Skin anti‐inflammatory activity of water‐soluble fullerene nanocomposites encompassed by sodium hyaluronate

2021 ◽  
Author(s):  
Tao Wang ◽  
Hui Li ◽  
Zhe Xu ◽  
Chunru Wang
Keyword(s):  
Sodium Hyaluronate ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals ASSESMENT OF ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF FREEZE DRIED HYDROALCOHOLIC EXTRACT OF Bidens andicola ON ISOLATED NEUTROPHILS

2017 ◽  
Vol 10 (6) ◽  
pp. 160
Author(s):  
Vinueza D ◽  
LÓpez E ◽  
Acosta K ◽  
Abdo S
Keyword(s):  
Freeze Drying ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Hydroalcoholic Extract ◽  
Cytotoxicity Assays ◽  
Aerial Parts ◽  
Controlled Conditions ◽  
Freeze Dried ◽  
Anti Inflammatory

Objective: The aim of this study was to evaluate anti-inflammatory activity and cytotoxicity in vitro of hydroalcoholic extract of Bidens andicola.Methods: B. andicola hydroalcoholic extract was obtained from aerial parts of B. andicola, following a standardized methodology. Briefly, aerial parts of B. andicola were extracted with ethanol 70% v/v and defatted with n-hexane, hydroalcoholic fraction was concentrated under controlled conditions in a rotary evaporator, and finally the residue was freeze-drying to obtain the hydroalcoholic extract of B. andicola. Anti-inflammatory activity and cytotoxicity assays were carried out using in vitro isolated neutrophils model using stable water-soluble tetrazolium salts.Results and Conclusions: The in vitro anti-inflammatory assay on isolated neutrophils demonstrated that the hydroalcoholic extract showed antiinflammatoryactivity compared to aspirin, with inflammatory inhibition percent values of 80.138±0.729 to hydroalcoholic extract of B. andicola and 82.117±0.762 to aspirin, each tested in five replicates at the concentration of 200 ppm of hydroalcoholic extract or reference. 

scholarly journals Anti-Inflammatory Activity of Water-Soluble Polysaccharide ofAgaricus blazeiMurill on Ovariectomized Osteopenic Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Peng Wang ◽  
Xiao-Tao Li ◽  
Lei Sun ◽  
Lei Shen
Keyword(s):  
Interleukin 1 ◽  
Total Antioxidant Status ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Ovx Rats ◽  
Total Antioxidant ◽  
Soluble Polysaccharide ◽  
Cox 2 ◽  
Anti Inflammatory

In the present study, we investigated the anti-inflammatory activity of water-soluble polysaccharide ofAgaricus blazeiMurill (WSP-AbM) on ovariectomized osteopenic rats. The rats were administered orally WSP-AbM (200 mg/kg BW) for 8 weeks. Subsequent serum maleic dialdehyde (MDA) level, total antioxidant status (TAOS), nuclear factor kappa B (NF-κB) level, polymorphonuclear (PMN) cells level, interleukin-1β(IL-1β) level, inducible nitric oxide synthase (iNOS) level, tumor necrosis factor-α(TNF-α) level, adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) were determined by enzyme linked immunosorbent assay (ELISA) and immunohistochemistry, respectively. WSP-AbM administration markedly (P<0.05) decreased serum IL-1βand TNF-αlevels and the expressions of ICAM-1, COX-2, and iNOS NF-κB compared with OVX rats. WSP-AbM administration alsomarkedly (P<0.05) decreased PMN infiltration. In conclusion, we observed that WSP-AbM supplementation had anti-inflammatory effects in a model of osteoporosis disease.

scholarly journals Freshwater Clam Extract Inhibits Inflammatory Responses in LPS-Activated Macrophages by Reducing the Activation of Mitogen-Activated Protein Kinases and NF-κB

2012 ◽  
Vol 7 (11) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Kuo-Feng Hua ◽  
Guan-Ming Chen ◽  
Chen-Lung Ho ◽  
Ming-Chung Chen ◽  
Yi-Lin Sophia Chen ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Inflammatory Responses ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Lipid Lowering ◽  
Spectrometric Analysis ◽  
Activated Macrophages ◽  
Freshwater Clam ◽  
Clam Corbicula ◽  
Anti Inflammatory

