scholarly journals Anxiety Sensitivity as a Mediator of the Relationship between Moderate-Intensity Exercise and Coping-Oriented Marijuana Use Motives

Author(s):  
Jasper A. J. Smits ◽  
Marcel O. Bonn-Miller ◽  
Candyce D. Tart ◽  
Jessica G. Irons ◽  
Michael J. Zvolensky
2008 ◽  
Vol 294 (2) ◽  
pp. R577-R584 ◽  
Author(s):  
B. J. Gurd ◽  
S. J. Peters ◽  
G. J. F. Heigenhauser ◽  
P. J. LeBlanc ◽  
T. J. Doherty ◽  
...  

The adaptation of pulmonary O2 uptake (V̇o2p) kinetics is slowed in older compared with young adults during the transition to moderate-intensity exercise. In this study, we examined the relationship between V̇o2p kinetics and mitochondrial pyruvate dehydrogenase (PDH) activity in young ( n = 7) and older ( n = 6) adults. Subjects performed cycle exercise to a work rate corresponding to ∼90% of estimated lactate threshold. Phase 2 V̇o2p kinetics were slower ( P < 0.05) in older (τ = 40 ± 17 s) compared with young (τ = 21 ± 6 s) adults. Relative phosphocreatine (PCr) breakdown was greater ( P < 0.05) at 30 s in older compared with young adults. Absolute PCr breakdown at 6 min was greater ( P < 0.05) in older compared with young adults. In young adults, PDH activity increased ( P < 0.05) from baseline to 30 s, with no further change observed at 6 min. In older adults, PDH activity during baseline exercise was similar to that seen in young adults. During the exercise transition, PDH activity did not increase ( P > 0.05) at 30 s of exercise but was elevated ( P < 0.05) after 6 min. The change in deoxyhemoglobin (HHb) was greater for a given V̇o2p in older adults, and there was a similar time course of HHb accompanying the slower V̇o2p kinetics in the older adults, suggesting a slower adaptation of bulk O2 delivery in older adults. In conclusion, the slower adaptation of V̇o2p in older adults is likely a result of both an increased metabolic inertia and lower O2 availability.


2001 ◽  
Vol 22 (3) ◽  
pp. 157-166 ◽  
Author(s):  
Lorena Siqueira ◽  
Marguerite Diab ◽  
Carol Bodian ◽  
Linda Rolnitzky

2011 ◽  
Vol 2011 ◽  
pp. 1-7
Author(s):  
Sheara Williamson ◽  
Deepti Varma ◽  
Michael Brown ◽  
Susan Jansen

Endothelial dysfunction and a sedentary lifestyle may be involved in the development of hypertension which is proliferative among middle-aged African Americans (AA). Signaling molecules derived from the oxidation of 20-carbon fatty acid molecules known as eicosanoids influence vascular tone. The relationship between aerobic fitness and eicosanoid formation following exercise in middle-aged African American hypertensives is unknown.Purpose. To determine the relationship between aerobic capacity and eicosanoid formation after a bout of moderate-intensity exercise in middle-aged AA hypertensives.Methods. Ten sedentary hypertensive AA underwent 50 min of aerobic exercise at 65% VO2max. Urine was collected for 24 hr on two occasions, prior to testing and immediately following the bout of exercise. Urinary metabolites of prostacyclin (6-keto PGF1α) and thromboxane (11-dTXB2) were measured during the day and night periods by high-performance liquid chromatography (HPLC).Results. 6-keto PGF1αlevels significantly increased () following the bout of exercise compared to the control day. There was a significant relationship (, ) between 6-keto PGF1αlevels and VO2max during the exercise day.Conclusion. Based on this preliminary study, there appears to be a relationship between aerobic capacity and exercise-induced 6-keto PGF1αproduction in middle-aged hypertensive AAs. AAs with lower VO2max had lower 6-keto PGF1αformation.


Author(s):  
Ramón F. Rodriguez ◽  
Robert J. Aughey ◽  
François Billaut

In healthy individuals at rest and while performing moderate-intensity exercise, systemic blood flow is distributed to tissues relative to their metabolic oxygen demands. During sustained high-intensity exercise, competition for oxygen delivery arises between locomotor and respiratory muscles, and the heightened metabolic work of breathing, therefore, contributes to limited skeletal muscle oxygenation and contractility. Intriguingly, this does not appear to be the case for intermittent-sprint work. This chapter presents new evidence, based on inspiratory muscle mechanical loading and hypoxic gas breathing, to support that the respiratory system of healthy men is capable of accommodating the oxygen needs of both locomotor and respiratory muscles when work is interspersed with short recovery periods. Only when moderate hypoxemia is induced, substantial oxygen competition arises in favour of the respiratory muscles. These findings extend our understanding of the relationship between mechanical and metabolic limits of varied exercise modes.


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