137 (5-6) ◽  
pp. 278-281
Author(s):  
Jelena Rudic ◽  
Rada Jesic ◽  
Djordje Culafic ◽  
Radmila Sarenac-Kovac ◽  
Vladislava Bulat ◽  
...  
Keyword(s):  
Antibiotic Treatment ◽  
Intrahepatic Cholestasis ◽  
Liver Function Tests ◽  
Biliary Cirrhosis ◽  
Abdominal Ultrasonography ◽  
Laboratory Findings ◽  
Bile Formation ◽  
Normocytic Normochromic Anaemia ◽  
Inflammatory Syndrome ◽  
Possible Cause

Introduction. The causes of intrahepatic cholestasis include cholestatic viral hepatitis, primary biliary cirrhosis, benign recurrent cholestasis, primary sclerosing cholangitis and sepsis. During sepsis, proinflammatory cytokines and nitric oxide cause cholestasis by impairing hepatocellular and ductal bile formation. Case Outline. We report a 48-year-old woman who was admitted to hospital due to malaise, jaundice, fever and pain in the neck. Physical examination revealed jaundice, tachycardia (pulse rate was 120/min), hypotension 90/60 mm Hg. Laboratory findings showed normocytic normochromic anaemia, inflammatory syndrome and abnormal liver function tests indicating cholestasis and hepatocellular necrosis. Abdominal ultrasonography detected hepatosplenomegaly. Chest computed tomography showed bronchopneumonic infiltrates. Percutaneous liver biopsy was performed using a Menghini needle of 1.4 mm. Pathohystological analysis of the liver tissue confirmed reactive, intrahepatic cholestasis. Blood cultures isolated Staphylococcus aureus. After the diagnosis was established the treatment with broad-spectrum antibiotics was carried out, resulting in the improvement of general condition of the patient, regression of inflammatory syndrome, disappearance of cholestasis and regression of pulmonary infiltrates. Abdominal ultrasonography after antibiotic treatment did not show hepatosplenomegaly. Conclusion. Concerning patients with cholestasis of uncertain origin, we should always think of sepsis as a possible cause in order to start antibiotic treatment in time.

scholarly journals Evaluation of anaemia

2017 ◽  
Vol 5 (10) ◽  
pp. 4481 ◽  
Author(s):  
Suchita V. Ingale ◽  
Milind P. Ullewar ◽  
Vikas C. Ingale ◽  
Jayshree J. Upadhye
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Complete Blood Count ◽  
Severe Anaemia ◽  
Peripheral Smear ◽  
Pathology Laboratory ◽  
Mild Anemia ◽  
Normocytic Normochromic Anaemia ◽  
Moderate Anemia ◽  
Mild Anaemia

Background: Often, the first test used to diagnose anemia is a complete blood count (CBC). It determines the number, size, volume, and hemoglobin content of red blood cells. Peripheral smear is done for typing of anaemia. Such evaluation is necessary for proper treatment.Methods: A retrospective study was done in 300 anaemic patients at Shakuntala pathology laboratory, Nagpur. Patients were randomly selected including males and females. CBC and peripheral smear were analyzed.Results: Out of total 300 patients evaluated, the prevalence of anaemia was quite significant in females 225 (75%) than males 75 (25%). 66 females (22%) had mild anemia while 129 females (43%) had moderate anemia and 30 females (10%) had severe anaemia 36 males (12%) had mild anaemia, 30 males (10%) had moderate anaemia while 9 males (3%) had severe anaemia. In morphology of red blood cells, normocytic normochromic anaemia was seen in 132 (44%) females and in 45 (15%) of males. Microcytic hypochromic anaemia was seen in 90 (30%) females and 27 (9%) males. Macrocytic anaemia was seen in 3 (1%) females and 3 (1%) males.Conclusions: Prevalence of anaemia is quite high in females than males. Also, the severity of anaemia is more in females than males. So, heath programmes should be directed more towards females since adolescent age.

Detection of a novel haemoplasma species in fattening pigs with skin alterations, fever and anaemia

2020 ◽  
Vol 187 (2) ◽  
pp. 66-66 ◽  
Author(s):  
Julia Stadler ◽  
Julia Ade ◽  
Mathias Ritzmann ◽  
Katharina Hoelzle ◽  
Ludwig E Hoelzle
Keyword(s):  
Phylogenetic Analyses ◽  
Clinical Signs ◽  
Blood Parameters ◽  
Blood Samples ◽  
Management Procedures ◽  
Spleen Sample ◽  
Normocytic Normochromic Anaemia ◽  
Inflammatory Drugs ◽  
On Farm ◽  
Fattening Pigs

BackgroundIn a fattening farm in Southern Germany, skin alterations (urticaria, haemorrhagic diathesis) and high fever were observed in 30% of the pigs 2 weeks after arrival. Feed intake was severely compromised in affected pigs.MethodsAfter detailed clinical observation, blood samples from affected pigs were collected for haematological, PCR and serological investigations. In addition, pathological investigations were performed on one pig.Results and conclusionAnalysis of blood parameters revealed a normocytic, normochromic anaemia. A novel porcine haemoplasma species was detected in blood samples of affected pigs and spleen sample of the necropsied pig by PCR. Phylogenetic analyses based on the 16S rDNA showed 99% identity to a novel porcine haemoplasma (‘Candidatus (Ca.) M. haemosuis’) species which has recently been described in China. Interestingly, this is the first report of ‘Ca. M. haemosuis’ in pigs with clinical signs resembling those of Mycoplasma (M) suis and the first description of this novel haemoplasma species outside Asia. On-farm affected pigs were treated with oxytetracycline and non-steroidal anti-inflammatory drugs. Clinical signs improved after implementation of treatment and optimisation of management procedures. This case might indicate that other porcine haemoplasma species than M suis can induce fever and skin alterations and may have an economic impact on affected farms.

