scholarly journals C-reactive protein gene polymorphism predicts the risk of thromboembolic stroke in patients with atrial fibrillation: a more than 10-year prospective follow-up study

2017 ◽  
Vol 15 (8) ◽  
pp. 1541-1546 ◽  
Author(s):  
S.-N. Chang ◽  
L.-P. Lai ◽  
F.-T. Chiang ◽  
J.-L. Lin ◽  
J.-J. Hwang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Gene Polymorphism ◽  
Protein Gene ◽  
Thromboembolic Stroke ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Follow Up Study

ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study

2017 ◽  
Vol 52 (7) ◽  
pp. 680-689
Author(s):  
Sheng-Yu Lee ◽  
Tzu-Yun Wang ◽  
Shiou-Lan Chen ◽  
Yun-Hsuan Chang ◽  
Po-See Chen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Function ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Follow Up Study ◽  
Cytokine Levels

Objectives: We investigated the association of the aldehyde dehydrogenase 2 ( ALDH2) polymorphism (rs671), which is involved with the dopaminergic function, and with changes in cytokine levels and cognitive function, in a 12-week follow-up study in patients with bipolar disorder. Methods: Patients with a first diagnosis of bipolar disorder were recruited. Symptom severity and levels of plasma cytokines (tumor necrosis factor α, C-reactive protein, interleukin 6 and transforming growth factor β1) were examined during weeks 0, 1, 2, 4, 8 and 12. Neurocognitive function was evaluated at baseline and endpoint. The ALDH2 polymorphism genotype was determined. Results: A total of 541 patients with bipolar disorder were recruited, and 355 (65.6%) completed the 12-week follow-up. A multiple linear regression analysis showed a significant ( p = 0.000226) association between the ALDH2 polymorphism and changes in C-reactive protein levels. Different aspects of cognitive function improved in patients with different ALDH2 genotypes. Only patients with the ALDH2*1*1 genotype showed significant correlations between improvement of cognitive function and increased transforming growth factor -β1. Conclusion: The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder. Additionally, changes in cytokine levels and cognitive function were correlated only in patients with specific ALDH2 genotypes.

C-reactive protein gene polymorphism 1009A>G is associated with serum CRP levels in Chinese men: A TCVGHAGE study

2007 ◽  
Vol 382 (1-2) ◽  
pp. 117-123 ◽  
Author(s):  
Wayne H.-H. Sheu ◽  
Yii-Der I. Chen ◽  
Chen-Yuan Yu ◽  
Xiuqing Guo ◽  
Tso-Ching Lee ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Protein Gene ◽  
C Reactive Protein ◽  
Chinese Men ◽  
Reactive Protein ◽  
Serum Crp
Sign in / Sign up

Export Citation Format

Share Document