In Silico Interaction of HOX Cluster‐Embedded MicroRNAs and Long Non‐Coding RNAs in Oral Cancer

2021 ◽  
Author(s):  
Kanaka Sai Ram Padam ◽  
Dhanraj Salur Basavarajappa ◽  
U Sangeetha Shenoy ◽  
Sanjiban Chakrabarty ◽  
Shama Prasada Kabekkodu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
In Silico ◽  
Hox Cluster ◽  
Non Coding Rnas

HOX cluster-embedded antisense long non-coding RNAs in lung cancer

2019 ◽  
Vol 450 ◽  
pp. 14-21 ◽  
Author(s):  
Lianlian Li ◽  
Yong Wang ◽  
Guoqiang Song ◽  
Xiaoyu Zhang ◽  
Shan Gao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Hox Cluster ◽  
Non Coding Rnas

scholarly journals MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 340 ◽  
Author(s):  
Pei-Ling Hsieh ◽  
Yi-Wen Liao ◽  
Martin Pichler ◽  
Cheng-Chia Yu
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Cancer Stemness ◽  
Aberrant Expression ◽  
The Past ◽  
Key Players ◽  
Non Coding Rnas ◽  
Theranostic Applications ◽  
Significant Attention

Oral cancer belongs to head and neck squamous cell carcinoma and has been recognized as one of the most prevalent malignancies worldwide. Recent studies have suggested that cancer stem cells (CSCs) may participate in tumor initiation, metastasis and even recurrence, so the regulation of CSCs has drawn significant attention over the past decade. Among various molecules that are associated with CSCs, non-coding RNAs (ncRNAs) have been indicated as key players in the acquisition and maintenance of cancer stemness. In addition, accumulating studies have shown that the aberrant expression of these ncRNAs may serve as surrogate diagnostic markers or even therapeutic targets for cancer treatment. The current study reviews the previous work by us and others to summarize how these ncRNAs affect oral cancer stemness and their potential theranostic applications. A better understanding of the implication of these ncRNAs in oral tumorigenesis will facilitate the translation of basic ncRNA research into clinical application in the future.

microRNAs: a new frontier in kallikrein research

2008 ◽  
Vol 389 (6) ◽  
Author(s):  
George M. Yousef
Keyword(s):  
Gene Expression ◽  
Human Tissue ◽  
In Silico ◽  
Regulatory Mechanism ◽  
Transcriptional Level ◽  
Regulate Gene Expression ◽  
New Frontier ◽  
Experimental Approaches ◽  
Non Coding Rnas ◽  
Regulate Gene

Abstract microRNAs (miRNAs) are a recently discovered class of small non-coding RNAs that regulate gene expression. Rapidly accumulating evidence has revealed that miRNAs are associated with cancer. The human tissue kalli-krein gene family is the largest contiguous family of proteases in the human genome, containing 15 genes. Many kallikreins have been reported as potential tumor markers. In this review, recent bioinformatics and experimental evidence is presented indicating that kallikreins are potential miRNA targets. The available experimental approaches to investigate these interactions and the potential diagnostic and therapeutic applications are also discussed. miRNAs represent a possible regulatory mechanism for controlling kallikrein expression at the post-transcriptional level. Many miRNAs were predicted to target kallikreins and a single miRNA can target more than one kallikrein. Recent evidence suggests that miRNAs can also exert ‘quantitative’ control of kallikreins by utilizing multiple targeting sites in the kallikrein mRNA. More research is needed to experimentally verify the in silico predictions and to investigate the possible role in tumor initiation and/or progression.

scholarly journals In-Silico Analysis of Chromatin Modifiers and Profiling of Histone Deacetylases (HDAC's) in Human Oral Cancer

2021 ◽  
Vol 57 (3) ◽  
pp. 176
Author(s):  
Anand K. Sajnani ◽  
Sanket G. Shah ◽  
Mudasir Rashid ◽  
Abhiram Natu ◽  
Poonam B. Gera ◽  
...  
Keyword(s):  
Oral Cancer ◽  
In Silico ◽  
Histone Deacetylases ◽  
In Silico Analysis ◽  
Silico Analysis ◽  
Chromatin Modifiers

scholarly journals Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence Conservation

Biology ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 61 ◽  
Author(s):  
Carlos Herrera-Úbeda ◽  
Marta Marín-Barba ◽  
Enrique Navas-Pérez ◽  
Jan Gravemeyer ◽  
Beatriz Albuixech-Crespo ◽  
...  
Keyword(s):  
Evolutionary Rate ◽  
Sequence Similarity ◽  
Anterior Part ◽  
Expression Domain ◽  
Hox Cluster ◽  
Human Genomes ◽  
Bona Fide ◽  
Non Coding Rnas ◽  
Early Origin ◽  
Origin Of Chordates

Homologous long non-coding RNAs (lncRNAs) are elusive to identify by sequence similarity due to their fast-evolutionary rate. Here we develop LincOFinder, a pipeline that finds conserved intergenic lncRNAs (lincRNAs) between distant related species by means of microsynteny analyses. Using this tool, we have identified 16 bona fide homologous lincRNAs between the amphioxus and human genomes. We characterized and compared in amphioxus and Xenopus the expression domain of one of them, Hotairm1, located in the anterior part of the Hox cluster. In addition, we analyzed the function of this lincRNA in Xenopus, showing that its disruption produces a severe headless phenotype, most probably by interfering with the regulation of the Hox cluster. Our results strongly suggest that this lincRNA has probably been regulating the Hox cluster since the early origin of chordates. Our work pioneers the use of syntenic searches to identify non-coding genes over long evolutionary distances and helps to further understand lncRNA evolution.

scholarly journals Publisher Correction: In silico prediction of housekeeping long intergenic non-coding RNAs reveals HKlincR1 as an essential player in lung cancer cell survival

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Danish Memon ◽  
Jing Bi ◽  
Crispin J. Miller
Keyword(s):  
Lung Cancer ◽  
Cell Survival ◽  
Cancer Cell ◽  
In Silico ◽  
In Silico Prediction ◽  
Lung Cancer Cell ◽  
Cancer Cell Survival ◽  
Non Coding Rnas

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals Cell-Free microRNAs as Potential Oral Cancer Biomarkers: From Diagnosis to Therapy

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1653 ◽  
Author(s):  
Óscar Rapado-González ◽  
Rafael López-López ◽  
José Luis López-Cedrún ◽  
Gabriel Triana-Martínez ◽  
Laura Muinelo-Romay ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Clinical Decision Making ◽  
Cancer Biomarkers ◽  
Clinical Decision ◽  
Educational Interventions ◽  
New Horizons ◽  
Oral Cancer Patients ◽  
Advanced Stages ◽  
Non Coding Rnas ◽  
Noninvasive Biomarkers

Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages associated with poor prognosis and life expectancy. Therefore, there is an urgent need to find noninvasive biomarkers to improve early detection of this tumor. Liquid biopsy has emerged as a valuable tool in medical oncology which provides new horizons for improving clinical decision making. Notably, cell-free microRNAs (miRNAs), a class of short non-coding RNAs, are emerging as novel noninvasive cancer biomarkers. Here, we provide an overview of the potential clinical application of cell-free miRNAs as diagnostic, prognostic, and therapeutic biomarkers in oral cancer.

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