scholarly journals INDUCTION OF MACROCYTIC-NORMOCHROMIC ANAEMIA IN Clarias gariepinus –Siluriform- EXPOSED TO SUB-LETHAL CONCENTRATIONS OF 1, 1-DIMETHYL 4, 4-BIPIRIDILLIUM DICHLORIDE (PARAQUAT) UNDER LABPRATORY CONDITIONS

2021 ◽  
Vol 14 (1) ◽  
pp. e3789
Author(s):  
Musa Idi-Ogede Abubakar ◽  
Adeshina Ibrahim
Keyword(s):  
Blood Cells ◽  
Clarias Gariepinus ◽  
White Blood Cells ◽  
Haemoglobin Concentration ◽  
Corpuscular Haemoglobin ◽  
Normochromic Anaemia ◽  
Mean Corpuscular Haemoglobin ◽  
L 14 ◽  
Corpuscular Haemoglobin Concentration ◽  
Sublethal Concentrations

Introduction: Macrocytic-normochromic anaemia was induced in Clarias gariepinus at intervals of 1, 7 and 14 days. Experimental fish were exposed to test water separately diluted with sub-lethal concentrations of paraquat of 0, 0.03, 0.05, 0.07 and 0.09mg/L. 14 days. No in-depth work has been carried out on Macrocytic-normochromic anaemia in Nigeria. Objective: to evaluate macrocytic-normochromic anaemia in Clarias gariepinus exposed to sublethal concentrations of paraquat. Methods: Blood were collected at intervals of 1, 7 and 14 days .Results: Blood dyscrasias  was observed with a significant (p<0.05) decrease in haemoglobin, haematocrit, red blood cells, white blood cells, lymphocytes and   monocytes. Mean corpuscular volume (MCV), Mean corpuscular haemoglobin (MCH), Neutrophils, Eosinophil and Basophil increased significantly (p<0.05) with increasing concentrations of the toxicant while Mean corpuscular haemoglobin concentration (MCHC) remained normal. Conclusion: Sublethal concentrations of paraquat induced macrocytic-normochromic anaemia in the exposed Clarias gariepinus.

An unusual large polythene bezoar in the rumen of a fallow deer (Dama dama)

2021 ◽  
Vol 14 (1) ◽  
pp. 56-60
Author(s):  
Hafiz Siddiq ◽  
◽  
Muhammad Amjad ◽  
Shahid Jaleel ◽  
Syed Ali ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Supportive Therapy ◽  
Fallow Deer ◽  
Haematocrit Level ◽  
Dama Dama ◽  
Biochemical Alterations ◽  
Blood Biochemical ◽  
Normocytic Normochromic Anaemia ◽  
Foreign Materials

Ingestion of indigestible foreign bodies in both domestic and wild ruminants are very common. Indigestible foreign materials can be ingested during free range grazing or under captivity in zoos or game parks. There are different types of bezoars in literature. The most common in animals are phytobezoars, trichobezoars, lactobezoars, phytotrichobezoars, lithobezoars or pharmacobezoars. This is a case study of an adult (4 years old), 40 kg body weight female Fallow Deer (Dama dama) which was reared with other four more Fallow Deer does at Riyadh Zoological Garden. The doe was found sluggish and weak. On presentation the veterinarian of the zoo noticed the anorexia, pale mucous membranes and dullness. There was Normocytic Normochromic anaemia, low RBCs and Haematocrit level, high neutrophil count and leucocytosis. The doe was subjected to medicinal and supportive therapy but she could not recover and found dead on very next day. On post-mortem examination, an unusual large polythene bezoar along with calcified stony mass recovered from the rumen. The results suggested that the rumen impaction in the Fallow Deer might be due scavenging on refused Plastic dumps in the premises left over by visitors to the zoo and that the blood biochemical alterations, alongside clinical signs, might be of some diagnostic assistance.

A case of parvovirus B19-induced pure red cell aplasia in a child following heart transplant

2014 ◽  
Vol 25 (2) ◽  
pp. 373-375 ◽  
Author(s):  
Eoin Kelleher ◽  
Corrina McMahon ◽  
Colin J. McMahon
Keyword(s):  
Bone Marrow ◽  
Heart Transplant ◽  
Parvovirus B19 ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Orthotopic Heart Transplant ◽  
Red Cell Aplasia ◽  
Normocytic Normochromic Anaemia ◽  
Immunosuppressed Patients ◽  
Parvovirus B19 Infection

AbstractWe describe a case of an 11-year-old boy who underwent orthotopic heart transplant for dilated cardiomyopathy. He developed a normocytic, normochromic anaemia with a low reticulocyte count 1 month after transplant. A bone marrow biopsy was performed, which showed a mildly hypocellular bone marrow with few red blood cell precursors with giant pro-erythroblasts indicative of a pure red cell aplasia. Parvovirus B19 polymerase chain reaction in the blood was positive 2 months after transplant. Intravenous immunoglobulin administration resulted in a resolution of the anaemia over several months. Unexplained pure red cell aplasia in immunosuppressed patients should alert one to the possibility of parvovirus B19 infection.

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