Recent studies demonstrated that freshwater clam (Corbicula fluminea) has lipid-lowering and hepatoprotective activities, but its effect on immune responses has not yet been addressed. Here we showed that ethanol extracts of C. fluminea (ECF) reduced nitrite oxide, interleukin-1β, interleukin-6, and tumor necrosis factor-α in lipopolysaccharide-activated macrophages. Further, ECF was fractionated into n-hexane, ethyl acetate, ethanol, and water soluble fractions. Of these, the ethyl acetate soluble fraction (EACF) had the highest capacity to inhibit pro-inflammatory mediators expression. The underlying mechanisms for the anti-inflammatory activity of EACF were demonstrated as down-regulation of ERK1/2, JNK1/2, and p38 phosphorylation and NF-κB activity. Using gas chromatography-mass spectrometric analysis EACF was found to be composed mainly of fatty acids and steroids. Our results provide evidence that freshwater clam has anti-inflammatory activity, and support the possibility for the development of freshwater clam as a health supplement or adjuvant therapeutic agent for either preventing or treating inflammation related diseases.

Anti-inflammatory activity of some water-soluble bioflavonoids

1959 ◽  
Vol 196 (6) ◽  
pp. 1205-1210 ◽  
Author(s):  
Valy Menkin
Keyword(s):  
Vitamin C ◽  
Capillary Permeability ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Inflammatory Exudate ◽  
Inflammatory Agent ◽  
Anti Inflammatory ◽  
Permeability Increase ◽  
Ph Range

The water-soluble citrus bioflavonoid mixture contained in the preparation C.V.P., without added vitamin C, is capable of inhibiting the increased capillary permeability referable in turn to an inflammatory exudate, irrespective of the pH of that exudate. The suppressing effect of these water-soluble bioflavonoids can be demonstrated in concentrations of 5 or 10 mg/0.25 ml of exudative material. They likewise inhibit the effect of leukotaxine that has been extracted from alkaline exudates. In this way they repress not only increased permeability of capillaries, but also the local emigration of leucocytes. Finally this water-soluble bioflavonoid mixture appears to behave as an anti-inflammatory agent over a larger pH range of exudates than either cortisone or corticotropin, (ACTH). Cortisone represses permeability increase and leucocytic migration of alkaline exudate. ACTH suppresses the activity of exudin in its ability to increase local capillary permeability induced by acid exudates. This bioflavonoid mixture is capable of inhibiting in this regard both alkaline and acid exudates. The possible potentials of C.V.P. are pointed out.

scholarly journals Anti-inflammatory activity of soluble chito-oligosaccharides (CHOS) on VitD3-induced human THP-1 monocytes

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246381
Author(s):  
Paiboon Jitprasertwong ◽  
Munthipha Khamphio ◽  
Phornsiri Petsrichuang ◽  
Vincent G. H. Eijsink ◽  
Wanangkan Poolsri ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Vitamin D3 ◽  
Biological Effects ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Low Molecular Weight ◽  
Dependent Manner ◽  
Human Immune ◽  
Anti Inflammatory ◽  
Dose Dependent

Chito-oligosaccharides (CHOS) are oligomers of D-glucosamine and N-acetyl-glucosamine. Anti-inflammatory activities of a wide variety of CHOS mixtures have previously been reported, mainly based on studies with mouse models and murine macrophages. Since the mouse and human immune systems are quite different, gaining insight into the activity of CHOS on human cell lines, using well-characterized CHOS mixtures, is of considerable interest. Bacillus subtilis chitosanase (BsCsn46A) can efficiently convert chitosan to mixtures of water soluble low molecular weight CHOS. Here, the anti-inflammatory activity of a properly characterized CHOS mixture was studied, using human THP-1 cells that were differentiated to mature monocytes using vitamin D3. Addition of CHOS reduced the production of multiple pro-inflammatory cytokines associated with bacterial lipopolyssacharide (LPS)-stimulated inflammation, in a dose-dependent manner and without affecting cell viability. Interestingly, only minimal effects of CHOS were observed in similar experiments with phorbol 12-myristate 13-acetate- (PMA-) differentiated, macrophage-like, THP-1 cells. Altogether, in addition to showing promising biological effects of well-characterized low molecular weight soluble CHOS in a human system, the present study also points at Vitamin D3-stimulated THP-1 cells as a favorable system for assessing the anti-inflammatory activity of bioactive compounds.

Structure of water-soluble polysaccharides in spore of Ganoderma lucidum and their anti-inflammatory activity

2021 ◽  
pp. 131374
Author(s):  
Lingrong Wen ◽  
Zhili Sheng ◽  
Jinping Wang ◽  
Yueming Jiang ◽  
Bao Yang
Keyword(s):  
Ganoderma Lucidum ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Structure Of Water ◽  
Anti Inflammatory

Phytochemical, Quantitative Proximate and In vitro Anti-inflammatory Study of the Crude Methanol Extract of Stachytarpheta indica Leaves (Verbenaceae)

2019 ◽  
pp. 153-162
Author(s):  
Cyril Ogbiko ◽  
Dickson Achimugu Musa ◽  
Musa Usman Dabai ◽  
Ibeabuchi Jude Ali ◽  
Abubakar Sani Yelwa ◽  
...  
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extract ◽  
Proximate Analysis ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Dependent Manner ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Crude Methanol Extract

Herbal medicine despite its increase usage globally is being plagued by inadequate research on their effectiveness. Stachytarpheta indica commonly known as snakeweed is used locally in the management of asthma, headache, alopecia, bronchitis, bruise, chest cold, constipation, itch, diarrhea, skin sore, vermifuge, dysentery, dysmenorrhea among others. This study investigated the phytochemical composition, quantitative proximate parameters and in vitro anti-inflammatory activity of the leaves of S. indica using established methods. Results confirmed the presence of alkaloids, saponins, carbohydrate, cardiac glycosides, terpenoid, tannin, anthraquinones, phenolics and flavonoid. Moisture content (9.16 ± 0.04%), total ash (19.42 ± 0.15%), water insoluble ash (7.17 ± 0.22%), acid insoluble ash (3.63 ± 0.26%), alcohol soluble extractive (0.99 ± 0.06%) and water-soluble extractive (0.36 ± 0.02%) values were obtained from the quantitative proximate analysis. An infusion of the methanol leaf extract of Stachytarpheta indica demonstrated significant anti-inflammatory activity in a dose dependent manner comparable to that of indomethacin standard.

scholarly journals Anti-Inflammatory Activity and Quality Control of Erysimum cheiri (L.) Crantz

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Ghazaleh Mosleh ◽  
Amir Azadi ◽  
Sedigheh Khademian ◽  
Reza Heidari ◽  
Abdolali Mohagheghzadeh
Keyword(s):  
Quality Control ◽  
Diclofenac Sodium ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Drug Candidate ◽  
Aerial Parts ◽  
Stretching Vibration ◽  
Ft Ir ◽  
Anti Inflammatory

Wallflower (Erysimum cheiri) is employed as a popular herbal drug in traditional Persian medicine. Topical formulations including cerates, lotions, sitz baths, and poultices for inflammatory disorders such as arthritis, anal fissure, endometriosis, and mastitis are known. However, there is no monograph in current pharmacopoeia for the wallflower drug. The present study is aimed to screen in vitro anti-inflammatory activity of wallflower and perform quality control and characterization tests for different organs of the herb. In this regard, albumin denaturation activity, macroscopic and microscopic, phytochemical, HPTLC, and FT-IR characteristics were investigated. Wallflower showed strong anti-inflammatory activity compared to diclofenac sodium. The root (1.25, 2.5, and 5 mg/mL) and flower (10 mg/mL) extract exhibited higher anti-inflammatory activities than that of other plant organs at the same concentrations. Moreover, total ash was found higher in aerial parts ( 21.52 ± 0.06 % ) than flower ( 11.01 ± 0.03 % ), root ( 5.03 ± 0.03 % ), and seed ( 6.95 ± 0.06 % ), while water-soluble ash was higher in seed ( 34.89 ± 0.26 % ) than flower ( 5.00 ± 0.03 % ), aerial parts ( 7.16 ± 0.06 % ), and root ( 5.04 ± 0.01 % ). Acid-insoluble ash and sulphated ash were higher in root ( 9.50 ± 0.04 % ) and aerial part ( 28.37 ± 0.57 % ), respectively. In addition, loss on drying was ranged from 2.20 ± 0.20 % in flowers to 6.00 ± 0.10 % in aerial parts. On the other hand, HPTLC analysis verified cardenolide compounds in all organs of the herb, and quercetin was detected in the flavonoid fingerprint of acid hydrolysed flowers. According to FT-IR results, the observed spectral region at ~3500 cm-1 attributed to -OH stretching vibration. Also, C–H (~2900-2950 cm-1), isothiocyanate (~2340 cm-1), -C=O (~1740 cm-1), conjugated C=C of the aromatic ring (~1650 cm-1), and structure of the aromatic group (~1200-1000 cm-1) were monitored. This work is the first study to the best of our knowledge, suggesting wallflower as a potential drug candidate with the basis for a monograph in addition to initial in vitro anti-inflammatory data.

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